Strain Name:
C57BL/6J-MtgxR6157Btlr
Stock Number:
044304-MU
Citation ID:
RRID:MMRRC_044304-MU
Other Names:
R6157 (G1)
Major Collection:

Gene Information

Nfatc2
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
Synonyms: NFATp, NFAT1, NFAT1-D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18019
HGNC: HGNC:7776
Homologene: 7861
Slc6a5
Name: solute carrier family 6 (neurotransmitter transporter, glycine), member 5
Synonyms: Glyt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 104245
Homologene: 37901
Rasgrp2
Name: RAS, guanyl releasing protein 2
Synonyms: Caldaggef1, CalDAG-GEFI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 19395
HGNC: HGNC:9879
Homologene: 4250
Kcns2
Name: K+ voltage-gated channel, subfamily S, 2
Synonyms: E130006J24Rik, Kv9.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16539
VEGA: 15
HGNC: HGNC:6301
Homologene: 22465
Dst
Name: dystonin
Synonyms: Bpag1, Bpag, 2310001O04Rik, nmf339, BPAG1, BPAG1-n, bullous pemphigoid antigen 1, Macf2, nmf203, bullous pemphigoid antigen 1, athetoid, A830042E19Rik, ah
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Tet1
Name: tet methylcytosine dioxygenase 1
Synonyms: Cxxc6, BB001228, 2510010B09Rik, D10Ertd17e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 52463
Homologene: 12735
Blm
Name: Bloom syndrome, RecQ like helicase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12144
HGNC: HGNC:1058
Homologene: 47902
Plaat1
Name: phospholipase A and acyltransferase 1
Synonyms: 2810012B06Rik, Hrasls, A-C1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 27281
Homologene: 8452
Csrnp3
Name: cysteine-serine-rich nuclear protein 3
Synonyms: CSRNP-3, mbu1, A330102K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77771
Homologene: 11803
Xrcc6
Name: X-ray repair complementing defective repair in Chinese hamster cells 6
Synonyms: G22p1, Ku70, Ku p70
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14375
HGNC: HGNC:4055
Homologene: 37483
Smpd4
Name: sphingomyelin phosphodiesterase 4
Synonyms: neutral membrane (neutral sphingomyelinase-3), 4122402O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77626
Homologene: 9813
Fer
Name: fer (fms/fps related) protein kinase
Synonyms: Fert2, Fert, C330004K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14158
VEGA: 17
HGNC: HGNC:3655
Homologene: 74300
Ufl1
Name: UFM1 specific ligase 1
Synonyms: Rcad, 1810074P20Rik, Maxer
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67490
Homologene: 9093
Tctex1d2
Name: Tctex1 domain containing 2
Synonyms: 0610012D17Rik, 2410011K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 66061
Homologene: 41625
Atg4c
Name: autophagy related 4C, cysteine peptidase
Synonyms: Autl1, autophagin 3, Apg4c, Apg4-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242557
Homologene: 56296
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Dnajc10
Name: DnaJ heat shock protein family (Hsp40) member C10
Synonyms: JPDI, 1200006L06Rik, D2Ertd706e, ERdj5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66861
Homologene: 10358
Ripor2
Name: RHO family interacting cell polarization regulator 2
Synonyms: 1700108N18Rik, 6330500D04Rik, Fam65b, E430013J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 193385
Homologene: 9284
Tln1
Name: talin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21894
Homologene: 21267
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: 2610100B16Rik, Ten-m3, Odz3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 23965
Homologene: 22673
Zbtb48
Name: zinc finger and BTB domain containing 48
Synonyms: 0610011D15Rik, Hkr3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100090
HGNC: HGNC:4930
Homologene: 3905
Atp2a3
Name: ATPase, Ca++ transporting, ubiquitous
Synonyms: Serca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53313
HGNC: HGNC:813
Homologene: 69131
Zfp534
Name: zinc finger protein 534
Synonyms: Gm13159
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100503584
Homologene: 133076
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hyrh, hy3, hy-3, 1700034M11Rik, 4930545D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244653
Homologene: 52118
Ush2a
Name: usherin
Synonyms: MUSH2A, A930011D15Rik, Ushrn, Ush2a, LOC269160, LOC381317, A930037M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22283
Homologene: 66151
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329178
Homologene: 122243
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20192
Homologene: 68151
Plcb3
Name: phospholipase C, beta 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18797
VEGA: 19
HGNC: HGNC:9056
Homologene: 47960
Rpgrip1
Name: retinitis pigmentosa GTPase regulator interacting protein 1
Synonyms: nmf247, 4930505G06Rik, 4930401L23Rik, A930002K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 77945
Homologene: 10679
Abcb1b
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1B
Synonyms: mdr, Mdr1b, Mdr1, Abcb1, Pgy1, Pgy-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18669
Homologene: 69084
Ecsit
Name: ECSIT signalling integrator
Synonyms: Sitpec
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 26940
Homologene: 8080
Psd3
Name: pleckstrin and Sec7 domain containing 3
Synonyms: EFA6D, 4931420C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234353
Homologene: 87257
Pld4
Name: phospholipase D family, member 4
Synonyms: thss
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104759
VEGA: 12
Homologene: 16350
4930407I10Rik
Name: RIKEN cDNA 4930407I10 gene
Synonyms: LOC328573
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 328573
VEGA: 15
Homologene: 130065
Hltf
Name: helicase-like transcription factor
Synonyms: Smarca3, P113, Snf2l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20585
Homologene: 30136
Meioc
Name: meiosis specific with coiled-coil domain
Synonyms: Gm1564, LOC268491, LOC380729
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268491
Homologene: 19559
Hdac9
Name: histone deacetylase 9
Synonyms: HDRP, Mitr, D030072B18Rik, Hdac7b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 79221
Homologene: 128578
Ssrp1
Name: structure specific recognition protein 1
Synonyms: Hmg1-rs1, T160, Hmgox, Hmgi-rs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20833
Homologene: 110735
Spsb4
Name: splA/ryanodine receptor domain and SOCS box containing 4
Synonyms: D030068E18Rik, Ssb4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 211949
Homologene: 25315
Mocs1
Name: molybdenum cofactor synthesis 1
Synonyms: 3110045D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56738
HGNC: HGNC:7190
Homologene: 4343
Pag1
Name: phosphoprotein associated with glycosphingolipid microdomains 1
Synonyms: Cbp, F730007C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 94212
Homologene: 10198
Inf2
Name: inverted formin, FH2 and WH2 domain containing
Synonyms: 2610204M08Rik, EG629699
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 70435
VEGA: 12
Homologene: 82406
Olfr640
Name: olfactory receptor 640
Synonyms: MOR13-4, GA_x6K02T2PBJ9-6756759-6755815
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258819
Homologene: 17404
Snx18
Name: sorting nexin 18
Synonyms: Snag1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 170625
VEGA: 13
Homologene: 14164
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,211,172 bp
  • A to T, chromosome 1 at 66,654,029 bp
  • A to T, chromosome 1 at 188,728,270 bp
  • A to T, chromosome 2 at 65,949,019 bp
  • A to T, chromosome 2 at 80,317,391 bp
  • A to G, chromosome 2 at 85,040,728 bp
  • A to T, chromosome 2 at 112,841,899 bp
  • A to G, chromosome 2 at 168,519,451 bp
  • A to T, chromosome 3 at 9,693,836 bp
  • T to A, chromosome 3 at 20,076,496 bp
  • T to A, chromosome 4 at 25,279,350 bp
  • G to A, chromosome 4 at 43,534,744 bp
  • C to T, chromosome 4 at 99,235,163 bp
  • C to T, chromosome 4 at 147,674,490 bp
  • A to G, chromosome 4 at 152,021,607 bp
  • A to T, chromosome 5 at 8,824,245 bp
  • A to G, chromosome 7 at 49,951,502 bp
  • T to C, chromosome 7 at 80,512,985 bp
  • T to A, chromosome 7 at 104,021,898 bp
  • C to T, chromosome 8 at 48,298,808 bp
  • T to G, chromosome 8 at 68,121,527 bp
  • T to A, chromosome 8 at 110,528,016 bp
  • T to C, chromosome 9 at 22,074,691 bp
  • G to T, chromosome 9 at 96,996,107 bp
  • A to G, chromosome 10 at 62,839,970 bp
  • G to A, chromosome 11 at 72,980,616 bp
  • T to C, chromosome 11 at 102,668,401 bp
  • A to T, chromosome 12 at 8,006,077 bp
  • G to T, chromosome 12 at 34,389,429 bp
  • A to G, chromosome 12 at 112,604,788 bp
  • C to T, chromosome 12 at 112,768,101 bp
  • T to C, chromosome 13 at 24,701,069 bp
  • T to C, chromosome 13 at 113,617,189 bp
  • A to T, chromosome 14 at 52,112,174 bp
  • A to G, chromosome 15 at 34,839,358 bp
  • C to A, chromosome 15 at 82,029,104 bp
  • A to G, chromosome 15 at 82,063,416 bp
  • G to T, chromosome 16 at 17,641,066 bp
  • A to G, chromosome 16 at 29,217,749 bp
  • G to A, chromosome 16 at 32,419,842 bp
  • G to T, chromosome 17 at 49,454,736 bp
  • A to G, chromosome 17 at 64,078,885 bp
  • C to A, chromosome 19 at 6,402,501 bp
  • G to A, chromosome 19 at 6,966,165 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6157 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044304-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.