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Strain Name:
C57BL/6J-MtgxR6119Btlr/Mmmh
Stock Number:
044429-MU
Citation ID:
RRID:MMRRC_044429-MU
Other Names:
R6119 (G1)
Major Collection:

Strain Information

Ppp1r16b
Name: protein phosphatase 1, regulatory subunit 16B
Synonyms: ANKRD4, Wdt4, C130078N17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228852
Homologene: 9194
Prss12
Name: serine protease 12 neurotrypsin (motopsin)
Synonyms: Bssp-3, motopsin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19142
HGNC: HGNC:9477
Homologene: 7490
Gtf2i
Name: general transcription factor II I
Synonyms: TFII-I, BAP-135, 6030441I21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14886
HGNC: HGNC:4659
Homologene: 7748
Mthfd1
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase
Synonyms: Mthfd, DCS, E430024A07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 108156
VEGA: 12
HGNC: HGNC:7432
Homologene: 55940
Msra
Name: methionine sulfoxide reductase A
Synonyms: MSR-A, 2310045J23Rik, 6530413P12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110265
HGNC: HGNC:7377
Homologene: 5812
Tnks2
Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Synonyms: 5430432P15Rik, Parp5b
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74493
Homologene: 11890
Tcf12
Name: transcription factor 12
Synonyms: ME1, ALF1, HEB, HTF4, HTF-4, REB, bHLHb20, HEBAlt
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21406
Homologene: 40774
Grb10
Name: growth factor receptor bound protein 10
Synonyms: Meg1, maternally expressed gene 1, 5730571D09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14783
HGNC: HGNC:4564
Homologene: 3882
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: MAP1C, dynein heavy chain, retrograde transport, Dnec1, Loa, 9930018I23Rik, Dnchc1, Swl
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Ddx47
Name: DEAD box helicase 47
Synonyms: 4930588A18Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67755
Homologene: 6092
Tasor2
Name: transcription activation suppressor family member 2
Synonyms: BC016423, Fam208b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105203
VEGA: 13
Homologene: 26435
Dusp3
Name: dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)
Synonyms: T-DSP11, VHR, 2210015O03Rik, 5031436O03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72349
HGNC: HGNC:3069
Homologene: 20870
Ypel3
Name: yippee like 3
Synonyms: 1190001G19Rik, Suap, 0610043B10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66090
Homologene: 116010
Ripor2
Name: RHO family interacting cell polarization regulator 2
Synonyms: 1700108N18Rik, E430013J17Rik, 6330500D04Rik, Fam65b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 193385
Homologene: 9284
Rmnd5b
Name: required for meiotic nuclear division 5 homolog B
Synonyms: 0610039K22Rik, Gid2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66089
Homologene: 100777
Pwwp3a
Name: PWWP domain containing 3A, DNA repair factor
Synonyms: 9430059D04Rik, Mum1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68114
Homologene: 11349
Tsc22d2
Name: TSC22 domain family, member 2
Synonyms: 1810043J12Rik, 5530402M19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72033
Homologene: 8860
Tmem131l
Name: transmembrane 131 like
Synonyms: D930015E06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229473
Homologene: 9057
Grin1
Name: glutamate receptor, ionotropic, NMDA1 (zeta 1)
Synonyms: NMDAR1, NR1, Nmdar, M100174, GluRzeta1, Rgsc174
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14810
HGNC: HGNC:4584
Homologene: 7187
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77505
Homologene: 131117
Optn
Name: optineurin
Synonyms: 4930441O07Rik, TFIIIA-INTP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71648
Homologene: 11085
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Sorcs1
Name: sortilin-related VPS10 domain containing receptor 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 58178
Homologene: 10967
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC234973, LOC382129, 9430076A06Rik, D430038H04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Tecta
Name: tectorin alpha
Synonyms: [a]-tectorin, Tctna
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21683
Homologene: 3955
Kif17
Name: kinesin family member 17
Synonyms: N-4 kinesin, 5930435E01Rik, Kif17b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16559
Homologene: 5883
Mamdc2
Name: MAM domain containing 2
Synonyms: 1200015L10Rik, mamcan
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71738
VEGA: 19
Homologene: 17722
Tmem106a
Name: transmembrane protein 106A
Synonyms: 0610008L10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217203
Homologene: 16996
Gnptab
Name: N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
Synonyms: EG432486
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432486
Homologene: 32576
Abtb2
Name: ankyrin repeat and BTB domain containing 2
Synonyms: BPOZ-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99382
Homologene: 15904
Synj1
Name: synaptojanin 1
Synonyms: A930006D20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 104015
Homologene: 48252
Ip6k3
Name: inositol hexaphosphate kinase 3
Synonyms: D830007E07Rik, Ihpk3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 271424
Homologene: 65257
4930544D05Rik
Name: RIKEN cDNA 4930544D05 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 668433
Homologene: 109413
Noxo1
Name: NADPH oxidase organizer 1
Synonyms: 2310034C04Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71893
Homologene: 12418
Vmn1r10
Name: vomeronasal 1 receptor 10
Synonyms: V1rc1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113858
Homologene: 76459
Ankk1
Name: ankyrin repeat and kinase domain containing 1
Synonyms: 9930020N01Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244859
VEGA: 9
Homologene: 18258
Ttll3
Name: tubulin tyrosine ligase-like family, member 3
Synonyms: 4833441J24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101100
Homologene: 134361
Lair1
Name: leukocyte-associated Ig-like receptor 1
Synonyms: 5133400O11Rik, mLair-1, Lair-1, D7Bwg0421e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 52855
Homologene: 48097
Or4c103
Name: olfactory receptor family 4 subfamily C member 103
Synonyms: GA_x6K02T2Q125-50163514-50162588, MOR230-12_p, MOR230-4, Olfr1195
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258748
Homologene: 103782
Arhgap11a
Name: Rho GTPase activating protein 11A
Synonyms: GAP (1-12), 6530401L14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228482
Homologene: 8862
Slc2a12
Name: solute carrier family 2 (facilitated glucose transporter), member 12
Synonyms: Glut12, GLUT-12
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 353169
Homologene: 59263
Or5k17
Name: olfactory receptor family 5 subfamily K member 17
Synonyms: GA_x54KRFPKG5P-55145984-55145034, MOR184-4, Olfr181
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 259001
Homologene: 74112
Or10ag58
Name: olfactory receptor family 10 subfamily AG member 58
Synonyms: GA_x6K02T2Q125-48936945-48937901, GA_x6K02T2Q125-48935224-48935664, MOR264-3, MOR264-24, Olfr1125, Olfr1124
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259030
Homologene: 133660
Zfp677
Name: zinc finger protein 677
Synonyms: A830058L05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210503
Homologene: 138402
Or6c215
Name: olfactory receptor family 6 subfamily C member 215
Synonyms: GA_x6K02T2PULF-11481207-11480248, MOR110-6, Olfr811
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258545
Homologene: 133725
Sftpa1
Name: surfactant associated protein A1
Synonyms: SP-A, surfactant pulmonary associated protein A1, SFTPA1, Sftp-1, Sftp1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 20387
Homologene: 3946
Gdpgp1
Name: GDP-D-glucose phosphorylase 1
Synonyms: D330012F22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269952
Homologene: 33436
Gimap8
Name: GTPase, IMAP family member 8
Synonyms: LOC243374, IAN9
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243374
Homologene: 69703
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 2 at 5,021,323 bp
  • T to G, chromosome 2 at 25,305,158 bp
  • A to G, chromosome 2 at 52,220,931 bp
  • A to T, chromosome 2 at 87,435,389 bp
  • A to G, chromosome 2 at 88,683,591 bp
  • A to T, chromosome 2 at 103,702,310 bp
  • C to A, chromosome 2 at 113,834,350 bp
  • A to G, chromosome 2 at 158,751,127 bp
  • T to A, chromosome 3 at 58,460,253 bp
  • A to T, chromosome 3 at 83,898,382 bp
  • A to G, chromosome 3 at 123,489,609 bp
  • A to T, chromosome 3 at 129,736,772 bp
  • T to A, chromosome 4 at 138,288,332 bp
  • A to G, chromosome 5 at 14,677,019 bp
  • A to T, chromosome 5 at 134,287,057 bp
  • A to G, chromosome 5 at 135,353,420 bp
  • T to C, chromosome 6 at 48,658,954 bp
  • A to G, chromosome 6 at 57,114,233 bp
  • T to A, chromosome 6 at 113,394,741 bp
  • T to C, chromosome 6 at 135,023,355 bp
  • T to C, chromosome 7 at 4,028,896 bp
  • C to T, chromosome 7 at 27,565,713 bp
  • T to C, chromosome 7 at 80,238,992 bp
  • A to G, chromosome 7 at 105,709,440 bp
  • T to C, chromosome 7 at 126,778,365 bp
  • A to G, chromosome 8 at 14,033,692 bp
  • T to A, chromosome 9 at 16,376,568 bp
  • A to T, chromosome 9 at 42,373,075 bp
  • A to T, chromosome 9 at 49,426,883 bp
  • T to A, chromosome 9 at 71,868,265 bp
  • T to A, chromosome 10 at 22,665,347 bp
  • A to G, chromosome 10 at 80,229,031 bp
  • C to A, chromosome 10 at 88,431,395 bp
  • G to A, chromosome 10 at 129,801,820 bp
  • C to A, chromosome 10 at 129,801,821 bp
  • T to C, chromosome 11 at 11,933,551 bp
  • A to G, chromosome 11 at 51,625,709 bp
  • G to A, chromosome 11 at 70,616,491 bp
  • A to G, chromosome 11 at 101,567,112 bp
  • T to A, chromosome 11 at 101,583,750 bp
  • A to G, chromosome 11 at 101,980,669 bp
  • A to T, chromosome 12 at 76,303,673 bp
  • A to G, chromosome 12 at 110,628,006 bp
  • C to T, chromosome 13 at 3,581,891 bp
  • C to T, chromosome 13 at 24,614,644 bp
  • G to A, chromosome 14 at 31,641,108 bp
  • T to A, chromosome 14 at 41,132,552 bp
  • G to A, chromosome 14 at 64,440,734 bp
  • A to T, chromosome 16 at 58,926,532 bp
  • T to C, chromosome 16 at 90,938,989 bp
  • A to G, chromosome 17 at 21,397,808 bp
  • A to G, chromosome 17 at 24,696,571 bp
  • A to G, chromosome 17 at 27,148,625 bp
  • G to A, chromosome 19 at 23,353,315 bp
  • T to C, chromosome 19 at 36,879,352 bp
  • T to C, chromosome 19 at 50,288,094 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6119 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044429-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.