Strain Name:
C57BL/6J-MtgxR6148Btlr/Mmmh
Stock Number:
044295-MU
Citation ID:
RRID:MMRRC_044295-MU
Other Names:
R6148 (G1)
Major Collection:

Strain Information

Gabrg1
Name: gamma-aminobutyric acid type A receptor subunit gamma 1
Synonyms: GabaA
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14405
HGNC: HGNC:4086
Homologene: 22570
Cyp19a1
Name: cytochrome P450, family 19, subfamily a, polypeptide 1
Synonyms: aromatase, Int-5, Cyp19, Int5, p450arom, Ar, ArKO
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13075
VEGA: 9
HGNC: HGNC:2594
Homologene: 30955
Galnt10
Name: polypeptide N-acetylgalactosaminyltransferase 10
Synonyms: GalNAc-T10, C330012K04Rik, Galnt9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 171212
Homologene: 14924
Dclre1c
Name: DNA cross-link repair 1C
Synonyms: Art, Artemis, 9930121L06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227525
Homologene: 32547
Hap1
Name: huntingtin-associated protein 1
Synonyms: HAP-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15114
HGNC: HGNC:4812
Homologene: 2935
Itsn1
Name: intersectin 1 (SH3 domain protein 1A)
Synonyms: Sh3p17, Intersectin-L, EHSH1, Eh domain, SH3 domain regulator of endocytosis 1, Ese1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16443
HGNC: HGNC:6183
Homologene: 2277
Prdm2
Name: PR domain containing 2, with ZNF domain
Synonyms: LOC381568, KMT8, Riz, E330024L24Rik, 4833427P12Rik, Riz1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 110593
HGNC: HGNC:9347
Homologene: 40822
Fmn2
Name: formin 2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 54418
Homologene: 137334
Kpna6
Name: karyopherin subunit alpha 6
Synonyms: NPI-2, importin alpha 7, IPOA7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16650
HGNC: HGNC:6399
Homologene: 22472
Rbbp4
Name: retinoblastoma binding protein 4, chromatin remodeling factor
Synonyms: RBAP48, CAF-1 p48 subunit
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19646
HGNC: HGNC:9887
Homologene: 21153
Os9
Name: amplified in osteosarcoma
Synonyms: 4632413K17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216440
VEGA: 10
Homologene: 31409
Cep78
Name: centrosomal protein 78
Synonyms: 5730599I05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 208518
VEGA: 19
Homologene: 11030
Mark4
Name: MAP/microtubule affinity regulating kinase 4
Synonyms: 2410090P21Rik, Markl1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232944
Homologene: 57146
Ipo8
Name: importin 8
Synonyms: C130009K11Rik, 6230418K12Rik, Ranbp8, OM-1, Om1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320727
HGNC: HGNC:9853
Homologene: 48430
Znhit1
Name: zinc finger, HIT domain containing 1
Synonyms: 2700001K05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70103
Homologene: 4630
Rnd2
Name: Rho family GTPase 2
Synonyms: Rohn, Arhn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11858
Homologene: 21123
Pex19
Name: peroxisomal biogenesis factor 19
Synonyms: Pxf, peroxisome biogenesis factor 19
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19298
HGNC: HGNC:9713
Homologene: 134253
2700049A03Rik
Name: RIKEN cDNA 2700049A03 gene
Synonyms: talpid3, Ta3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76967
Homologene: 8839
Cwc22
Name: CWC22 spliceosome-associated protein
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 80744
Homologene: 6048
Wdcp
Name: WD repeat and coiled coil containing
Synonyms: BC068281
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238037
VEGA: 12
Homologene: 49822
Cd34
Name: CD34 antigen
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12490
HGNC: HGNC:1662
Homologene: 1343
AAdacl4fm3
Name: AADACL4 family member 3
Synonyms: Gm13178
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 546849
Homologene: 82586
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Cxcl5
Name: C-X-C motif chemokine ligand 5
Synonyms: LIX, Scyb5, AMCF-II, Cxcl6, ENA-78, granulocyte chemotactic protein-2, GCP-2, Scyb6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20311
Homologene: 88671
Ccdc73
Name: coiled-coil domain containing 73
Synonyms: 2210415I11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 211936
Homologene: 52235
Bbs7
Name: Bardet-Biedl syndrome 7
Synonyms: 8430406N16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71492
Homologene: 12395
Gsap
Name: gamma-secretase activating protein
Synonyms: Pion, A530088I07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212167
Homologene: 45504
Unc13c
Name: unc-13 homolog C
Synonyms: D9Ertd414e, 1500037O19Rik, Munc13-3, Unc13h3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208898
Homologene: 45443
Gucy2d
Name: guanylate cyclase 2d
Synonyms: guanylyl cyclase D
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14918
Homologene: 71540
Agbl3
Name: ATP/GTP binding protein-like 3
Synonyms: 2900053G10Rik, Ccp3, Ccp3, 6530406M24Rik, 4930431N21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76223
Homologene: 35330
Cfap69
Name: cilia and flagella associated protein 69
Synonyms: A330021E22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 207686
Homologene: 11718
Or11g27
Name: olfactory receptor family 11 subfamily G member 27
Synonyms: Olfr743-ps1, Olfr265, MOR106-8P, MOR106-14, GA_x6K02T2PMLR-6243196-6244132, GA_x6K02T2N6FY-3870-3385, GA_x6K02T2N6FY-2320-2039, Olfr264, Olfr743
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219019
Homologene: 74163
Sult1e1
Name: sulfotransferase family 1E, member 1
Synonyms: EST, Ste
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20860
Homologene: 101388
Mrpl21
Name: mitochondrial ribosomal protein L21
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 353242
Homologene: 32936
Tns1
Name: tensin 1
Synonyms: 1200014E20Rik, E030037J05Rik, 1110018I21Rik, Tns, E030018G17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21961
Homologene: 11219
Irf5
Name: interferon regulatory factor 5
Synonyms: mirf5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27056
HGNC: HGNC:6120
Homologene: 8088
Gpr39
Name: G protein-coupled receptor 39
Synonyms: 4933415E13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71111
HGNC: HGNC:4496
Homologene: 20380
Fes
Name: feline sarcoma oncogene
Synonyms: c-fes
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14159
HGNC: HGNC:3657
Homologene: 37563
Ano9
Name: anoctamin 9
Synonyms: 5430425C04Rik, Tp53i5, Trp53i5, Tmem16j
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71345
Homologene: 67083
Vmn2r55
Name: vomeronasal 2, receptor 55
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042499
Homologene: 104040
Pcdhb14
Name: protocadherin beta 14
Synonyms: PcdhbN, Pcdhb17, 2210006M07Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93885
Homologene: 70876
Vmn2r52
Name: vomeronasal 2, receptor 52
Synonyms: EG384534
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384534
Homologene: 129605
Or4c15
Name: olfactory receptor family 4 subfamily C member 15
Synonyms: GA_x6K02T2Q125-50409367-50408432, MOR233-16P, Olfr1211, MOR233-21
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258025
Homologene: 81548
Klf11
Name: Kruppel-like transcription factor 11
Synonyms: Tieg3, Tieg2b, D12Ertd427e, Tieg2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 194655
Homologene: 2668
Cpne7
Name: copine VII
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102278
HGNC: HGNC:2320
Homologene: 65128
Fkbpl
Name: FK506 binding protein-like
Synonyms: DIR1, Ppiase-X, WISp39, NG7, WAF-1/CIP1 stabilizing protein 39
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56299
Homologene: 10529
Fmo1
Name: flavin containing monooxygenase 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14261
HGNC: HGNC:3769
Homologene: 55520
Myrf
Name: myelin regulatory factor
Synonyms: LOC225908, LOC386531, Gm98
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225908
HGNC: HGNC:1181
Homologene: 32167
Or10d4c
Name: olfactory receptor family 10 subfamily D member 4C
Synonyms: GA_x6K02T2PVTD-33343617-33344561, Olfr961, MOR224-5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258497
VEGA: 9
Homologene: 74020
Or52n3
Name: olfactory receptor family 52 subfamily N member 3
Synonyms: Olfr665, GA_x6K02T2PBJ9-7509539-7510489, MOR34-7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258810
Homologene: 110477
Spaca9
Name: sperm acrosome associated 9
Synonyms: Mast, 1700026L06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69987
HGNC: HGNC:1367
Homologene: 10346
Zbtb3
Name: zinc finger and BTB domain containing 3
Synonyms: 4930563M09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 75291
VEGA: 19
Homologene: 23485
Birc3
Name: baculoviral IAP repeat-containing 3
Synonyms: RNF49, Api2, cIAP2, MIAP2, MIHC, HIAP2, IAP2, cIAP-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11796
HGNC: HGNC:591
Homologene: 899
Cd177
Name: CD177 antigen
Synonyms: Pdp3, 1190003K14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68891
Homologene: 49628
Dvl1
Name: dishevelled segment polarity protein 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13542
Homologene: 20926
Catsper4
Name: cation channel, sperm associated 4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329954
Homologene: 18638
Defa41
Name: defensin, alpha, 41
Synonyms: Gm15293
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100041759
Homologene: 113382
Ppdpf
Name: pancreatic progenitor cell differentiation and proliferation factor
Synonyms: 3110053G12Rik, 2610317A05Rik, 0610012G23Rik, 2700038C09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66496
Homologene: 11511
Olfr515-ps1
Name: olfactory receptor 515, pseudogene 1
Synonyms: GA_x6K02T2PBJ9-11173791-11173651
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 404398
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 73,953,453 bp
  • T to C, chromosome 1 at 125,872,586 bp
  • T to G, chromosome 1 at 162,851,519 bp
  • G to A, chromosome 1 at 172,134,039 bp
  • T to C, chromosome 1 at 174,666,663 bp
  • T to C, chromosome 1 at 194,948,008 bp
  • A to G, chromosome 2 at 3,437,705 bp
  • G to A, chromosome 2 at 28,693,781 bp
  • ATCTCTCTCTCTCTCTCT to ATCTCTCTCTCTCTCT, chromosome 2 at 77,929,459 bp
  • C to T, chromosome 2 at 88,930,253 bp
  • T to G, chromosome 2 at 104,992,137 bp
  • G to A, chromosome 2 at 181,187,848 bp
  • C to A, chromosome 3 at 36,613,266 bp
  • T to C, chromosome 4 at 129,321,958 bp
  • G to A, chromosome 4 at 129,649,306 bp
  • A to G, chromosome 4 at 134,217,929 bp
  • A to G, chromosome 4 at 143,132,907 bp
  • T to C, chromosome 4 at 144,721,317 bp
  • A to G, chromosome 4 at 155,854,952 bp
  • T to C, chromosome 5 at 5,663,996 bp
  • A to G, chromosome 5 at 21,226,325 bp
  • A to T, chromosome 5 at 21,270,577 bp
  • A to T, chromosome 5 at 70,774,461 bp
  • A to T, chromosome 5 at 87,579,911 bp
  • A to T, chromosome 5 at 90,759,706 bp
  • A to T, chromosome 5 at 136,982,633 bp
  • T to C, chromosome 6 at 29,535,959 bp
  • T to A, chromosome 6 at 34,857,753 bp
  • A to G, chromosome 6 at 148,799,780 bp
  • T to C, chromosome 7 at 10,171,163 bp
  • C to A, chromosome 7 at 12,668,142 bp
  • A to T, chromosome 7 at 19,429,516 bp
  • A to T, chromosome 7 at 24,744,273 bp
  • A to G, chromosome 7 at 80,380,296 bp
  • A to T, chromosome 7 at 98,443,823 bp
  • A to G, chromosome 7 at 104,881,082 bp
  • A to T, chromosome 7 at 108,844,971 bp
  • A to G, chromosome 7 at 141,106,785 bp
  • A to G, chromosome 8 at 21,202,412 bp
  • A to G, chromosome 8 at 123,127,432 bp
  • T to A, chromosome 9 at 7,849,683 bp
  • G to T, chromosome 9 at 39,647,259 bp
  • C to T, chromosome 9 at 54,180,256 bp
  • G to C, chromosome 9 at 73,693,366 bp
  • T to C, chromosome 10 at 127,099,943 bp
  • T to C, chromosome 11 at 57,784,648 bp
  • A to T, chromosome 11 at 100,349,392 bp
  • C to T, chromosome 11 at 101,468,999 bp
  • T to C, chromosome 12 at 4,850,621 bp
  • T to C, chromosome 12 at 24,651,568 bp
  • T to A, chromosome 12 at 71,187,426 bp
  • A to G, chromosome 14 at 50,534,321 bp
  • T to C, chromosome 16 at 32,753,802 bp
  • C to T, chromosome 16 at 91,816,852 bp
  • G to A, chromosome 17 at 34,645,329 bp
  • A to G, chromosome 18 at 37,449,230 bp
  • A to T, chromosome 19 at 3,283,084 bp
  • C to T, chromosome 19 at 8,804,196 bp
  • G to A, chromosome 19 at 10,212,475 bp
  • G to A, chromosome 19 at 15,981,786 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6148 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044295-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.