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Strain Name:
C57BL/6J-MtgxR6173Btlr/Mmmh
Stock Number:
044316-MU
Citation ID:
RRID:MMRRC_044316-MU
Other Names:
R6173 (G1)
Major Collection:

Strain Information

Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Strn
Name: striatin, calmodulin binding protein
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268980
Homologene: 2380
Mfap4
Name: microfibrillar-associated protein 4
Synonyms: 1110007F23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76293
HGNC: HGNC:7035
Homologene: 134529
Foxp1
Name: forkhead box P1
Synonyms: 4932443N09Rik, 3110052D19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108655
HGNC: HGNC:3823
Homologene: 13092
Gid4
Name: GID complex subunit 4, VID24 homolog
Synonyms: 4933439F18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66771
Homologene: 5971
Rc3h2
Name: ring finger and CCCH-type zinc finger domains 2
Synonyms: Rnf164, D930043C02Rik, 2900024N03Rik, 9430019J22Rik, Mnab
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319817
Homologene: 28276
Baz1b
Name: bromodomain adjacent to zinc finger domain, 1B
Synonyms: Wbscr9, WSTF
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22385
HGNC: HGNC:961
Homologene: 22651
Safb
Name: scaffold attachment factor B
Synonyms: 5330423C17Rik, SAFB1, 3110021E02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224903
Homologene: 2229
Sart3
Name: squamous cell carcinoma antigen recognized by T cells 3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53890
Homologene: 40977
Bend3
Name: BEN domain containing 3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 331623
VEGA: 10
Homologene: 19511
Arap2
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Synonyms: Centd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212285
Homologene: 9064
Parn
Name: poly(A)-specific ribonuclease (deadenylation nuclease)
Synonyms: DAN, 1200003I18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74108
VEGA: 16
HGNC: HGNC:8609
Homologene: 31098
Esr1
Name: estrogen receptor 1 (alpha)
Synonyms: ESR, ERalpha, ER[a], Nr3a1, ERa, Estr, Estra, ER-alpha
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13982
HGNC: HGNC:3467
Homologene: 47906
Rad17
Name: RAD17 checkpoint clamp loader component
Synonyms: MmRad24, 9430035O09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19356
VEGA: 13
HGNC: HGNC:9807
Homologene: 32117
Psip1
Name: PC4 and SFRS1 interacting protein 1
Synonyms: Psip2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 101739
HGNC: HGNC:9527
Homologene: 13242
Vps8
Name: VPS8 CORVET complex subunit
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 209018
Homologene: 44592
Ptprc
Name: protein tyrosine phosphatase receptor type C
Synonyms: T200, B220, CD45, Lyt-4, Ly-5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19264
HGNC: HGNC:9666
Homologene: 2126
Mfsd2a
Name: MFSD2 lysolipid transporter A, lysophospholipid
Synonyms: major facilitator superfamily domain containing 2A, 1700018O18Rik, Mfsd2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76574
Homologene: 19229
Zfp998
Name: zinc finger protein 998
Synonyms: Gt(pU21)35Imeg, Gt(Ayu21)35Imeg, 2410141K09Rik, Snerv1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76803
Homologene: 136362
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: MBC, CED-5, Hch
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Ttll5
Name: tubulin tyrosine ligase-like family, member 5
Synonyms: 4930556H18Rik, 1700048H13Rik, 2310009M18Rik, D630041K24Rik, STAMP
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320244
Homologene: 9013
Sohlh2
Name: spermatogenesis and oogenesis specific basic helix-loop-helix 2
Synonyms: 4933406N12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74434
Homologene: 9864
Trp73
Name: transformation related protein 73
Synonyms: p73, TAp73, deltaNp73
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22062
Homologene: 3960
Tespa1
Name: thymocyte expressed, positive selection associated 1
Synonyms: A430001F24Rik, 5830405N20Rik, Itprid3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67596
VEGA: 10
Homologene: 106645
Mocos
Name: molybdenum cofactor sulfurase
Synonyms: 1110018O12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 68591
VEGA: 18
Homologene: 9931
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Chia1
Name: chitinase, acidic 1
Synonyms: AMCase, YNL, 2200003E03Rik, Chia
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 81600
Homologene: 75168
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, 2810003K23Rik, Dnahcl1, Dnahc17
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Bbs7
Name: Bardet-Biedl syndrome 7
Synonyms: 8430406N16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71492
Homologene: 12395
Vmn2r6
Name: vomeronasal 2, receptor 6
Synonyms: EG620718, EG667069
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 667069
Homologene: 129754
Tbx15
Name: T-box 15
Synonyms: Tbx8, de, Tbx14
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21384
Homologene: 7967
Slc13a5
Name: solute carrier family 13 (sodium-dependent citrate transporter), member 5
Synonyms: Nact, NaC2/NaCT, mINDY, Indy
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237831
Homologene: 21941
Fshb
Name: follicle stimulating hormone beta
Synonyms: Fshbeta, FSH
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14308
HGNC: HGNC:3964
Homologene: 430
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242627
Homologene: 135888
Nlrp2
Name: NLR family, pyrin domain containing 2
Synonyms: PYPAF2, E330007A02Rik, Nalp2, Pan1, Nbs1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232827
Homologene: 56789
Cadm2
Name: cell adhesion molecule 2
Synonyms: A830029E02Rik, Necl3, SynCAM2, Igsf4d, 2900078E11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239857
Homologene: 17705
Or6z5
Name: olfactory receptor family 6 subfamily Z member 5
Synonyms: GA_x6K02T2QGBW-3203957-3204898, MOR103-6, Olfr1346
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258918
Homologene: 74134
F830045P16Rik
Name: RIKEN cDNA F830045P16 gene
Synonyms: Sirpb3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228592
Homologene: 136180
Dazl
Name: deleted in azoospermia-like
Synonyms: Tpx-2, Tpx2, Dazla, Daz-like
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13164
VEGA: 17
Homologene: 86954
Chd5
Name: chromodomain helicase DNA binding protein 5
Synonyms: B230399N07Rik, 4930532L22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269610
Homologene: 56712
Mrto4
Name: mRNA turnover 4, ribosome maturation factor
Synonyms: 2610012O22Rik, Mrt4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69902
Homologene: 6379
Mug1
Name: murinoglobulin 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17836
HGNC: HGNC:9750
Homologene: 136663
Clpx
Name: caseinolytic mitochondrial matrix peptidase chaperone subunit
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270166
HGNC: HGNC:2088
Homologene: 4851
Galk2
Name: galactokinase 2
Synonyms: Gk2, 2810017M24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69976
HGNC: HGNC:4119
Homologene: 13654
Zp3r
Name: zona pellucida 3 receptor
Synonyms: SP56
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22789
HGNC: HGNC:1325
Homologene: 7609
Or11g1
Name: olfactory receptor family 11 subfamily G member 1
Synonyms: GA_x6K02T2PMLR-6110726-6111661, MOR106-3, Olfr738
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258662
Homologene: 74220
Utp14b
Name: UTP14B small subunit processome component
Synonyms: jsd, 4932411L21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 195434
Homologene: 78703
Ch25h
Name: cholesterol 25-hydroxylase
Synonyms: m25OH
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12642
VEGA: 19
HGNC: HGNC:1907
Homologene: 2942
Or2y16
Name: olfactory receptor family 2 subfamily Y member 16
Synonyms: GA_x6K02T2QP88-5991012-5990077, MOR256-28, Olfr1388
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258459
Homologene: 74258
Vmn2r29
Name: vomeronasal 2, receptor 29
Synonyms: 6430701C03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76229
Homologene: 113703
Or12k7
Name: olfactory receptor family 12 subfamily K member 7
Synonyms: GA_x6K02T2NLDC-33760081-33761034, MOR159-1, Olfr360
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258615
Homologene: 73997
Zfp36l1
Name: zinc finger protein 36, C3H type-like 1
Synonyms: TIS11b, cMG1, Brf1, D530020L18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 12192
VEGA: 12
HGNC: HGNC:1107
Homologene: 31276
Iqank1
Name: IQ motif and ankyrin repeat containing 1
Synonyms: K230010J24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 432964
Homologene: 141000
Mup20
Name: major urinary protein 20
Synonyms: darcin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381530
Homologene: 74304
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 78,665,837 bp
  • A to C, chromosome 1 at 78,665,840 bp
  • A to T, chromosome 1 at 130,591,568 bp
  • A to C, chromosome 1 at 138,067,890 bp
  • A to G, chromosome 2 at 37,069,079 bp
  • GCC to GCCC, chromosome 2 at 37,414,733 bp
  • T to C, chromosome 2 at 107,057,293 bp
  • A to G, chromosome 2 at 125,859,217 bp
  • A to G, chromosome 2 at 129,463,668 bp
  • G to A, chromosome 2 at 177,314,537 bp
  • A to T, chromosome 3 at 36,592,374 bp
  • G to T, chromosome 3 at 55,196,998 bp
  • G to C, chromosome 3 at 64,559,755 bp
  • G to T, chromosome 3 at 99,253,887 bp
  • T to C, chromosome 3 at 106,129,022 bp
  • T to C, chromosome 3 at 127,052,746 bp
  • A to T, chromosome 4 at 62,054,030 bp
  • T to A, chromosome 4 at 83,473,049 bp
  • T to C, chromosome 4 at 113,535,710 bp
  • A to G, chromosome 4 at 122,951,246 bp
  • T to C, chromosome 4 at 139,350,444 bp
  • A to T, chromosome 4 at 152,379,391 bp
  • A to T, chromosome 4 at 154,104,341 bp
  • A to T, chromosome 5 at 62,749,622 bp
  • C to T, chromosome 5 at 113,743,206 bp
  • T to C, chromosome 5 at 135,242,507 bp
  • G to A, chromosome 6 at 99,015,510 bp
  • C to A, chromosome 6 at 99,015,514 bp
  • T to A, chromosome 6 at 121,863,793 bp
  • T to C, chromosome 7 at 5,337,809 bp
  • C to T, chromosome 7 at 6,474,836 bp
  • T to C, chromosome 7 at 7,231,370 bp
  • C to A, chromosome 9 at 65,301,879 bp
  • T to C, chromosome 10 at 4,746,760 bp
  • A to G, chromosome 10 at 43,509,868 bp
  • A to G, chromosome 10 at 130,347,303 bp
  • T to C, chromosome 11 at 34,262,388 bp
  • T to C, chromosome 11 at 49,444,472 bp
  • A to G, chromosome 11 at 60,432,415 bp
  • A to G, chromosome 11 at 61,485,419 bp
  • C to T, chromosome 11 at 72,253,197 bp
  • A to G, chromosome 11 at 118,039,946 bp
  • A to T, chromosome 12 at 80,109,546 bp
  • A to T, chromosome 12 at 85,933,377 bp
  • T to A, chromosome 13 at 66,431,549 bp
  • A to C, chromosome 13 at 100,622,881 bp
  • A to G, chromosome 14 at 50,414,197 bp
  • A to G, chromosome 15 at 76,045,388 bp
  • T to C, chromosome 16 at 13,651,811 bp
  • T to G, chromosome 16 at 21,495,932 bp
  • A to G, chromosome 16 at 32,736,140 bp
  • C to T, chromosome 16 at 66,882,841 bp
  • A to T, chromosome 17 at 50,287,571 bp
  • A to G, chromosome 17 at 56,597,798 bp
  • A to G, chromosome 17 at 78,700,869 bp
  • A to T, chromosome 18 at 24,676,582 bp
  • A to G, chromosome 19 at 34,474,496 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6173 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044316-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.