Strain Name:
C57BL/6J-MtgxR6194Btlr/Mmmh
Stock Number:
044334-MU
Citation ID:
RRID:MMRRC_044334-MU
Other Names:
R6194 (G1)
Major Collection:

Gene Information

Baz1b
Name: bromodomain adjacent to zinc finger domain, 1B
Synonyms: Wbscr9, WSTF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22385
HGNC: HGNC:961
Homologene: 22651
Naa15
Name: N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Synonyms: tubedown, Tbdn-1, mNAT1, 5730450D16Rik, Narg1, ASTBDN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74838
Homologene: 14211
Ltn1
Name: listerin E3 ubiquitin protein ligase 1
Synonyms: 4930528H02Rik, Zfp294, Listerin, Rnf160
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 78913
VEGA: 16
Homologene: 32272
Rbfox2
Name: RNA binding protein, fox-1 homolog (C. elegans) 2
Synonyms: Fxh, 2810460A15Rik, Fbm2, Rbm9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 93686
VEGA: 15
HGNC: HGNC:9906
Homologene: 49375
Asap1
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain1
Synonyms: Ddef1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13196
HGNC: HGNC:2720
Homologene: 7684
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: A630086P08Rik, opm, b2b327Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Hunk
Name: hormonally upregulated Neu-associated kinase
Synonyms: Mak-v, Bstk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 26559
VEGA: 16
Homologene: 8742
Myo9a
Name: myosin IXa
Synonyms: 4732465J09Rik, C130068I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270163
HGNC: HGNC:7608
Homologene: 21371
Card6
Name: caspase recruitment domain family, member 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239319
Homologene: 13067
Elapor1
Name: endosome-lysosome associated apoptosis and autophagy regulator 1
Synonyms: Inceptor, Iir, 5330417C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229722
Homologene: 23249
Atp13a5
Name: ATPase type 13A5
Synonyms: C630015F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 268878
Homologene: 77451
Ighmbp2
Name: immunoglobulin mu DNA binding protein 2
Synonyms: Catf1, AEP, Smbp2, sma, Smubp2, p110 subunit, RIPE3b1, Smbp-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20589
HGNC: HGNC:5542
Homologene: 1642
Atg5
Name: autophagy related 5
Synonyms: 3110067M24Rik, 2010107M05Rik, Paddy, Apg5l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11793
VEGA: 10
HGNC: HGNC:589
Homologene: 3566
Hnrnph1
Name: heterogeneous nuclear ribonucleoprotein H1
Synonyms: E430005G16Rik, Hnrph1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 59013
HGNC: HGNC:5041
Homologene: 31318
Trap1
Name: TNF receptor-associated protein 1
Synonyms: HSP75, 2410002K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 68015
Homologene: 9457
AW209491
Name: expressed sequence AW209491
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105351
VEGA: 13
Homologene: 11439
Zcchc2
Name: zinc finger, CCHC domain containing 2
Synonyms: 9930114B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227449
Homologene: 9808
Nbeal1
Name: neurobeachin like 1
Synonyms: A530050O19Rik, ALS2CR17, A530083I02Rik, 2310076G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269198
Homologene: 16453
Tbc1d2
Name: TBC1 domain family, member 2
Synonyms: LOC381605, PARIS-1, PARIS1, A630005A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381605
Homologene: 10190
Zfp345
Name: zinc finger protein 345
Synonyms: OTTMUSG00000015743
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 545471
Homologene: 134546
Peg10
Name: paternally expressed 10
Synonyms: MEF3L, HB-1, MyEF-3, MyEF-3 like, Edr, Mart2, Mar2, Rtl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 170676
Homologene: 116067
Cntnap4
Name: contactin associated protein-like 4
Synonyms: Caspr4, E130114F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 170571
Homologene: 24912
Stxbp5
Name: syntaxin binding protein 5 (tomosyn)
Synonyms: 0710001E20Rik, LGL3, 4930565N16Rik, tomosyn 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 78808
Homologene: 16402
Or13f5
Name: olfactory receptor family 13 subfamily F member 5
Synonyms: GA_x6K02T2N78B-7168533-7167574, MOR262-2, Olfr275
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 258857
Homologene: 17418
Pfkfb2
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Synonyms: PFK-2/FBPase-2 gene B, 4930568D07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18640
HGNC: HGNC:8873
Homologene: 88554
Serpina3i
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3I
Synonyms: 2B2, antitrypsin, alpha-1 antiproteinase, Gm6930
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 628900
HGNC: HGNC:16
Homologene: 115927
Afap1l2
Name: actin filament associated protein 1-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226250
Homologene: 13057
Naalad2
Name: N-acetylated alpha-linked acidic dipeptidase 2
Synonyms: NAALADASE2, NAADALASE2, D9Ertd285e, GCPIII, GCP3, Folh1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72560
Homologene: 3294
Chrna1
Name: cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
Synonyms: Achr-1, Acra
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11435
HGNC: HGNC:1955
Homologene: 59
Prodh
Name: proline dehydrogenase
Synonyms: Pro1, Pro-1, Ym24d07
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19125
HGNC: HGNC:9453
Homologene: 40764
Pcdhb7
Name: protocadherin beta 7
Synonyms: Pcdhb4B, PcdhbG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93878
HGNC: HGNC:8689
Homologene: 87123
Mapk8ip1
Name: mitogen-activated protein kinase 8 interacting protein 1
Synonyms: JIP-1, MAPK8IP1, IB1, Prkm8ip, mjip-2a, Skip, Jip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19099
HGNC: HGNC:6882
Homologene: 31314
Alcam
Name: activated leukocyte cell adhesion molecule
Synonyms: DM-GRASP, CD166, MuSC, SC1, BEN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11658
HGNC: HGNC:400
Homologene: 1229
Cluap1
Name: clusterin associated protein 1
Synonyms: 2310030D15Rik, 2610111M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 76779
Homologene: 14831
Rbks
Name: ribokinase
Synonyms: 5230400M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71336
Homologene: 5482
Irag1
Name: inositol 1,4,5-triphosphate receptor associated 1
Synonyms: Ris1, Mrvi1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17540
HGNC: HGNC:7237
Homologene: 4425
Gusb
Name: glucuronidase, beta
Synonyms: g, Gur, Gut, asd, adipose storage deficiency, Gus-u, Gus-t, Gus-s, Gus-r, Gus
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 110006
HGNC: HGNC:4696
Homologene: 37271
Chil6
Name: chitinase-like 6
Synonyms: BYm, BC051070
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229688
Homologene: 77638
Tfpt
Name: TCF3 (E2A) fusion partner
Synonyms: 2400004F01Rik, Amida, FB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69714
Homologene: 8349
Slc36a4
Name: solute carrier family 36 (proton/amino acid symporter), member 4
Synonyms: 6330573I15Rik, PAT4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 234967
Homologene: 56300
Slx1b
Name: SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
Synonyms: 4833422P03Rik, 2410170E21Rik, 1110030E23Rik, Giyd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75764
Homologene: 11434
Or56a3b
Name: olfactory receptor family 56 subfamily A member 3B
Synonyms: GA_x6K02T2PBJ9-7750163-7751110, MOR40-14, Olfr681
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 404318
Homologene: 81538
Fbxw2
Name: F-box and WD-40 domain protein 2
Synonyms: MD6, Fwd2, FBW2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 30050
Homologene: 8131
Lrrc56
Name: leucine rich repeat containing 56
Synonyms: 5730427C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70552
Homologene: 115748
Gc
Name: vitamin D binding protein
Synonyms: DBP, vitamin D binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14473
HGNC: HGNC:4187
Homologene: 486
Nras
Name: neuroblastoma ras oncogene
Synonyms: N-ras
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18176
HGNC: HGNC:7989
Homologene: 55661
Igkv13-84
Name: immunoglobulin kappa chain variable 13-84
Synonyms: Igk-V33
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 692152
Lim2
Name: lens intrinsic membrane protein 2
Synonyms: MP19, 19kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233187
Homologene: 12744
Mboat2
Name: membrane bound O-acyltransferase domain containing 2
Synonyms: 2810049G06Rik, Oact2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 67216
VEGA: 12
Homologene: 6971
Hs3st1
Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 1
Synonyms: 3-OST, D5Wsu110e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15476
HGNC: HGNC:5194
Homologene: 3751
Mmel1
Name: membrane metallo-endopeptidase-like 1
Synonyms: Nl1, NEPLP gamma, NEPLP beta, NEPLP alpha, SEP, Mell1, Nep2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 27390
Homologene: 22778
Araf
Name: Araf proto-oncogene, serine/threonine kinase
Synonyms: 1200013E08Rik, A-Raf, Araf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 11836
HGNC: HGNC:646
Homologene: 1249
Scyl1
Name: SCY1-like 1 (S. cerevisiae)
Synonyms: p105, mfd, 2810011O19Rik, Ntkl, mdf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 78891
VEGA: 19
Homologene: 6947
Cptp
Name: ceramide-1-phosphate transfer protein
Synonyms: Gltpd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 79554
Homologene: 11550
Ifit3
Name: interferon-induced protein with tetratricopeptide repeats 3
Synonyms: Ifi49
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 15959
HGNC: HGNC:5411
Homologene: 1189
5031410I06Rik
Name: RIKEN cDNA 5031410I06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381622
Homologene: 69402
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 60,257,484 bp
  • T to A, chromosome 1 at 105,991,117 bp
  • A to G, chromosome 1 at 130,697,887 bp
  • G to A, chromosome 2 at 34,807,404 bp
  • A to G, chromosome 2 at 73,570,472 bp
  • C to A, chromosome 2 at 92,389,244 bp
  • A to T, chromosome 2 at 150,472,631 bp
  • A to G, chromosome 3 at 51,463,300 bp
  • C to A, chromosome 3 at 103,058,953 bp
  • A to G, chromosome 3 at 106,404,876 bp
  • T to C, chromosome 3 at 108,465,779 bp
  • C to T, chromosome 4 at 46,629,912 bp
  • T to A, chromosome 4 at 52,825,779 bp
  • T to A, chromosome 4 at 88,691,125 bp
  • G to T, chromosome 4 at 88,691,126 bp
  • T to A, chromosome 4 at 154,883,216 bp
  • A to G, chromosome 4 at 155,866,641 bp
  • T to C, chromosome 5 at 26,104,035 bp
  • T to C, chromosome 5 at 31,666,890 bp
  • C to A, chromosome 5 at 39,614,405 bp
  • A to T, chromosome 5 at 89,441,579 bp
  • C to T, chromosome 5 at 129,990,065 bp
  • T to C, chromosome 5 at 135,243,890 bp
  • C to CCCATCAGGA, chromosome 6 at 4,756,351 bp
  • C to T, chromosome 6 at 68,939,932 bp
  • A to T, chromosome 7 at 3,629,027 bp
  • T to A, chromosome 7 at 43,435,662 bp
  • G to T, chromosome 7 at 105,122,170 bp
  • T to C, chromosome 7 at 110,899,694 bp
  • C to T, chromosome 7 at 126,692,331 bp
  • T to C, chromosome 7 at 141,205,651 bp
  • A to G, chromosome 8 at 112,875,429 bp
  • T to A, chromosome 9 at 15,726,876 bp
  • C to T, chromosome 9 at 18,351,147 bp
  • A to G, chromosome 9 at 59,869,750 bp
  • A to G, chromosome 10 at 9,817,339 bp
  • T to C, chromosome 10 at 44,294,616 bp
  • T to A, chromosome 11 at 50,383,277 bp
  • T to A, chromosome 12 at 24,946,638 bp
  • A to T, chromosome 12 at 51,748,445 bp
  • T to A, chromosome 12 at 104,266,503 bp
  • T to A, chromosome 13 at 14,637,120 bp
  • A to T, chromosome 15 at 5,098,444 bp
  • A to G, chromosome 15 at 64,129,209 bp
  • T to C, chromosome 15 at 77,084,157 bp
  • A to G, chromosome 16 at 3,929,906 bp
  • G to A, chromosome 16 at 4,054,800 bp
  • A to T, chromosome 16 at 18,072,517 bp
  • G to A, chromosome 16 at 29,308,239 bp
  • A to G, chromosome 16 at 52,268,398 bp
  • A to G, chromosome 16 at 87,415,810 bp
  • A to T, chromosome 16 at 90,496,395 bp
  • A to G, chromosome 18 at 37,342,146 bp
  • C to A, chromosome 19 at 3,262,003 bp
  • G to T, chromosome 19 at 5,770,306 bp
  • T to C, chromosome 19 at 34,587,627 bp
  • T to A, chromosome 19 at 56,922,951 bp
  • G to T, chromosome X at 20,860,100 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6194 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044334-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.