Strain Name:
C57BL/6J-MtgxR6275Btlr/Mmmh
Stock Number:
044445-MU
Citation ID:
RRID:MMRRC_044445-MU
Other Names:
R6275 (G1)
Major Collection:

Strain Information

Tanc1
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Synonyms: 1200003E16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66860
Homologene: 18946
Tpgs1
Name: tubulin polyglutamylase complex subunit 1
Synonyms: Gm16517, Gtrgeo22
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 110012
VEGA: 10
Homologene: 17525
Rnf38
Name: ring finger protein 38
Synonyms: Oip1, 1700065B19Rik, 2610202O07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73469
Homologene: 32550
Ano6
Name: anoctamin 6
Synonyms: 2900059G15Rik, F730003B03Rik, Tmem16f
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105722
VEGA: 15
Homologene: 27888
Rbm25
Name: RNA binding motif protein 25
Synonyms: 2610015J01Rik, A130095G20Rik, 2600011C06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67039
Sec62
Name: SEC62 homolog, preprotein translocation
Synonyms: Dtrp1, Tloc1, 3100002M17Rik, SEC62, HTP1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69276
Homologene: 2449
Laptm4b
Name: lysosomal-associated protein transmembrane 4B
Synonyms: C330023P13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 114128
VEGA: 15
Homologene: 10182
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, p325, C030033M12Rik, Hbxap, XAP8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Zfp292
Name: zinc finger protein 292
Synonyms: 9430062L07Rik, Zfp-15, Krox-10, Zn-15, Zfp15, Zn-16, 5730450D02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 30046
Homologene: 8493
Cntfr
Name: ciliary neurotrophic factor receptor
Synonyms: Cntfralpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12804
HGNC: HGNC:2170
Homologene: 9619
Il17rc
Name: interleukin 17 receptor C
Synonyms: IL17-RL, Il17rl, 1110025H02Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171095
Homologene: 15894
Txnl4a
Name: thioredoxin-like 4A
Synonyms: D18Wsu98e, U5-15kDa, ENSMUSG00000057130, Txnl4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 27366
Homologene: 7150
Psmd11
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
Synonyms: P44.5, S9, 1810019E17Rik, C78232, 2810055C24Rik, 2610024G20Rik, 1700089D09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69077
HGNC: HGNC:9556
Homologene: 2108
Edrf1
Name: erythroid differentiation regulatory factor 1
Synonyms: 2700050L05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 214764
Homologene: 27985
Usp42
Name: ubiquitin specific peptidase 42
Synonyms: D5Ertd591e, 2410140K03Rik, A630018G05Rik, 3110031A07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76800
Homologene: 35425
Sf3b2
Name: splicing factor 3b, subunit 2
Synonyms: SAP145, 2610311M13Rik, 2810441F20Rik, 145kDa, SF3b150, SF3b145, B230398H18Rik, SF3b1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 319322
VEGA: 19
Homologene: 6678
Abcb6
Name: ATP-binding cassette, sub-family B member 6
Synonyms: 1200005B17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74104
HGNC: HGNC:47
Homologene: 11375
Mov10l1
Name: Mov10 like RISC complex RNA helicase 1
Synonyms: CHAMP, Csm
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 83456
HGNC: HGNC:7201
Homologene: 56835
Tsc2
Name: TSC complex subunit 2
Synonyms: tuberous sclerosis 2, Nafld, tuberin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22084
VEGA: 17
Homologene: 462
Ccr7
Name: C-C motif chemokine receptor 7
Synonyms: EBI1, Ebi1h, CD197, Cmkbr7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12775
HGNC: HGNC:1608
Homologene: 1387
Ces1h
Name: carboxylesterase 1H
Synonyms: 2310039D24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75704
HGNC: HGNC:1863
Homologene: 119757
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Myh15
Name: myosin, heavy chain 15
Synonyms: EG667772
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 667772
VEGA: 16
Homologene: 18929
Tnr
Name: tenascin R
Synonyms: J1-tenascin, janusin, restrictin, TN-R
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21960
Homologene: 124416
Fgfbp3
Name: fibroblast growth factor binding protein 3
Synonyms: 2610306H15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72514
Homologene: 49899
Ermap
Name: erythroblast membrane-associated protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 27028
Homologene: 22782
Fsip1
Name: fibrous sheath-interacting protein 1
Synonyms: 4933432K11Rik, 1700012M13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71313
Homologene: 12390
Stac3
Name: SH3 and cysteine rich domain 3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237611
Homologene: 17039
Tulp4
Name: TUB like protein 4
Synonyms: 2210038L17Rik, 1110057P05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68842
Homologene: 32467
Folr1
Name: folate receptor alpha
Synonyms: FBP1, folate receptor [a], folate-binding protein 1, Folbp1, Folbp-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14275
HGNC: HGNC:3791
Homologene: 7322
Slc13a2
Name: solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
Synonyms: sodium/dicarboxylate co-transporter, mNaDC-1, Nadc1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20500
Homologene: 2965
Pcnx1
Name: pecanex 1
Synonyms: 3526401J03Rik, 2900024E21Rik, Pcnx
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Ccdc81
Name: coiled-coil domain containing 81
Synonyms: 4921513D09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70884
Homologene: 128447
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Hps1
Name: HPS1, biogenesis of lysosomal organelles complex 3 subunit 1
Synonyms: 6030422N11Rik, Hermansky-Pudlak syndrome 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 192236
HGNC: HGNC:5163
Homologene: 163
Itga10
Name: integrin, alpha 10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213119
HGNC: HGNC:6135
Homologene: 2697
Serpina6
Name: serine (or cysteine) peptidase inhibitor, clade A, member 6
Synonyms: Cbg
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 12401
HGNC: HGNC:1540
Homologene: 20417
Slc26a11
Name: solute carrier family 26, member 11
Synonyms: F630021I08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268512
Homologene: 13685
Cdca3
Name: cell division cycle associated 3
Synonyms: 2410005A12Rik, TOME-1, Grcc8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14793
Homologene: 8403
Or51q1
Name: olfactory receptor family 51 subfamily Q member 1
Synonyms: GA_x6K02T2PBJ9-6713641-6714588, MOR5-2, Olfr635
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259122
Homologene: 133592
Psg28
Name: pregnancy-specific beta-1-glycoprotein 28
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 114871
Homologene: 110989
Pidd1
Name: p53 induced death domain protein 1
Synonyms: 1200011D09Rik, Pidd, Lrdd
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57913
Homologene: 11220
Fam13a
Name: family with sequence similarity 13, member A
Synonyms: D430015B01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58909
Homologene: 135847
Acsbg1
Name: acyl-CoA synthetase bubblegum family member 1
Synonyms: E230019G03Rik, BG1, Lpd, Bgm
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 94180
Homologene: 9044
Jchain
Name: immunoglobulin joining chain
Synonyms: Jch, J chain, 9530090F24Rik, Igj
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16069
HGNC: HGNC:5713
Homologene: 16958
Cyp2d12
Name: cytochrome P450, family 2, subfamily d, polypeptide 12
Synonyms: 9030605E09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 380997
VEGA: 15
Homologene: 86099
Mpp2
Name: membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
Synonyms: Dlg2, Dlgh2, Pals4, D11Bwg0652e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 50997
HGNC: HGNC:7220
Homologene: 3920
Abca7
Name: ATP-binding cassette, sub-family A member 7
Synonyms: Abc51
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 27403
HGNC: HGNC:37
Homologene: 22783
Tll1
Name: tolloid-like
Synonyms: Tll-1, b2b2476Clo
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21892
Homologene: 49202
Stoml3
Name: stomatin (Epb7.2)-like 3
Synonyms: SRO, SLP3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229277
Homologene: 16628
H2-Oa
Name: histocompatibility 2, O region alpha locus
Synonyms: H-2Oa
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15001
HGNC: HGNC:4936
Homologene: 1601
Mal2
Name: mal, T cell differentiation protein 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105853
VEGA: 15
Homologene: 14167
Rapgefl1
Name: Rap guanine nucleotide exchange factor (GEF)-like 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268480
Homologene: 41126
Gm5493
Name: predicted gene 5493
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 433078
Eif1ad16
Name: eukaryotic translation initiation factor 1A domain containing 16
Synonyms: Gm6803
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 627873
VEGA: 12
Zfp994
Name: zinc finger protein 994
Synonyms: Gm4944
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240038
VEGA: 17
Homologene: 133246
Eif1ad15
Name: eukaryotic translation initiation factor 1A domain containing 15
Synonyms: Gm5039
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 266459
VEGA: 12
C1ql1
Name: complement component 1, q subcomponent-like 1
Synonyms: C1qrf
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23829
Homologene: 4867
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 75,172,551 bp
  • A to C, chromosome 1 at 159,861,270 bp
  • A to T, chromosome 2 at 59,843,510 bp
  • T to C, chromosome 2 at 118,205,102 bp
  • A to G, chromosome 3 at 30,809,836 bp
  • G to A, chromosome 3 at 53,507,506 bp
  • A to G, chromosome 3 at 96,658,185 bp
  • G to A, chromosome 4 at 34,808,883 bp
  • T to C, chromosome 4 at 41,663,216 bp
  • T to A, chromosome 4 at 44,152,408 bp
  • C to T, chromosome 4 at 119,178,550 bp
  • A to T, chromosome 5 at 88,521,353 bp
  • A to G, chromosome 5 at 124,785,184 bp
  • G to A, chromosome 5 at 143,714,972 bp
  • A to G, chromosome 6 at 58,954,257 bp
  • A to T, chromosome 6 at 113,480,347 bp
  • C to T, chromosome 6 at 124,832,664 bp
  • A to C, chromosome 7 at 18,430,440 bp
  • T to C, chromosome 7 at 89,882,311 bp
  • CGGCGGCGG to CGGCGGCGGTGGCGGCGG, chromosome 7 at 97,579,923 bp
  • T to A, chromosome 7 at 101,859,535 bp
  • T to A, chromosome 7 at 103,979,974 bp
  • A to T, chromosome 7 at 133,667,582 bp
  • C to T, chromosome 7 at 141,439,795 bp
  • A to T, chromosome 8 at 64,051,367 bp
  • A to T, chromosome 8 at 93,372,646 bp
  • T to A, chromosome 9 at 54,609,772 bp
  • C to A, chromosome 10 at 79,675,520 bp
  • T to A, chromosome 10 at 79,997,791 bp
  • T to C, chromosome 10 at 82,285,368 bp
  • T to A, chromosome 10 at 127,507,746 bp
  • CGTTATCTGT to CGT, chromosome 11 at 78,403,480 bp
  • T to C, chromosome 11 at 80,438,632 bp
  • T to A, chromosome 11 at 98,851,120 bp
  • C to T, chromosome 11 at 99,145,663 bp
  • T to A, chromosome 11 at 102,060,969 bp
  • A to G, chromosome 11 at 102,939,749 bp
  • T to C, chromosome 11 at 119,359,299 bp
  • G to T, chromosome 12 at 81,918,607 bp
  • T to A, chromosome 12 at 83,644,432 bp
  • T to C, chromosome 12 at 88,018,485 bp
  • T to C, chromosome 12 at 88,321,225 bp
  • T to A, chromosome 12 at 103,648,720 bp
  • A to G, chromosome 15 at 34,283,327 bp
  • T to C, chromosome 15 at 54,571,639 bp
  • C to A, chromosome 15 at 82,556,658 bp
  • T to A, chromosome 15 at 89,026,620 bp
  • A to T, chromosome 15 at 95,913,433 bp
  • A to G, chromosome 16 at 49,145,247 bp
  • A to G, chromosome 17 at 6,198,736 bp
  • A to T, chromosome 17 at 22,199,991 bp
  • A to T, chromosome 17 at 22,750,070 bp
  • A to G, chromosome 17 at 24,600,420 bp
  • A to G, chromosome 17 at 34,094,566 bp
  • T to A, chromosome 18 at 80,218,765 bp
  • A to C, chromosome 19 at 5,283,650 bp
  • T to C, chromosome 19 at 36,918,753 bp
  • T to C, chromosome 19 at 42,769,607 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6275 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044445-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.