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Strain Name:
C57BL/6J-MtgxR6166Btlr/Mmmh
Stock Number:
044312-MU
Citation ID:
RRID:MMRRC_044312-MU
Other Names:
R6166 (G1)
Major Collection:

Strain Information

Plg
Name: plasminogen
Synonyms: Pg
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18815
VEGA: 17
HGNC: HGNC:9071
Homologene: 55452
Arpp21
Name: cyclic AMP-regulated phosphoprotein, 21
Synonyms: ARPP-21, Tarpp, D9Bwg1012e, 0710001E13Rik, R3hdm3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74100
Homologene: 32306
Fancd2
Name: Fanconi anemia, complementation group D2
Synonyms: 2410150O07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 211651
HGNC: HGNC:3585
Homologene: 13212
Lgals9
Name: lectin, galactose binding, soluble 9
Synonyms: LGALS35, galectin-9, gal-9, Lgals5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16859
Homologene: 134662
Fam117a
Name: family with sequence similarity 117, member A
Synonyms: 5730593F17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 215512
Homologene: 12775
Prdm2
Name: PR domain containing 2, with ZNF domain
Synonyms: Riz, Riz1, LOC381568, E330024L24Rik, 4833427P12Rik, KMT8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 110593
HGNC: HGNC:9347
Homologene: 40822
Wdr59
Name: WD repeat domain 59
Synonyms: 5430401O09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319481
Homologene: 38685
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 174,159,093 bp
  • A to G, chromosome 1 at 178,103,837 bp
  • G to A, chromosome 2 at 31,369,262 bp
  • G to T, chromosome 2 at 82,980,727 bp
  • G to T, chromosome 2 at 91,676,391 bp
  • A to G, chromosome 2 at 119,334,626 bp
  • A to G, chromosome 2 at 121,099,058 bp
  • A to G, chromosome 2 at 157,468,522 bp
  • G to A, chromosome 3 at 86,354,307 bp
  • T to A, chromosome 3 at 115,122,425 bp
  • A to G, chromosome 3 at 127,812,528 bp
  • T to C, chromosome 4 at 123,324,678 bp
  • T to C, chromosome 4 at 124,723,384 bp
  • A to C, chromosome 4 at 143,134,736 bp
  • T to C, chromosome 5 at 96,079,940 bp
  • T to A, chromosome 5 at 109,942,780 bp
  • T to A, chromosome 5 at 144,781,981 bp
  • T to A, chromosome 6 at 113,555,251 bp
  • A to T, chromosome 7 at 3,983,785 bp
  • A to G, chromosome 7 at 12,694,020 bp
  • A to T, chromosome 7 at 18,656,739 bp
  • A to T, chromosome 7 at 24,714,219 bp
  • A to G, chromosome 7 at 85,565,981 bp
  • GCG to GCGACGGCGACG, chromosome 7 at 97,579,907 bp
  • A to T, chromosome 7 at 100,876,492 bp
  • T to C, chromosome 8 at 40,279,840 bp
  • T to C, chromosome 8 at 44,952,485 bp
  • C to T, chromosome 8 at 111,472,661 bp
  • T to C, chromosome 9 at 79,819,454 bp
  • T to C, chromosome 9 at 112,119,198 bp
  • A to G, chromosome 10 at 59,222,360 bp
  • C to A, chromosome 10 at 61,424,558 bp
  • A to G, chromosome 10 at 79,988,727 bp
  • C to T, chromosome 10 at 83,493,424 bp
  • A to T, chromosome 10 at 120,072,718 bp
  • A to T, chromosome 10 at 129,691,279 bp
  • A to G, chromosome 11 at 50,135,846 bp
  • G to C, chromosome 11 at 70,674,261 bp
  • C to T, chromosome 11 at 78,971,358 bp
  • T to C, chromosome 11 at 95,380,781 bp
  • T to C, chromosome 11 at 119,232,001 bp
  • A to T, chromosome 12 at 83,992,604 bp
  • A to T, chromosome 13 at 21,289,265 bp
  • G to A, chromosome 13 at 73,317,941 bp
  • T to G, chromosome 13 at 112,695,267 bp
  • C to T, chromosome 14 at 50,186,768 bp
  • T to C, chromosome 14 at 69,798,178 bp
  • A to G, chromosome 15 at 8,186,560 bp
  • C to T, chromosome 15 at 27,818,071 bp
  • T to A, chromosome 15 at 73,124,240 bp
  • T to C, chromosome 15 at 75,891,477 bp
  • A to G, chromosome 15 at 78,344,566 bp
  • A to G, chromosome 15 at 83,896,115 bp
  • A to T, chromosome 15 at 96,424,662 bp
  • T to C, chromosome 16 at 32,407,863 bp
  • T to A, chromosome 17 at 12,398,114 bp
  • C to T, chromosome 17 at 14,680,388 bp
  • T to C, chromosome 17 at 86,099,268 bp
  • T to C, chromosome 18 at 37,974,370 bp
  • T to C, chromosome 19 at 40,597,479 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6166 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044312-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.