Strain Name:
C57BL/6J-MtgxR6223Btlr
Stock Number:
044354-MU
Citation ID:
RRID:MMRRC_044354-MU
Other Names:
R6223 (G1)
Major Collection:

Gene Information

Cdc25a
Name: cell division cycle 25A
Synonyms: D9Ertd393e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12530
HGNC: HGNC:1725
Homologene: 1355
Acadm
Name: acyl-Coenzyme A dehydrogenase, medium chain
Synonyms: MCAD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11364
HGNC: HGNC:89
Homologene: 3
Pcdh9
Name: protocadherin 9
Synonyms: C630029H24Rik, A730003J17Rik, 1500001L12Rik, LOC382930, C530050I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 211712
HGNC: HGNC:8661
Homologene: 10698
Ulk2
Name: unc-51 like kinase 2
Synonyms: Unc51.2, A830085I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 29869
Homologene: 5891
Stub1
Name: STIP1 homology and U-Box containing protein 1
Synonyms: CHIP, 2210017D18Rik, 2310040B03Rik, 0610033N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56424
VEGA: 17
Homologene: 4281
Prdm2
Name: PR domain containing 2, with ZNF domain
Synonyms: 4833427P12Rik, E330024L24Rik, KMT8, Riz, LOC381568, Riz1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 110593
HGNC: HGNC:9347
Homologene: 40822
Tab1
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1
Synonyms: Map3k7ip1, 2310012M03Rik, Tak1-binding protein 1, b2b449Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66513
VEGA: 15
Homologene: 4461
Gtf3c1
Name: general transcription factor III C 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233863
HGNC: HGNC:4664
Homologene: 31040
Eed
Name: embryonic ectoderm development
Synonyms: l7Rn5, l(7)5Rn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13626
HGNC: HGNC:3188
Homologene: 2814
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 21819
Homologene: 2430
Vdac2
Name: voltage-dependent anion channel 2
Synonyms: Vdac6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 22334
Homologene: 37765
Ifnar2
Name: interferon (alpha and beta) receptor 2
Synonyms: Ifnar-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 15976
HGNC: HGNC:5433
Homologene: 49242
Casz1
Name: castor zinc finger 1
Synonyms: 2410019P08Rik, D4Ertd432e, Cst, castor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69743
Homologene: 9824
Nol11
Name: nucleolar protein 11
Synonyms: 1500002M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68979
Homologene: 32264
Qser1
Name: glutamine and serine rich 1
Synonyms: 4732486I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99003
Homologene: 11710
Ttc7b
Name: tetratricopeptide repeat domain 7B
Synonyms: Ttc7l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104718
VEGA: 12
Homologene: 14675
Kat6a
Name: K(lysine) acetyltransferase 6A
Synonyms: 9930021N24Rik, MOZ, Zfp220, Myst3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244349
Homologene: 4924
Wdr60
Name: WD repeat domain 60
Synonyms: D430033N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217935
VEGA: 12
Homologene: 23067
Pi16
Name: peptidase inhibitor 16
Synonyms: 1200009H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74116
Homologene: 134317
Dock8
Name: dedicator of cytokinesis 8
Synonyms: 5830472H07Rik, 1200017A24Rik, A130095G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76088
VEGA: 19
Homologene: 52414
Ubb
Name: ubiquitin B
Synonyms: Ubb2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22187
Homologene: 74981
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Clspn
Name: claspin
Synonyms: C85083, E130314M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269582
Homologene: 11138
Ap3b2
Name: adaptor-related protein complex 3, beta 2 subunit
Synonyms: beta3B, Naptb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11775
HGNC: HGNC:567
Homologene: 55837
Ssu2
Name: ssu-2 homolog (C. elegans)
Synonyms: D630042P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243612
Homologene: 136556
Myh3
Name: myosin, heavy polypeptide 3, skeletal muscle, embryonic
Synonyms: Myhse, Myhs-e, MyHC-emb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17883
HGNC: HGNC:7573
Homologene: 20553
Abca8b
Name: ATP-binding cassette, sub-family A (ABC1), member 8b
Synonyms: Abca8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 27404
HGNC: HGNC:38
Homologene: 56029
Olfr1362
Name: olfactory receptor 1362
Synonyms: GA_x6K02T2QHY8-11628399-11628868, GA_x6K02T2QHY8-11617756-11618682, MOR256-8, Olfr1363-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 258739
Homologene: 105885
Tdrd1
Name: tudor domain containing 1
Synonyms: MTR-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 83561
Homologene: 12850
Tex10
Name: testis expressed gene 10
Synonyms: 2810462N03Rik, clone 18330, 2610206N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269536
Homologene: 32361
Ccdc13
Name: coiled-coil domain containing 13
Synonyms: 2900041A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 100502861
Homologene: 87213
Olfml3
Name: olfactomedin-like 3
Synonyms: HNOEL-iso, ONT3, mONT3, 2810002E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99543
Homologene: 10613
Crat
Name: carnitine acetyltransferase
Synonyms: CARAT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12908
HGNC: HGNC:2342
Homologene: 598
Rchy1
Name: ring finger and CHY zinc finger domain containing 1
Synonyms: Pirh2, 6720407C15Rik, Zfp363, PRO1996
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68098
Homologene: 22894
Tll2
Name: tolloid-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 24087
VEGA: 19
Homologene: 56545
Cyp2d26
Name: cytochrome P450, family 2, subfamily d, polypeptide 26
Synonyms: 1300006E06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 76279
VEGA: 15
Homologene: 130660
Pcolce
Name: procollagen C-endopeptidase enhancer protein
Synonyms: Astt-2, Astt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18542
HGNC: HGNC:8738
Homologene: 1946
Zfp651
Name: zinc finger protein 651
Synonyms: 4732420M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270210
VEGA: 9
Homologene: 136302
Ncan
Name: neurocan
Synonyms: Cspg3, Cspg3-rs, Tgfbit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13004
HGNC: HGNC:2465
Homologene: 3229
Olfr1509
Name: olfactory receptor 1509
Synonyms: GA_x6K02T2RJGY-534312-533386, MOR83, MOR244-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 57271
HGNC: HGNC:8297
Homologene: 41378
Sirpb1a
Name: signal-regulatory protein beta 1A
Synonyms: 9930027N05Rik, Sirpb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 320832
Homologene: 82993
Tmem232
Name: transmembrane protein 232
Synonyms: LOC381107, E130009J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 381107
VEGA: 17
Homologene: 54378
Vmn2r45
Name: vomeronasal 2, receptor 45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100042810
Homologene: 113703
Prss56
Name: protease, serine 56
Synonyms: Prss56, 1700027L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 69453
Homologene: 79885
Pik3c2b
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
Synonyms: PI3K-C2beta, C330011J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240752
HGNC: HGNC:8972
Homologene: 20582
6820408C15Rik
Name: RIKEN cDNA 6820408C15 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228778
Homologene: 51916
Ggcx
Name: gamma-glutamyl carboxylase
Synonyms: vitamin K-dependent carboxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56316
HGNC: HGNC:4247
Homologene: 639
Ifih1
Name: interferon induced with helicase C domain 1
Synonyms: MDA-5, MDA5, 9130009C22Rik, Helicard
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71586
Homologene: 32535
Mgat5
Name: mannoside acetylglucosaminyltransferase 5
Synonyms: GlcNAc-TV, 4930471A21Rik, 5330407H02Rik, beta1,6N-acetylglucosaminyltransferase V
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 107895
HGNC: HGNC:7049
Homologene: 1808
Prx
Name: periaxin
Synonyms: L-Periaxin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19153
Homologene: 76542
Col10a1
Name: collagen, type X, alpha 1
Synonyms: Col10, Col10a-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12813
HGNC: HGNC:2185
Homologene: 55466
Mmel1
Name: membrane metallo-endopeptidase-like 1
Synonyms: Nep2, NEPLP alpha, Nl1, Mell1, SEP, NEPLP gamma, NEPLP beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 27390
Homologene: 22778
Art2b
Name: ADP-ribosyltransferase 2b
Synonyms: ART2.2, Rt6, Rt6-2, Rt-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11872
Homologene: 113756
Cidea
Name: cell death-inducing DNA fragmentation factor, alpha subunit-like effector A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12683
VEGA: 18
HGNC: HGNC:1976
Homologene: 77852
Fabp5
Name: fatty acid binding protein 5, epidermal
Synonyms: mal1, Fabpe E-FABP, Klbp, Unknown Klbp, keratinocyte lipid binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 16592
HGNC: HGNC:3560
Homologene: 108238
Glrp1
Name: glutamine repeat protein 1
Synonyms: GRP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14659
Scp2d1
Name: SCP2 sterol-binding domain containing 1
Synonyms: 1700010M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66328
Homologene: 11947
Qpctl
Name: glutaminyl-peptide cyclotransferase-like
Synonyms: 1810019P04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67369
Homologene: 9765
C1rb
Name: complement component 1, r subcomponent B
Synonyms: Gm8551, mC1rB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 667277
HGNC: HGNC:1246
Homologene: 1313
Gm29797
Name: predicted gene, 29797
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 101056205
Homologene: 90439
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 87,185,412 bp
  • G to A, chromosome 1 at 88,503,442 bp
  • A to T, chromosome 1 at 127,382,979 bp
  • T to A, chromosome 1 at 133,070,357 bp
  • C to T, chromosome 2 at 30,407,030 bp
  • T to C, chromosome 2 at 62,598,259 bp
  • A to G, chromosome 2 at 104,787,648 bp
  • C to T, chromosome 2 at 125,412,671 bp
  • T to C, chromosome 2 at 144,823,948 bp
  • A to C, chromosome 2 at 152,427,953 bp
  • T to C, chromosome 2 at 181,659,057 bp
  • T to A, chromosome 3 at 10,015,110 bp
  • A to G, chromosome 3 at 15,379,026 bp
  • G to A, chromosome 3 at 103,736,460 bp
  • C to A, chromosome 3 at 153,938,549 bp
  • T to C, chromosome 4 at 48,468,525 bp
  • T to A, chromosome 4 at 126,586,168 bp
  • T to C, chromosome 4 at 143,142,207 bp
  • C to A, chromosome 4 at 148,933,383 bp
  • A to G, chromosome 4 at 154,871,702 bp
  • G to A, chromosome 5 at 91,957,967 bp
  • A to G, chromosome 5 at 137,605,299 bp
  • T to C, chromosome 6 at 72,429,605 bp
  • G to T, chromosome 6 at 112,376,448 bp
  • T to A, chromosome 6 at 124,574,580 bp
  • A to T, chromosome 7 at 8,483,302 bp
  • T to C, chromosome 7 at 19,143,209 bp
  • T to G, chromosome 7 at 27,516,836 bp
  • G to A, chromosome 7 at 81,473,462 bp
  • A to G, chromosome 7 at 89,956,287 bp
  • A to G, chromosome 7 at 101,579,951 bp
  • C to T, chromosome 7 at 125,676,625 bp
  • C to A, chromosome 8 at 22,940,426 bp
  • A to C, chromosome 8 at 70,109,954 bp
  • C to A, chromosome 9 at 109,889,774 bp
  • G to A, chromosome 9 at 121,763,787 bp
  • A to G, chromosome 9 at 121,798,909 bp
  • A to T, chromosome 10 at 34,395,187 bp
  • A to T, chromosome 11 at 61,787,504 bp
  • A to G, chromosome 11 at 62,552,525 bp
  • G to T, chromosome 11 at 67,098,017 bp
  • G to T, chromosome 11 at 107,171,616 bp
  • A to G, chromosome 11 at 109,977,846 bp
  • A to G, chromosome 12 at 100,387,109 bp
  • T to C, chromosome 12 at 116,257,458 bp
  • G to A, chromosome 13 at 21,611,366 bp
  • G to A, chromosome 14 at 21,845,178 bp
  • A to G, chromosome 14 at 52,450,679 bp
  • T to C, chromosome 14 at 93,015,733 bp
  • T to A, chromosome 15 at 66,707,922 bp
  • T to A, chromosome 15 at 80,148,263 bp
  • A to T, chromosome 15 at 82,791,717 bp
  • A to T, chromosome 16 at 17,357,571 bp
  • C to T, chromosome 16 at 91,387,988 bp
  • C to T, chromosome 17 at 25,832,813 bp
  • C to A, chromosome 17 at 29,327,439 bp
  • T to C, chromosome 17 at 65,500,196 bp
  • A to C, chromosome 18 at 67,358,739 bp
  • A to T, chromosome 19 at 25,161,052 bp
  • G to A, chromosome 19 at 41,135,952 bp
  • T to C, chromosome 19 at 56,865,850 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6223 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044354-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.