Strain Name:
C57BL/6J-MtgxR6461Btlr
Stock Number:
044390-MU
Citation ID:
RRID:MMRRC_044390-MU
Other Names:
R6461 (G1)
Major Collection:

Gene Information

Mon1b
Name: MON1 homolog B, secretory traffciking associated
Synonyms: 5033413H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270096
Homologene: 69174
Smarca4
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Synonyms: SNF2beta, Brg1, SW1/SNF, b2b692Clo, b2b508.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20586
Homologene: 135927
Dnmbp
Name: dynamin binding protein
Synonyms: 2410003M15Rik, Tuba, 2410003L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 71972
Homologene: 9061
Btbd11
Name: BTB (POZ) domain containing 11
Synonyms: 6330404E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 74007
Homologene: 72536
Pelp1
Name: proline, glutamic acid and leucine rich protein 1
Synonyms: 4930563C04Rik, MNAR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75273
Homologene: 8664
Lman2
Name: lectin, mannose-binding 2
Synonyms: VIP36, GP36B, 1300009F09Rik, 1110003H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66890
VEGA: 13
Homologene: 4962
Sec24a
Name: Sec24 related gene family, member A (S. cerevisiae)
Synonyms: 9430090N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77371
Homologene: 70131
Scube1
Name: signal peptide, CUB domain, EGF-like 1
Synonyms: A630023E24Rik, 7330410C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 64706
Homologene: 11224
Grin2c
Name: glutamate receptor, ionotropic, NMDA2C (epsilon 3)
Synonyms: NMDAR2C, NR2C, GluRepsilon3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14813
HGNC: HGNC:4587
Homologene: 647
Hnrnpk
Name: heterogeneous nuclear ribonucleoprotein K
Synonyms: hnRNPK, Hnrpk, KBBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 15387
HGNC: HGNC:5044
Homologene: 81909
Syngap1
Name: synaptic Ras GTPase activating protein 1 homolog (rat)
Synonyms: Syngap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240057
Homologene: 84739
Enpp5
Name: ectonucleotide pyrophosphatase/phosphodiesterase 5
Synonyms: D17Abb1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 83965
Homologene: 23313
Zfp142
Name: zinc finger protein 142
Synonyms: 9330177B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 77264
Homologene: 3723
Zbtb11
Name: zinc finger and BTB domain containing 11
Synonyms: ZNF-U69274, 9230110G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 271377
Homologene: 8678
Papln
Name: papilin, proteoglycan-like sulfated glycoprotein
Synonyms: E030033C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 170721
Homologene: 71541
Atp12a
Name: ATPase, H+/K+ transporting, nongastric, alpha polypeptide
Synonyms: Atp1al1, HKalpha2, cHKA, ATPase H+K+-transporting, alpha 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 192113
VEGA: 14
Homologene: 68197
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20265
Homologene: 21375
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 81877
Homologene: 49589
Irf6
Name: interferon regulatory factor 6
Synonyms: E230028I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 54139
HGNC: HGNC:6121
Homologene: 4479
Gne
Name: glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Synonyms: 2310066H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 50798
Homologene: 3996
Olfr571
Name: olfactory receptor 571
Synonyms: GA_x6K02T2PBJ9-5620890-5619922, MOR21-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259089
Homologene: 17498
Olfr93
Name: olfactory receptor 93
Synonyms: MOR256-39P, GA_x6K02T2PSCP-1592036-1591098
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258051
HGNC: HGNC:8252
Homologene: 79436
Fbxo40
Name: F-box protein 40
Synonyms: 9830003A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 207215
Homologene: 9459
Slc29a2
Name: solute carrier family 29 (nucleoside transporters), member 2
Synonyms: ENT2, Der12, HNP36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13340
VEGA: 19
Homologene: 37493
Olfr156
Name: olfactory receptor 156
Synonyms: OR37B, mOR37b, Olfr37b, MOR262-6, GA_x6K02T2N78B-16125144-16126100
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 29846
Homologene: 133652
Mcfd2
Name: multiple coagulation factor deficiency 2
Synonyms: 1810021C21Rik, LMAN1IP, F5F8D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 193813
Homologene: 44552
Mup10
Name: major urinary protein 10
Synonyms: 2610016E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100039008
Homologene: 74304
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 74,567,185 bp
  • G to C, chromosome 1 at 193,167,471 bp
  • T to C, chromosome 2 at 66,326,122 bp
  • T to C, chromosome 4 at 43,821,355 bp
  • T to C, chromosome 4 at 44,060,078 bp
  • T to A, chromosome 4 at 60,582,079 bp
  • T to A, chromosome 7 at 102,909,028 bp
  • A to G, chromosome 8 at 113,638,538 bp
  • T to A, chromosome 9 at 21,679,020 bp
  • T to A, chromosome 10 at 85,640,564 bp
  • T to C, chromosome 11 at 51,713,546 bp
  • A to T, chromosome 11 at 70,396,306 bp
  • A to T, chromosome 11 at 115,255,696 bp
  • A to G, chromosome 12 at 83,781,813 bp
  • A to G, chromosome 13 at 55,346,915 bp
  • A to G, chromosome 13 at 58,393,194 bp
  • C to T, chromosome 14 at 56,373,238 bp
  • G to A, chromosome 15 at 83,612,427 bp
  • T to C, chromosome 16 at 36,970,028 bp
  • G to A, chromosome 16 at 56,006,871 bp
  • A to G, chromosome 17 at 26,964,848 bp
  • G to T, chromosome 17 at 34,671,898 bp
  • C to T, chromosome 17 at 37,151,471 bp
  • G to A, chromosome 17 at 44,085,264 bp
  • G to A, chromosome 17 at 87,258,066 bp
  • A to G, chromosome 19 at 5,027,740 bp
  • A to G, chromosome 19 at 43,867,525 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6461 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044390-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.