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Strain Name:
C57BL/6J-MtgxR6168Btlr/Mmmh
Stock Number:
044430-MU
Citation ID:
RRID:MMRRC_044430-MU
Other Names:
R6168 (G1)
Major Collection:

Strain Information

Notch2
Name: notch 2
Synonyms: Motch B, N2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18129
HGNC: HGNC:7882
Homologene: 7865
Ark2n
Name: arkadia (RNF111) N-terminal like PKA signaling regulator 2N
Synonyms: Ark2N, 8030462N17Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 212163
VEGA: 18
Homologene: 17035
Dnmbp
Name: dynamin binding protein
Synonyms: 2410003M15Rik, Tuba, 2410003L07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71972
Homologene: 9061
Alox12b
Name: arachidonate 12-lipoxygenase, 12R type
Synonyms: e-LOX2, Aloxe2, 12R-LOX
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11686
HGNC: HGNC:430
Homologene: 884
Yeats2
Name: YEATS domain containing 2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208146
VEGA: 16
Homologene: 9967
Fbrsl1
Name: fibrosin-like 1
Synonyms: LOC381668, 2410025L10Rik, Gm29766
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381668
Homologene: 45966
Atf7ip
Name: activating transcription factor 7 interacting protein
Synonyms: ATFa-associated Modulator, AM, 2610204M12Rik, Mcaf1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54343
Homologene: 10051
Wdr7
Name: WD repeat domain 7
Synonyms: TGF-beta resistance associated gene, TRAG
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 104082
VEGA: 18
Homologene: 11408
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: chromatin remodeling factor, 8030453L17Rik, E430018P19Rik, KMT2H
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 192195
Homologene: 10225
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: LOC381341, Dnahc7, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Lepr
Name: leptin receptor
Synonyms: Obr, leptin receptor gene-related protein, OB-RGRP, LEPROT, obl, obese-like, Modb1, Leprb
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16847
HGNC: HGNC:6554
Homologene: 1731
Zswim6
Name: zinc finger SWIM-type containing 6
Synonyms: 2900036G02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67263
VEGA: 13
Homologene: 83517
Mcf2l
Name: mcf.2 transforming sequence-like
Synonyms: Dbs, C130040G20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17207
Homologene: 11804
Gm14496
Name: predicted gene 14496
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 672125
Homologene: 129606
Crcp
Name: calcitonin gene-related peptide-receptor component protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12909
Homologene: 40587
Psmc6
Name: proteasome (prosome, macropain) 26S subunit, ATPase, 6
Synonyms: 2300001E01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67089
VEGA: 14
HGNC: HGNC:9553
Homologene: 100630
Zfta
Name: zinc finger translocation associated
Synonyms: 2700081O15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 108899
Homologene: 52179
Adarb1
Name: adenosine deaminase, RNA-specific, B1
Synonyms: RED1, ADAR2, D10Bwg0447e, 1700057H01Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 110532
HGNC: HGNC:226
Homologene: 8280
Adamts13
Name: ADAM metallopeptidase with thrombospondin type 1 motif 13
Synonyms: LOC279028, vWF-CP mRNA for von Willebrand factor-cleaving
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 279028
HGNC: HGNC:1366
Homologene: 16372
Tarbp1
Name: TAR RNA binding protein 1
Synonyms: Gm17296
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212728
Homologene: 38082
Ahnak2
Name: AHNAK nucleoprotein 2
Synonyms: LOC382643
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100041194
Homologene: 131081
Or8g35
Name: olfactory receptor family 8 subfamily G member 35
Synonyms: GA_x6K02T2PVTD-33167297-33166353, MOR171-34, MOR171-50, Olfr955
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258242
VEGA: 9
Homologene: 133698
S100a16
Name: S100 calcium binding protein A16
Synonyms: 2300002L21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67860
Homologene: 12201
Vmn2r102
Name: vomeronasal 2, receptor 102
Synonyms: EG224572
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224572
Homologene: 115024
Pik3r5
Name: phosphoinositide-3-kinase regulatory subunit 5
Synonyms: Foap2, p101
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320207
Homologene: 8627
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Col6a5, Gm7455
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 665033
Homologene: 122792
Slc6a7
Name: solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
Synonyms: Prot
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240332
VEGA: 18
Homologene: 8592
Hoxa2
Name: homeobox A2
Synonyms: Hox-1.11
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15399
HGNC: HGNC:5103
Homologene: 4901
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Kcnc2
Name: potassium voltage gated channel, Shaw-related subfamily, member 2
Synonyms: Kv3.2, KShIIIA
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268345
VEGA: 10
HGNC: HGNC:6234
Homologene: 71199
Nsd3
Name: nuclear receptor binding SET domain protein 3
Synonyms: WHISTLE, Whsc1l1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234135
Homologene: 56960
Efcab12
Name: EF-hand calcium binding domain 12
Synonyms: BC060267
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 212516
Homologene: 18905
Piwil2
Name: piwi-like RNA-mediated gene silencing 2
Synonyms: Miwi like, mili
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57746
VEGA: 14
Homologene: 23071
Ppm1l
Name: protein phosphatase 1 (formerly 2C)-like
Synonyms: PP2C-epsilon, Pp2ce, 5930404J21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242083
Homologene: 33158
4932414N04Rik
Name: RIKEN cDNA 4932414N04 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75721
Homologene: 138468
Nkd1
Name: naked cuticle 1
Synonyms: 2810434J10Rik, 9030215G15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 93960
Homologene: 12343
Itgax
Name: integrin alpha X
Synonyms: CD11C (p150) alpha polypeptide, Cd11c, CR4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16411
HGNC: HGNC:6152
Homologene: 55493
Vmn2r49
Name: vomeronasal 2, receptor 49
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 625605
Homologene: 113703
Or8k3
Name: olfactory receptor family 8 subfamily K member 3
Synonyms: GA_x6K02T2Q125-47703682-47702723, MOR188-3, Olfr1047
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259014
Homologene: 133664
Pdgfb
Name: platelet derived growth factor, B polypeptide
Synonyms: Sis, PDGF-B
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18591
VEGA: 15
HGNC: HGNC:8800
Homologene: 74303
Pde4c
Name: phosphodiesterase 4C, cAMP specific
Synonyms: dunce, Dpde1, E130301F19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 110385
HGNC: HGNC:8782
Homologene: 20256
Or8u8
Name: olfactory receptor family 8 subfamily U member 8
Synonyms: IE6, MOR185-6, GA_x6K02T2Q125-47650922-47649963, Olfr52
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18352
Homologene: 105200
Vmn1r197
Name: vomeronasal 1 receptor 197
Synonyms: V1rh21
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171278
Homologene: 110880
Adam3
Name: ADAM metallopeptidase domain 3
Synonyms: Taz83, tMDC, Cyrn1, ADAM3, Taz83
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11497
HGNC: HGNC:209
Homologene: 69052
Slc5a12
Name: solute carrier family 5 (sodium/glucose cotransporter), member 12
Synonyms: SMCT2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241612
Homologene: 15107
Rhov
Name: ras homolog family member V
Synonyms: A030005A06Rik, Arhv
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228543
Homologene: 26426
Defb15
Name: defensin beta 15
Synonyms: Defb11, mBD-11
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 246082
Rasl10a
Name: RAS-like, family 10, member A
Synonyms: 2210403B10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 75668
Homologene: 4732
Or6c203
Name: olfactory receptor family 6 subfamily C member 203
Synonyms: GA_x6K02T2PULF-10860457-10859522, MOR114-3, Olfr772
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 257666
Homologene: 123776
Or2w1
Name: olfactory receptor family 2 subfamily W member 1
Synonyms: IA3, GA_x6K02T2N5E5-9379-8514, MOR256-31, GA_x6K02T2QHY8-12114828-12113875, MOR256-37P, MOR256-61, Olfr42, Olfr263-ps1, Olfr263
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18341
HGNC: HGNC:8281
Homologene: 12791
Igkv8-27
Name: immunoglobulin kappa chain variable 8-27
Synonyms: Gm16944
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 434041
HGNC: HGNC:5834
Igkv4-58
Name: immunoglobulin kappa variable 4-58
Synonyms: LOC381831
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381831
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 46,290,703 bp
  • T to A, chromosome 1 at 53,411,568 bp
  • G to T, chromosome 2 at 27,004,886 bp
  • C to T, chromosome 2 at 68,741,483 bp
  • T to C, chromosome 2 at 86,181,965 bp
  • T to G, chromosome 2 at 86,228,594 bp
  • T to C, chromosome 2 at 110,616,744 bp
  • T to C, chromosome 2 at 119,270,972 bp
  • T to A, chromosome 2 at 182,000,957 bp
  • A to G, chromosome 3 at 69,549,407 bp
  • C to T, chromosome 3 at 89,052,773 bp
  • C to T, chromosome 3 at 90,542,572 bp
  • A to G, chromosome 3 at 98,145,217 bp
  • G to A, chromosome 4 at 101,735,592 bp
  • C to T, chromosome 5 at 110,396,056 bp
  • A to G, chromosome 5 at 130,037,896 bp
  • A to G, chromosome 6 at 52,163,481 bp
  • A to C, chromosome 6 at 69,500,297 bp
  • A to T, chromosome 6 at 70,171,896 bp
  • T to C, chromosome 6 at 115,814,616 bp
  • A to G, chromosome 6 at 136,559,819 bp
  • G to T, chromosome 7 at 9,984,786 bp
  • T to C, chromosome 7 at 128,133,097 bp
  • A to G, chromosome 8 at 13,001,823 bp
  • A to C, chromosome 8 at 21,930,053 bp
  • A to T, chromosome 8 at 24,681,614 bp
  • G to A, chromosome 8 at 25,691,161 bp
  • G to A, chromosome 8 at 70,750,039 bp
  • T to A, chromosome 8 at 88,585,231 bp
  • A to G, chromosome 8 at 126,448,405 bp
  • A to G, chromosome 9 at 39,470,657 bp
  • A to G, chromosome 9 at 105,875,787 bp
  • A to G, chromosome 10 at 77,322,319 bp
  • A to G, chromosome 10 at 112,455,756 bp
  • A to G, chromosome 10 at 129,174,166 bp
  • T to C, chromosome 11 at 5,058,442 bp
  • T to C, chromosome 11 at 68,492,675 bp
  • T to A, chromosome 11 at 69,169,634 bp
  • T to C, chromosome 12 at 112,783,122 bp
  • T to A, chromosome 12 at 113,123,119 bp
  • T to G, chromosome 13 at 21,133,229 bp
  • T to C, chromosome 13 at 22,328,508 bp
  • G to A, chromosome 13 at 107,787,764 bp
  • T to C, chromosome 14 at 45,343,683 bp
  • T to C, chromosome 14 at 70,395,351 bp
  • T to C, chromosome 15 at 80,000,386 bp
  • T to C, chromosome 16 at 20,179,558 bp
  • G to A, chromosome 17 at 19,694,140 bp
  • A to T, chromosome 18 at 61,001,662 bp
  • T to A, chromosome 18 at 63,777,977 bp
  • A to G, chromosome 18 at 77,673,957 bp
  • T to C, chromosome 19 at 7,422,940 bp
  • A to G, chromosome 19 at 43,850,240 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6168 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044430-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.