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Strain Name:
C57BL/6J-MtgxR6285Btlr/Mmmh
Stock Number:
044455-MU
Citation ID:
RRID:MMRRC_044455-MU
Other Names:
R6285 (G1)
Major Collection:

Strain Information

Cpe
Name: carboxypeptidase E
Synonyms: carboxypeptidase H, CPH, Cph1, Cph-1, NF-alpha1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12876
HGNC: HGNC:2303
Homologene: 48052
Pecam1
Name: platelet/endothelial cell adhesion molecule 1
Synonyms: PECAM-1, Cd31
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18613
HGNC: HGNC:8823
Homologene: 47925
Jak2
Name: Janus kinase 2
Synonyms: C81284
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16452
VEGA: 19
HGNC: HGNC:6192
Homologene: 21033
Map3k4
Name: mitogen-activated protein kinase kinase kinase 4
Synonyms: MTK1, MAPKKK4, D17Rp17, RP17, D17Rp17e, Mekk4, T-associated sex reversal, Tas
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26407
VEGA: 17
HGNC: HGNC:6856
Homologene: 31346
Igf1r
Name: insulin-like growth factor I receptor
Synonyms: CD221, IGF-1R, line 186, hyft, A330103N21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16001
HGNC: HGNC:5465
Homologene: 30997
Sirt2
Name: sirtuin 2
Synonyms: SIR2L2, Sir2l, 5730427M03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 64383
Homologene: 40823
Golga4
Name: golgin A4
Synonyms: golgin-245, Olp-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54214
HGNC: HGNC:4427
Homologene: 68224
Dido1
Name: death inducer-obliterator 1
Synonyms: DIO-1, 6720461J16Rik, D130048F08Rik, Datf1, dido, C130092D22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 23856
HGNC: HGNC:2680
Homologene: 34139
Cep290
Name: centrosomal protein 290
Synonyms: Nphp6, b2b1454Clo, b2b1752Clo, Kiaa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Cabin1
Name: calcineurin binding protein 1
Synonyms: Ppp3in, Cain, A330070M20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 104248
VEGA: 10
Homologene: 49307
Wdr48
Name: WD repeat domain 48
Synonyms: 8430408H12Rik, Uaf1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67561
VEGA: 9
Homologene: 10830
Knl1
Name: kinetochore scaffold 1
Synonyms: 2310043D08Rik, 5730505K17Rik, Casc5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76464
Homologene: 44890
Usp24
Name: ubiquitin specific peptidase 24
Synonyms: 2810030C21Rik, 2700066K03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329908
Homologene: 35420
Cep350
Name: centrosomal protein 350
Synonyms: 6430546F08Rik, 4933409L06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74081
Homologene: 8879
Dek
Name: DEK proto-oncogene
Synonyms: D13H6S231E, 1810019E15Rik, DEK proto-oncogene (DNA binding)
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110052
HGNC: HGNC:2768
Homologene: 2593
Aimp1
Name: aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
Synonyms: Emap2, AIMP1/p43, 9830137A06Rik, Scye1, EMAPII
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13722
Homologene: 31260
Ctnnd1
Name: catenin delta 1
Synonyms: P120, Ctnnd, p120-catenin, Catns, catenin (cadherin associated protein), delta 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12388
HGNC: HGNC:2515
Homologene: 1017
Cd79a
Name: CD79A antigen (immunoglobulin-associated alpha)
Synonyms: mb-1, Iga, Ig alpha, Ly54, Cd79a, Ig-alpha, Ly-54, Igalpha
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12518
HGNC: HGNC:1698
Homologene: 31053
D5Ertd579e
Name: DNA segment, Chr 5, ERATO Doi 579, expressed
Synonyms: 9030221A05Rik, A930018H20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320661
Homologene: 19716
Sqstm1
Name: sequestosome 1
Synonyms: A170, OSF-6, STAP, Osi, p62
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18412
Homologene: 31202
Cdc7
Name: cell division cycle 7
Synonyms: Cdc7, muCdc7, Cdc7l1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12545
HGNC: HGNC:1745
Homologene: 31166
Nol11
Name: nucleolar protein 11
Synonyms: 1500002M01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68979
Homologene: 32264
Dennd1a
Name: DENN domain containing 1A
Synonyms: 6030446I19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227801
Homologene: 17141
Tbc1d2
Name: TBC1 domain family, member 2
Synonyms: LOC381605, PARIS-1, PARIS1, A630005A06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381605
Homologene: 10190
Nr2f1
Name: nuclear receptor subfamily 2, group F, member 1
Synonyms: COUP-TFI, Erbal3, Tcfcoup1, COUP-TF1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13865
HGNC: HGNC:7975
Homologene: 21158
Ppp2r5b
Name: protein phosphatase 2, regulatory subunit B', beta
Synonyms: B'beta
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225849
HGNC: HGNC:9310
Homologene: 38157
Rspo3
Name: R-spondin 3
Synonyms: 2810459H04Rik, Thsd2, Cristin1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72780
VEGA: 10
Homologene: 12484
Cfap46
Name: cilia and flagella associated protein 46
Synonyms: 9330101J02Rik, Ttc40
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 212124
Kcp
Name: kielin/chordin-like protein
Synonyms: LOC333088, KCP, Crim2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 333088
Homologene: 87817
Vmn2r103
Name: vomeronasal 2, receptor 103
Synonyms: EG627636
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627636
Homologene: 115024
Hoxc11
Name: homeobox C11
Synonyms: Hox-3.7
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 109663
HGNC: HGNC:5123
Homologene: 130362
Evc2
Name: EvC ciliary complex subunit 2
Synonyms: limbin, Lbn, Ellis van Creveld syndrome 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68525
Homologene: 17117
Vinac1
Name: vinculin/alpha-catenin family member 1
Synonyms: Gm14025
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668894
Homologene: 86340
Faap100
Name: Fanconi anemia core complex associated protein 100
Synonyms: 2310003H01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71885
Homologene: 69394
Or10j7
Name: olfactory receptor family 10 subfamily J member 7
Synonyms: GA_x6K02T2R7CC-664297-665229, MOR267-5, Olfr1406
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258758
Homologene: 133644
Ptprt
Name: protein tyrosine phosphatase receptor type T
Synonyms: RPTPrho
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19281
HGNC: HGNC:9682
Homologene: 56924
Pfkfb2
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Synonyms: PFK-2/FBPase-2 gene B, 4930568D07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18640
HGNC: HGNC:8873
Homologene: 88554
Rasgrp4
Name: RAS guanyl releasing protein 4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233046
Homologene: 15635
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: EG235580, 1110001D15Rik, Dvwa, Vwa6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68553
Homologene: 130754
Bbs10
Name: Bardet-Biedl syndrome 10
Synonyms: 1300007O09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71769
VEGA: 10
Homologene: 49781
Acad9
Name: acyl-Coenzyme A dehydrogenase family, member 9
Synonyms: NPD002, 2600017P15Rik, C630012L17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229211
Homologene: 8539
Ptk6
Name: PTK6 protein tyrosine kinase 6
Synonyms: Sik, Tksk
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20459
HGNC: HGNC:9617
Homologene: 68494
Hipk3
Name: homeodomain interacting protein kinase 3
Synonyms: DYRK6, FIST3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15259
HGNC: HGNC:4915
Homologene: 55923
Eva1b
Name: eva-1 homolog B
Synonyms: 2610027C15Rik, Fam176b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230752
Homologene: 18151
Minar2
Name: membrane integral NOTCH2 associated receptor 2
Synonyms: A730017C20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225583
Homologene: 18350
Atp8a1
Name: ATPase phospholipid transporting 8A1
Synonyms: Atp3a2, B230107D19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11980
Homologene: 48402
P2rx1
Name: purinergic receptor P2X, ligand-gated ion channel, 1
Synonyms: P2x, RP-2, P2X1 receptor, Pdcd3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18436
HGNC: HGNC:8533
Homologene: 1921
Psg26
Name: pregnancy-specific beta-1-glycoprotein 26
Synonyms: cea14, EG574429
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 574429
Homologene: 110989
Nrdc
Name: nardilysin convertase
Synonyms: NRD-C, Nrd1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230598
HGNC: HGNC:7995
Homologene: 68260
Poldip2
Name: polymerase (DNA-directed), delta interacting protein 2
Synonyms: 1300003F06Rik, mitogenin 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67811
Homologene: 9201
Pramel26
Name: PRAME like 26
Synonyms: Gm13084
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381569
Homologene: 77858
Fbxw15
Name: F-box and WD-40 domain protein 15
Synonyms: Fbxo12J
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382105
Homologene: 110776
Gbp10
Name: guanylate-binding protein 10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 626578
Homologene: 128731
Lilra5
Name: leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
Synonyms: Gm4878
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232801
Homologene: 83297
Mdfic2
Name: MyoD family inhibitor domain containing 2
Synonyms: LOC330390, Gm765
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330390
Homologene: 66631
Gpank1
Name: G patch domain and ankyrin repeats 1
Synonyms: G5, D17H6S54E, Bat4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 81845
Homologene: 13035
Slc6a20b
Name: solute carrier family 6 (neurotransmitter transporter), member 20B
Synonyms: XT3, Xtrp3, Sit1, Slc6a20
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22599
Homologene: 130652
Tada2b
Name: transcriptional adaptor 2B
Synonyms: LOC231151
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231151
Homologene: 51007
Mrpl16
Name: mitochondrial ribosomal protein L16
Synonyms: 2310039D06Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 94063
VEGA: 19
Homologene: 9872
Or10z1
Name: olfactory receptor family 10 subfamily Z member 1
Synonyms: GA_x6K02T2P20D-20891507-20892448, MOR267-6, Olfr419
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258710
Homologene: 72017
Or13a22
Name: olfactory receptor family 13 subfamily A member 22
Synonyms: GA_x6K02T2PBJ9-42641642-42642574, MOR253-7, Olfr535
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258956
Homologene: 138320
Susd3
Name: sushi domain containing 3
Synonyms: 2810440J20Rik, 1700017I11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66329
Homologene: 11948
Larp6
Name: La ribonucleoprotein 6, translational regulator
Synonyms: 5430431G03Rik, Achn, acheron
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67557
Homologene: 32408
Pcdhgc5
Name: protocadherin gamma subfamily C, 5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93708
HGNC: HGNC:8718
Homologene: 110933
Gm4181
Name: predicted gene 4181
Type: Gene
Species: Mouse
Chromosome: 14
Krtap10-33
Name: keratin associated protein 10-33
Synonyms: Gm19402
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100502831
VEGA: 10
Homologene: 115744
Or13m2-ps1
Name: olfactory receptor family 13 subfamily M member 2, pseudogene 1
Synonyms: GA_x6K02T2P3E9-4759141-4758206, MOR257-6, Olfr451-ps1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258017
Gm2244
Name: predicted gene 2244
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100039452
Homologene: 115686
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 130,707,562 bp
  • A to T, chromosome 1 at 155,953,374 bp
  • G to T, chromosome 1 at 173,183,910 bp
  • A to T, chromosome 1 at 174,250,829 bp
  • A to T, chromosome 2 at 37,852,441 bp
  • C to T, chromosome 2 at 84,613,887 bp
  • T to C, chromosome 2 at 104,471,425 bp
  • T to G, chromosome 2 at 119,071,941 bp
  • T to G, chromosome 2 at 129,037,799 bp
  • A to T, chromosome 2 at 161,901,497 bp
  • C to T, chromosome 2 at 180,661,147 bp
  • A to T, chromosome 2 at 181,197,093 bp
  • A to T, chromosome 3 at 36,082,175 bp
  • A to G, chromosome 3 at 132,667,504 bp
  • A to T, chromosome 4 at 46,615,045 bp
  • T to G, chromosome 4 at 106,374,100 bp
  • G to T, chromosome 4 at 109,038,006 bp
  • A to G, chromosome 4 at 126,149,485 bp
  • A to G, chromosome 4 at 143,816,039 bp
  • G to A, chromosome 5 at 36,476,842 bp
  • A to C, chromosome 5 at 36,615,577 bp
  • G to T, chromosome 5 at 37,424,579 bp
  • T to C, chromosome 5 at 67,667,607 bp
  • A to T, chromosome 5 at 105,218,460 bp
  • G to A, chromosome 5 at 106,983,059 bp
  • C to A, chromosome 6 at 29,502,365 bp
  • A to T, chromosome 6 at 42,800,909 bp
  • T to C, chromosome 6 at 98,238,173 bp
  • G to A, chromosome 7 at 4,242,115 bp
  • A to G, chromosome 7 at 18,482,828 bp
  • A to G, chromosome 7 at 24,899,347 bp
  • A to C, chromosome 7 at 28,788,046 bp
  • T to C, chromosome 7 at 29,148,383 bp
  • T to G, chromosome 7 at 68,004,137 bp
  • A to G, chromosome 7 at 126,781,568 bp
  • T to A, chromosome 7 at 139,661,085 bp
  • T to A, chromosome 7 at 140,492,713 bp
  • A to C, chromosome 8 at 64,617,611 bp
  • A to T, chromosome 9 at 60,737,760 bp
  • T to C, chromosome 9 at 106,074,986 bp
  • T to A, chromosome 9 at 109,557,166 bp
  • C to T, chromosome 9 at 118,558,627 bp
  • C to T, chromosome 9 at 119,920,610 bp
  • T to C, chromosome 9 at 123,609,096 bp
  • A to G, chromosome 10 at 29,499,930 bp
  • A to T, chromosome 10 at 75,684,323 bp
  • A to C, chromosome 10 at 77,690,520 bp
  • A to G, chromosome 10 at 100,523,329 bp
  • A to G, chromosome 10 at 111,299,761 bp
  • G to A, chromosome 11 at 50,202,591 bp
  • G to T, chromosome 11 at 53,534,767 bp
  • A to G, chromosome 11 at 73,008,148 bp
  • A to G, chromosome 11 at 78,517,632 bp
  • T to C, chromosome 11 at 106,685,239 bp
  • C to G, chromosome 11 at 107,181,034 bp
  • A to T, chromosome 11 at 120,376,732 bp
  • A to G, chromosome 13 at 47,099,380 bp
  • T to A, chromosome 13 at 49,237,521 bp
  • T to C, chromosome 13 at 78,195,663 bp
  • A to G, chromosome 14 at 19,540,797 bp
  • A to T, chromosome 14 at 51,633,209 bp
  • T to C, chromosome 15 at 102,954,743 bp
  • A to G, chromosome 17 at 12,264,058 bp
  • A to G, chromosome 17 at 19,812,144 bp
  • T to A, chromosome 17 at 35,124,290 bp
  • A to T, chromosome 18 at 37,820,621 bp
  • A to G, chromosome 18 at 59,072,224 bp
  • T to A, chromosome 19 at 6,230,536 bp
  • T to A, chromosome 19 at 11,772,968 bp
  • T to A, chromosome 19 at 29,295,659 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6285 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044455-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.