Strain Name:
C57BL/6J-MtgxR6321Btlr/Mmmh
Stock Number:
044418-MU
Citation ID:
RRID:MMRRC_044418-MU
Other Names:
R6321 (G1)
Major Collection:

Strain Information

Ank2
Name: ankyrin 2, brain
Synonyms: Ankyrin-2, ankyrin B, Ank-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Scarb1
Name: scavenger receptor class B, member 1
Synonyms: Chohd1, Srb1, Chohd1, SRBI, SR-BI, D5Ertd460e, Cd36l1, Hlb398, Hdlq1, Cla-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20778
HGNC: HGNC:1664
Homologene: 21132
Ltbp3
Name: latent transforming growth factor beta binding protein 3
Synonyms: Ltbp2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16998
VEGA: 19
HGNC: HGNC:6716
Homologene: 7405
Arrdc4
Name: arrestin domain containing 4
Synonyms: 2410003C09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66412
Homologene: 41636
Ppp1r9a
Name: protein phosphatase 1, regulatory subunit 9A
Synonyms: NRB, A230094E16Rik, neurabin-I, 2810430P21Rik, Neurabin I, 4930518N04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243725
Homologene: 14247
Epb41l2
Name: erythrocyte membrane protein band 4.1 like 2
Synonyms: D10Ertd398e, NBL2, 4.1G, Epb4.1l2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13822
VEGA: 10
HGNC: HGNC:3379
Homologene: 37478
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNAPDcs, DNA-PK, DNA-PKcs, dxnph, DOXNPH, XRCC7, slip
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Smc2
Name: structural maintenance of chromosomes 2
Synonyms: Smc2l1, Fin16, CAP-E, 5730502P04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14211
Homologene: 4705
Dock9
Name: dedicator of cytokinesis 9
Synonyms: D14Wsu89e, B230309H04Rik, Zizimin1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105445
Homologene: 41026
Auts2
Name: autism susceptibility candidate 2
Synonyms: D830032G16Rik, 2700063G02Rik, A730011F23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319974
Homologene: 22907
Snx6
Name: sorting nexin 6
Synonyms: 2610032J07Rik, 2810425K19Rik, 2010006G21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 72183
VEGA: 12
Homologene: 12304
Zbtb17
Name: zinc finger and BTB domain containing 17
Synonyms: Zfp100, Miz1, mZ13
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22642
Homologene: 2575
Cyfip2
Name: cytoplasmic FMR1 interacting protein 2
Synonyms: 6430511D02Rik, Pir121, 1500004I01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76884
Homologene: 7936
Aldh16a1
Name: aldehyde dehydrogenase 16 family, member A1
Synonyms: 2410004H02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69748
Homologene: 34938
Muc2
Name: mucin 2
Synonyms: 2010015E03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17831
HGNC: HGNC:7512
Homologene: 136755
Zfp451
Name: zinc finger protein 451
Synonyms: Kiaa0576-hp, 4933435G09Rik, 4930515K21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98403
Homologene: 9188
Mfsd2a
Name: MFSD2 lysolipid transporter A, lysophospholipid
Synonyms: 1700018O18Rik, major facilitator superfamily domain containing 2A, Mfsd2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76574
Homologene: 19229
Pnpla6
Name: patatin-like phospholipase domain containing 6
Synonyms: Swiss-cheese, Nte, MSws
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50767
Homologene: 21333
Chd1l
Name: chromodomain helicase DNA binding protein 1-like
Synonyms: Snf2p, 4432404A22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68058
HGNC: HGNC:1916
Homologene: 11590
Blnk
Name: B cell linker
Synonyms: BLNK, Ly57, BCA, Bca, BASH, SLP-65, Ly-57
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17060
Homologene: 32038
Mecom
Name: MDS1 and EVI1 complex locus
Synonyms: MDS1-EVI1, D630039M04Rik, ZNFPR1B1, Evi-1, Evi1, Mds1, Jbo, Prdm3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14013
HGNC: HGNC:3498
Homologene: 21086
Mrgprd
Name: MAS-related GPR, member D
Synonyms: LOC211578, MrgD
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 211578
Homologene: 18893
Cenpl
Name: centromere protein L
Synonyms: 2610300B10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70454
Homologene: 19618
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b1537Clo, b2b1565Clo, Mdnah5, Dnahc5, b2b1134Clo, b2b1154Clo, b2b3491Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Kidins220
Name: kinase D-interacting substrate 220
Synonyms: C330002I19Rik, 3110039L19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 77480
VEGA: 12
Homologene: 14254
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: b2b1203Clo, b2b1289Clo, lrd, avc4, Dnahc11, b2b1279Clo, b2b598Clo, b2b1727Clo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Ush2a
Name: usherin
Synonyms: MUSH2A, A930037M10Rik, LOC381317, LOC269160, Ushrn, A930011D15Rik, Ush2a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Slc4a8
Name: solute carrier family 4 (anion exchanger), member 8
Synonyms: sodium bicarbonate cotransporter isoform 3 kNBC-3, NDCBE, KNBC-3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 59033
Homologene: 68419
Cdcp3
Name: CUB domain containing protein 3
Synonyms: 5430419D17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71395
Homologene: 138430
Tpo
Name: thyroid peroxidase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22018
Homologene: 461
Naip6
Name: NLR family, apoptosis inhibitory protein 6
Synonyms: Naip-rs4A, Naip-rs4, Birc1f
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17952
HGNC: HGNC:7634
Homologene: 113589
Chrnd
Name: cholinergic receptor, nicotinic, delta polypeptide
Synonyms: Achr-4, Acrd
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11447
HGNC: HGNC:1965
Homologene: 37340
Golgb1
Name: golgin B1
Synonyms: Giantin, Gm6840, C130074L01Rik, 6330407A06Rik, F730017E11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224139
HGNC: HGNC:4429
Homologene: 68401
Heca
Name: hdc homolog, cell cycle regulator
Synonyms: LOC380629
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380629
VEGA: 10
Homologene: 32300
Spag17
Name: sperm associated antigen 17
Synonyms: PF6, 4931427F14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74362
Homologene: 52601
Zfp454
Name: zinc finger protein 454
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237758
Homologene: 72226
Evi5l
Name: ecotropic viral integration site 5 like
Synonyms: 1700084G18Rik, B130050I23Rik, 2310039H16Rik, 3110007G05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 213027
Homologene: 134635
Upf3a
Name: UPF3 regulator of nonsense transcripts homolog A (yeast)
Synonyms: UPF3, 4930546M19Rik, 2600001C03Rik, RENT3A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67031
Homologene: 23395
Hs3st6
Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328779
VEGA: 17
Homologene: 84633
Gm10549
Name: predicted gene 10549
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 433171
VEGA: 18
Zfp639
Name: zinc finger protein 639
Synonyms: 6230400O18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67778
Homologene: 9473
Klk9
Name: kallikrein related-peptidase 9
Synonyms: 1200016C12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101533
HGNC: HGNC:6370
Homologene: 40832
Capsl
Name: calcyphosine-like
Synonyms: 1700028N11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75568
VEGA: 15
Homologene: 16959
Krtap4-22
Name: keratin associated protein 4-22
Synonyms: Gm11595
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100040276
Homologene: 124486
Hecw1
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms: NEDL1, E130207I19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94253
VEGA: 13
Homologene: 9004
Adgra2
Name: adhesion G protein-coupled receptor A2
Synonyms: 9530074E10Rik, 8430414O08Rik, Gpr124, Tem5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78560
Homologene: 13112
Erich3
Name: glutamate rich 3
Synonyms: 5031409G23Rik, 4922501L14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 209601
Homologene: 27877
Or52w1
Name: olfactory receptor family 52 subfamily W member 1
Synonyms: MOR36-1, GA_x6K02T2PBJ9-7994144-7995106, Olfr692
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258352
Homologene: 64859
Or4f59
Name: olfactory receptor family 4 subfamily F member 59
Synonyms: MOR245-20, Olfr1312, GA_x6K02T2Q125-73090482-73089529
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258359
Homologene: 128122
Actbl2
Name: actin, beta-like 2
Synonyms: 4732495G21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238880
Homologene: 134276
Myl10
Name: myosin, light chain 10, regulatory
Synonyms: PLRLC, Mylc2pl, 1700027I08Rik, PLRLC-B, PLRLC-A, PLRLC-C
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 59310
Homologene: 69341
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 33,813,735 bp
  • C to T, chromosome 1 at 87,192,229 bp
  • T to C, chromosome 1 at 161,074,895 bp
  • C to T, chromosome 1 at 188,849,046 bp
  • A to G, chromosome 2 at 112,042,768 bp
  • A to G, chromosome 3 at 29,980,592 bp
  • T to C, chromosome 3 at 32,517,088 bp
  • G to A, chromosome 3 at 97,587,167 bp
  • A to C, chromosome 3 at 100,088,427 bp
  • T to C, chromosome 3 at 126,946,938 bp
  • A to T, chromosome 3 at 154,727,502 bp
  • C to A, chromosome 4 at 52,462,814 bp
  • A to G, chromosome 4 at 122,949,372 bp
  • G to A, chromosome 4 at 141,463,383 bp
  • T to A, chromosome 5 at 125,304,331 bp
  • A to G, chromosome 5 at 131,466,115 bp
  • G to C, chromosome 5 at 136,697,971 bp
  • A to G, chromosome 6 at 5,115,151 bp
  • A to G, chromosome 7 at 43,794,308 bp
  • G to A, chromosome 7 at 45,149,765 bp
  • C to A, chromosome 7 at 68,749,045 bp
  • A to G, chromosome 7 at 105,368,902 bp
  • T to C, chromosome 7 at 131,257,006 bp
  • A to G, chromosome 7 at 141,700,828 bp
  • A to G, chromosome 7 at 145,322,142 bp
  • T to C, chromosome 8 at 3,544,015 bp
  • C to A, chromosome 8 at 4,203,080 bp
  • A to T, chromosome 8 at 13,787,466 bp
  • T to A, chromosome 8 at 27,114,162 bp
  • C to A, chromosome 8 at 124,683,191 bp
  • G to C, chromosome 10 at 17,915,243 bp
  • A to T, chromosome 10 at 25,468,128 bp
  • A to T, chromosome 11 at 46,291,520 bp
  • A to G, chromosome 11 at 50,873,049 bp
  • G to A, chromosome 11 at 99,772,555 bp
  • C to T, chromosome 12 at 25,057,534 bp
  • A to G, chromosome 12 at 30,103,108 bp
  • C to A, chromosome 12 at 54,752,013 bp
  • T to C, chromosome 12 at 118,142,292 bp
  • C to T, chromosome 13 at 14,522,829 bp
  • C to A, chromosome 13 at 100,300,401 bp
  • G to T, chromosome 13 at 111,255,381 bp
  • A to G, chromosome 14 at 121,546,021 bp
  • T to C, chromosome 15 at 9,461,769 bp
  • T to G, chromosome 15 at 28,372,411 bp
  • C to T, chromosome 15 at 100,789,164 bp
  • A to G, chromosome 16 at 15,714,919 bp
  • T to A, chromosome 16 at 36,918,197 bp
  • T to A, chromosome 17 at 24,758,568 bp
  • C to A, chromosome 18 at 33,464,305 bp
  • C to A, chromosome 19 at 5,745,657 bp
  • A to T, chromosome 19 at 40,934,459 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6321 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044418-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.