Strain Name:
C57BL/6J-MtgxR6219Btlr
Stock Number:
044351-MU
Citation ID:
RRID:MMRRC_044351-MU
Other Names:
R6219 (G1)
Major Collection:

Gene Information

Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Pip5k1b
Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
Synonyms: Pipk5b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18719
HGNC: HGNC:8995
Homologene: 100644
Sirt2
Name: sirtuin 2
Synonyms: SIR2L2, Sir2l, 5730427M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 64383
Homologene: 40823
Cyfip1
Name: cytoplasmic FMR1 interacting protein 1
Synonyms: P140SRA-1, Shyc, pl-1, l(7)1Rl, Sra-1, E030028J09Rik, l7Rl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20430
Homologene: 22628
Tnks2
Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Synonyms: 5430432P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 74493
Homologene: 11890
Nup133
Name: nucleoporin 133
Synonyms: 4832420O05Rik, mermaid
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234865
Homologene: 32402
Mdc1
Name: mediator of DNA damage checkpoint 1
Synonyms: NFBD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240087
Homologene: 67092
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Tfap4
Name: transcription factor AP4
Synonyms: AP-4, D930048N17Rik, bHLHc41, Tcfap4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 83383
VEGA: 16
Homologene: 2424
Ccnf
Name: cyclin F
Synonyms: CycF, Fbxo1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12449
VEGA: 17
HGNC: HGNC:1591
Homologene: 1335
Nr2c1
Name: nuclear receptor subfamily 2, group C, member 1
Synonyms: TR2, Tr2-11, 4831444H07Rik, Eenr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22025
HGNC: HGNC:7971
Homologene: 55731
Slit2
Name: slit guidance ligand 2
Synonyms: Slil3, Drad-1, E130320P19Rik, E030015M03Rik, b2b1200.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20563
Homologene: 3516
Ino80d
Name: INO80 complex subunit D
Synonyms: A430093A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227195
Homologene: 9819
Zdhhc20
Name: zinc finger, DHHC domain containing 20
Synonyms: B230110O18Rik, 5033406L14Rik, ENSMUSG00000055956, 4930542A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 75965
VEGA: 14
Homologene: 57105
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269700
Homologene: 28297
Sp8
Name: trans-acting transcription factor 8
Synonyms: mBtd, D930049B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320145
VEGA: 12
Homologene: 18548
Acat2
Name: acetyl-Coenzyme A acetyltransferase 2
Synonyms: Tcp-1x, Tcp1-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 110460
HGNC: HGNC:94
Homologene: 55855
Tgm3
Name: transglutaminase 3, E polypeptide
Synonyms: TG E, we
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21818
Homologene: 20690
Reln
Name: reelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Vwa3b
Name: von Willebrand factor A domain containing 3B
Synonyms: A230074B11Rik, 4921511C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70853
Homologene: 27053
Cmya5
Name: cardiomyopathy associated 5
Synonyms: Myospryn, 2310076E16Rik, 2310076E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Arsi
Name: arylsulfatase i
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 545260
Homologene: 44428
Sptbn5
Name: spectrin beta, non-erythrocytic 5
Synonyms: EG640524, Spnb5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 640524
Homologene: 41150
Dock3
Name: dedicator of cyto-kinesis 3
Synonyms: PBP, Moca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208869
HGNC: HGNC:2989
Homologene: 21030
Lcn10
Name: lipocalin 10
Synonyms: 9230112J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 332578
Homologene: 52253
Fbxw7
Name: F-box and WD-40 domain protein 7
Synonyms: SEL-10, AGO, Fbxo30, Fbxw6, 1110001A17Rik, Cdc4, Fbw7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 50754
Homologene: 117451
Fmo2
Name: flavin containing monooxygenase 2
Synonyms: 2310008D08Rik, 2310042I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 55990
HGNC: HGNC:3770
Homologene: 86882
Irs2
Name: insulin receptor substrate 2
Synonyms: Irs-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 384783
HGNC: HGNC:6126
Homologene: 2778
Snx15
Name: sorting nexin 15
Synonyms: E130013C21Rik, 1500032B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 69024
Homologene: 12294
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227058
Homologene: 41287
Gpr141
Name: G protein-coupled receptor 141
Synonyms: Pgr13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 353346
VEGA: 13
Homologene: 18771
Ano2
Name: anoctamin 2
Synonyms: Tmem16b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243634
HGNC: HGNC:1183
Homologene: 23221
Cyp4a29
Name: cytochrome P450, family 4, subfamily a, polypeptide 29
Synonyms: Cyp4a29-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230639
Ttll11
Name: tubulin tyrosine ligase-like family, member 11
Synonyms: 4932702F08Rik, D2Ertd624e, 4933424A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74410
Homologene: 77534
Gm10549
Name: predicted gene 10549
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 433171
VEGA: 18
Cdc14b
Name: CDC14 cell division cycle 14B
Synonyms: 2810432N10Rik, A530086E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218294
VEGA: 13
HGNC: HGNC:1719
Homologene: 104197
Glis1
Name: GLIS family zinc finger 1
Synonyms: GliH1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230587
Homologene: 77390
Gm14548
Name: predicted gene 14548
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100038909
HGNC: HGNC:6607
Homologene: 134028
Olfr1356
Name: olfactory receptor 1356
Synonyms: GA_x6K02T2QGN0-2962025-2962987, MOR142-2_p, MOR142-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258305
HGNC: HGNC:8374
Homologene: 71958
Ccr10
Name: chemokine (C-C motif) receptor 10
Synonyms: CCR10, GPR2, Cmkbr9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12777
HGNC: HGNC:4474
Homologene: 7271
Gm35315
Name: predicted gene, 35315
Synonyms: Gm20090
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 102638847
Homologene: 141161
6030445D17Rik
Name: RIKEN cDNA 6030445D17 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 37,100,698 bp
  • A to G, chromosome 1 at 46,233,585 bp
  • C to T, chromosome 1 at 63,079,047 bp
  • A to T, chromosome 1 at 162,880,516 bp
  • A to T, chromosome 2 at 25,683,575 bp
  • A to T, chromosome 2 at 35,752,499 bp
  • A to T, chromosome 2 at 69,469,478 bp
  • T to C, chromosome 2 at 120,077,322 bp
  • T to C, chromosome 2 at 130,038,610 bp
  • G to A, chromosome 3 at 84,969,213 bp
  • C to T, chromosome 4 at 107,631,905 bp
  • A to C, chromosome 4 at 115,249,730 bp
  • T to C, chromosome 4 at 136,462,748 bp
  • T to C, chromosome 5 at 21,948,596 bp
  • A to T, chromosome 5 at 48,302,428 bp
  • G to T, chromosome 5 at 110,078,544 bp
  • T to G, chromosome 5 at 121,308,878 bp
  • A to G, chromosome 6 at 125,815,590 bp
  • A to T, chromosome 7 at 3,894,641 bp
  • A to G, chromosome 7 at 28,767,515 bp
  • A to G, chromosome 7 at 55,908,441 bp
  • A to G, chromosome 8 at 11,005,121 bp
  • A to T, chromosome 8 at 123,936,873 bp
  • T to A, chromosome 9 at 106,994,881 bp
  • A to G, chromosome 10 at 78,847,259 bp
  • G to T, chromosome 10 at 94,163,786 bp
  • C to T, chromosome 11 at 101,174,549 bp
  • T to G, chromosome 12 at 118,848,667 bp
  • A to G, chromosome 13 at 19,752,527 bp
  • C to T, chromosome 13 at 64,205,524 bp
  • T to C, chromosome 13 at 93,094,443 bp
  • A to T, chromosome 14 at 57,840,883 bp
  • A to G, chromosome 16 at 4,547,311 bp
  • T to C, chromosome 17 at 12,960,717 bp
  • C to A, chromosome 17 at 24,226,704 bp
  • T to A, chromosome 17 at 35,850,674 bp
  • T to C, chromosome 17 at 67,790,856 bp
  • C to A, chromosome 18 at 33,464,305 bp
  • A to T, chromosome 18 at 49,902,367 bp
  • G to A, chromosome 18 at 60,916,651 bp
  • A to G, chromosome 19 at 6,121,508 bp
  • T to A, chromosome 19 at 24,381,823 bp
  • T to C, chromosome 19 at 36,866,204 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6219 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044351-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.