Strain Name:
C57BL/6J-MtgxR6423Btlr
Stock Number:
044386-MU
Citation ID:
RRID:MMRRC_044386-MU
Other Names:
R6423 (G1)
Major Collection:

Gene Information

Arhgap10
Name: Rho GTPase activating protein 10
Synonyms: PSGAP-s, PSGAP-m, A930033B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78514
Homologene: 12695
H2-DMa
Name: histocompatibility 2, class II, locus DMa
Synonyms: H2-Ma, H-2Ma, H2-M alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14998
HGNC: HGNC:4934
Homologene: 4464
Kif1b
Name: kinesin family member 1B
Synonyms: D4Mil1e, Kif1b alpha, Kif1b beta, KIF1Bp130, KIF1Bp204, N-3 kinesin, A530096N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16561
Homologene: 99835
Ncor2
Name: nuclear receptor co-repressor 2
Synonyms: SMRTe, SMRT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20602
HGNC: HGNC:7673
Homologene: 31370
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235627
Homologene: 86422
Zfp386
Name: zinc finger protein 386 (Kruppel-like)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56220
Homologene: 51668
Qrfprl
Name: pyroglutamylated RFamide peptide receptor like
Synonyms: C130060K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243407
Homologene: 135976
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Ets1
Name: E26 avian leukemia oncogene 1, 5' domain
Synonyms: Ets-1, Tpl1, p51Ets-1, p42Ets-1, vs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 23871
HGNC: HGNC:3488
Homologene: 3837
Chia1
Name: chitinase, acidic 1
Synonyms: AMCase, YNL, 2200003E03Rik, Chia
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 81600
Homologene: 75168
Mgam
Name: maltase-glucoamylase
Synonyms: 6030407P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232714
HGNC: HGNC:7043
Homologene: 130099
Insr
Name: insulin receptor
Synonyms: IR, CD220, 4932439J01Rik, D630014A15Rik, IR-B, IR-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16337
HGNC: HGNC:6091
Homologene: 20090
Bcl11b
Name: B cell leukemia/lymphoma 11B
Synonyms: COUP-TF interacting protein 2, CTIP2, B630002E05Rik, Rit1, 9130430L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 58208
Homologene: 10974
Or11l3
Name: olfactory receptor family 11 subfamily L member 3
Synonyms: GA_x6K02T2NKPP-794386-795357, MOR107-1, Olfr323
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258373
Homologene: 64865
Flnc
Name: filamin C, gamma
Synonyms: Fln2, 1110055E19Rik, actin binding protein 280
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Nell2
Name: NEL-like 2
Synonyms: mel91, A330108N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 54003
VEGA: 15
HGNC: HGNC:7751
Homologene: 4488
Adgrb1
Name: adhesion G protein-coupled receptor B1
Synonyms: B830018M07Rik, Bai1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 107831
HGNC: HGNC:943
Homologene: 1287
Actl7b
Name: actin-like 7b
Synonyms: Tact1, t-actin 1, ENSMUSG00000070980
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11471
HGNC: HGNC:162
Homologene: 21330
Iqub
Name: IQ motif and ubiquitin domain containing
Synonyms: 4932408B21Rik, Trs4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 214704
Homologene: 44790
Foxf1
Name: forkhead box F1
Synonyms: FREAC1, Hfh8, Freac-1, HFH-8, Foxf1, Foxf1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 15227
HGNC: HGNC:3809
Homologene: 1114
Kcna3
Name: potassium voltage-gated channel, shaker-related subfamily, member 3
Synonyms: Kv1.3, Mk-3, Kca1-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 16491
HGNC: HGNC:6221
Homologene: 128570
Fbxo4
Name: F-box protein 4
Synonyms: 1700096C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 106052
Homologene: 8134
Cnrip1
Name: cannabinoid receptor interacting protein 1
Synonyms: 5330437A18Rik, 3110054C06Rik, 1500041B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380686
Homologene: 9153
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 3 at 106,128,988 bp
  • C to A, chromosome 3 at 107,036,842 bp
  • T to C, chromosome 4 at 56,741,213 bp
  • T to C, chromosome 4 at 149,192,596 bp
  • A to G, chromosome 5 at 125,087,902 bp
  • T to C, chromosome 6 at 24,491,529 bp
  • G to A, chromosome 6 at 29,445,156 bp
  • A to G, chromosome 6 at 40,677,045 bp
  • A to G, chromosome 6 at 65,456,093 bp
  • C to T, chromosome 8 at 3,173,566 bp
  • G to T, chromosome 8 at 77,517,757 bp
  • G to A, chromosome 8 at 121,085,095 bp
  • A to G, chromosome 9 at 32,738,315 bp
  • T to C, chromosome 9 at 110,625,994 bp
  • A to T, chromosome 11 at 9,298,778 bp
  • T to C, chromosome 11 at 17,052,350 bp
  • T to C, chromosome 11 at 58,625,363 bp
  • T to C, chromosome 12 at 107,915,419 bp
  • A to G, chromosome 12 at 116,060,113 bp
  • C to T, chromosome 15 at 3,965,792 bp
  • G to T, chromosome 15 at 74,588,143 bp
  • A to T, chromosome 15 at 95,527,282 bp
  • A to G, chromosome 17 at 34,137,196 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6423 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044386-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.