Strain Name:
C57BL/6J-MtgxR6234Btlr/Mmmh
Stock Number:
044399-MU
Citation ID:
RRID:MMRRC_044399-MU
Other Names:
R6234 (G1)
Major Collection:

Strain Information

Gabrg1
Name: gamma-aminobutyric acid type A receptor subunit gamma 1
Synonyms: GabaA
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14405
HGNC: HGNC:4086
Homologene: 22570
Bcl2l2
Name: BCL2-like 2
Synonyms: bclw, Gtrosa41, Gtrgal2, Bcl-w
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12050
Homologene: 2989
Il21r
Name: interleukin 21 receptor
Synonyms: NILR
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 60504
HGNC: HGNC:6006
Homologene: 11040
Timmdc1
Name: translocase of inner mitochondrial membrane domain containing 1
Synonyms: 4930455C21Rik, 2810021C21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 76916
HGNC: HGNC:1321
Homologene: 9578
Ptpra
Name: protein tyrosine phosphatase receptor type A
Synonyms: PTP[a], Ptpa, RPTPalpha, PTPalpha, RPTRalpha
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19262
HGNC: HGNC:9664
Homologene: 20621
Hspa4
Name: heat shock protein 4
Synonyms: 70kDa, Hsp110, Hsp70RY, APG-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15525
HGNC: HGNC:5237
Homologene: 1624
Ube2o
Name: ubiquitin-conjugating enzyme E2O
Synonyms: B230113M03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217342
Homologene: 11113
Nfkb1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Synonyms: nuclear factor kappaB p50, NF-kappaB p50, NF kappaB1, p50 subunit of NF kappaB, p50/p105, NF-kappaB, p50
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18033
HGNC: HGNC:7794
Homologene: 2971
Fbrsl1
Name: fibrosin-like 1
Synonyms: 2410025L10Rik, Gm29766, LOC381668
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381668
Homologene: 45966
Ptprg
Name: protein tyrosine phosphatase receptor type G
Synonyms: 5430405N12Rik, RPTPgamma
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19270
HGNC: HGNC:9671
Homologene: 2129
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108989
Homologene: 37753
Trrap
Name: transformation/transcription domain-associated protein
Synonyms: transactivation/transformation-domain associated protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100683
Homologene: 39246
Wdr7
Name: WD repeat domain 7
Synonyms: TRAG, TGF-beta resistance associated gene
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 104082
VEGA: 18
Homologene: 11408
Heatr5a
Name: HEAT repeat containing 5A
Synonyms: D930036F22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320487
VEGA: 12
Homologene: 19635
Bltp1
Name: bridge-like lipid transfer protein family member 1
Synonyms: Tweek, FSA, 4932438A13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229227
Homologene: 52105
Nasp
Name: nuclear autoantigenic sperm protein (histone-binding)
Synonyms: 5033430J04Rik, Nasp-T, D4Ertd767e, Epcs32
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50927
HGNC: HGNC:7644
Homologene: 133894
Clic6
Name: chloride intracellular channel 6
Synonyms: 5730466J16Rik, CLIC1L
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 209195
HGNC: HGNC:2065
Homologene: 43154
Mtch1
Name: mitochondrial carrier 1
Synonyms: 2310034O17Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56462
Homologene: 22807
Zfp871
Name: zinc finger protein 871
Synonyms: 9030612M13Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 208292
Homologene: 138401
Homer3
Name: homer scaffolding protein 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 26558
Homologene: 37972
Usp54
Name: ubiquitin specific peptidase 54
Synonyms: 4930429G18Rik, C030002J06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 78787
Homologene: 90902
Cd34
Name: CD34 antigen
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12490
HGNC: HGNC:1662
Homologene: 1343
Stradb
Name: STE20-related kinase adaptor beta
Synonyms: Als2cr2, D1Ucla2, PRO1038
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227154
Homologene: 10237
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 4833413O10Rik, D430029O09Rik, 1110021D17Rik, Polydom
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64817
Homologene: 23386
Fer1l6
Name: fer-1 like family member 6
Synonyms: EG631797
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 631797
Homologene: 53396
Hsf5
Name: heat shock transcription factor family member 5
Synonyms: LOC327992
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327992
Homologene: 52701
Cnga4
Name: cyclic nucleotide gated channel alpha 4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233649
HGNC: HGNC:2152
Homologene: 13579
Hc
Name: hemolytic complement
Synonyms: C5, He, Hfib2, C5a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15139
HGNC: HGNC:1331
Homologene: 20412
Vwf
Name: Von Willebrand factor
Synonyms: B130011O06Rik, 6820430P06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22371
Homologene: 466
Tcaf2
Name: TRPM8 channel-associated factor 2
Synonyms: Fam115c
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232748
Homologene: 17147
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: ENSMUSG00000044873, OTTMUSG00000020804, Heatr7b1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Gm5114
Name: predicted gene 5114
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330513
Homologene: 45597
Tdrd5
Name: tudor domain containing 5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214575
Homologene: 18312
Adam34l
Name: a disintegrin and metallopeptidase domain 34 like
Synonyms: Gm5346
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384813
Homologene: 78104
Adgb
Name: androglobin
Synonyms: 9130014G24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215772
Homologene: 100289
Eef1akmt2
Name: EEF1A lysine methyltransferase 2
Synonyms: 2010208K18Rik, Mettl10
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72096
Homologene: 6175
Sap30
Name: sin3 associated polypeptide
Synonyms: 30kDa
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 60406
Homologene: 2869
Mamdc4
Name: MAM domain containing 4
Synonyms: LOC381352
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381352
Homologene: 17102
Aldoart1
Name: aldolase 1 A, retrogene 1
Synonyms: Aldoa-ps2, Aldo1-ps2, 4921524E03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 353204
Homologene: 128442
Fmn1
Name: formin 1
Synonyms: Fmn, formin-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14260
HGNC: HGNC:3768
Homologene: 121778
Gfm1
Name: G elongation factor, mitochondrial 1
Synonyms: D3Wsu133e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 28030
Homologene: 6449
Neil3
Name: nei like 3 (E. coli)
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234258
Homologene: 10094
Ftdc1
Name: ferritin domain containing 1
Synonyms: Gm813, LOC385656, LOC328695
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 328695
VEGA: 16
Serpinb2
Name: serine (or cysteine) peptidase inhibitor, clade B, member 2
Synonyms: PAI-2, ovalbumin, Planh2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18788
HGNC: HGNC:8584
Homologene: 20571
Gm9925
Name: predicted gene 9925
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 433202
VEGA: 18
Kctd14
Name: potassium channel tetramerisation domain containing 14
Synonyms: AI449310, D7Ertd760e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233529
Homologene: 11396
Tmbim4
Name: transmembrane BAX inhibitor motif containing 4
Synonyms: 0610007H07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68212
Homologene: 56740
Dnase1l1
Name: deoxyribonuclease 1-like 1
Synonyms: Dnl1ll, G4.8, Dnase1ll, 2310005K03Rik
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 69537
HGNC: HGNC:2957
Homologene: 4896
Trav6-5
Name: T cell receptor alpha variable 6-5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100126464
Chmp1b
Name: charged multivesicular body protein 1B
Synonyms: 2810405I11Rik, chromatin modifying protein 1B
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67064
Homologene: 41374
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 58,988,548 bp
  • T to C, chromosome 1 at 88,234,612 bp
  • T to C, chromosome 1 at 88,256,754 bp
  • G to A, chromosome 1 at 107,524,771 bp
  • A to G, chromosome 1 at 150,418,039 bp
  • A to T, chromosome 1 at 156,293,377 bp
  • A to T, chromosome 1 at 194,948,000 bp
  • C to G, chromosome 2 at 25,570,080 bp
  • T to C, chromosome 2 at 35,028,046 bp
  • T to C, chromosome 2 at 113,365,655 bp
  • T to A, chromosome 2 at 130,537,588 bp
  • A to G, chromosome 3 at 36,983,471 bp
  • A to G, chromosome 3 at 67,435,514 bp
  • C to T, chromosome 3 at 135,626,710 bp
  • A to T, chromosome 4 at 58,113,458 bp
  • A to G, chromosome 4 at 72,852,172 bp
  • G to A, chromosome 4 at 116,622,782 bp
  • A to T, chromosome 5 at 70,842,141 bp
  • G to A, chromosome 5 at 110,378,051 bp
  • T to A, chromosome 5 at 144,839,713 bp
  • A to T, chromosome 6 at 42,630,374 bp
  • T to G, chromosome 6 at 125,657,165 bp
  • T to A, chromosome 7 at 39,409,344 bp
  • T to A, chromosome 7 at 97,458,012 bp
  • T to G, chromosome 7 at 105,407,699 bp
  • A to G, chromosome 7 at 125,632,585 bp
  • T to C, chromosome 7 at 132,827,856 bp
  • T to G, chromosome 8 at 43,625,912 bp
  • G to T, chromosome 8 at 53,608,739 bp
  • A to G, chromosome 8 at 57,485,118 bp
  • T to C, chromosome 8 at 70,291,165 bp
  • A to C, chromosome 10 at 10,353,080 bp
  • T to A, chromosome 10 at 120,221,723 bp
  • C to T, chromosome 11 at 53,262,939 bp
  • C to G, chromosome 11 at 87,617,294 bp
  • A to T, chromosome 11 at 116,539,490 bp
  • A to T, chromosome 12 at 51,877,454 bp
  • C to A, chromosome 14 at 12,213,747 bp
  • T to A, chromosome 14 at 20,583,450 bp
  • A to G, chromosome 14 at 53,491,375 bp
  • A to G, chromosome 14 at 54,884,788 bp
  • T to C, chromosome 15 at 58,560,639 bp
  • A to T, chromosome 16 at 38,518,499 bp
  • T to A, chromosome 16 at 58,614,671 bp
  • T to C, chromosome 16 at 92,499,222 bp
  • A to T, chromosome 17 at 29,340,511 bp
  • CCACAC to CC, chromosome 17 at 32,775,520 bp
  • T to C, chromosome 18 at 63,724,132 bp
  • T to A, chromosome 18 at 67,206,098 bp
  • A to T, chromosome 18 at 74,065,237 bp
  • C to T, chromosome X at 74,277,038 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6234 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044399-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.