Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR6268Btlr/Mmmh
Stock Number:
044439-MU
Citation ID:
RRID:MMRRC_044439-MU
Other Names:
R6268 (G1)
Major Collection:

Strain Information

Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: Myhc-b, Myhcb, beta-MHC, B-MHC, MYH-beta/slow, MyHC-I, betaMHC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Frrs1
Name: ferric-chelate reductase 1
Synonyms: Sdfr2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20321
Homologene: 40653
Xrn1
Name: 5'-3' exoribonuclease 1
Synonyms: mXrn1, Dhm2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 24127
Homologene: 5894
Dock5
Name: dedicator of cytokinesis 5
Synonyms: lr2, 1110060D06Rik, rlc
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68813
VEGA: 14
Homologene: 57016
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Rapgef6
Name: Rap guanine nucleotide exchange factor (GEF) 6
Synonyms: PDZ-GEF2, RA-GEF-2, Pdzgef2, C030018K18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192786
Homologene: 22968
Ahctf1
Name: AT hook containing transcription factor 1
Synonyms: 6230412P20Rik, Elys
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226747
Homologene: 9142
Zc3h11a
Name: zinc finger CCCH type containing 11A
Synonyms: 1110003F06Rik, 5730454B08Rik, G630041M05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70579
Homologene: 8888
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, XAP8, Hbxap, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Urb1
Name: URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Synonyms: 5730405K23Rik, 4921511H13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207932
Homologene: 45941
Elp1
Name: elongator complex protein 1
Synonyms: 3110040G09Rik, C78473, IKAP, Ikbkap
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230233
HGNC: HGNC:5959
Homologene: 2699
Mtch2
Name: mitochondrial carrier 2
Synonyms: 2310034D24Rik, HSPC032, 4930539J07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56428
Homologene: 8645
C2cd2l
Name: C2 calcium-dependent domain containing 2-like
Synonyms: 1300006O23Rik, Tmem24
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71764
VEGA: 9
Homologene: 8876
Anxa6
Name: annexin A6
Synonyms: Camb, Anx6, AnxVI, Annexin VI, Cabm
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11749
HGNC: HGNC:544
Homologene: 55558
Ap1b1
Name: adaptor protein complex AP-1, beta 1 subunit
Synonyms: beta-prime adaptin, Adtb1, b2b1660Clo
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11764
HGNC: HGNC:554
Homologene: 21972
Zfp410
Name: zinc finger protein 410
Synonyms: D12Ertd748e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 52708
VEGA: 12
Homologene: 10918
Zfp748
Name: zinc finger protein 748
Synonyms: 2610014M12Rik, mszf54, KRAB-O, Zfp208
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 212276
Homologene: 134552
Plekhm2
Name: pleckstrin homology domain containing, family M (with RUN domain) member 2
Synonyms: 2310034J19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69582
Homologene: 19575
Dapk1
Name: death associated protein kinase 1
Synonyms: 2310039H24Rik, 2810425C21Rik, D13Ucla1, DAP-Kinase
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69635
VEGA: 13
HGNC: HGNC:2674
Homologene: 3626
Afg3l1
Name: AFG3-like AAA ATPase 1
Synonyms: 3110061K15Rik, 1700047G05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 114896
HGNC: HGNC:314
Homologene: 134198
Cars2
Name: cysteinyl-tRNA synthetase 2, mitochondrial
Synonyms: D530030H10Rik, 2310051N18Rik, 2410044A07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71941
Homologene: 11575
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Stxbp4
Name: syntaxin binding protein 4
Synonyms: Synip, 6030470M02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20913
Homologene: 7963
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Scyl3
Name: SCY1-like 3 (S. cerevisiae)
Synonyms: Pace1, 1200016D23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240880
Homologene: 10706
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Csf1
Name: colony stimulating factor 1 (macrophage)
Synonyms: CSF-1, M-CSF, colony-stimulating factor-1, Csfm, BAP025
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12977
HGNC: HGNC:2432
Homologene: 7282
Degs2
Name: delta 4-desaturase, sphingolipid 2
Synonyms: Des2, 2210008A03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70059
VEGA: 12
Homologene: 23617
Flg
Name: filaggrin
Synonyms: profilaggrin, fillagrin, ft
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14246
VEGA: 3
Mmp3
Name: matrix metallopeptidase 3
Synonyms: progelatinase, stromelysin 1, Str1, SLN1, SLN-1, stromelysin-1, Stmy1, STR-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17392
VEGA: 9
HGNC: HGNC:7173
Homologene: 20545
Ugt2a3
Name: UDP glucuronosyltransferase 2 family, polypeptide A3
Synonyms: 2010321J07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72094
Homologene: 55988
Kcnt1
Name: potassium channel, subfamily T, member 1
Synonyms: slo2, Slack, C030030G16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227632
Homologene: 11055
Dsg1b
Name: desmoglein 1 beta
Synonyms: Dsg5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225256
HGNC: HGNC:3048
Homologene: 1463
Rasgrp4
Name: RAS guanyl releasing protein 4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233046
Homologene: 15635
Lhcgr
Name: luteinizing hormone/choriogonadotropin receptor
Synonyms: Lhr, Gpcr19-rs1, LH-R
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16867
VEGA: 17
HGNC: HGNC:6585
Homologene: 37276
Traf3ip3
Name: TRAF3 interacting protein 3
Synonyms: 6030423D04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215243
Homologene: 11885
Cox15
Name: cytochrome c oxidase assembly protein 15
Synonyms: 2900026G05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226139
HGNC: HGNC:2263
Homologene: 5848
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, LOC384050, 1110020C03Rik, Wdr65
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68625
Homologene: 51350
Crygn
Name: crystallin, gamma N
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 214301
Homologene: 16986
Or9i14
Name: olfactory receptor family 9 subfamily I member 14
Synonyms: GA_x6K02T2RE5P-4147744-4146800, MOR211-2, Olfr1499
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258792
Homologene: 17393
Slc5a5
Name: solute carrier family 5 (sodium iodide symporter), member 5
Synonyms: NIS
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 114479
Homologene: 37311
Tmem63c
Name: transmembrane protein 63c
Synonyms: 9330187M14Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217733
Homologene: 33129
Or8c11
Name: olfactory receptor family 8 subfamily C member 11
Synonyms: GA_x6K02T2MYUG-9124-8183, MOR170-15, Olfr251, MOR170-13, MOR170-2, GA_x6K02T2PVTD-32071567-32072508, Olfr900
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 404313
VEGA: 9
Homologene: 133654
Llgl1
Name: LLGL1 scribble cell polarity complex component
Synonyms: Lgl1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16897
HGNC: HGNC:6628
Homologene: 31220
Aoc1l1
Name: amine oxidase copper containing 1-like 1
Synonyms: Doxl2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243376
HGNC: HGNC:80
Homologene: 19443
Or5h26
Name: olfactory receptor family 5 subfamily H member 26
Synonyms: GA_x54KRFPKG5P-55389051-55388122, MOR183-1, Olfr196
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258775
Homologene: 74113
Vmn2r14
Name: vomeronasal 2, receptor 14
Synonyms: EG231591
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231591
Homologene: 129606
Mocs1
Name: molybdenum cofactor synthesis 1
Synonyms: 3110045D15Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56738
HGNC: HGNC:7190
Homologene: 4343
Slc23a1
Name: solute carrier family 23 (nucleobase transporters), member 1
Synonyms: YSPL3, SVCT1, D18Ucla2, Slc23a2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20522
Homologene: 40769
Sorcs3
Name: sortilin-related VPS10 domain containing receptor 3
Synonyms: 6330404A12Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66673
VEGA: 19
Homologene: 8986
Ttll3
Name: tubulin tyrosine ligase-like family, member 3
Synonyms: 4833441J24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101100
Homologene: 134361
Coq9
Name: coenzyme Q9
Synonyms: 2310005O14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67914
Homologene: 6477
Prr22
Name: proline rich 22
Synonyms: LOC224908, Gm546
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100504446
Homologene: 51921
4921504E06Rik
Name: RIKEN cDNA 4921504E06 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70909
Homologene: 87049
Hoxd9
Name: homeobox D9
Synonyms: Hox-5.2, Hox-4.4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15438
HGNC: HGNC:5140
Homologene: 8409
Cpa5
Name: carboxypeptidase A5
Synonyms: 4930430M09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74649
Homologene: 62246
Klhl3
Name: kelch-like 3
Synonyms: 7530408C15Rik, EG627648
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100503085
HGNC: HGNC:6354
Homologene: 79542
Mrpl42
Name: mitochondrial ribosomal protein L42
Synonyms: MRP-L31, Rpml31, PTD007, HSPC204, 2700009F22Rik, 2900055D03Rik, D10Ertd322e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67270
VEGA: 10
Homologene: 12106
Fam78b
Name: family with sequence similarity 78, member B
Synonyms: C030020L09Rik, C030014K22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226610
Homologene: 18451
Rhbdd2
Name: rhomboid domain containing 2
Synonyms: 0610011L13Rik, Rhbdl7, Usmg1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 215160
Homologene: 32481
Naa11
Name: N(alpha)-acetyltransferase 11, NatA catalytic subunit
Synonyms: Ard1b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 97243
Homologene: 39206
Cfap54
Name: cilia and flagella associated protein 54
Synonyms: LOC380653, Gm872, 4930485B16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380654
Homologene: 133438
Fam181a
Name: family with sequence similarity 181, member A
Synonyms: EG544888
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100504156
Homologene: 34701
Fbxw25
Name: F-box and WD-40 domain protein 25
Synonyms: E330001B16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 546160
Scgb2b20
Name: secretoglobin, family 2B, member 20
Synonyms: C2c, Abpd, Abpbg20
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 494519
Homologene: 83171
Pcdha12
Name: protocadherin alpha 12
Synonyms: Cnr5, Crnr5, Pcdha13
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 192164
HGNC: HGNC:8667
Homologene: 135870
Trgv2
Name: T cell receptor gamma variable 2
Synonyms: Vgamma2, Tcrg-V2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21636
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 133,624,557 bp
  • C to T, chromosome 1 at 163,946,217 bp
  • C to A, chromosome 1 at 167,078,553 bp
  • T to C, chromosome 1 at 179,763,483 bp
  • C to T, chromosome 1 at 193,198,036 bp
  • A to G, chromosome 2 at 19,540,408 bp
  • A to G, chromosome 2 at 25,903,597 bp
  • T to A, chromosome 2 at 40,821,717 bp
  • G to T, chromosome 2 at 74,698,089 bp
  • T to C, chromosome 2 at 90,863,648 bp
  • C to A, chromosome 3 at 93,288,175 bp
  • G to T, chromosome 3 at 107,747,157 bp
  • T to C, chromosome 3 at 109,935,035 bp
  • G to T, chromosome 3 at 116,903,099 bp
  • T to C, chromosome 4 at 56,762,305 bp
  • G to T, chromosome 4 at 118,569,451 bp
  • G to A, chromosome 4 at 141,632,341 bp
  • A to T, chromosome 5 at 24,756,191 bp
  • A to C, chromosome 5 at 87,329,613 bp
  • A to G, chromosome 5 at 97,392,210 bp
  • A to C, chromosome 5 at 109,221,417 bp
  • C to T, chromosome 5 at 135,643,260 bp
  • A to G, chromosome 6 at 30,615,173 bp
  • T to A, chromosome 6 at 48,977,682 bp
  • C to T, chromosome 6 at 113,392,563 bp
  • A to G, chromosome 6 at 121,779,073 bp
  • G to A, chromosome 7 at 29,143,068 bp
  • A to T, chromosome 7 at 33,364,548 bp
  • CG to CGACGGCGGTG, chromosome 7 at 97,579,908 bp
  • TCCCC to TCCC, chromosome 8 at 11,529,599 bp
  • A to T, chromosome 8 at 23,109,671 bp
  • A to T, chromosome 8 at 70,888,620 bp
  • A to G, chromosome 8 at 94,850,234 bp
  • A to G, chromosome 8 at 119,870,667 bp
  • A to T, chromosome 8 at 123,492,926 bp
  • T to G, chromosome 9 at 7,447,622 bp
  • T to C, chromosome 9 at 38,378,088 bp
  • T to C, chromosome 9 at 44,317,666 bp
  • C to A, chromosome 9 at 67,951,449 bp
  • T to A, chromosome 9 at 95,964,014 bp
  • T to G, chromosome 9 at 109,654,650 bp
  • T to A, chromosome 10 at 93,038,909 bp
  • A to T, chromosome 10 at 95,496,707 bp
  • T to A, chromosome 11 at 5,019,493 bp
  • T to A, chromosome 11 at 54,649,247 bp
  • G to T, chromosome 11 at 54,987,077 bp
  • T to C, chromosome 11 at 60,712,163 bp
  • T to A, chromosome 11 at 90,540,201 bp
  • G to A, chromosome 12 at 84,331,838 bp
  • T to A, chromosome 12 at 87,081,953 bp
  • T to C, chromosome 12 at 103,316,544 bp
  • C to A, chromosome 12 at 108,692,580 bp
  • G to A, chromosome 13 at 19,336,831 bp
  • G to T, chromosome 13 at 58,013,842 bp
  • G to A, chromosome 13 at 60,761,766 bp
  • A to G, chromosome 13 at 67,542,586 bp
  • T to C, chromosome 14 at 54,989,284 bp
  • C to A, chromosome 14 at 67,790,275 bp
  • A to T, chromosome 16 at 32,768,767 bp
  • A to C, chromosome 16 at 59,167,293 bp
  • A to G, chromosome 16 at 90,753,919 bp
  • C to A, chromosome 17 at 49,435,155 bp
  • G to A, chromosome 17 at 56,771,587 bp
  • T to C, chromosome 17 at 88,742,704 bp
  • T to A, chromosome 18 at 12,524,737 bp
  • C to A, chromosome 18 at 20,388,163 bp
  • T to C, chromosome 18 at 35,619,571 bp
  • G to A, chromosome 18 at 37,022,424 bp
  • A to T, chromosome 19 at 13,815,307 bp
  • A to T, chromosome 19 at 43,739,926 bp
  • T to A, chromosome 19 at 48,790,166 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6268 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044439-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.