Strain Name:
C57BL/6J-MtgxR6293Btlr/Mmmh
Stock Number:
044462-MU
Citation ID:
RRID:MMRRC_044462-MU
Other Names:
R6293 (G1)
Major Collection:

Strain Information

Elf1
Name: E74 like ETS transcription factor 1
Synonyms: Elf-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13709
VEGA: 14
HGNC: HGNC:3316
Homologene: 7303
Arfgef2
Name: ADP ribosylation factor guanine nucleotide exchange factor 2
Synonyms: BIG2, E230011G24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99371
Homologene: 111880
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNAPDcs, DNA-PK, slip, XRCC7, DNA-PKcs, dxnph, DOXNPH
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Nup210l
Name: nucleoporin 210-like
Synonyms: 4930548O11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77595
Homologene: 28122
Ylpm1
Name: YLP motif containing 1
Synonyms: ZAP, A930013E17Rik, Zap3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56531
Homologene: 87707
Uba3
Name: ubiquitin-like modifier activating enzyme 3
Synonyms: Ube1c, ubiquitin activating enzyme 3, A830034N06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22200
Homologene: 2951
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: 6230420N16Rik, Depdc2, C030045D06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109294
Homologene: 23523
Alkbh8
Name: alkB homolog 8, tRNA methyltransferase
Synonyms: Abh8, 8030431D03Rik, 9430088N01Rik, 4930562C03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67667
Homologene: 44488
Rapgef6
Name: Rap guanine nucleotide exchange factor (GEF) 6
Synonyms: PDZ-GEF2, C030018K18Rik, Pdzgef2, RA-GEF-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192786
Homologene: 22968
Lrch2
Name: leucine-rich repeats and calponin homology (CH) domain containing 2
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 210297
Homologene: 32491
Pkn2
Name: protein kinase N2
Synonyms: Prkcl2, 6030436C20Rik, PRK2, Stk7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109333
HGNC: HGNC:9406
Homologene: 2054
Osbpl8
Name: oxysterol binding protein-like 8
Synonyms: ORP-8, D330025H14Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237542
VEGA: 10
Homologene: 68813
Mbtd1
Name: mbt domain containing 1
Synonyms: hemp
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103537
Homologene: 41185
Camsap2
Name: calmodulin regulated spectrin-associated protein family, member 2
Synonyms: 1600013L13Rik, 4930541M15Rik, Camsap1l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67886
Homologene: 18927
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, p325, C030033M12Rik, Hbxap, XAP8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Slc44a1
Name: solute carrier family 44, member 1
Synonyms: CHTL1, CTL1, 4833416H08Rik, Cdw92, 2210409B22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100434
Homologene: 11137
Ankrd27
Name: ankyrin repeat domain 27
Synonyms: Varp, D330003H11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 245886
Homologene: 12956
Mcm3ap
Name: minichromosome maintenance complex component 3 associated protein
Synonyms: GANP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54387
VEGA: 10
HGNC: HGNC:6946
Homologene: 2902
Ndel1
Name: nudE neurodevelopment protein 1 like 1
Synonyms: 2600006O07Rik, mNudel
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 83431
Homologene: 32567
Adgra3
Name: adhesion G protein-coupled receptor A3
Synonyms: Gpr125, Tem5-like, 3830613O22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70693
Homologene: 19235
Cdk12
Name: cyclin dependent kinase 12
Synonyms: Crkrs, D11Ertd752e, 1810022J16Rik, Crk7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69131
Homologene: 128632
Gcnt2
Name: glucosaminyl (N-acetyl) transferase 2 (I blood group)
Synonyms: IGnTA, 5330430K10Rik, IGnT, IGnTC, IGnTB
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14538
VEGA: 13
HGNC: HGNC:4204
Homologene: 41535
Mpdz
Name: multiple PDZ domain crumbs cell polarity complex component
Synonyms: MUPP1, B930003D11Rik, multiple PDZ domain protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17475
HGNC: HGNC:7208
Homologene: 2841
Nxf1
Name: nuclear RNA export factor 1
Synonyms: Tip associated protein, Mvb1, Mex67, TAP
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 53319
HGNC: HGNC:8071
Homologene: 38176
Rpp30
Name: ribonuclease P/MRP 30 subunit
Synonyms: TSG15, Rnasep2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54364
VEGA: 19
Homologene: 38180
Zscan22
Name: zinc finger and SCAN domain containing 22
Synonyms: Hkr2, D530006B18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232878
HGNC: HGNC:4929
Homologene: 68122
Gpr155
Name: G protein-coupled receptor 155
Synonyms: 1110017O10Rik, PGR22, F730029F15Rik, DEPDC3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68526
Homologene: 16584
Lrrc8c
Name: leucine rich repeat containing 8 family, member C
Synonyms: E430036I04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100604
Homologene: 12997
Pkd2l2
Name: polycystic kidney disease 2-like 2
Synonyms: TRPP5, Polycystin - L2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 53871
VEGA: 18
HGNC: HGNC:9012
Homologene: 22812
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 665700
Homologene: 90772
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy3, hyrh, hy-3, 1700034M11Rik, 4930545D19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Abca4
Name: ATP-binding cassette, sub-family A member 4
Synonyms: Abc10, Rim protein, RmP, D430003I15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11304
HGNC: HGNC:34
Homologene: 298
Ccdc38
Name: coiled-coil domain containing 38
Synonyms: 4933417K05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237465
Homologene: 52182
Haus5
Name: HAUS augmin-like complex, subunit 5
Synonyms: 2310022K01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71909
Homologene: 18969
Abcb1b
Name: ATP-binding cassette, sub-family B member 1B
Synonyms: mdr, Pgy1, Pgy-1, Abcb1, Mdr1b, Mdr1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18669
HGNC: HGNC:40
Homologene: 69084
Myt1l
Name: myelin transcription factor 1-like
Synonyms: 2900093J19Rik, C630034G21Rik, Nztf1, Pmng1, 2900046C06Rik, Png-1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17933
VEGA: 12
HGNC: HGNC:7623
Homologene: 7435
Rbm11
Name: RNA binding motif protein 11
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224344
HGNC: HGNC:9897
Homologene: 16988
Tyro3
Name: TYRO3 protein tyrosine kinase 3
Synonyms: Dtk, Rse, Sky, Tif, Etk-2, Sky, Brt
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22174
Homologene: 4585
Cfap251
Name: cilia and flagella associated protein 251
Synonyms: 4930415N18Rik, 4933428F06Rik, Wdr66
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269701
Homologene: 16964
Dthd1
Name: death domain containing 1
Synonyms: Gm17384
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100322896
Homologene: 123510
Pla2g4a
Name: phospholipase A2, group IVA (cytosolic, calcium-dependent)
Synonyms: cytosolic phospholipase A2, cPLA2, Type IV PLA2, cytosolic PLA2, cPLA2alpha, Pla2g4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18783
HGNC: HGNC:9035
Homologene: 32059
Ptk6
Name: PTK6 protein tyrosine kinase 6
Synonyms: Sik, Tksk
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20459
HGNC: HGNC:9617
Homologene: 68494
Or2ag15
Name: olfactory receptor family 2 subfamily AG member 15
Synonyms: MOR283-5, GA_x6K02T2PBJ9-9119301-9118348, Olfr697
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258592
Slco2a1
Name: solute carrier organic anion transporter family, member 2a1
Synonyms: mPgt, Slc21a2, Pgt, 2310021C19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 24059
Homologene: 38077
Vstm2b
Name: V-set and transmembrane domain containing 2B
Synonyms: 2900093B09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 58188
Homologene: 10970
Rhbg
Name: Rhesus blood group-associated B glycoprotein
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 58176
Homologene: 9469
Tmem50b
Name: transmembrane protein 50B
Synonyms: B230114J08Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77975
HGNC: HGNC:1280
Homologene: 21234
Nudt21
Name: nudix hydrolase 21
Synonyms: nudix (nucleoside diphosphate linked moiety X)-type motif 21, 5730530J16Rik, 25kDa, 3110048P04Rik, Cpsf5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68219
Homologene: 5090
Rhbdl1
Name: rhomboid like 1
Synonyms: Rhbdl
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 214951
Homologene: 2946
Vmn1r21
Name: vomeronasal 1 receptor 21
Synonyms: V1rc28
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171201
Homologene: 74363
Gm9964
Name: predicted gene 9964
Type: Gene
Species: Mouse
Chromosome: 11
Apoc1
Name: apolipoprotein C-I
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11812
HGNC: HGNC:607
Homologene: 136426
Or4s2
Name: olfactory receptor family 4 subfamily S member 2
Synonyms: GA_x6K02T2Q125-50121628-50122030, Olfr526-ps1, GA_x6K02T2PRF0-44595-45531, MOR230-9, Olfr1191
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404399
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 11,162,298 bp
  • C to A, chromosome 1 at 136,287,920 bp
  • T to C, chromosome 1 at 149,880,047 bp
  • T to C, chromosome 2 at 31,335,451 bp
  • A to G, chromosome 2 at 73,373,997 bp
  • G to A, chromosome 2 at 76,749,329 bp
  • A to G, chromosome 2 at 88,643,280 bp
  • A to G, chromosome 2 at 119,808,000 bp
  • T to A, chromosome 2 at 166,873,588 bp
  • T to C, chromosome 2 at 181,198,460 bp
  • G to A, chromosome 3 at 88,245,826 bp
  • A to T, chromosome 3 at 90,115,064 bp
  • A to G, chromosome 3 at 122,141,746 bp
  • A to G, chromosome 3 at 142,809,704 bp
  • A to G, chromosome 4 at 53,561,099 bp
  • A to G, chromosome 4 at 81,360,056 bp
  • T to C, chromosome 5 at 8,853,493 bp
  • G to A, chromosome 5 at 49,960,847 bp
  • A to G, chromosome 5 at 62,842,850 bp
  • A to G, chromosome 5 at 105,606,746 bp
  • A to C, chromosome 5 at 123,322,448 bp
  • T to C, chromosome 6 at 57,844,270 bp
  • A to T, chromosome 6 at 97,196,908 bp
  • T to A, chromosome 7 at 12,906,907 bp
  • T to A, chromosome 7 at 19,691,892 bp
  • C to T, chromosome 7 at 30,658,976 bp
  • T to C, chromosome 7 at 35,608,460 bp
  • T to A, chromosome 7 at 40,900,109 bp
  • GGCG to GGCGACGGCCGCG, chromosome 7 at 97,579,906 bp
  • T to C, chromosome 7 at 106,741,406 bp
  • T to C, chromosome 8 at 94,028,878 bp
  • A to G, chromosome 8 at 110,597,911 bp
  • G to T, chromosome 9 at 3,347,841 bp
  • A to T, chromosome 9 at 79,614,358 bp
  • A to G, chromosome 9 at 103,050,147 bp
  • C to G, chromosome 10 at 76,471,478 bp
  • C to T, chromosome 10 at 93,562,797 bp
  • A to G, chromosome 10 at 111,272,238 bp
  • T to A, chromosome 11 at 54,634,781 bp
  • C to T, chromosome 11 at 68,836,275 bp
  • T to A, chromosome 11 at 79,296,594 bp
  • C to T, chromosome 11 at 93,932,232 bp
  • T to A, chromosome 11 at 98,224,553 bp
  • A to G, chromosome 12 at 29,827,628 bp
  • C to G, chromosome 12 at 85,015,277 bp
  • T to A, chromosome 13 at 40,918,697 bp
  • C to T, chromosome 14 at 79,560,786 bp
  • A to G, chromosome 16 at 15,787,155 bp
  • A to T, chromosome 16 at 75,596,767 bp
  • A to T, chromosome 16 at 91,583,276 bp
  • A to G, chromosome 17 at 25,834,969 bp
  • A to G, chromosome 18 at 34,427,444 bp
  • A to G, chromosome 19 at 8,769,182 bp
  • A to G, chromosome 19 at 36,104,445 bp
  • C to T, chromosome X at 147,480,557 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6293 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044462-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.