Strain Name:
C57BL/6J-MtgxR6140Btlr/Mmmh
Stock Number:
044287-MU
Citation ID:
RRID:MMRRC_044287-MU
Other Names:
R6140 (G1)
Major Collection:

Gene Information

Wsb1
Name: WD repeat and SOCS box-containing 1
Synonyms: 2700038M07Rik, 1110056B13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 78889
Homologene: 9218
Slc7a7
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
Synonyms: my+lat1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 20540
Homologene: 88701
Dlgap4
Name: DLG associated protein 4
Synonyms: WBP16, SAP90/PSD-95-associated protein 4, PSD-95/SAP90 binding protein 4, DAP4, Sapap4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228836
Homologene: 8935
Suclg2
Name: succinate-Coenzyme A ligase, GDP-forming, beta subunit
Synonyms: D6Wsu120e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20917
Homologene: 2854
Nf1
Name: neurofibromin 1
Synonyms: neurofibromin, Nf-1, Dsk9, Mhdadsk9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Ralgapb
Name: Ral GTPase activating protein, beta subunit (non-catalytic)
Synonyms: B230339M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228850
Homologene: 10666
Lima1
Name: LIM domain and actin binding 1
Synonyms: 1110021C24Rik, 3526402A12Rik, epithelial protein lost in neoplasm, EPLIN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 65970
Homologene: 9484
Nup214
Name: nucleoporin 214
Synonyms: D2H9S46E, CAN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227720
HGNC: HGNC:8064
Homologene: 38008
Snupn
Name: snurportin 1
Synonyms: 0610031A09Rik, Rnut1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66069
Homologene: 4166
Clic6
Name: chloride intracellular channel 6
Synonyms: CLIC1L, 5730466J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 209195
HGNC: HGNC:2065
Homologene: 43154
Lss
Name: lanosterol synthase
Synonyms: 2810025N20Rik, D10Ertd116e, Osc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16987
HGNC: HGNC:6708
Homologene: 37408
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: 4833421P10Rik, A130030D10Rik, 1110059H15Rik, Zfp650
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68795
Homologene: 52092
Oxt
Name: oxytocin
Synonyms: Oxy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18429
HGNC: HGNC:8528
Homologene: 55494
Zfp507
Name: zinc finger protein 507
Synonyms: A230056M16Rik, 1810022O10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 668501
Homologene: 8942
Lins1
Name: lines homolog 1
Synonyms: 2700083B01Rik, Wins2, Lins
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72635
Homologene: 10034
Ccdc171
Name: coiled-coil domain containing 171
Synonyms: 4930418J05Rik, A330015D16Rik, 4930473A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320226
Homologene: 27942
Ddrgk1
Name: DDRGK domain containing 1
Synonyms: 1110001I20Rik, 2600009E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77006
Homologene: 11400
Baz2b
Name: bromodomain adjacent to zinc finger domain, 2B
Synonyms: D2Ertd794e, 5830435C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 407823
HGNC: HGNC:963
Homologene: 8394
Ssh1
Name: slingshot protein phosphatase 1
Synonyms: mSSH-1L, LOC384311
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231637
Homologene: 41299
Kcnk2
Name: potassium channel, subfamily K, member 2
Synonyms: TREK-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16526
HGNC: HGNC:6277
Homologene: 7794
Hps3
Name: HPS3, biogenesis of lysosomal organelles complex 2 subunit 1
Synonyms: Hermansky-Pudlak syndrome 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12807
Homologene: 13019
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 545370
Homologene: 23741
Agfg2
Name: ArfGAP with FG repeats 2
Synonyms: A630095P14Rik, Hrbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231801
HGNC: HGNC:5177
Homologene: 4430
Slc7a14
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 241919
Homologene: 76320
Cspg4
Name: chondroitin sulfate proteoglycan 4
Synonyms: NG2, AN2, 4732461B14Rik, Cspg4a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 121021
VEGA: 9
HGNC: HGNC:2466
Homologene: 20445
Olfr952
Name: olfactory receptor 952
Synonyms: GA_x6K02T2PVTD-33124064-33123120, MOR171-21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235248
VEGA: 9
Homologene: 133698
2410004P03Rik
Name: RIKEN cDNA 2410004P03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73667
Homologene: 77698
Tpk1
Name: thiamine pyrophosphokinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 29807
Homologene: 6960
Ankrd42
Name: ankyrin repeat domain 42
Synonyms: 4933417L02Rik, Ikbn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 73845
Homologene: 23652
Cfhr4
Name: complement factor H-related 4
Synonyms: Gm4788
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214403
Il18rap
Name: interleukin 18 receptor accessory protein
Synonyms: AcPL accessory protein-like)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16174
HGNC: HGNC:5989
Homologene: 2859
Nrd1
Name: nardilysin, N-arginine dibasic convertase, NRD convertase 1
Synonyms: NRD-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230598
HGNC: HGNC:7995
Homologene: 68260
Mrc2
Name: mannose receptor, C type 2
Synonyms: novel lectin, Endo180, uPARAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17534
Homologene: 4408
Hgd
Name: homogentisate 1, 2-dioxygenase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 15233
HGNC: HGNC:4892
Homologene: 156
Olfr1082
Name: olfactory receptor 1082
Synonyms: GA_x6K02T2Q125-48079993-48079157, MOR192-4_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 404473
Homologene: 104285
Ifih1
Name: interferon induced with helicase C domain 1
Synonyms: Helicard, MDA5, MDA-5, 9130009C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71586
Homologene: 32535
Vmn2r69
Name: vomeronasal 2, receptor 69
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330581
Homologene: 115466
Igsf21
Name: immunoglobulin superfamily, member 21
Synonyms: LOC230868
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230868
Homologene: 13153
Adgra2
Name: adhesion G protein-coupled receptor A2
Synonyms: Tem5, 9530074E10Rik, 8430414O08Rik, Gpr124
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78560
Homologene: 13112
Pla2g12b
Name: phospholipase A2, group XIIB
Synonyms: 2010002E04Rik, Pla2g13, hlb218
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 69836
Homologene: 11356
Vmn1r3
Name: vomeronasal 1 receptor 3
Synonyms: Gm11778
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100312471
Homologene: 128342
Zfp263
Name: zinc finger protein 263
Synonyms: 1200014J04Rik, NT2, mFPM315
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74120
Homologene: 4197
Rnls
Name: renalase, FAD-dependent amine oxidase
Synonyms: 6530404N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67795
Homologene: 41254
Dhrs7c
Name: dehydrogenase/reductase (SDR family) member 7C
Synonyms: 1110001P11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68460
Homologene: 19108
Olfr806
Name: olfactory receptor 806
Synonyms: GA_x6K02T2PULF-11417610-11416669, MOR110-5, MOR110-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258546
Homologene: 73936
Cela1
Name: chymotrypsin-like elastase family, member 1
Synonyms: PC-TsF, Ela-1, 1810009A17Rik, 1810062B19Rik, Ela1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 109901
VEGA: 15
HGNC: HGNC:3308
Homologene: 20454
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 40,525,052 bp
  • A to G, chromosome 1 at 139,732,395 bp
  • A to C, chromosome 1 at 150,732,846 bp
  • G to T, chromosome 1 at 189,209,907 bp
  • C to T, chromosome 2 at 32,051,796 bp
  • T to C, chromosome 2 at 59,912,527 bp
  • A to G, chromosome 2 at 62,601,460 bp
  • A to G, chromosome 2 at 69,973,329 bp
  • A to T, chromosome 2 at 86,594,104 bp
  • A to G, chromosome 2 at 130,576,271 bp
  • A to G, chromosome 2 at 130,658,614 bp
  • A to T, chromosome 2 at 156,762,729 bp
  • T to C, chromosome 2 at 158,456,572 bp
  • A to G, chromosome 3 at 19,996,987 bp
  • C to A, chromosome 3 at 31,237,548 bp
  • A to G, chromosome 4 at 3,185,031 bp
  • C to T, chromosome 4 at 83,696,317 bp
  • G to T, chromosome 4 at 109,049,111 bp
  • T to A, chromosome 4 at 140,107,373 bp
  • A to G, chromosome 5 at 113,942,631 bp
  • T to C, chromosome 5 at 137,667,085 bp
  • A to T, chromosome 6 at 43,423,701 bp
  • T to C, chromosome 6 at 95,569,721 bp
  • A to G, chromosome 7 at 35,794,188 bp
  • T to C, chromosome 7 at 66,711,924 bp
  • G to A, chromosome 7 at 85,411,449 bp
  • T to C, chromosome 7 at 92,591,828 bp
  • A to T, chromosome 8 at 27,115,405 bp
  • A to G, chromosome 9 at 39,426,247 bp
  • A to T, chromosome 9 at 56,897,224 bp
  • C to A, chromosome 9 at 56,982,824 bp
  • G to A, chromosome 10 at 59,421,441 bp
  • T to C, chromosome 10 at 76,550,688 bp
  • T to G, chromosome 10 at 129,738,654 bp
  • A to T, chromosome 11 at 67,815,074 bp
  • A to T, chromosome 11 at 79,241,618 bp
  • T to A, chromosome 11 at 79,473,320 bp
  • A to G, chromosome 11 at 105,346,789 bp
  • T to C, chromosome 12 at 17,005,922 bp
  • G to A, chromosome 14 at 54,379,058 bp
  • C to T, chromosome 15 at 99,781,058 bp
  • C to T, chromosome 15 at 100,681,156 bp
  • A to G, chromosome 16 at 3,748,217 bp
  • A to T, chromosome 16 at 37,589,713 bp
  • A to G, chromosome 16 at 92,539,492 bp
  • A to T, chromosome 19 at 33,138,200 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6140 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044287-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.