Strain Name:
C57BL/6J-MtgxR6143Btlr
Stock Number:
044290-MU
Citation ID:
RRID:MMRRC_044290-MU
Other Names:
R6143 (G1)
Major Collection:

Gene Information

Nrp2
Name: neuropilin 2
Synonyms: NP2, Npn-2, Npn2, NP-2, 1110048P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18187
HGNC: HGNC:8005
Homologene: 2875
Neurod4
Name: neurogenic differentiation 4
Synonyms: MATH-3, Math3, Atoh3, bHLHa4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11923
VEGA: 10
Homologene: 7234
Dnmt1
Name: DNA methyltransferase (cytosine-5) 1
Synonyms: MTase, Dnmt1o, Cxxc9, MommeD2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13433
VEGA: 9
HGNC: HGNC:2976
Homologene: 124071
Arhgap39
Name: Rho GTPase activating protein 39
Synonyms: D15Wsu169e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223666
Homologene: 27825
Pck1
Name: phosphoenolpyruvate carboxykinase 1, cytosolic
Synonyms: Pck-1, PEPCK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18534
HGNC: HGNC:8724
Homologene: 1944
Ncaph2
Name: non-SMC condensin II complex, subunit H2
Synonyms: 0610010J20Rik, 2610524G04Rik, D15Ertd785e, Kleisin beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 52683
Homologene: 12045
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 328329
Homologene: 42094
Gpbp1
Name: GC-rich promoter binding protein 1
Synonyms: 1700034P14Rik, D230035M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 73274
Homologene: 11292
Papola
Name: poly (A) polymerase alpha
Synonyms: Plap, PapIII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18789
Homologene: 23389
Bzw2
Name: basic leucine zipper and W2 domains 2
Synonyms: HSPC028, 1110001I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 66912
VEGA: 12
Homologene: 8530
Brwd1
Name: bromodomain and WD repeat domain containing 1
Synonyms: 5330419I02Rik, D530019K20Rik, G1-403-16, Wdr9, repro5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 93871
Homologene: 23130
Nvl
Name: nuclear VCP-like
Synonyms: 1200009I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67459
HGNC: HGNC:8070
Homologene: 1902
Cyfip2
Name: cytoplasmic FMR1 interacting protein 2
Synonyms: Pir121, 6430511D02Rik, 1500004I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76884
Homologene: 7936
Pten
Name: phosphatase and tensin homolog
Synonyms: MMAC1, TEP1, 2310035O07Rik, A130070J02Rik, B430203M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 19211
HGNC: HGNC:9588
Homologene: 265
Atp13a1
Name: ATPase type 13A1
Synonyms: catp, Cgi152, Atp13a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 170759
VEGA: 8
Homologene: 5791
Srsf1
Name: serine and arginine-rich splicing factor 1
Synonyms: 1110054N12Rik, 6330415C05Rik, 5730507C05Rik, Sfrs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 110809
Homologene: 31411
Naf1
Name: nuclear assembly factor 1 ribonucleoprotein
Synonyms: LOC234344
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234344
Homologene: 128518
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: 1810042B05Rik, Coh1, C330002D13Rik, 2310042E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230895
Homologene: 15583
Klhl23
Name: kelch-like 23
Synonyms: C130068N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 277396
Homologene: 18628
Csgalnact1
Name: chondroitin sulfate N-acetylgalactosaminyltransferase 1
Synonyms: CSGalNAcT-1, 4732435N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234356
Homologene: 23099
Mme
Name: membrane metallo endopeptidase
Synonyms: CD10, neprilysin, 6030454K05Rik, NEP, neutral endopeptidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17380
HGNC: HGNC:7154
Homologene: 5275
Pfkl
Name: phosphofructokinase, liver, B-type
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18641
HGNC: HGNC:8876
Homologene: 55668
Dnpep
Name: aspartyl aminopeptidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13437
HGNC: HGNC:2981
Homologene: 6110
Hnrnpdl
Name: heterogeneous nuclear ribonucleoprotein D-like
Synonyms: JKTBP, D5Wsu145e, D5Ertd650e, hnRNP-DL, Hnrpdl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 50926
HGNC: HGNC:5037
Homologene: 75314
Nbeal1
Name: neurobeachin like 1
Synonyms: A530050O19Rik, ALS2CR17, A530083I02Rik, 2310076G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269198
Homologene: 16453
Edc4
Name: enhancer of mRNA decapping 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234699
Homologene: 40937
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94109
Homologene: 69536
Cebpb
Name: CCAAT/enhancer binding protein (C/EBP), beta
Synonyms: NF-IL6, C/EBP BETA, NF-M, CRP2, LAP, IL-6DBP, Nfil6, C/EBPbeta, LIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12608
HGNC: HGNC:1834
Homologene: 3807
Col9a2
Name: collagen, type IX, alpha 2
Synonyms: Col9a-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12840
HGNC: HGNC:2218
Homologene: 37535
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Mdnah5, b2b1154Clo, b2b1134Clo, b2b1537Clo, b2b1565Clo, Dnahc5, b2b3491Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Drc3
Name: dynein regulatory complex subunit 3
Synonyms: 4930449E07Rik, m6Bei, Lrrc48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74665
Homologene: 12581
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: Cchl1a3, fmd, mdg, sj, muscle dysgenesis, Cav1.1, DHPR alpha1s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Scn9a
Name: sodium channel, voltage-gated, type IX, alpha
Synonyms: PN1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20274
Homologene: 2237
Cep162
Name: centrosomal protein 162
Synonyms: 4922501C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382090
Homologene: 8930
Speg
Name: SPEG complex locus
Synonyms: BPEG, SPEGbeta, SPEGalpha, D1Bwg1450e, SPEG, Apeg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11790
Homologene: 55619
Tmprss11f
Name: transmembrane protease, serine 11f
Synonyms: 4732406D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243083
Homologene: 65356
Myo5c
Name: myosin VC
Synonyms: 9130003O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208943
VEGA: 9
HGNC: HGNC:7604
Homologene: 135711
Iqsec1
Name: IQ motif and Sec7 domain 1
Synonyms: cI-43, D6Ertd349e, BRAG2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232227
Homologene: 82429
Retreg2
Name: reticulophagy regulator family member 2
Synonyms: MGC47289, Fam134a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227298
Homologene: 11507
Enthd1
Name: ENTH domain containing 1
Synonyms: LOC383075
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 383075
VEGA: 15
Homologene: 45131
Prtn3
Name: proteinase 3
Synonyms: myeloblastin, mPR3, PR3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19152
HGNC: HGNC:9495
Homologene: 120934
Irgm2
Name: immunity-related GTPase family M member 2
Synonyms: Gtpi, Iigp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 54396
Homologene: 78363
Mrps31
Name: mitochondrial ribosomal protein S31
Synonyms: Imogen44, 1500002D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 57312
Homologene: 4255
Vmn2r118
Name: vomeronasal 2, receptor 118
Synonyms: EG668547, Vmn2r119, EG383258
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 383258
Homologene: 129687
Sgk2
Name: serum/glucocorticoid regulated kinase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27219
Homologene: 8446
Tctn3
Name: tectonic family member 3
Synonyms: Tect3, 4930521E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67590
Homologene: 9221
Slc19a3
Name: solute carrier family 19, member 3
Synonyms: ThTr2, A230084E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 80721
Homologene: 23530
Abcd2
Name: ATP-binding cassette, sub-family D (ALD), member 2
Synonyms: ALDR, ALDL1, adrenoleukodystrophy related, ABC39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 26874
VEGA: 15
HGNC: HGNC:66
Homologene: 55873
Psg22
Name: pregnancy-specific glycoprotein 22
Synonyms: cea9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243862
Homologene: 110989
Dvl3
Name: dishevelled segment polarity protein 3
Synonyms: b2b2866Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13544
HGNC: HGNC:3087
Homologene: 20928
Hsd3b7
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101502
Homologene: 41617
Dnajb5
Name: DnaJ heat shock protein family (Hsp40) member B5
Synonyms: Hsp40-3, Hsc40, 1110058L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56323
Homologene: 8176
Dyrk4
Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
Synonyms: Dyrk4b, Dyrk4a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101320
HGNC: HGNC:3095
Homologene: 37858
Pdilt
Name: protein disulfide isomerase-like, testis expressed
Synonyms: PDILT, 1700007B13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71830
Homologene: 18382
Olfr483
Name: olfactory receptor 483
Synonyms: GA_x6K02T2PBJ9-10432095-10433042, MOR204-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258730
Homologene: 133602
Cyp2d34
Name: cytochrome P450, family 2, subfamily d, polypeptide 34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223706
VEGA: 15
Homologene: 86099
A730061H03Rik
Name: RIKEN cDNA A730061H03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Snai2
Name: snail family zinc finger 2
Synonyms: Slugh, Slug, Snail2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 20583
VEGA: 16
Homologene: 31127
Dbndd2
Name: dysbindin (dystrobrevin binding protein 1) domain containing 2
Synonyms: 2900022J10Rik, 1110017A21Rik, D2Bwg0891e, NKIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 52840
Homologene: 12276
Gm5622
Name: predicted gene 5622
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 434459
Homologene: 115686
Pcdhgc4
Name: protocadherin gamma subfamily C, 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93707
HGNC: HGNC:8717
Homologene: 110932
Art2a
Name: ADP-ribosyltransferase 2a
Synonyms: Rt6-1, Rt-6, Rt6, Art2a-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11871
Ighv5-16
Name: immunoglobulin heavy variable 5-16
Synonyms: Gm16632
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 633568
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 60,251,307 bp
  • A to T, chromosome 1 at 62,760,815 bp
  • A to G, chromosome 1 at 75,146,886 bp
  • G to A, chromosome 1 at 75,315,228 bp
  • G to A, chromosome 1 at 75,414,387 bp
  • C to T, chromosome 1 at 83,026,339 bp
  • T to G, chromosome 1 at 136,076,758 bp
  • T to G, chromosome 1 at 181,134,995 bp
  • T to C, chromosome 2 at 66,487,524 bp
  • C to A, chromosome 2 at 69,833,696 bp
  • G to A, chromosome 2 at 76,852,069 bp
  • T to A, chromosome 2 at 162,999,254 bp
  • C to A, chromosome 2 at 164,488,286 bp
  • C to A, chromosome 2 at 167,689,300 bp
  • A to T, chromosome 2 at 173,154,012 bp
  • T to G, chromosome 3 at 63,300,111 bp
  • A to T, chromosome 4 at 42,956,990 bp
  • A to T, chromosome 4 at 121,053,863 bp
  • G to T, chromosome 4 at 145,148,565 bp
  • T to A, chromosome 5 at 86,539,699 bp
  • A to T, chromosome 5 at 100,036,551 bp
  • C to T, chromosome 6 at 90,809,684 bp
  • C to T, chromosome 6 at 126,886,651 bp
  • C to T, chromosome 7 at 18,722,798 bp
  • T to C, chromosome 7 at 101,555,223 bp
  • A to G, chromosome 7 at 108,104,128 bp
  • T to A, chromosome 7 at 119,495,042 bp
  • A to C, chromosome 7 at 127,801,232 bp
  • T to C, chromosome 8 at 16,088,301 bp
  • T to G, chromosome 8 at 22,411,523 bp
  • T to C, chromosome 8 at 66,877,695 bp
  • T to A, chromosome 8 at 68,373,550 bp
  • C to T, chromosome 8 at 69,805,360 bp
  • T to A, chromosome 8 at 105,885,874 bp
  • T to C, chromosome 9 at 20,927,134 bp
  • A to G, chromosome 9 at 75,249,809 bp
  • C to A, chromosome 9 at 87,212,851 bp
  • T to A, chromosome 10 at 77,989,613 bp
  • T to A, chromosome 10 at 79,880,548 bp
  • T to G, chromosome 10 at 130,271,000 bp
  • A to C, chromosome 11 at 46,253,965 bp
  • A to T, chromosome 11 at 58,220,609 bp
  • G to A, chromosome 11 at 60,370,580 bp
  • G to A, chromosome 11 at 88,049,599 bp
  • A to T, chromosome 12 at 36,120,726 bp
  • T to C, chromosome 12 at 105,826,960 bp
  • G to T, chromosome 12 at 113,838,618 bp
  • A to T, chromosome 13 at 102,853,883 bp
  • G to A, chromosome 13 at 111,466,855 bp
  • A to T, chromosome 14 at 51,654,915 bp
  • A to G, chromosome 14 at 55,560,279 bp
  • T to A, chromosome 15 at 28,233,231 bp
  • T to C, chromosome 15 at 35,668,738 bp
  • T to A, chromosome 15 at 76,730,406 bp
  • T to C, chromosome 15 at 80,509,286 bp
  • G to A, chromosome 15 at 82,620,776 bp
  • T to C, chromosome 15 at 89,364,003 bp
  • A to T, chromosome 15 at 91,190,947 bp
  • A to T, chromosome 16 at 14,708,243 bp
  • A to G, chromosome 16 at 20,527,039 bp
  • C to T, chromosome 16 at 96,002,956 bp
  • G to T, chromosome 17 at 55,592,871 bp
  • T to A, chromosome 18 at 37,817,600 bp
  • A to G, chromosome 19 at 32,800,085 bp
  • G to T, chromosome 19 at 40,609,227 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6143 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044290-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.