Strain Name:
C57BL/6J-MtgxR6177Btlr
Stock Number:
044319-MU
Citation ID:
RRID:MMRRC_044319-MU
Other Names:
R6177 (G1)
Major Collection:

Gene Information

Txndc2
Name: thioredoxin domain containing 2 (spermatozoa)
Synonyms: Sptrx-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 213272
VEGA: 17
Homologene: 41856
Epb41l4a
Name: erythrocyte membrane protein band 4.1 like 4a
Synonyms: NBL4, Epb4.1l4a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13824
VEGA: 18
Homologene: 8398
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, b2b1625.2Clo, D230004K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Ano1
Name: anoctamin 1, calcium activated chloride channel
Synonyms: Tmem16a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101772
Homologene: 75079
Rc3h2
Name: ring finger and CCCH-type zinc finger domains 2
Synonyms: Rnf164, 9430019J22Rik, 2900024N03Rik, Mnab, D930043C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 319817
Homologene: 28276
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: 6230420N16Rik, Depdc2, C030045D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 109294
Homologene: 23523
Rapgef6
Name: Rap guanine nucleotide exchange factor (GEF) 6
Synonyms: PDZ-GEF2, RA-GEF-2, Pdzgef2, C030018K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192786
Homologene: 22968
Gstcd
Name: glutathione S-transferase, C-terminal domain containing
Synonyms: 4933434L15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67553
Homologene: 11693
Septin7
Name: septin 7
Synonyms: Cdc10, Sept7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235072
VEGA: 9
HGNC: HGNC:1717
Homologene: 1354
Sde2
Name: SDE2 telomere maintenance homolog (S. pombe)
Synonyms: BC031781
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208768
Homologene: 134327
Cdk5rap2
Name: CDK5 regulatory subunit associated protein 2
Synonyms: 2900018K03Rik, an
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 214444
Homologene: 49533
Ankfy1
Name: ankyrin repeat and FYVE domain containing 1
Synonyms: Ankhzn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11736
Homologene: 9491
Wdr3
Name: WD repeat domain 3
Synonyms: D030020G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 269470
Homologene: 4937
Pdcd11
Name: programmed cell death 11
Synonyms: ALG-4, 1110021I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18572
VEGA: 19
Homologene: 74968
Atp6v1c1
Name: ATPase, H+ transporting, lysosomal V1 subunit C1
Synonyms: 1700025B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66335
VEGA: 15
HGNC: HGNC:856
Homologene: 1281
St7
Name: suppression of tumorigenicity 7
Synonyms: SEN4, Fam4a2, RAY1, HELG, 9430001H04Rik, TSG7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 64213
Homologene: 10185
Dpep2
Name: dipeptidase 2
Synonyms: MBD-2, F630103D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319446
Homologene: 49703
Tnks1bp1
Name: tankyrase 1 binding protein 1
Synonyms: TAB182
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228140
Homologene: 14117
Cat
Name: catalase
Synonyms: Cas1, Cs-1, Cas-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12359
HGNC: HGNC:1516
Homologene: 55514
Marveld2
Name: MARVEL (membrane-associating) domain containing 2
Synonyms: Tricellulin, Tric-c, Tric-a, Tric, Tric-b, Mrvldc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218518
VEGA: 13
Homologene: 27037
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 665700
Homologene: 90772
Hyal4
Name: hyaluronoglucosaminidase 4
Synonyms: 4632428M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 77042
HGNC: HGNC:5323
Homologene: 69117
Dhx57
Name: DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106794
VEGA: 17
Homologene: 56267
Nkpd1
Name: NTPase, KAP family P-loop domain containing 1
Synonyms: 2310015G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69547
Homologene: 18876
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Polr2g
Name: polymerase (RNA) II (DNA directed) polypeptide G
Synonyms: 2410046K11Rik, A230108L04Rik, RBP7, Rpo2-7l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67710
VEGA: 19
HGNC: HGNC:9194
Homologene: 2019
Actrt3
Name: actin related protein T3
Synonyms: Arpm1, 1700119I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76652
Homologene: 13038
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Cadm4
Name: cell adhesion molecule 4
Synonyms: SynCAM 4, Necl-4, Tsll2, Igsf4c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 260299
Homologene: 17063
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Mast3
Name: microtubule associated serine/threonine kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 546071
Homologene: 66191
Edem1
Name: ER degradation enhancer, mannosidase alpha-like 1
Synonyms: A130059K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 192193
Homologene: 33836
Tmed6
Name: transmembrane p24 trafficking protein 6
Synonyms: 1810015P03Rik, 1810018I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66269
Homologene: 11938
Myo3b
Name: myosin IIIB
Synonyms: A430065P19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329421
Homologene: 51393
Spef2
Name: sperm flagellar 2
Synonyms: C230086A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 320277
Homologene: 23371
Ighv2-7
Name: immunoglobulin heavy variable 2-7
Synonyms: Gm16597
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 780793
Trim43c
Name: tripartite motif-containing 43C
Synonyms: Trim43
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 666731
Homologene: 105432
Gm281
Name: predicted gene 281
Synonyms: LOC238939
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 238939
Homologene: 141164
Plxnb1
Name: plexin B1
Synonyms: 2900002G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235611
HGNC: HGNC:9103
Homologene: 130508
Fam111a
Name: family with sequence similarity 111, member A
Synonyms: 4632417K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107373
Homologene: 49696
Cabs1
Name: calcium binding protein, spermatid specific 1
Synonyms: 4931407G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70977
Homologene: 13225
Psg21
Name: pregnancy-specific glycoprotein 21
Synonyms: cea8, 1600025N01Rik, 1600026N13Rik, 1600019C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72242
Homologene: 110989
Tmcc3
Name: transmembrane and coiled coil domains 3
Synonyms: A230066D03Rik, LOC380656, C630016B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 319880
Homologene: 10792
Ms4a20
Name: membrane-spanning 4-domains, subfamily A, member 20
Synonyms: 1700017D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 69369
Clip1
Name: CAP-GLY domain containing linker protein 1
Synonyms: CLIP-170, cytoplasmic linker protein 50, Rsn, Clip 170, 4631429H07Rik, Clip50, restin, 1110007I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56430
Homologene: 74455
Ptpru
Name: protein tyrosine phosphatase, receptor type, U
Synonyms: Ptprl, RPTPlambda
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19273
HGNC: HGNC:9683
Homologene: 4168
Olfr1015
Name: olfactory receptor 1015
Synonyms: MOR213-3, GA_x6K02T2Q125-47264151-47265089
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258564
Homologene: 115499
Apol10b
Name: apolipoprotein L 10B
Synonyms: 9130218O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 328561
Homologene: 129975
Olfr1246
Name: olfactory receptor 1246
Synonyms: GA_x6K02T2Q125-51034790-51033846, MOR231-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258788
Homologene: 74246
Fstl4
Name: follistatin-like 4
Synonyms: SPIG1, B230374F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 320027
Homologene: 18543
Zfp39
Name: zinc finger protein 39
Synonyms: CTfin33, Zfp-39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22698
Homologene: 69102
Abcd2
Name: ATP-binding cassette, sub-family D (ALD), member 2
Synonyms: ALDL1, ABC39, adrenoleukodystrophy related, ALDR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 26874
VEGA: 15
HGNC: HGNC:66
Homologene: 55873
Pramel16
Name: PRAME like 16
Synonyms: Gm13109, Pramef25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329984
Homologene: 83161
C1s2
Name: complement component 1, s subcomponent 2
Synonyms: Gm5077
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 317677
HGNC: HGNC:1247
Homologene: 1314
Vtn
Name: vitronectin
Synonyms: Vn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22370
Homologene: 532
Olfr1
Name: olfactory receptor 1
Synonyms: MOR135-13, GA_x6K02T2P1NL-3556334-3555390, I54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258923
Homologene: 115482
Phc3
Name: polyhomeotic 3
Synonyms: EDR3, HPH3, E030046K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 241915
Homologene: 69390
Zdhhc16
Name: zinc finger, DHHC domain containing 16
Synonyms: Abl-philin 2, APH2, Ablphilin 2, 1500015N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 74168
VEGA: 19
Homologene: 11377
Polh
Name: polymerase (DNA directed), eta (RAD 30 related)
Synonyms: RAD30A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 80905
VEGA: 17
HGNC: HGNC:9181
Homologene: 38189
Cavin2
Name: caveolae associated 2
Synonyms: Sdpr, cavin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20324
Homologene: 3422
Vmn1r91
Name: vomeronasal 1 receptor 91
Synonyms: Gm8442
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 667067
Homologene: 104166
Zfp612
Name: zinc finger protein 612
Synonyms: B230354B21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234725
Homologene: 27083
Esp1
Name: exocrine gland secreted peptide 1
Synonyms: Gm6084, ESP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 619517
Jdp2
Name: Jun dimerization protein 2
Synonyms: Jundm2, TIF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 81703
VEGA: 12
Homologene: 12787
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 11,136,777 bp
  • G to T, chromosome 1 at 51,289,495 bp
  • T to C, chromosome 1 at 180,858,219 bp
  • T to A, chromosome 2 at 31,420,106 bp
  • C to T, chromosome 2 at 37,389,646 bp
  • A to T, chromosome 2 at 41,123,736 bp
  • AC to A, chromosome 2 at 69,510,419 bp
  • T to C, chromosome 2 at 70,313,363 bp
  • C to T, chromosome 2 at 85,059,280 bp
  • C to T, chromosome 2 at 85,785,660 bp
  • T to C, chromosome 2 at 89,590,317 bp
  • T to C, chromosome 2 at 103,473,075 bp
  • A to T, chromosome 3 at 30,598,167 bp
  • A to T, chromosome 3 at 30,942,565 bp
  • A to T, chromosome 3 at 100,161,152 bp
  • T to C, chromosome 3 at 133,082,073 bp
  • G to A, chromosome 4 at 70,281,482 bp
  • A to T, chromosome 4 at 131,793,525 bp
  • G to A, chromosome 4 at 143,949,006 bp
  • C to T, chromosome 5 at 87,979,754 bp
  • A to G, chromosome 5 at 123,613,834 bp
  • T to C, chromosome 6 at 17,819,334 bp
  • T to A, chromosome 6 at 24,766,090 bp
  • T to A, chromosome 6 at 108,851,198 bp
  • T to G, chromosome 6 at 124,630,001 bp
  • T to A, chromosome 7 at 18,652,354 bp
  • T to A, chromosome 7 at 19,523,084 bp
  • T to A, chromosome 7 at 20,101,479 bp
  • G to A, chromosome 7 at 24,502,761 bp
  • T to A, chromosome 7 at 144,678,741 bp
  • A to G, chromosome 8 at 70,790,018 bp
  • T to C, chromosome 8 at 105,986,199 bp
  • T to C, chromosome 8 at 107,065,451 bp
  • A to T, chromosome 8 at 110,089,974 bp
  • T to C, chromosome 9 at 25,293,804 bp
  • T to C, chromosome 9 at 88,840,547 bp
  • C to T, chromosome 9 at 109,102,925 bp
  • A to T, chromosome 10 at 94,582,387 bp
  • A to G, chromosome 11 at 53,168,204 bp
  • G to A, chromosome 11 at 54,620,016 bp
  • A to T, chromosome 11 at 58,891,061 bp
  • A to G, chromosome 11 at 59,032,664 bp
  • G to A, chromosome 11 at 72,754,459 bp
  • AGCGGTCGTAGGC to AGC, chromosome 11 at 73,395,654 bp
  • A to T, chromosome 11 at 78,500,010 bp
  • G to T, chromosome 12 at 85,638,840 bp
  • A to G, chromosome 12 at 113,807,435 bp
  • C to T, chromosome 13 at 100,597,378 bp
  • T to C, chromosome 14 at 13,868,002 bp
  • A to G, chromosome 15 at 9,727,532 bp
  • C to A, chromosome 15 at 38,673,928 bp
  • A to T, chromosome 15 at 77,585,787 bp
  • T to C, chromosome 15 at 91,190,693 bp
  • T to A, chromosome 16 at 37,071,709 bp
  • T to C, chromosome 17 at 40,728,832 bp
  • T to C, chromosome 17 at 46,184,744 bp
  • T to C, chromosome 17 at 65,638,471 bp
  • T to C, chromosome 17 at 80,272,966 bp
  • A to T, chromosome 18 at 33,798,815 bp
  • G to A, chromosome 19 at 8,794,177 bp
  • A to G, chromosome 19 at 11,105,750 bp
  • A to G, chromosome 19 at 12,587,382 bp
  • A to G, chromosome 19 at 41,937,759 bp
  • G to T, chromosome 19 at 47,120,283 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6177 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044319-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.