Strain Name:
C57BL/6J-MtgxR6319Btlr/Mmmh
Stock Number:
044474-MU
Citation ID:
RRID:MMRRC_044474-MU
Other Names:
R6319 (G1)
Major Collection:

Strain Information

Bmp6
Name: bone morphogenetic protein 6
Synonyms: Vgr1, D13Wsu115e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12161
VEGA: 13
HGNC: HGNC:1073
Homologene: 1300
Tdh
Name: L-threonine dehydrogenase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 58865
Homologene: 10987
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Smg6
Name: SMG6 nonsense mediated mRNA decay factor
Synonyms: Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103677
Homologene: 23024
Lrp6
Name: low density lipoprotein receptor-related protein 6
Synonyms: Cd, skam26Jus, skax26, ska26
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16974
HGNC: HGNC:6698
Homologene: 1747
Abcg2
Name: ATP binding cassette subfamily G member 2 (Junior blood group)
Synonyms: Bcrp, 4930430M16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 26357
HGNC: HGNC:74
Homologene: 55852
Dcaf13
Name: DDB1 and CUL4 associated factor 13
Synonyms: Wdsof1, LOC223499
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223499
Homologene: 6430
Cdca8
Name: cell division cycle associated 8
Synonyms: 4831429J16Rik, DasraB, Borealin, D4Ertd421e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 52276
Homologene: 23075
Unc5b
Name: unc-5 netrin receptor B
Synonyms: D10Bwg0792e, 6330415E02Rik, Unc5h2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 107449
VEGA: 10
Homologene: 32538
Dhx32
Name: DEAH-box helicase 32 (putative)
Synonyms: DEAH (Asp-Glu-Ala-His) box polypeptide 32, Ddx32
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101437
Homologene: 56798
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: p600, LOC381562, 1810009A16Rik, D930005K06Rik, A930005E13Rik, Zubr1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69116
Homologene: 10804
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: A130030D10Rik, 4833421P10Rik, Zfp650, 1110059H15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68795
Homologene: 52092
Grik4
Name: glutamate receptor, ionotropic, kainate 4
Synonyms: KA-1, 6330551K01Rik, GluRgamma1, KA1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110637
HGNC: HGNC:4582
Homologene: 81829
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: CI-MPR, IGF-II/CI-MPR, Mpr300, M6P/IGF2R, CD222, mannose-6-phosphate receptor, cation independent
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Pcca
Name: propionyl-Coenzyme A carboxylase, alpha polypeptide
Synonyms: C79630
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110821
HGNC: HGNC:8653
Homologene: 236
Itfg1
Name: integrin alpha FG-GAP repeat containing 1
Synonyms: D8Wsu49e, 2310047C21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71927
Homologene: 12423
Gpn3
Name: GPN-loop GTPase 3
Synonyms: Atpbd1c, A930018B01Rik, D5Ertd708e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68080
Homologene: 6487
Gga2
Name: golgi associated, gamma adaptin ear containing, ARF binding protein 2
Synonyms: 1200007E24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74105
Homologene: 22860
Mnd1
Name: meiotic nuclear divisions 1
Synonyms: 2610034E18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76915
Homologene: 5890
Plekhm3
Name: pleckstrin homology domain containing, family M, member 3
Synonyms: Plekhm1l, 9430067K14Rik, A230102O09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241075
Homologene: 18459
Akap11
Name: A kinase anchor protein 11
Synonyms: 6330501D17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219181
HGNC: HGNC:369
Homologene: 8279
Kel
Name: Kell blood group
Synonyms: CD238
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 23925
HGNC: HGNC:6308
Homologene: 362
Enpp1
Name: ectonucleotide pyrophosphatase/phosphodiesterase 1
Synonyms: CD203c, twy, PC-1, Pca, Pca-1, 4833416E15Rik, Npps, NPP1, E-NPP1, Pdnp1, Ly-41
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18605
HGNC: HGNC:3356
Homologene: 38151
Cpsf1
Name: cleavage and polyadenylation specific factor 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 94230
VEGA: 15
HGNC: HGNC:2324
Homologene: 40865
Kcnn4
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
Synonyms: mIKCa1, IK1, SK4, KCa3.1, IKCa1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16534
HGNC: HGNC:6293
Homologene: 1696
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Vmn2r115
Name: vomeronasal 2, receptor 115
Synonyms: V2Rp4, EG638102
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 638102
Homologene: 86604
Spata31e2
Name: spermatogenesis associated 31 subfamily E member 2
Synonyms: 4931408C20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210940
Homologene: 86827
Dxo
Name: decapping exoribonuclease
Synonyms: Dom3z
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 112403
HGNC: HGNC:2992
Homologene: 38061
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: Megf7, mdig, 6430526J12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Col14a1
Name: collagen, type XIV, alpha 1
Synonyms: 5730412L22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12818
HGNC: HGNC:2191
Homologene: 18741
Adam34
Name: a disintegrin and metallopeptidase domain 34
Synonyms: testase 4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 252866
Homologene: 78104
Mical2
Name: microtubule associated monooxygenase, calponin and LIM domain containing 2
Synonyms: 5330438E18Rik, Ebitein1, 4921517J23Rik, Micalcl
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320878
Homologene: 8760
Atp1a2
Name: ATPase, Na+/K+ transporting, alpha 2 polypeptide
Synonyms: Atpa-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98660
HGNC: HGNC:800
Homologene: 47947
Or5h23
Name: olfactory receptor family 5 subfamily H member 23
Synonyms: GA_x54KRFPKG5P-55314632-55313703, Olfr191, MOR183-5P
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258035
Homologene: 128162
Adgrg6
Name: adhesion G protein-coupled receptor G6
Synonyms: DREG, 1190004A11Rik, Gpr126, LOC215798
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215798
Homologene: 10724
Vill
Name: villin-like
Synonyms: Villp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22351
Homologene: 22650
Tmem200a
Name: transmembrane protein 200A
Synonyms: C030003D03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77220
VEGA: 10
Homologene: 14175
Or8g17
Name: olfactory receptor family 8 subfamily G member 17
Synonyms: GA_x6K02T2PVTD-32715386-32714466, MOR171-10, Olfr146, M15
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258742
VEGA: 9
Or51af1
Name: olfactory receptor family 51 subfamily AF member 1
Synonyms: MOR9-1, Olfr609, GA_x6K02T2PBJ9-6207735-6206776
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259086
Homologene: 64952
Rnf25
Name: ring finger protein 25
Synonyms: 0610009H16Rik, AO7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 57751
Homologene: 11193
Trem6l
Name: triggering receptor expressed on myeloid cells-like 6
Synonyms: B430306N03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320148
Homologene: 138443
Prr18
Name: proline rich 18
Synonyms: 9630019K15Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320111
VEGA: 17
Homologene: 52195
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 26,685,401 bp
  • A to T, chromosome 1 at 64,921,934 bp
  • T to C, chromosome 1 at 74,595,731 bp
  • C to G, chromosome 1 at 172,289,336 bp
  • T to A, chromosome 2 at 52,163,011 bp
  • T to C, chromosome 2 at 69,973,414 bp
  • A to G, chromosome 2 at 91,480,321 bp
  • A to G, chromosome 3 at 84,141,764 bp
  • C to A, chromosome 4 at 124,921,294 bp
  • G to A, chromosome 4 at 139,408,889 bp
  • C to T, chromosome 5 at 122,372,575 bp
  • C to A, chromosome 6 at 41,702,447 bp
  • T to C, chromosome 6 at 58,674,738 bp
  • A to T, chromosome 6 at 134,541,835 bp
  • T to A, chromosome 7 at 24,381,740 bp
  • T to C, chromosome 7 at 103,492,725 bp
  • A to G, chromosome 7 at 112,328,677 bp
  • T to C, chromosome 7 at 122,002,166 bp
  • A to C, chromosome 7 at 133,737,226 bp
  • A to G, chromosome 8 at 43,651,915 bp
  • G to T, chromosome 8 at 85,840,629 bp
  • A to G, chromosome 9 at 39,019,514 bp
  • A to T, chromosome 9 at 42,566,336 bp
  • G to C, chromosome 9 at 119,063,648 bp
  • T to A, chromosome 10 at 14,431,622 bp
  • T to C, chromosome 10 at 24,648,031 bp
  • A to G, chromosome 10 at 25,993,495 bp
  • G to A, chromosome 10 at 60,778,801 bp
  • T to C, chromosome 11 at 75,156,222 bp
  • A to T, chromosome 13 at 38,346,414 bp
  • T to C, chromosome 14 at 63,495,737 bp
  • T to C, chromosome 14 at 78,513,538 bp
  • G to A, chromosome 14 at 122,582,623 bp
  • A to G, chromosome 15 at 39,143,672 bp
  • A to G, chromosome 15 at 55,516,169 bp
  • A to G, chromosome 15 at 76,596,967 bp
  • A to G, chromosome 16 at 59,086,021 bp
  • G to T, chromosome 17 at 8,341,311 bp
  • T to A, chromosome 17 at 12,714,113 bp
  • A to G, chromosome 17 at 23,347,903 bp
  • A to G, chromosome 17 at 34,838,391 bp
  • A to T, chromosome 17 at 48,316,743 bp
  • A to G, chromosome 18 at 49,852,300 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6319 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044474-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.