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Strain Name:
C57BL/6J-MtgxR6311Btlr/Mmmh
Stock Number:
044469-MU
Citation ID:
RRID:MMRRC_044469-MU
Other Names:
R6311 (G1)
Major Collection:

Strain Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Pdzd2
Name: PDZ domain containing 2
Synonyms: 4930537L06Rik, LOC223364, A930022H17Rik, Pdzk3, Gm21706
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68070
Homologene: 23393
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Pdcl3
Name: phosducin-like 3
Synonyms: 1110061A19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68833
Homologene: 7012
Slc9a8
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 8
Synonyms: NHE8, 1200006P13Rik, 6430709P13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77031
Homologene: 75041
Zbtb17
Name: zinc finger and BTB domain containing 17
Synonyms: mZ13, Miz1, Zfp100
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22642
Homologene: 2575
Prdm15
Name: PR domain containing 15
Synonyms: Zfp298, E130018M06Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 114604
Homologene: 56941
Clca4a
Name: chloride channel accessory 4A
Synonyms: 9130020L07Rik, Clca6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99663
HGNC: HGNC:2018
Homologene: 40808
Ddx24
Name: DEAD box helicase 24
Synonyms: 2510027P10Rik, 1700055J08Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 24
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 27225
VEGA: 12
Homologene: 10702
Nr6a1
Name: nuclear receptor subfamily 6, group A, member 1
Synonyms: Gcnf, NCNF, 1700113M01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14536
HGNC: HGNC:7985
Homologene: 36308
Chd1l
Name: chromodomain helicase DNA binding protein 1-like
Synonyms: Snf2p, 4432404A22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68058
HGNC: HGNC:1916
Homologene: 11590
Chst10
Name: carbohydrate sulfotransferase 10
Synonyms: ST, Hnk-1st
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98388
Homologene: 21013
Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Synonyms: Idh-2, IDPm
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269951
HGNC: HGNC:5383
Homologene: 37590
Sult2a3
Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 3
Synonyms: Gm6955
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 629203
Homologene: 37741
Adcy2
Name: adenylate cyclase 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210044
VEGA: 13
HGNC: HGNC:233
Homologene: 75133
Hsd3b5
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
Synonyms: 3(beta)HSDV
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15496
Homologene: 104115
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: LOC380658, 4930503E15Rik, Gm1557
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74978
Homologene: 46007
Cgn
Name: cingulin
Synonyms: 6330408J11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70737
Homologene: 41394
Arhgef4
Name: Rho guanine nucleotide exchange factor 4
Synonyms: 9330140K16Rik, Asef, C230030N03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226970
HGNC: HGNC:684
Homologene: 49414
Mical2
Name: microtubule associated monooxygenase, calponin and LIM domain containing 2
Synonyms: 5330438E18Rik, Ebitein1, 4921517J23Rik, Micalcl
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320878
Homologene: 8760
Fam227a
Name: family with sequence similarity 227, member A
Synonyms: 4933432B09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75729
Homologene: 123434
Pgm2
Name: phosphoglucomutase 2
Synonyms: Pgm-1, 3230402E02Rik, Pgm1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66681
HGNC: HGNC:8906
Homologene: 6693
Cntnap5a
Name: contactin associated protein-like 5A
Synonyms: Caspr5-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 636808
Homologene: 43974
Tlr1
Name: toll-like receptor 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21897
Homologene: 20694
Grik2
Name: glutamate receptor, ionotropic, kainate 2 (beta 2)
Synonyms: Glur-6, Glur6, Glurbeta2, C130030K03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14806
HGNC: HGNC:4580
Homologene: 40717
Pgm1
Name: phosphoglucomutase 1
Synonyms: Pgm-2, 2610020G18Rik, Pgm1a, Pgm2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72157
HGNC: HGNC:8905
Homologene: 1979
Plbd1
Name: phospholipase B domain containing 1
Synonyms: 1100001H23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66857
Homologene: 11745
Pcdhb17
Name: protocadherin beta 17
Synonyms: Pcdhb16, PcdhbQ
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93888
Homologene: 81881
Fstl4
Name: follistatin-like 4
Synonyms: B230374F23Rik, SPIG1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320027
Homologene: 18543
B4galnt4
Name: beta-1,4-N-acetyl-galactosaminyl transferase 4
Synonyms: LOC381951
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330671
Homologene: 27982
Fut2
Name: fucosyltransferase 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14344
HGNC: HGNC:4013
Homologene: 10325
Ugt3a1
Name: UDP glycosyltransferases 3 family, polypeptide A1
Synonyms: Ugt3a2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223337
Homologene: 122787
Slc17a2
Name: solute carrier family 17 (sodium phosphate), member 2
Synonyms: NPT3, C730032N17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218103
Homologene: 4260
Prdm12
Name: PR domain containing 12
Synonyms: LOC381359
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381359
Homologene: 10999
Ermn
Name: ermin, ERM-like protein
Synonyms: A330104H05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77767
Homologene: 12683
Or6c216
Name: olfactory receptor family 6 subfamily C member 216
Synonyms: GA_x6K02T2PULF-11521598-11520666, MOR110-1, Olfr812
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258791
Homologene: 73931
Or5b100-ps1
Name: olfactory receptor family 5 subfamily B member 100, pseudogene 1
Synonyms: GA_x6K02T2RE5P-3345724-3346648, MOR202-23, Olfr1452-ps1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258126
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 34,723,981 bp
  • A to G, chromosome 1 at 38,868,047 bp
  • A to G, chromosome 1 at 38,987,844 bp
  • G to A, chromosome 1 at 116,412,106 bp
  • A to G, chromosome 2 at 31,654,309 bp
  • T to C, chromosome 2 at 38,739,071 bp
  • A to G, chromosome 2 at 58,051,759 bp
  • G to T, chromosome 2 at 153,674,005 bp
  • T to A, chromosome 2 at 167,451,220 bp
  • C to T, chromosome 3 at 94,778,176 bp
  • G to A, chromosome 3 at 97,587,167 bp
  • T to C, chromosome 3 at 98,630,090 bp
  • T to A, chromosome 3 at 144,966,413 bp
  • T to C, chromosome 4 at 99,970,040 bp
  • G to A, chromosome 4 at 141,463,383 bp
  • A to G, chromosome 5 at 25,443,818 bp
  • G to A, chromosome 5 at 64,116,415 bp
  • C to T, chromosome 5 at 64,926,845 bp
  • T to A, chromosome 6 at 136,613,947 bp
  • T to C, chromosome 7 at 14,111,557 bp
  • T to A, chromosome 7 at 45,650,380 bp
  • TCCCAGG to T, chromosome 7 at 80,098,331 bp
  • T to A, chromosome 7 at 112,323,558 bp
  • A to G, chromosome 7 at 141,068,659 bp
  • T to C, chromosome 8 at 99,400,895 bp
  • T to A, chromosome 8 at 104,614,433 bp
  • T to G, chromosome 10 at 49,578,138 bp
  • A to T, chromosome 10 at 103,173,393 bp
  • A to G, chromosome 10 at 129,842,907 bp
  • T to C, chromosome 11 at 53,176,977 bp
  • C to A, chromosome 12 at 103,423,907 bp
  • A to G, chromosome 13 at 23,815,022 bp
  • A to G, chromosome 13 at 68,625,792 bp
  • A to G, chromosome 14 at 103,262,740 bp
  • A to T, chromosome 15 at 9,361,518 bp
  • T to A, chromosome 15 at 12,458,188 bp
  • C to T, chromosome 15 at 79,640,694 bp
  • T to C, chromosome 16 at 97,799,055 bp
  • A to T, chromosome 18 at 37,486,263 bp
  • T to A, chromosome 19 at 13,016,571 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6311 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044469-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.