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Strain Name:
C57BL/6J-MtgxR6300Btlr/Mmmh
Stock Number:
044409-MU
Citation ID:
RRID:MMRRC_044409-MU
Other Names:
R6300 (G1)
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Sez6
Name: seizure related gene 6
Synonyms: sez-6, D11Bhm177e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20370
Homologene: 10948
Pds5b
Name: PDS5 cohesin associated factor B
Synonyms: AS3, Aprin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100710
Homologene: 41001
Pepd
Name: peptidase D
Synonyms: Pep-4, peptidase D, Pep4, dal
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18624
HGNC: HGNC:8840
Homologene: 239
Arfgap2
Name: ADP-ribosylation factor GTPase activating protein 2
Synonyms: 2310032E02Rik, Zfp289
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77038
Homologene: 8735
Cct2
Name: chaperonin containing TCP1 subunit 2
Synonyms: Cctb
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12461
VEGA: 10
HGNC: HGNC:1615
Homologene: 4696
Ctdp1
Name: CTD phosphatase subunit 1
Synonyms: 4930563P03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67655
HGNC: HGNC:2498
Homologene: 31254
Smc4
Name: structural maintenance of chromosomes 4
Synonyms: 2500002A22Rik, Smc4l1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70099
Homologene: 4015
Safb2
Name: scaffold attachment factor B2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224902
Homologene: 35210
Mars1
Name: methionine-tRNA synthetase 1
Synonyms: MetRS, methionine tRNA ligase, methionyl-tRNA synthetase, Mars
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216443
HGNC: HGNC:6898
Homologene: 90878
Slc19a2
Name: solute carrier family 19 (thiamine transporter), member 2
Synonyms: TRMA, THTR1, DDA1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 116914
Homologene: 38258
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Sfrp4
Name: secreted frizzled-related protein 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20379
VEGA: 13
Homologene: 2267
Dzip3
Name: DAZ interacting protein 3, zinc finger
Synonyms: 6430549P11Rik, 2310047C04Rik, 2A-HUB
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224170
Homologene: 8771
Hspe1
Name: heat shock protein 1 (chaperonin 10)
Synonyms: mitochondrial chaperonin 10, Hsp10
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15528
HGNC: HGNC:5269
Homologene: 20500
Adamtsl1
Name: ADAMTS-like 1
Synonyms: punctin-1, 6720426B09Rik, 5930437A14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77739
Homologene: 64642
Top3a
Name: topoisomerase (DNA) III alpha
Synonyms: Top IIIa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21975
Homologene: 3394
Prdm4
Name: PR domain containing 4
Synonyms: 2810470D21Rik, SC-1, 1700031E19Rik, SC1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72843
VEGA: 10
HGNC: HGNC:9348
Homologene: 8235
Apip
Name: APAF1 interacting protein
Synonyms: CGI-29, APIP2, Mmrp19
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56369
Homologene: 6277
Kat6a
Name: K(lysine) acetyltransferase 6A
Synonyms: MOZ, Zfp220, 9930021N24Rik, Myst3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244349
Homologene: 4924
Skor1
Name: SKI family transcriptional corepressor 1
Synonyms: C230094B15Rik, Corl1, Lbxcor1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 207667
Homologene: 18175
Apeh
Name: acylpeptide hydrolase
Synonyms: N-acylaminoacyl peptide hydrolase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235606
HGNC: HGNC:586
Homologene: 1240
Pla2g4e
Name: phospholipase A2, group IVE
Synonyms: 2310026J01Rik, Pla2epsilon
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329502
Homologene: 65339
Mef2b
Name: myocyte enhancer factor 2B
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17259
Homologene: 48381
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Mmrn2
Name: multimerin 2
Synonyms: EndoGlyx-1, ENDOGLYX1, Emilin3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105450
VEGA: 14
Homologene: 11697
Exph5
Name: exophilin 5
Synonyms: slac2-b, B130009M24Rik, AC079869.22gm5, Slac2b
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320051
Homologene: 9007
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, 2810003K23Rik, Dnahcl1, Dnahc17
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Snapc4
Name: small nuclear RNA activating complex, polypeptide 4
Synonyms: 5730436L13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227644
Homologene: 2321
Vwa3a
Name: von Willebrand factor A domain containing 3A
Synonyms: E030013G06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233813
Homologene: 18607
Tm7sf2
Name: transmembrane 7 superfamily member 2
Synonyms: ANG1, 3110041O18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73166
Homologene: 68305
Duox1
Name: dual oxidase 1
Synonyms: NOXEF1, THOX1, LNOX1, 9930101G15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99439
HGNC: HGNC:3062
Homologene: 68136
Slc8a3
Name: solute carrier family 8 (sodium/calcium exchanger), member 3
Synonyms: Ncx3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 110893
Homologene: 62645
Bmal2
Name: basic helix-loop-helix ARNT like 2
Synonyms: 4632430A05Rik, MOP9, bHLHe6, Arntl2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 272322
Homologene: 10609
Ttc21a
Name: tetratricopeptide repeat domain 21A
Synonyms: 4921538N17Rik, Thm2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74052
Homologene: 14728
Slc13a2
Name: solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
Synonyms: sodium/dicarboxylate co-transporter, mNaDC-1, Nadc1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20500
Homologene: 2965
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 435626
Homologene: 52359
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330267
Homologene: 46582
Il6ra
Name: interleukin 6 receptor, alpha
Synonyms: IL-6 receptor alpha chain, CD126, Il6r, IL-6R
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16194
HGNC: HGNC:6019
Homologene: 474
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Cacna1e
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms: Cav2.3, Cchra1, alpha1E
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12290
HGNC: HGNC:1392
Homologene: 20185
Defb36
Name: defensin beta 36
Synonyms: Defb123
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 266620
Homologene: 134587
Ankdd1a
Name: ankyrin repeat and death domain containing 1A
Synonyms: LOC384945, EG330963
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330963
VEGA: 9
Homologene: 65619
Cers5
Name: ceramide synthase 5
Synonyms: 2310081H14Rik, Trh4, CerS5, Lass5
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71949
Homologene: 23634
Marchf10
Name: membrane associated ring-CH-type finger 10
Synonyms: 4933417C16Rik, Rnf190, OTTMUSG00000002847, March10
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 632687
Homologene: 34988
Bag6
Name: BCL2-associated athanogene 6
Synonyms: D17H6S52E, 2410045D21Rik, G3, Scythe, Bat3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224727
Homologene: 3409
Zfp672
Name: zinc finger protein 672
Synonyms: 4930488P06Rik, 4930511N19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319475
Homologene: 23493
4932414N04Rik
Name: RIKEN cDNA 4932414N04 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75721
Homologene: 138468
Armh1
Name: armadillo-like helical domain containing 1
Synonyms: LOC381544, LOC381543, Ncrna00082, Gm1661
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381544
Homologene: 28727
Apol6
Name: apolipoprotein L 6
Synonyms: 2310076O14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71939
Homologene: 49940
Amn
Name: amnionless
Synonyms: 5033428N14Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 93835
VEGA: 12
Homologene: 12804
Tcte1
Name: t-complex-associated testis expressed 1
Synonyms: Tcte-1, D17Sil1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21645
VEGA: 17
Homologene: 8434
Gabrg2
Name: gamma-aminobutyric acid type A receptor, subunit gamma 2
Synonyms: Gabrg-2, gamma2, GABAA-R
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14406
HGNC: HGNC:4087
Homologene: 22443
4930433I11Rik
Name: RIKEN cDNA 4930433I11 gene
Synonyms: LOC243944
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243944
Homologene: 77912
Nek5
Name: NIMA (never in mitosis gene a)-related expressed kinase 5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330721
HGNC: HGNC:7748
Homologene: 87952
Tjp3
Name: tight junction protein 3
Synonyms: ZO-3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 27375
VEGA: 10
Homologene: 8458
Or52e19
Name: olfactory receptor family 52 subfamily E member 19
Synonyms: GA_x6K02T2PBJ9-6019769-6019943, ENSMUSG00000073953, Olfr596-ps1, Gm15117, Olfr596
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100041187
Homologene: 121535
Endod1
Name: endonuclease domain containing 1
Synonyms: 2210414F18Rik, 2310067E08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71946
VEGA: 9
Homologene: 12425
Or8b36
Name: olfactory receptor family 8 subfamily B member 36
Synonyms: GA_x6K02T2PVTD-31705144-31706073, MOR162-6, Olfr883
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258414
Homologene: 86689
Or2y15
Name: olfactory receptor family 2 subfamily Y member 15
Synonyms: GA_x6K02T2QP88-5975166-5974231, MOR256-22, Olfr1387
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258465
Homologene: 74034
Zfp382
Name: zinc finger protein 382
Synonyms: 5930415A09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233060
Homologene: 32798
Serpina3k
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3K
Synonyms: contrapsin, Spi-2, D12Rp54, RP54, Spi2, MMSpi2, MMCM2, alpha-1 antiproteinase, 1300001I07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20714
HGNC: HGNC:16
Homologene: 111129
Or52e7
Name: olfactory receptor family 52 subfamily E member 7
Synonyms: GA_x6K02T2PBJ9-7664016-7664969, MOR32-1, Olfr676
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259099
Homologene: 64955
Hoxd3
Name: homeobox D3
Synonyms: Hox-4.1, Hox-5.5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15434
HGNC: HGNC:5137
Homologene: 5034
Ap1s3
Name: adaptor-related protein complex AP-1, sigma 3
Synonyms: [s]3A, Jr2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 252903
Homologene: 65622
Pcdhgb5
Name: protocadherin gamma subfamily B, 5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93702
HGNC: HGNC:8712
Homologene: 55773
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 46,325,886 bp
  • T to A, chromosome 1 at 55,090,701 bp
  • T to A, chromosome 1 at 74,133,224 bp
  • T to C, chromosome 1 at 79,625,123 bp
  • A to G, chromosome 1 at 80,286,952 bp
  • T to A, chromosome 1 at 154,425,932 bp
  • C to T, chromosome 1 at 164,256,775 bp
  • A to G, chromosome 2 at 26,378,551 bp
  • A to G, chromosome 2 at 68,731,109 bp
  • A to G, chromosome 2 at 74,744,076 bp
  • A to G, chromosome 2 at 91,267,195 bp
  • C to T, chromosome 2 at 103,087,153 bp
  • A to T, chromosome 2 at 120,182,738 bp
  • T to G, chromosome 2 at 122,337,700 bp
  • T to A, chromosome 2 at 152,612,498 bp
  • T to C, chromosome 3 at 69,027,891 bp
  • A to G, chromosome 3 at 89,887,129 bp
  • G to A, chromosome 4 at 86,248,017 bp
  • A to G, chromosome 4 at 117,231,782 bp
  • A to G, chromosome 5 at 21,896,841 bp
  • T to A, chromosome 5 at 150,723,248 bp
  • G to T, chromosome 6 at 12,471,104 bp
  • A to T, chromosome 6 at 73,065,815 bp
  • T to A, chromosome 6 at 124,317,991 bp
  • A to G, chromosome 6 at 146,821,946 bp
  • G to A, chromosome 7 at 30,131,629 bp
  • G to A, chromosome 7 at 34,969,543 bp
  • A to G, chromosome 7 at 40,993,461 bp
  • A to T, chromosome 7 at 103,310,429 bp
  • A to G, chromosome 7 at 104,840,691 bp
  • G to A, chromosome 7 at 105,035,671 bp
  • A to G, chromosome 7 at 120,782,400 bp
  • T to A, chromosome 8 at 22,107,721 bp
  • A to G, chromosome 8 at 22,939,612 bp
  • C to T, chromosome 8 at 70,167,119 bp
  • T to C, chromosome 9 at 14,356,870 bp
  • ATTGCTGTTT to ATTGCTGTTTGCTGTTT, chromosome 9 at 38,026,540 bp
  • A to G, chromosome 9 at 53,373,946 bp
  • A to T, chromosome 9 at 63,145,314 bp
  • C to T, chromosome 9 at 65,508,061 bp
  • G to A, chromosome 9 at 108,092,679 bp
  • T to A, chromosome 9 at 110,436,062 bp
  • T to C, chromosome 9 at 119,961,839 bp
  • T to A, chromosome 10 at 12,501,476 bp
  • T to A, chromosome 10 at 81,281,117 bp
  • A to G, chromosome 10 at 85,910,221 bp
  • C to T, chromosome 10 at 117,056,159 bp
  • G to A, chromosome 10 at 127,296,560 bp
  • T to C, chromosome 11 at 42,000,523 bp
  • T to A, chromosome 11 at 49,460,212 bp
  • A to T, chromosome 11 at 58,317,268 bp
  • T to C, chromosome 11 at 60,749,408 bp
  • T to C, chromosome 11 at 77,976,541 bp
  • CGTTATCTGT to CGT, chromosome 11 at 78,403,480 bp
  • T to C, chromosome 11 at 105,382,237 bp
  • T to C, chromosome 11 at 118,034,310 bp
  • C to T, chromosome 12 at 8,007,769 bp
  • T to A, chromosome 12 at 81,314,978 bp
  • A to T, chromosome 12 at 104,340,722 bp
  • T to C, chromosome 12 at 111,274,189 bp
  • T to A, chromosome 13 at 11,680,999 bp
  • G to A, chromosome 13 at 19,623,853 bp
  • T to C, chromosome 14 at 34,397,657 bp
  • A to T, chromosome 15 at 77,051,271 bp
  • G to T, chromosome 15 at 99,772,219 bp
  • A to G, chromosome 16 at 48,951,807 bp
  • T to C, chromosome 17 at 35,138,601 bp
  • T to C, chromosome 17 at 45,533,289 bp
  • T to C, chromosome 17 at 56,563,226 bp
  • T to A, chromosome 18 at 37,732,699 bp
  • T to A, chromosome 18 at 80,459,240 bp
  • A to T, chromosome 19 at 6,067,200 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6300 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044409-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.