Strain Name:
C57BL/6J-MtgxR6278Btlr/Mmmh
Stock Number:
044448-MU
Citation ID:
RRID:MMRRC_044448-MU
Other Names:
R6278 (G1)
Major Collection:

Strain Information

Cdk11b
Name: cyclin dependent kinase 11B
Synonyms: Cdc2l1, CDK11-p58, CDK11-p46, PITSLRE proteins, CDK11-p110, Cdc2l2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12537
Homologene: 22416
Synj2
Name: synaptojanin 2
Synonyms: SJ2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20975
Homologene: 117703
Ube2o
Name: ubiquitin-conjugating enzyme E2O
Synonyms: B230113M03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217342
Homologene: 11113
Eif4g3
Name: eukaryotic translation initiation factor 4 gamma, 3
Synonyms: 1500002J22Rik, repro8, G1-419-52, eIF4GII, 4930523M17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230861
HGNC: HGNC:3298
Homologene: 2789
Brpf3
Name: bromodomain and PHD finger containing, 3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268936
Homologene: 16092
Trip13
Name: thyroid hormone receptor interactor 13
Synonyms: D13Ertd328e, 2410002G23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69716
Homologene: 3125
Cenpc1
Name: centromere protein C1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12617
HGNC: HGNC:1854
Homologene: 1371
Zc3h13
Name: zinc finger CCCH type containing 13
Synonyms: 4930570G11Rik, C87618, 3110050K21Rik, 2600010B19Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67302
VEGA: 14
Txnl4b
Name: thioredoxin-like 4B
Synonyms: Dim2, D530025J19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234723
Homologene: 9880
Eif5
Name: eukaryotic translation initiation factor 5
Synonyms: D12Ertd549e, 2810011H21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217869
VEGA: 12
HGNC: HGNC:3299
Homologene: 49610
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Gucy1a1
Name: guanylate cyclase 1, soluble, alpha 1
Synonyms: alpha 1 sGC, Gucy1a3, 1200016O07Rik, sGC-alpha1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 60596
HGNC: HGNC:4685
Homologene: 37360
Cldn14
Name: claudin 14
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 56173
HGNC: HGNC:2035
Homologene: 8115
Far1
Name: fatty acyl CoA reductase 1
Synonyms: 2900034E22Rik, Mlstd2, 2600011M19Rik, 3732409C05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67420
Homologene: 41718
Rpl6
Name: ribosomal protein L6
Synonyms: Taxreb107
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19988
Homologene: 31001
Ston2
Name: stonin 2
Synonyms: 4933401N24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 108800
Homologene: 84338
Kif24
Name: kinesin family member 24
Synonyms: 4933425J19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 109242
Homologene: 52346
Pdia5
Name: protein disulfide isomerase associated 5
Synonyms: Pdir, 2700053F16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72599
VEGA: 16
Homologene: 4957
Tmem131l
Name: transmembrane 131 like
Synonyms: D930015E06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229473
Homologene: 9057
Amy1
Name: amylase 1, salivary
Synonyms: Amy-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11722
Homologene: 20179
Itga2
Name: integrin alpha 2
Synonyms: DX5, VLA-2 receptor, alpha 2 subunit, CD49B
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16398
VEGA: 13
HGNC: HGNC:6137
Homologene: 1662
Ppm1m
Name: protein phosphatase 1M
Synonyms: PP2C eta, 2810423O19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67905
Homologene: 44900
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, Dnahcl1, Dnahc17, 2810003K23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Cdk5rap3
Name: CDK5 regulatory subunit associated protein 3
Synonyms: OK/SW-cl.114, MST016, C53, IC53, HSF-27, 1810007E24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 80280
Homologene: 12718
Plce1
Name: phospholipase C, epsilon 1
Synonyms: PLCepsilon, 4933403A21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74055
Homologene: 9478
Vmn2r73
Name: vomeronasal 2, receptor 73
Synonyms: EG620928
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 620928
Homologene: 115466
Scoc
Name: short coiled-coil protein
Synonyms: 2810002J11Rik, short coiled-coil protein, 0610011C06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56367
Homologene: 134118
Or5g29
Name: olfactory receptor family 5 subfamily G member 29
Synonyms: MOR175-5, Olfr998, GA_x6K02T2Q125-47069356-47070300
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258428
Homologene: 74236
Gli3
Name: GLI-Kruppel family member GLI3
Synonyms: brachyphalangy, Bph
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14634
HGNC: HGNC:4319
Homologene: 139
Tmcc2
Name: transmembrane and coiled-coil domains 2
Synonyms: 1110063G11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68875
Homologene: 8905
P2ry1
Name: purinergic receptor P2Y, G-protein coupled 1
Synonyms: P2y1r, P2Y1 receptor, P2Y1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18441
HGNC: HGNC:8539
Homologene: 1926
Or8g26
Name: olfactory receptor family 8 subfamily G member 26
Synonyms: Olfr943, GA_x6K02T2PVTD-32881408-32882343, MOR171-44
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258323
VEGA: 9
HGNC: HGNC:8484
Homologene: 110526
Prkcz
Name: protein kinase C, zeta
Synonyms: zetaPKC, aPKCzeta, Pkcz
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18762
HGNC: HGNC:9412
Homologene: 55681
Acsm3
Name: acyl-CoA synthetase medium-chain family member 3
Synonyms: Sah, Sa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20216
Homologene: 74559
Or5w14
Name: olfactory receptor family 5 subfamily W member 14
Synonyms: MOR40-9P, MOR177-20, Olfr1137, GA_x6K02T2Q125-49215724-49214792
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258101
Homologene: 79380
Or5b119
Name: olfactory receptor family 5 subfamily B member 119
Synonyms: Olfr1475, MOR202-36, GA_x6K02T2RE5P-3812807-3811863
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258298
Homologene: 77370
Cage1
Name: cancer antigen 1
Synonyms: Ctag3, 4933427I01Rik, CAGE1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 71213
Homologene: 18484
Pcdh1
Name: protocadherin 1
Synonyms: 2010005A06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75599
HGNC: HGNC:8655
Homologene: 12613
Cyp2c69
Name: cytochrome P450, family 2, subfamily c, polypeptide 69
Synonyms: AI098658
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 100043108
VEGA: 19
Homologene: 74936
Fam47e
Name: family with sequence similarity 47, member E
Synonyms: Gm1381, LOC384198
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384198
Homologene: 129958
Gykl1
Name: glycerol kinase-like 1
Synonyms: Gk-rs1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14625
VEGA: 18
HGNC: HGNC:4289
Homologene: 21848
Spesp1
Name: sperm equatorial segment protein 1
Synonyms: 4921508E09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66712
VEGA: 9
Homologene: 49838
Vmn1r123
Name: vomeronasal 1 receptor 123
Synonyms: Gm1446, LOC384695
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384695
Homologene: 104166
Tigd5
Name: tigger transposable element derived 5
Synonyms: FLJ14926
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105734
Homologene: 129878
Nupr1
Name: nuclear protein transcription regulator 1
Synonyms: Com1, 2310032H04Rik, p8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56312
Homologene: 8229
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 132,358,982 bp
  • C to T, chromosome 1 at 150,697,419 bp
  • A to T, chromosome 2 at 82,988,898 bp
  • A to G, chromosome 2 at 85,590,998 bp
  • A to T, chromosome 2 at 87,711,471 bp
  • T to A, chromosome 3 at 61,003,794 bp
  • T to C, chromosome 3 at 82,097,634 bp
  • A to T, chromosome 3 at 83,942,491 bp
  • T to A, chromosome 3 at 113,561,690 bp
  • A to T, chromosome 4 at 41,423,498 bp
  • G to T, chromosome 4 at 138,188,083 bp
  • C to T, chromosome 4 at 144,330,267 bp
  • A to T, chromosome 4 at 155,268,195 bp
  • A to G, chromosome 4 at 155,649,603 bp
  • T to C, chromosome 5 at 86,035,535 bp
  • T to C, chromosome 5 at 92,562,517 bp
  • T to C, chromosome 5 at 121,208,849 bp
  • A to G, chromosome 7 at 21,162,849 bp
  • G to T, chromosome 7 at 85,872,932 bp
  • A to G, chromosome 7 at 113,568,137 bp
  • T to C, chromosome 7 at 119,773,849 bp
  • T to C, chromosome 7 at 126,625,346 bp
  • T to C, chromosome 8 at 83,458,336 bp
  • T to C, chromosome 8 at 109,569,103 bp
  • T to A, chromosome 9 at 39,184,298 bp
  • T to A, chromosome 9 at 54,415,762 bp
  • A to T, chromosome 9 at 62,272,639 bp
  • T to C, chromosome 9 at 106,197,228 bp
  • T to C, chromosome 11 at 96,911,903 bp
  • T to C, chromosome 11 at 116,539,543 bp
  • T to A, chromosome 11 at 118,126,290 bp
  • T to C, chromosome 12 at 91,648,330 bp
  • T to A, chromosome 12 at 111,542,793 bp
  • T to A, chromosome 13 at 15,725,113 bp
  • T to C, chromosome 13 at 38,016,419 bp
  • T to C, chromosome 13 at 73,913,320 bp
  • T to A, chromosome 13 at 114,845,888 bp
  • T to A, chromosome 14 at 75,330,423 bp
  • T to C, chromosome 15 at 75,909,993 bp
  • A to G, chromosome 16 at 35,429,923 bp
  • A to C, chromosome 16 at 93,919,598 bp
  • A to T, chromosome 17 at 5,975,874 bp
  • C to A, chromosome 17 at 28,821,284 bp
  • C to T, chromosome 18 at 38,199,210 bp
  • G to T, chromosome 18 at 52,695,208 bp
  • T to A, chromosome 19 at 13,479,755 bp
  • G to A, chromosome 19 at 38,725,051 bp
  • A to T, chromosome 19 at 39,843,063 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6278 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044448-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.