Strain Name:
C57BL/6J-MtgxR6222Btlr
Stock Number:
044353-MU
Citation ID:
RRID:MMRRC_044353-MU
Other Names:
R6222 (G1)
Major Collection:

Gene Information

Snx2
Name: sorting nexin 2
Synonyms: 0610030A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67804
VEGA: 18
Homologene: 2332
Cacng7
Name: calcium channel, voltage-dependent, gamma subunit 7
Synonyms: TARP gamma 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 81904
Homologene: 12895
Cwf19l2
Name: CWF19-like 2, cell cycle control (S. pombe)
Synonyms: 3230401L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244672
Homologene: 12366
Pdzd2
Name: PDZ domain containing 2
Synonyms: LOC223364, Pdzk3, Gm21706, A930022H17Rik, 4930537L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 68070
Homologene: 23393
Virma
Name: vir like m6A methyltransferase associated
Synonyms: 1110037F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66185
Homologene: 41043
Sart3
Name: squamous cell carcinoma antigen recognized by T cells 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 53890
Homologene: 40977
Abcc4
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Synonyms: MOAT-B, MRP4, D630049P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239273
VEGA: 14
HGNC: HGNC:55
Homologene: 74563
Bicd1
Name: BICD cargo adaptor 1
Synonyms: B830009D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12121
HGNC: HGNC:1049
Homologene: 37518
Als2
Name: alsin Rho guanine nucleotide exchange factor
Synonyms: Alsin, Als2cr6, 9430073A21Rik, 3222402C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74018
HGNC: HGNC:443
Homologene: 23264
Arid1b
Name: AT rich interactive domain 1B (SWI-like)
Synonyms: 9330189K18Rik, B230217J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 239985
Homologene: 32344
Arl10
Name: ADP-ribosylation factor-like 10
Synonyms: ARL10, Arl10a, Arm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56795
Homologene: 10550
Fam204a
Name: family with sequence similarity 204, member A
Synonyms: 2610015K05Rik, D19Ertd737e, 2310065H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76539
VEGA: 19
Homologene: 41463
Cftr
Name: cystic fibrosis transmembrane conductance regulator
Synonyms: Abcc7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12638
HGNC: HGNC:1884
Homologene: 55465
Ino80d
Name: INO80 complex subunit D
Synonyms: A430093A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227195
Homologene: 9819
Bbs9
Name: Bardet-Biedl syndrome 9 (human)
Synonyms: E130103I17Rik, EST 3159894
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319845
Homologene: 44480
Izumo4
Name: IZUMO family member 4
Synonyms: 9030607L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71564
VEGA: 10
Homologene: 50465
Gna15
Name: guanine nucleotide binding protein, alpha 15
Synonyms: Galpha15, G[a]15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14676
HGNC: HGNC:4383
Homologene: 1563
Akap7
Name: A kinase (PRKA) anchor protein 7
Synonyms: AKAP15, Akap18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432442
HGNC: HGNC:377
Homologene: 49463
Nol11
Name: nucleolar protein 11
Synonyms: 1500002M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68979
Homologene: 32264
Dusp27
Name: dual specificity phosphatase 27 (putative)
Synonyms: C130085G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240892
Homologene: 18949
Ruvbl2
Name: RuvB-like protein 2
Synonyms: mp47, p47
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20174
Homologene: 4856
Ano4
Name: anoctamin 4
Synonyms: A330096O15Rik, Tmem16d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320091
Homologene: 66599
Tmem116
Name: transmembrane protein 116
Synonyms: 4930513P12Rik, 4930406A18Rik, C030022K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 77462
Homologene: 12676
C7
Name: complement component 7
Synonyms: LOC383055
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 109828
VEGA: 15
HGNC: HGNC:1346
Homologene: 489
Cntnap4
Name: contactin associated protein-like 4
Synonyms: E130114F09Rik, Caspr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 170571
Homologene: 24912
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: mdg, fmd, muscle dysgenesis, sj, DHPR alpha1s, Cchl1a3, Cav1.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Wdr53
Name: WD repeat domain 53
Synonyms: 1500002B03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 68980
Homologene: 15591
Gbe1
Name: glucan (1,4-alpha-), branching enzyme 1
Synonyms: 2810426P10Rik, 2310045H19Rik, D16Ertd536e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74185
HGNC: HGNC:4180
Homologene: 129
Umodl1
Name: uromodulin-like 1
Synonyms: D17Ertd488e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 52020
VEGA: 17
Homologene: 45466
Olfr1186
Name: olfactory receptor 1186
Synonyms: MOR230-5, GA_x6K02T2Q125-50012960-50013871
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258523
Homologene: 110555
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: Adlican2, CMF608, 6530405F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242050
Homologene: 18712
Kcnt1
Name: potassium channel, subfamily T, member 1
Synonyms: Slack, slo2, C030030G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227632
Homologene: 11055
Ccdc13
Name: coiled-coil domain containing 13
Synonyms: 2900041A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 100502861
Homologene: 87213
Ldlrap1
Name: low density lipoprotein receptor adaptor protein 1
Synonyms: Arh1, Arh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100017
Homologene: 9219
Olfr1368
Name: olfactory receptor 1368
Synonyms: MOR256-15, GA_x6K02T2QHY8-12104556-12105500
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 258527
Homologene: 105156
Bmi1
Name: Bmi1 polycomb ring finger oncogene
Synonyms: Bmi-1, Bmi1, Pcgf4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12151
Homologene: 3797
B130006D01Rik
Name: RIKEN cDNA B130006D01 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 320616
VEGA: 11
Gm5771
Name: predicted gene 5771
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 436523
Homologene: 88408
4930596D02Rik
Name: RIKEN cDNA 4930596D02 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239036
Abcc3
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 3
Synonyms: MRP3, 1700019L09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76408
HGNC: HGNC:54
Homologene: 68364
Galnt1
Name: polypeptide N-acetylgalactosaminyltransferase 1
Synonyms: ppGaNTase-T1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14423
HGNC: HGNC:4123
Homologene: 8469
Tiam2
Name: T cell lymphoma invasion and metastasis 2
Synonyms: 3000002F19Rik, STEF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 24001
VEGA: 17
Homologene: 40796
Kiz
Name: kizuna centrosomal protein
Synonyms: LOC228730, Plk1s1, Ncrna00153, Gm114
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228730
Homologene: 10219
Ing2
Name: inhibitor of growth family, member 2
Synonyms: ING2, 2810011M06Rik, Ing1l, P33ING2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69260
HGNC: HGNC:6063
Homologene: 20388
Sorcs3
Name: sortilin-related VPS10 domain containing receptor 3
Synonyms: 6330404A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66673
VEGA: 19
Homologene: 8986
Cma2
Name: chymase 2, mast cell
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 545055
VEGA: 14
Homologene: 115745
Gm6871
Name: predicted gene 6871
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 102642386
Ceacam5
Name: carcinoembryonic antigen-related cell adhesion molecule 5
Synonyms: Psg30, 1600029H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 73250
Homologene: 115938
Tll1
Name: tolloid-like
Synonyms: b2b2476Clo, Tll-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 21892
Homologene: 49202
Reg1
Name: regenerating islet-derived 1
Synonyms: pancreatic stone protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19692
Homologene: 68282
Sh2d4b
Name: SH2 domain containing 4B
Synonyms: A430109M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 328381
Homologene: 19164
Serpinb5
Name: serine (or cysteine) peptidase inhibitor, clade B, member 5
Synonyms: Spi7, 1110036M19Rik, ovalbumin, Maspin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20724
HGNC: HGNC:8949
Homologene: 20580
Tmem181a
Name: transmembrane protein 181A
Synonyms: Gpr178, Tmem181, 5930418K15Rik, C76977
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 77106
Homologene: 44787
Prl3a1
Name: prolactin family 3, subfamily a, member 1
Synonyms: PLP-I, Prlpi, PLP-H, 1600016E11Rik, Plpi
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67000
Homologene: 49844
Zcchc10
Name: zinc finger, CCHC domain containing 10
Synonyms: 2410141K03Rik, D11Ertd416e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67966
Cdpf1
Name: cysteine rich, DPF motif domain containing 1
Synonyms: 2210021J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72355
Homologene: 45673
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 59,180,125 bp
  • G to A, chromosome 1 at 63,058,525 bp
  • T to A, chromosome 1 at 106,870,340 bp
  • A to T, chromosome 1 at 136,104,622 bp
  • G to T, chromosome 1 at 166,098,645 bp
  • T to A, chromosome 2 at 18,683,702 bp
  • G to A, chromosome 2 at 25,892,510 bp
  • T to C, chromosome 2 at 88,499,270 bp
  • A to T, chromosome 2 at 146,891,061 bp
  • C to T, chromosome 3 at 59,318,915 bp
  • C to T, chromosome 4 at 11,527,820 bp
  • C to T, chromosome 4 at 134,757,360 bp
  • C to T, chromosome 5 at 113,743,206 bp
  • C to T, chromosome 5 at 121,491,108 bp
  • A to C, chromosome 6 at 18,282,501 bp
  • A to T, chromosome 6 at 41,397,166 bp
  • A to T, chromosome 6 at 78,427,374 bp
  • A to T, chromosome 6 at 149,512,965 bp
  • A to G, chromosome 7 at 3,336,612 bp
  • A to T, chromosome 7 at 17,745,547 bp
  • C to T, chromosome 7 at 41,546,582 bp
  • G to T, chromosome 7 at 45,424,725 bp
  • T to C, chromosome 8 at 47,668,931 bp
  • C to A, chromosome 8 at 64,098,534 bp
  • A to G, chromosome 8 at 112,842,721 bp
  • T to A, chromosome 9 at 3,454,569 bp
  • T to A, chromosome 9 at 22,567,851 bp
  • A to G, chromosome 9 at 121,798,909 bp
  • T to A, chromosome 10 at 25,283,946 bp
  • C to T, chromosome 10 at 80,703,051 bp
  • T to C, chromosome 10 at 81,512,046 bp
  • T to C, chromosome 10 at 89,027,222 bp
  • T to C, chromosome 11 at 53,332,462 bp
  • A to G, chromosome 11 at 94,368,605 bp
  • T to C, chromosome 11 at 95,726,162 bp
  • G to T, chromosome 11 at 107,171,616 bp
  • T to C, chromosome 13 at 21,142,877 bp
  • T to C, chromosome 13 at 27,276,114 bp
  • T to C, chromosome 13 at 54,578,831 bp
  • T to C, chromosome 14 at 35,809,966 bp
  • A to C, chromosome 14 at 40,820,737 bp
  • T to C, chromosome 14 at 55,973,192 bp
  • T to A, chromosome 14 at 118,529,956 bp
  • A to T, chromosome 15 at 5,011,941 bp
  • T to C, chromosome 15 at 12,374,566 bp
  • T to C, chromosome 15 at 85,807,442 bp
  • T to C, chromosome 16 at 32,256,664 bp
  • T to C, chromosome 16 at 70,529,012 bp
  • A to G, chromosome 17 at 3,453,338 bp
  • A to G, chromosome 17 at 5,327,647 bp
  • T to C, chromosome 17 at 6,300,917 bp
  • T to C, chromosome 17 at 31,002,892 bp
  • T to A, chromosome 18 at 24,264,534 bp
  • T to A, chromosome 18 at 53,199,824 bp
  • A to T, chromosome 19 at 48,759,857 bp
  • A to G, chromosome 19 at 60,199,968 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6222 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044353-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.