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Strain Name:
C57BL/6J-MtgxR6317Btlr/Mmmh
Stock Number:
044417-MU
Citation ID:
RRID:MMRRC_044417-MU
Other Names:
R6317 (G1)
Major Collection:

Strain Information

Polr3e
Name: polymerase (RNA) III (DNA directed) polypeptide E
Synonyms: RPC5, Sin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26939
Homologene: 14052
Gria2
Name: glutamate receptor, ionotropic, AMPA2 (alpha 2)
Synonyms: GluR-B, GluR2, Glur-2, Glur2, GluA2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14800
HGNC: HGNC:4572
Homologene: 20225
Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, DPEAAE, Cspg2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Prpf6
Name: pre-mRNA splicing factor 6
Synonyms: 1190003A07Rik, U5-102K, ANT-1, 2610031L17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68879
Homologene: 5368
Cwc27
Name: CWC27 spliceosome-associated protein
Synonyms: NY-CO-10, 3110009E13Rik, Sdccag10
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67285
Homologene: 21192
Map3k8
Name: mitogen-activated protein kinase kinase kinase 8
Synonyms: Cot, Tpl2, c-COT, Tpl-2, Cot/Tpl2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 26410
HGNC: HGNC:6860
Homologene: 3812
Rabgap1
Name: RAB GTPase activating protein 1
Synonyms: Gapcena
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227800
Homologene: 49301
Ptpn21
Name: protein tyrosine phosphatase, non-receptor type 21
Synonyms: PTPD1, PTPRL10
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 24000
VEGA: 12
HGNC: HGNC:9651
Homologene: 5110
Nol9
Name: nucleolar protein 9
Synonyms: 6030462G04Rik, 4632412I24Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74035
Homologene: 32589
Ints4
Name: integrator complex subunit 4
Synonyms: 2610034N24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101861
Homologene: 69427
Gspt1
Name: G1 to S phase transition 1
Synonyms: Gst-1, Gst-1, G1st
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14852
HGNC: HGNC:4621
Homologene: 68226
Qrich1
Name: glutamine-rich 1
Synonyms: 2610028H07Rik, b2b2404Clo
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69232
Homologene: 9803
Oga
Name: O-GlcNAcase
Synonyms: Hy5, 5830447M11Rik, 4833427O07Rik, 2810009A20Rik, Mgea5
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76055
VEGA: 19
HGNC: HGNC:7056
Homologene: 8154
Prmt2
Name: protein arginine N-methyltransferase 2
Synonyms: Hrmt1l1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15468
HGNC: HGNC:5186
Homologene: 55587
Naca
Name: nascent polypeptide-associated complex alpha polypeptide
Synonyms: skNAC, LOC380777
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17938
VEGA: 10
HGNC: HGNC:7629
Homologene: 136025
Pcca
Name: propionyl-Coenzyme A carboxylase, alpha polypeptide
Synonyms: C79630
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110821
HGNC: HGNC:8653
Homologene: 236
Kif13a
Name: kinesin family member 13A
Synonyms: N-3 kinesin, 4930505I07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16553
VEGA: 13
Homologene: 22589
Zfp644
Name: zinc finger protein 644
Synonyms: 1110068L01Rik, BM-005, Zep-2, D5Ertd689e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52397
Homologene: 12971
Baz1a
Name: bromodomain adjacent to zinc finger domain 1A
Synonyms: Gtl5, Wcrf180, Acf1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217578
HGNC: HGNC:960
Homologene: 45654
Map3k2
Name: mitogen-activated protein kinase kinase kinase 2
Synonyms: Mekk2, MEK kinase 2, 9630061B06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 26405
VEGA: 18
HGNC: HGNC:6854
Homologene: 74576
Abcf2
Name: ATP-binding cassette, sub-family F member 2
Synonyms: 0710005O05Rik, Drr3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27407
Homologene: 21408
Cyp20a1
Name: cytochrome P450, family 20, subfamily a, polypeptide 1
Synonyms: A930011N14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77951
Homologene: 18584
Patl1
Name: protein associated with topoisomerase II homolog 1 (yeast)
Synonyms: Pat1b
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225929
VEGA: 19
Homologene: 82269
Podn
Name: podocan
Synonyms: SLRR5A
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242608
Homologene: 17803
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Reg3d
Name: regenerating islet-derived 3 delta
Synonyms: Ingaprp, INGAP
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 30053
Homologene: 137262
Ces1h
Name: carboxylesterase 1H
Synonyms: 2310039D24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75704
HGNC: HGNC:1863
Homologene: 119757
Cspg4b
Name: chondroitin sulfate proteoglycan 4B
Synonyms: BC067074
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408066
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: Spna-1, erythroid, ihj, Spna1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20739
Homologene: 74460
Sema6b
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
Synonyms: VIb, semaZ, Sema, Seman
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20359
VEGA: 17
Homologene: 8428
Otog
Name: otogelin
Synonyms: Otgn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18419
HGNC: HGNC:8516
Homologene: 8421
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: oxygen-regulated protein 1, Orp1, mG145, Dcdc3, Rp1h
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19888
Homologene: 4564
Bhlhe22
Name: basic helix-loop-helix family, member e22
Synonyms: Beta3, Bhlhb5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 59058
Homologene: 10994
Plce1
Name: phospholipase C, epsilon 1
Synonyms: 4933403A21Rik, PLCepsilon
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74055
Homologene: 9478
Slc7a6
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 6
Synonyms: LAT-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330836
Homologene: 62496
Aoc2
Name: amine oxidase copper containing 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237940
HGNC: HGNC:549
Homologene: 56457
Shank2
Name: SH3 and multiple ankyrin repeat domains 2
Synonyms: ProSAP1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210274
Homologene: 105965
Corin
Name: corin, serine peptidase
Synonyms: Lrp4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53419
Homologene: 4804
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Col6a5, Gm7455
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 665033
Homologene: 122792
Or8a1
Name: olfactory receptor family 8 subfamily A member 1
Synonyms: M71, MOR171-2, GA_x6K02T2PVTD-31408136-31407207, Olfr151
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 406176
HGNC: HGNC:8469
Homologene: 12726
Adck1
Name: aarF domain containing kinase 1
Synonyms: 2610005A10Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 72113
VEGA: 12
Homologene: 6493
Mcemp1
Name: mast cell expressed membrane protein 1
Synonyms: 1810033B17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69189
Homologene: 52162
4930503L19Rik
Name: RIKEN cDNA 4930503L19 gene
Synonyms: Las2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269033
Homologene: 52120
Atp1a2
Name: ATPase, Na+/K+ transporting, alpha 2 polypeptide
Synonyms: Atpa-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98660
HGNC: HGNC:800
Homologene: 47947
Slc28a2
Name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
Synonyms: CNT2, 2010208B10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269346
Homologene: 20891
Vmn1r181
Name: vomeronasal 1 receptor 181
Synonyms: V1rd20
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404289
Homologene: 104166
Daxx
Name: Fas death domain-associated protein
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13163
HGNC: HGNC:2681
Homologene: 1033
Slc9a9
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 9
Synonyms: 5730527A11Rik, Nhe9
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 331004
Homologene: 69753
Plch1
Name: phospholipase C, eta 1
Synonyms: PLCeta1, Plcl3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269437
Homologene: 88833
Vmn1r172
Name: vomeronasal 1 receptor 172
Synonyms: V3R9, V1rd9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81010
Homologene: 79577
Serpinb7
Name: serine (or cysteine) peptidase inhibitor, clade B, member 7
Synonyms: 4631416M05Rik, megsin, ovalbumin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 116872
Homologene: 68363
Cdo1
Name: cysteine dioxygenase 1, cytosolic
Synonyms: Cdo, D18Ucla3, 1300002L19Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12583
VEGA: 18
HGNC: HGNC:1795
Homologene: 1365
Tgm2
Name: transglutaminase 2, C polypeptide
Synonyms: tissue transglutaminase, protein-glutamine gamma-glutamyltransferase, G[a]h, TG C, tTGas, tTG, TG2, TGase2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21817
Homologene: 3391
Vmn1r3
Name: vomeronasal 1 receptor 3
Synonyms: Gm11778
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100312471
Homologene: 128342
Ubl7
Name: ubiquitin-like 7 (bone marrow stromal cell-derived)
Synonyms: 2300004C15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69459
VEGA: 9
Homologene: 12312
Sult2a1
Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
Synonyms: mSTa1, Std, Sth1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20859
Homologene: 37741
As3mt
Name: arsenite methyltransferase
Synonyms: Cyt19, 2310045H08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 57344
VEGA: 19
Homologene: 10754
Pex11g
Name: peroxisomal biogenesis factor 11 gamma
Synonyms: Pex11gamma, 1810049N02Rik, 1810022F11Rik, Pex11c
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69129
Homologene: 12298
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 4,041,989 bp
  • T to C, chromosome 1 at 60,352,124 bp
  • A to G, chromosome 1 at 75,489,629 bp
  • T to C, chromosome 1 at 107,451,706 bp
  • C to G, chromosome 1 at 172,289,336 bp
  • A to G, chromosome 1 at 174,241,087 bp
  • T to A, chromosome 2 at 37,542,647 bp
  • A to G, chromosome 2 at 122,454,499 bp
  • T to C, chromosome 2 at 158,124,150 bp
  • T to C, chromosome 2 at 181,631,436 bp
  • A to G, chromosome 3 at 18,055,614 bp
  • C to T, chromosome 3 at 63,781,390 bp
  • A to C, chromosome 3 at 80,741,004 bp
  • T to C, chromosome 4 at 3,184,993 bp
  • A to G, chromosome 4 at 108,027,160 bp
  • T to C, chromosome 4 at 152,041,057 bp
  • A to T, chromosome 5 at 24,569,158 bp
  • A to T, chromosome 5 at 72,339,045 bp
  • A to T, chromosome 5 at 106,635,845 bp
  • G to A, chromosome 6 at 78,377,445 bp
  • T to A, chromosome 7 at 13,836,020 bp
  • T to C, chromosome 7 at 23,660,317 bp
  • G to A, chromosome 7 at 23,984,758 bp
  • C to A, chromosome 7 at 46,301,215 bp
  • T to A, chromosome 7 at 97,529,218 bp
  • A to G, chromosome 7 at 120,927,982 bp
  • T to C, chromosome 7 at 144,285,084 bp
  • G to T, chromosome 8 at 3,464,092 bp
  • G to A, chromosome 8 at 3,667,284 bp
  • G to T, chromosome 8 at 16,710,642 bp
  • A to G, chromosome 8 at 93,357,418 bp
  • A to T, chromosome 8 at 106,192,467 bp
  • T to C, chromosome 9 at 37,730,429 bp
  • T to C, chromosome 9 at 57,911,173 bp
  • A to G, chromosome 9 at 94,939,459 bp
  • T to A, chromosome 9 at 105,889,067 bp
  • A to T, chromosome 9 at 108,534,292 bp
  • A to T, chromosome 10 at 13,261,882 bp
  • T to A, chromosome 10 at 76,222,517 bp
  • T to C, chromosome 10 at 128,044,124 bp
  • C to A, chromosome 11 at 59,069,895 bp
  • T to C, chromosome 11 at 101,325,466 bp
  • T to C, chromosome 12 at 54,954,800 bp
  • T to G, chromosome 12 at 88,402,151 bp
  • G to T, chromosome 12 at 98,689,262 bp
  • A to T, chromosome 12 at 115,912,645 bp
  • C to T, chromosome 13 at 46,826,757 bp
  • T to A, chromosome 13 at 89,691,597 bp
  • T to A, chromosome 13 at 104,804,261 bp
  • T to A, chromosome 13 at 113,368,268 bp
  • G to A, chromosome 14 at 122,582,623 bp
  • T to C, chromosome 16 at 11,223,208 bp
  • T to A, chromosome 17 at 33,911,975 bp
  • A to G, chromosome 17 at 56,124,047 bp
  • A to G, chromosome 18 at 4,348,979 bp
  • T to C, chromosome 18 at 32,203,033 bp
  • C to A, chromosome 18 at 46,728,037 bp
  • T to C, chromosome 18 at 70,468,193 bp
  • T to C, chromosome 19 at 11,920,878 bp
  • G to A, chromosome 19 at 38,524,530 bp
  • A to T, chromosome 19 at 45,771,680 bp
  • A to G, chromosome 19 at 46,724,971 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6317 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044417-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.