Strain Name:
C57BL/6J-MtgxR6165Btlr/Mmmh
Stock Number:
044311-MU
Citation ID:
RRID:MMRRC_044311-MU
Other Names:
R6165 (G1)
Major Collection:

Gene Information

Uso1
Name: USO1 vesicle docking factor
Synonyms: transcytosis associated protein p115, TAP, Vdp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56041
Homologene: 2754
Macroh2a1
Name: macroH2A.1 histone
Synonyms: mH2a1, MACROH2A1.2, H2AF12M, H2afy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 26914
HGNC: HGNC:4740
Homologene: 3598
Zfp704
Name: zinc finger protein 704
Synonyms: Gig1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 170753
Homologene: 64370
Zfp384
Name: zinc finger protein 384
Synonyms: C130073D16Rik, Ciz, Nmp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 269800
Homologene: 15849
Tfr2
Name: transferrin receptor 2
Synonyms: Tfr2, Trfr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 50765
Homologene: 2428
Morc3
Name: microrchidia 3
Synonyms: 1110051N18Rik, D16Jhu32e, 1110051N18Rik, Zcwcc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 338467
Homologene: 32257
Kif13b
Name: kinesin family member 13B
Synonyms: GAKIN, N-3 kinesin, C130021D12Rik, 5330429L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16554
VEGA: 14
Homologene: 9073
Zfr
Name: zinc finger RNA binding protein
Synonyms: C920030H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22763
Homologene: 8009
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, XAP8, Hbxap, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233532
Homologene: 41142
Cnot9
Name: CCR4-NOT transcription complex, subunit 9
Synonyms: FL10, 2610007F23Rik, Rqcd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 58184
Homologene: 3973
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: nesprin-1, SYNE-1, enaptin165, A330049M09Rik, C130039F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Xpo5
Name: exportin 5
Synonyms: 2410004H11Rik, 2700038C24Rik, Exp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72322
VEGA: 17
Homologene: 69316
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: eyem02Jus, heb, QBRICK, eyes2, crf11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329872
Homologene: 27049
C2cd5
Name: C2 calcium-dependent domain containing 5
Synonyms: C030008B15Rik, CDP138, 5730419I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74741
Homologene: 8873
Far1
Name: fatty acyl CoA reductase 1
Synonyms: 2600011M19Rik, 3732409C05Rik, Mlstd2, 2900034E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67420
Homologene: 41718
Zfc3h1
Name: zinc finger, C3H1-type containing
Synonyms: Psrc2, Ccdc131
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216345
Homologene: 17017
Kcnj14
Name: potassium inwardly-rectifying channel, subfamily J, member 14
Synonyms: A930026G01Rik, Kir2.4, IRK4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 211480
HGNC: HGNC:6260
Homologene: 27086
Fance
Name: Fanconi anemia, complementation group E
Synonyms: 2810451D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72775
HGNC: HGNC:3586
Homologene: 11066
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Ankrd35
Name: ankyrin repeat domain 35
Synonyms: 4732436F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213121
Homologene: 16977
Wdr24
Name: WD repeat domain 24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268933
Homologene: 6870
Nwd1
Name: NACHT and WD repeat domain containing 1
Synonyms: A230063L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319555
Homologene: 72261
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: A230061D21Rik, LOC235639, C030048J01Rik, Lba1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320429
Homologene: 45845
Hspb7
Name: heat shock protein family, member 7 (cardiovascular)
Synonyms: cvHsp, Hsp25-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 29818
HGNC: HGNC:5249
Homologene: 8480
Fam214a
Name: family with sequence similarity 214, member A
Synonyms: 6330415I01Rik, C130047D21Rik, BC031353
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235493
VEGA: 9
Homologene: 35065
Sobp
Name: sine oculis binding protein
Synonyms: 2900009C16Rik, 5330439J01Rik, Jxc1, jc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 109205
Homologene: 41216
Cyld
Name: CYLD lysine 63 deubiquitinase
Synonyms: CYLD1, 2010013M14Rik, C130039D01Rik, 2900009M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74256
HGNC: HGNC:2584
Homologene: 9069
Serpinb9
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9
Synonyms: ovalbumin, PI-9, Spi6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20723
HGNC: HGNC:8955
Homologene: 37888
Olfr1489
Name: olfactory receptor 1489
Synonyms: GA_x6K02T2RE5P-3965668-3966609, MOR202-19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258628
Homologene: 45021
Phf2
Name: PHD finger protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18676
VEGA: 13
HGNC: HGNC:8920
Homologene: 3934
Etfdh
Name: electron transferring flavoprotein, dehydrogenase
Synonyms: 0610010I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66841
HGNC: HGNC:3483
Homologene: 3275
Rgl2
Name: ral guanine nucleotide dissociation stimulator-like 2
Synonyms: Rlf, KE1.5, Rab2l, Rgt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19732
HGNC: HGNC:9769
Homologene: 3494
Itgb5
Name: integrin beta 5
Synonyms: [b]5B, [b]5A, [b]-5, beta-5, beta5, [b]5, ESTM23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16419
HGNC: HGNC:6160
Homologene: 20511
Catsperb
Name: cation channel sperm associated auxiliary subunit beta
Synonyms: 4932415G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 271036
VEGA: 12
Homologene: 81904
Slc17a2
Name: solute carrier family 17 (sodium phosphate), member 2
Synonyms: NPT3, C730032N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218103
Homologene: 4260
Itga7
Name: integrin alpha 7
Synonyms: [a]7, alpha7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16404
VEGA: 10
HGNC: HGNC:6143
Homologene: 37592
Mrgprb8
Name: MAS-related GPR, member B8
Synonyms: MrgB8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 404240
Homologene: 83620
Trim35
Name: tripartite motif-containing 35
Synonyms: Mair, 0710005M05Rik, A430106H13Rik, Hls5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66854
Homologene: 134331
Zfp319
Name: zinc finger protein 319
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 79233
Homologene: 11548
Msl1
Name: male specific lethal 1
Synonyms: 4930463F05Rik, 2810017F12Rik, 4121402D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74026
Homologene: 129785
Tmem151b
Name: transmembrane protein 151B
Synonyms: LOC210573
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 210573
VEGA: 17
Homologene: 19365
Ghdc
Name: GH3 domain containing
Synonyms: D11Lgp1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 80860
Homologene: 32760
Gpt
Name: glutamic pyruvic transaminase, soluble
Synonyms: Gpt-1, 1300007J06Rik, 2310022B03Rik, ALT, Gpt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 76282
VEGA: 15
HGNC: HGNC:4552
Homologene: 134231
Rtkn
Name: rhotekin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20166
Homologene: 7522
Pjvk
Name: pejvakin
Synonyms: LOC381375, pejvakin, Dfnb59
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381375
Homologene: 19773
Cfap91
Name: cilia and flagella associated protein 91
Synonyms: Spata26, 4932425I24Rik, Maats1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 320214
Homologene: 33470
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 74,528,793 bp
  • T to G, chromosome 2 at 76,650,218 bp
  • T to C, chromosome 2 at 125,332,363 bp
  • G to T, chromosome 3 at 9,443,886 bp
  • A to T, chromosome 3 at 79,604,944 bp
  • A to G, chromosome 3 at 96,683,307 bp
  • T to C, chromosome 4 at 82,956,255 bp
  • T to C, chromosome 4 at 141,422,551 bp
  • A to T, chromosome 5 at 92,187,267 bp
  • T to A, chromosome 5 at 137,580,257 bp
  • G to T, chromosome 6 at 83,145,963 bp
  • T to G, chromosome 6 at 125,024,933 bp
  • T to C, chromosome 6 at 143,050,228 bp
  • G to T, chromosome 7 at 45,820,000 bp
  • T to A, chromosome 7 at 48,388,817 bp
  • ATGGCG to ATGGCGACGGTGGCG, chromosome 7 at 97,579,904 bp
  • A to G, chromosome 7 at 113,554,218 bp
  • C to T, chromosome 8 at 72,662,186 bp
  • A to G, chromosome 8 at 88,746,933 bp
  • CA to C, chromosome 8 at 95,328,105 bp
  • A to G, chromosome 9 at 75,025,672 bp
  • T to C, chromosome 9 at 111,391,872 bp
  • A to T, chromosome 10 at 5,425,678 bp
  • A to G, chromosome 10 at 43,022,603 bp
  • A to G, chromosome 10 at 115,420,669 bp
  • A to G, chromosome 10 at 128,942,935 bp
  • T to C, chromosome 11 at 98,804,847 bp
  • T to G, chromosome 11 at 100,769,102 bp
  • T to A, chromosome 12 at 101,575,816 bp
  • G to A, chromosome 13 at 23,815,070 bp
  • T to A, chromosome 13 at 33,008,824 bp
  • C to A, chromosome 13 at 48,813,865 bp
  • A to T, chromosome 13 at 56,104,455 bp
  • A to G, chromosome 14 at 64,742,311 bp
  • T to C, chromosome 14 at 66,309,205 bp
  • T to A, chromosome 15 at 4,918,350 bp
  • C to T, chromosome 15 at 12,146,245 bp
  • A to G, chromosome 15 at 76,697,970 bp
  • A to G, chromosome 16 at 33,899,242 bp
  • A to G, chromosome 16 at 38,333,811 bp
  • T to C, chromosome 16 at 93,841,383 bp
  • A to G, chromosome 17 at 25,826,421 bp
  • C to T, chromosome 17 at 28,326,094 bp
  • A to G, chromosome 17 at 33,931,765 bp
  • T to C, chromosome 17 at 45,545,785 bp
  • T to A, chromosome 17 at 46,235,957 bp
  • A to T, chromosome 19 at 13,633,143 bp
  • C to T, chromosome 19 at 13,633,588 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6165 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044311-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.