Strain Name:
C57BL/6J-MtgxR6212Btlr
Stock Number:
044345-MU
Citation ID:
RRID:MMRRC_044345-MU
Other Names:
R6212 (G1)
Major Collection:

Gene Information

Ncam2
Name: neural cell adhesion molecule 2
Synonyms: Ocam, RNCAM, R4B12 antigen, Ncam-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 17968
HGNC: HGNC:7657
Homologene: 3336
Ptpn3
Name: protein tyrosine phosphatase, non-receptor type 3
Synonyms: PTP-H1, PTPCL, 9530011I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 545622
HGNC: HGNC:9655
Homologene: 74451
Ggnbp2
Name: gametogenetin binding protein 2
Synonyms: Zfp403, D330017P12Rik, DIF-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217039
Homologene: 11750
Tnrc6a
Name: trinucleotide repeat containing 6a
Synonyms: 3110054G10Rik, D130023A07Rik, CAGH26, Tnrc6, 2010321I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233833
Homologene: 41399
Brd4
Name: bromodomain containing 4
Synonyms: HUNK1, WI-11513, MCAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 57261
Homologene: 136213
Ap3b1
Name: adaptor-related protein complex 3, beta 1 subunit
Synonyms: AP-3, beta3A, rim2, Hps2, recombination induced mutation 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 11774
VEGA: 13
HGNC: HGNC:566
Homologene: 68125
Rsf1
Name: remodeling and spacing factor 1
Synonyms: XAP8, p325, 4832420A03Rik, C030033M12Rik, Hbxap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233532
Homologene: 41142
Kars
Name: lysyl-tRNA synthetase
Synonyms: D8Ertd698e, D8Wsu108e, LysRS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 85305
HGNC: HGNC:6215
Homologene: 4053
Hk2
Name: hexokinase 2
Synonyms: HKII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 15277
HGNC: HGNC:4923
Homologene: 37273
Chd8
Name: chromodomain helicase DNA binding protein 8
Synonyms: 5830451P18Rik, Duplin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 67772
Homologene: 72405
Hoxa5
Name: homeobox A5
Synonyms: Hox-1.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 15402
HGNC: HGNC:5106
Homologene: 40726
Nodal
Name: nodal
Synonyms: Tg.413d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 18119
HGNC: HGNC:7865
Homologene: 8417
Gapdh
Name: glyceraldehyde-3-phosphate dehydrogenase
Synonyms: Gapd, Gapd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 14433
HGNC: HGNC:4141
Homologene: 107053
Mcf2l
Name: mcf.2 transforming sequence-like
Synonyms: C130040G20Rik, Dbs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 17207
Homologene: 11804
Epha6
Name: Eph receptor A6
Synonyms: Hek12, m-ehk2, Ehk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 13840
Homologene: 56396
Apex1
Name: apurinic/apyrimidinic endonuclease 1
Synonyms: Ref-1, HAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 11792
HGNC: HGNC:587
Homologene: 1241
Cmip
Name: c-Maf inducing protein
Synonyms: 5830471E12Rik, 4933407C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 74440
Homologene: 18869
Pgap1
Name: post-GPI attachment to proteins 1
Synonyms: PGAP1, oto, 9030223K07Rik, 5033403E17Rik, D230012E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 241062
Homologene: 41605
Srcap
Name: Snf2-related CREBBP activator protein
Synonyms: B930091H02Rik, F630004O05Rik, D030022P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 100043597
Homologene: 38213
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 77505
Homologene: 131117
Zfp831
Name: zinc finger protein 831
Synonyms: ENSMUSG00000050600, OTTMUSG00000017459
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 100043757
Homologene: 19013
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Scy, crash, Adgrc1, Crsh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
P3h3
Name: prolyl 3-hydroxylase 3
Synonyms: Grcb, Leprel2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 14789
Homologene: 8401
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Slc4a8
Name: solute carrier family 4 (anion exchanger), member 8
Synonyms: sodium bicarbonate cotransporter isoform 3 kNBC-3, KNBC-3, NDCBE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 59033
Homologene: 68419
Nwd1
Name: NACHT and WD repeat domain containing 1
Synonyms: A230063L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 319555
Homologene: 72261
Serpinb6e
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6e
Synonyms: ovalbumin, Gm11396, SPI3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 435350
HGNC: HGNC:8950
Homologene: 50933
Dusp26
Name: dual specificity phosphatase 26 (putative)
Synonyms: 2310043K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 66959
Homologene: 11421
Capn3
Name: calpain 3
Synonyms: Capa3, Lp82, p94, Capa-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 12335
HGNC: HGNC:1480
Homologene: 52
Prkce
Name: protein kinase C, epsilon
Synonyms: PKCepsilon, PKC[e], 5830406C15Rik, Pkce
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 18754
HGNC: HGNC:9401
Homologene: 48343
Whrn
Name: whirlin
Synonyms: Dfnb31, Ush2d, C430046P22Rik, wi, 1110035G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 73750
Homologene: 18739
Smgc
Name: submandibular gland protein C
Synonyms: Sfc21, DXImx49e, 2310010P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223809
Txlnb
Name: taxilin beta
Synonyms: Mdp77, 2310001N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 378431
Homologene: 44534
Ccdc13
Name: coiled-coil domain containing 13
Synonyms: 2900041A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 100502861
Homologene: 87213
Oaz3
Name: ornithine decarboxylase antizyme 3
Synonyms: ornithine decarboxylase antizyme in testis, AZ-3, Oaz-t, antizyme 3, AZ3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 53814
HGNC: HGNC:8097
Homologene: 9410
Gabbr2
Name: gamma-aminobutyric acid (GABA) B receptor, 2
Synonyms: Gababr2, Gpr51, GB2, LOC242425
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242425
HGNC: HGNC:4507
Homologene: 55902
Bag6
Name: BCL2-associated athanogene 6
Synonyms: G3, Scythe, 2410045D21Rik, D17H6S52E, Bat3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224727
Homologene: 3409
Olfr1347
Name: olfactory receptor 1347
Synonyms: MOR103-11, GA_x6K02T2QGBW-3218686-3217748, MOR103-19_i
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258383
Homologene: 128065
Mocs1
Name: molybdenum cofactor synthesis 1
Synonyms: 3110045D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 56738
HGNC: HGNC:7190
Homologene: 4343
Zfp326
Name: zinc finger protein 326
Synonyms: ZAN75, 5730470H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 54367
Homologene: 10297
Itgax
Name: integrin alpha X
Synonyms: Cd11c, CD11C (p150) alpha polypeptide
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16411
HGNC: HGNC:6152
Homologene: 55493
Map2k1
Name: mitogen-activated protein kinase kinase 1
Synonyms: Mek1, Prkmk1, MAP kinase kinase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 26395
HGNC: HGNC:6840
Homologene: 2063
Acsm2
Name: acyl-CoA synthetase medium-chain family member 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233799
Homologene: 70404
Fam71f1
Name: family with sequence similarity 71, member F1
Synonyms: LOC330277
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 330277
Homologene: 13077
Nfxl1
Name: nuclear transcription factor, X-box binding-like 1
Synonyms: LOC381696, TCF9, 1700012H24Rik, D430033A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100978
Homologene: 26752
Erg
Name: ETS transcription factor
Synonyms: D030036I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 13876
HGNC: HGNC:3446
Homologene: 15848
Fbxo6
Name: F-box protein 6
Synonyms: Fbs2, FBG2, Fbx6b, Fbxo6b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 50762
Homologene: 9274
Olfr58
Name: olfactory receptor 58
Synonyms: MOR146-3, MOR146-7P, IG6, GA_x6K02T2PVTD-13523015-13523944
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 18358
Homologene: 134093
Arhgap27
Name: Rho GTPase activating protein 27
Synonyms: 2310069I04Rik, Sh3d20, 5730442P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 544817
Homologene: 45715
Stra6l
Name: STRA6-like
Synonyms: 1300002K09Rik, Rbpr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 74152
Homologene: 81924
Tmem262
Name: transmembrane protein 262
Synonyms: BC048609
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 433215
Homologene: 104835
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 54,514,893 bp
  • A to G, chromosome 2 at 120,477,186 bp
  • A to G, chromosome 2 at 174,645,868 bp
  • T to A, chromosome 3 at 94,435,068 bp
  • T to C, chromosome 4 at 45,884,664 bp
  • T to C, chromosome 4 at 46,681,189 bp
  • A to T, chromosome 4 at 57,270,070 bp
  • A to T, chromosome 4 at 63,494,686 bp
  • A to T, chromosome 4 at 148,149,522 bp
  • A to G, chromosome 5 at 72,516,210 bp
  • T to A, chromosome 5 at 105,910,231 bp
  • T to C, chromosome 6 at 29,319,374 bp
  • T to C, chromosome 6 at 52,202,714 bp
  • C to A, chromosome 6 at 82,728,842 bp
  • T to A, chromosome 6 at 124,845,643 bp
  • T to C, chromosome 6 at 125,162,698 bp
  • T to C, chromosome 7 at 6,488,368 bp
  • G to GACGGCGGCA, chromosome 7 at 97,579,909 bp
  • C to T, chromosome 7 at 105,704,048 bp
  • T to A, chromosome 7 at 119,573,282 bp
  • T to A, chromosome 7 at 123,143,742 bp
  • T to A, chromosome 7 at 127,549,689 bp
  • C to A, chromosome 7 at 128,130,332 bp
  • A to G, chromosome 7 at 128,147,853 bp
  • A to T, chromosome 8 at 13,017,431 bp
  • G to A, chromosome 8 at 31,094,224 bp
  • G to A, chromosome 8 at 72,695,322 bp
  • A to T, chromosome 8 at 112,000,197 bp
  • T to C, chromosome 8 at 117,377,156 bp
  • A to G, chromosome 9 at 19,783,289 bp
  • A to T, chromosome 9 at 64,205,163 bp
  • A to G, chromosome 9 at 121,798,909 bp
  • T to C, chromosome 10 at 17,799,309 bp
  • C to T, chromosome 10 at 61,423,521 bp
  • T to C, chromosome 11 at 84,836,677 bp
  • T to C, chromosome 11 at 103,360,872 bp
  • T to A, chromosome 13 at 33,841,237 bp
  • T to C, chromosome 13 at 94,451,073 bp
  • C to A, chromosome 13 at 94,493,699 bp
  • C to T, chromosome 14 at 50,926,893 bp
  • T to A, chromosome 14 at 52,201,698 bp
  • T to C, chromosome 15 at 85,916,687 bp
  • T to A, chromosome 15 at 91,850,627 bp
  • T to C, chromosome 15 at 100,811,571 bp
  • T to C, chromosome 16 at 60,425,356 bp
  • T to C, chromosome 16 at 81,432,762 bp
  • C to T, chromosome 16 at 95,379,163 bp
  • G to T, chromosome 17 at 32,202,449 bp
  • A to G, chromosome 17 at 35,140,302 bp
  • G to A, chromosome 17 at 49,435,196 bp
  • T to C, chromosome 17 at 86,559,301 bp
  • T to C, chromosome 18 at 12,513,645 bp
  • A to G, chromosome 19 at 6,080,638 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6212 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044345-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.