Strain Name:
C57BL/6J-MtgxR6320Btlr/Mmmh
Stock Number:
044475-MU
Citation ID:
RRID:MMRRC_044475-MU
Other Names:
R6320 (G1)
Major Collection:

Strain Information

Smarca4
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Synonyms: SNF2beta, Brg1, SW1/SNF, b2b692Clo, b2b508.1Clo
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20586
Homologene: 135927
Ptprf
Name: protein tyrosine phosphatase receptor type F
Synonyms: LAR, RPTP-LAR
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19268
HGNC: HGNC:9670
Homologene: 20623
Zfp7
Name: zinc finger protein 7
Synonyms: Krox-2, Zfp-7, KRAB7, Zfp65, mszf73-2, Zfp80, KRAB20, Zfp86-rs1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223669
VEGA: 15
Homologene: 20729
Vps35l
Name: VPS35 endosomal protein sorting factor like
Synonyms: 9030624J02Rik, Vsp35l
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71517
Homologene: 10659
Dnm1l
Name: dynamin 1-like
Synonyms: 6330417M19Rik, Drp1, python, Dnmlp1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74006
VEGA: 16
HGNC: HGNC:2973
Homologene: 6384
Lig3
Name: ligase III, DNA, ATP-dependent
Synonyms: D11Wsu78e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16882
HGNC: HGNC:6600
Homologene: 32109
Sart3
Name: squamous cell carcinoma antigen recognized by T cells 3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53890
Homologene: 40977
Phkb
Name: phosphorylase kinase beta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102093
HGNC: HGNC:8927
Homologene: 247
Usp34
Name: ubiquitin specific peptidase 34
Synonyms: A530081C03Rik, Murr2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17847
Homologene: 40978
Zbtb17
Name: zinc finger and BTB domain containing 17
Synonyms: mZ13, Miz1, Zfp100
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22642
Homologene: 2575
Slu7
Name: SLU7 splicing factor homolog (S. cerevisiae)
Synonyms: D3Bwg0878e, D11Ertd730e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 193116
Homologene: 4690
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Epg5
Name: ectopic P-granules 5 autophagy tethering factor
Synonyms: 5430411K18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 100502841
VEGA: 18
Homologene: 14575
Fgf22
Name: fibroblast growth factor 22
Synonyms: 2210414E06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67112
VEGA: 10
HGNC: HGNC:3679
Homologene: 10770
Eif2a
Name: eukaryotic translation initiation factor 2A
Synonyms: D3Ertd194e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229317
HGNC: HGNC:3254
Homologene: 5969
Mapk8ip3
Name: mitogen-activated protein kinase 8 interacting protein 3
Synonyms: JNK-interacting protein 3, Jip3, JSAP1, JUN/SAPK-associated protein 1, JSAP1d, JSAP1c, JSAP1b, JSAP1a, c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1, sunday driver 2, Syd2, D17Wsu15e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 30957
HGNC: HGNC:6884
Homologene: 22790
Zfyve26
Name: zinc finger, FYVE domain containing 26
Synonyms: 9330197E15Rik, LOC380767, A630028O16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 211978
VEGA: 12
Homologene: 9102
Cyp20a1
Name: cytochrome P450, family 20, subfamily a, polypeptide 1
Synonyms: A930011N14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77951
Homologene: 18584
Brd8
Name: bromodomain containing 8
Synonyms: p120, SMAP, 2610007E11Rik, 4432404P07Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 78656
Homologene: 41790
Mphosph9
Name: M-phase phosphoprotein 9
Synonyms: 4930548D04Rik, MPP-9, MPP9, B930097C17Rik, 9630025B04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269702
HGNC: HGNC:7215
Homologene: 11256
Fbxo46
Name: F-box protein 46
Synonyms: 4932704E22Rik, 20D7-FC4, Fbxo34l
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243867
Homologene: 18467
Ska3
Name: spindle and kinetochore associated complex subunit 3
Synonyms: F630043A04Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219114
VEGA: 14
Homologene: 124284
Trpc1
Name: transient receptor potential cation channel, subfamily C, member 1
Synonyms: Trrp1, Trp1, Mtrp1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22063
Homologene: 2478
Cubn
Name: cubilin
Synonyms: D2Wsu88e, intrinsic factor-cobalamin receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, syne-2, D12Ertd777e, 6820443O06Rik, Nesp2g, Cpfl8, diminished cone electroretinogram, dice
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Scy, Crsh, crash, Adgrc1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237954
Homologene: 138824
P3h3
Name: prolyl 3-hydroxylase 3
Synonyms: Grcb, Leprel2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14789
Homologene: 8401
Ush2a
Name: usherin
Synonyms: MUSH2A, A930011D15Rik, LOC381317, LOC269160, A930037M10Rik, Ushrn, Ush2a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Zscan18
Name: zinc finger and SCAN domain containing 18
Synonyms: EG232875
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232875
Homologene: 122136
Fhod1
Name: formin homology 2 domain containing 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234686
Homologene: 136406
Strc
Name: stereocilin
Synonyms: DFNB16
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 140476
Homologene: 15401
Krt6a
Name: keratin 6A
Synonyms: mK6[a], MK6a, Krt2-6c, Krt2-6a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16687
VEGA: 15
Homologene: 136794
Chi3l1
Name: chitinase 3 like 1
Synonyms: Brp39, Gp39, Chil1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12654
HGNC: HGNC:1932
Homologene: 55569
Crybg2
Name: crystallin beta-gamma domain containing 2
Synonyms: Aim1l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230806
Homologene: 19232
Or1j21
Name: olfactory receptor family 1 subfamily J member 21
Synonyms: ID3, MOR136-6, GA_x6K02T2NLDC-33487752-33488690, Olfr50
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18350
Homologene: 74212
Nlrp10
Name: NLR family, pyrin domain containing 10
Synonyms: 6430548I20Rik, Pynod, Nalp10
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244202
Homologene: 18468
Flnc
Name: filamin C, gamma
Synonyms: Fln2, 1110055E19Rik, actin binding protein 280
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Gmpr
Name: guanosine monophosphate reductase
Synonyms: 2310004P21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66355
HGNC: HGNC:4376
Homologene: 5009
Cacna1e
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms: Cav2.3, Cchra1, alpha1E
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12290
HGNC: HGNC:1392
Homologene: 20185
Agtr1b
Name: angiotensin II receptor, type 1b
Synonyms: Agtr-1b, AT1B, Angtr-1b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11608
HGNC: HGNC:336
Homologene: 84871
Bmi1
Name: Bmi1 polycomb ring finger oncogene
Synonyms: Bmi-1, Bmi1, Pcgf4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12151
Homologene: 3797
Palm2
Name: paralemmin 2
Synonyms: 53-H12, pEN70
Type: Gene
Species: Mouse
Chromosome: 4
Tbc1d7
Name: TBC1 domain family, member 7
Synonyms: 2610009C09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67046
VEGA: 13
Homologene: 9538
Msh5
Name: mutS homolog 5
Synonyms: G7, Mut5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17687
HGNC: HGNC:7328
Homologene: 8415
P2ry6
Name: pyrimidinergic receptor P2Y, G-protein coupled, 6
Synonyms: 2010204J23Rik, P2Y6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233571
HGNC: HGNC:8543
Homologene: 14289
Slc26a7
Name: solute carrier family 26, member 7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 208890
Homologene: 13770
Sh3bp1
Name: SH3-domain binding protein 1
Synonyms: 3BP-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20401
Homologene: 7534
Aldh18a1
Name: aldehyde dehydrogenase 18 family, member A1
Synonyms: 2810433K04Rik, Pycs
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56454
HGNC: HGNC:9722
Homologene: 2142
Cdh15
Name: cadherin 15
Synonyms: Cdh14, Mcad, M cadherin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12555
HGNC: HGNC:1754
Homologene: 3622
Smg9
Name: SMG9 nonsense mediated mRNA decay factor
Synonyms: N28092, 1500002O20Rik, smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71997
Homologene: 10426
Cyp24a1
Name: cytochrome P450, family 24, subfamily a, polypeptide 1
Synonyms: 25-hydroxyvitamin D-24-hydroxylase, 24-OHase, Cyp24, CP24
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13081
HGNC: HGNC:2602
Homologene: 68094
Psg16
Name: pregnancy specific beta-1-glycoprotein 16
Synonyms: bCEA, Cea11
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26436
Mks1
Name: MKS transition zone complex subunit 1
Synonyms: B8d3, avc6, Meckel syndrome, type 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380718
HGNC: HGNC:7121
Homologene: 9833
Ceacam5
Name: CEA cell adhesion molecule 5
Synonyms: 1600029H12Rik, Psg30
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73250
HGNC: HGNC:1819
Homologene: 115938
Naga
Name: N-acetyl galactosaminidase, alpha
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17939
VEGA: 15
HGNC: HGNC:7631
Homologene: 221
Or2b6
Name: olfactory receptor family 2 subfamily B member 6
Synonyms: MOR256-11, GA_x6K02T2QHY8-11597382-11598323, Olfr11
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218066
HGNC: HGNC:8241
Homologene: 40838
Nherf4
Name: NHERF family PDZ scaffold protein 4
Synonyms: sodium-phosphate cotransporter IIa C-terminal-associated protein 2, NaPi-Cap2, Pdzk2, Pdzd3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 170761
VEGA: 9
Homologene: 11719
Cyp2a12
Name: cytochrome P450, family 2, subfamily a, polypeptide 12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13085
Homologene: 69128
Terb1
Name: telomere repeat binding bouquet formation protein 1
Synonyms: 4930532D21Rik, Ccdc79
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320022
Homologene: 18330
Ptgr2
Name: prostaglandin reductase 2
Synonyms: B830026H24Rik, 9630002F03Rik, 1810016I24Rik, PGR-2, Zadh1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 77219
Homologene: 39824
Nqo1
Name: NAD(P)H dehydrogenase, quinone 1
Synonyms: NMO1, NQO1, QR1, NAD(P)H dehydrogenase (quinone), Ox-1, Ox1, Nmor1, Dia4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18104
HGNC: HGNC:2874
Homologene: 695
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 60,352,172 bp
  • T to A, chromosome 1 at 134,182,258 bp
  • C to A, chromosome 1 at 154,441,524 bp
  • A to G, chromosome 1 at 188,356,846 bp
  • C to A, chromosome 2 at 13,280,195 bp
  • C to T, chromosome 2 at 18,684,375 bp
  • C to G, chromosome 2 at 36,793,573 bp
  • T to A, chromosome 2 at 121,374,958 bp
  • G to T, chromosome 2 at 170,486,784 bp
  • G to T, chromosome 3 at 20,315,779 bp
  • A to G, chromosome 3 at 58,557,096 bp
  • A to G, chromosome 4 at 14,524,498 bp
  • T to A, chromosome 4 at 57,710,173 bp
  • A to G, chromosome 4 at 118,212,814 bp
  • T to C, chromosome 4 at 134,081,426 bp
  • G to A, chromosome 4 at 141,463,383 bp
  • A to T, chromosome 5 at 113,751,240 bp
  • A to T, chromosome 5 at 124,324,961 bp
  • T to A, chromosome 6 at 29,459,063 bp
  • G to A, chromosome 6 at 124,854,872 bp
  • G to A, chromosome 7 at 12,775,220 bp
  • G to A, chromosome 7 at 17,088,187 bp
  • T to A, chromosome 7 at 17,747,198 bp
  • T to C, chromosome 7 at 19,136,541 bp
  • A to G, chromosome 7 at 24,420,861 bp
  • A to T, chromosome 7 at 27,031,152 bp
  • A to G, chromosome 7 at 100,938,396 bp
  • T to A, chromosome 7 at 108,925,746 bp
  • T to C, chromosome 7 at 118,753,849 bp
  • T to A, chromosome 8 at 85,875,698 bp
  • C to A, chromosome 8 at 104,447,199 bp
  • A to C, chromosome 8 at 105,337,350 bp
  • T to C, chromosome 8 at 107,388,950 bp
  • A to G, chromosome 8 at 122,864,347 bp
  • C to T, chromosome 9 at 21,637,375 bp
  • A to G, chromosome 9 at 44,248,683 bp
  • A to G, chromosome 9 at 95,721,250 bp
  • G to T, chromosome 10 at 77,836,138 bp
  • A to G, chromosome 10 at 79,756,996 bp
  • T to C, chromosome 11 at 23,452,520 bp
  • C to T, chromosome 11 at 43,441,489 bp
  • T to A, chromosome 11 at 82,794,007 bp
  • T to C, chromosome 11 at 87,855,499 bp
  • T to A, chromosome 11 at 103,504,051 bp
  • G to A, chromosome 12 at 7,989,194 bp
  • T to G, chromosome 12 at 76,061,650 bp
  • A to G, chromosome 12 at 79,240,002 bp
  • T to A, chromosome 12 at 84,302,337 bp
  • T to A, chromosome 13 at 21,639,248 bp
  • C to T, chromosome 13 at 43,152,933 bp
  • T to C, chromosome 13 at 45,532,398 bp
  • A to T, chromosome 14 at 57,816,691 bp
  • G to A, chromosome 15 at 76,890,610 bp
  • C to T, chromosome 15 at 78,911,515 bp
  • T to A, chromosome 15 at 82,332,203 bp
  • G to T, chromosome 15 at 85,900,959 bp
  • A to G, chromosome 15 at 101,692,309 bp
  • A to T, chromosome 16 at 16,332,088 bp
  • C to A, chromosome 17 at 24,906,905 bp
  • A to G, chromosome 17 at 35,029,924 bp
  • A to T, chromosome 18 at 34,613,239 bp
  • T to C, chromosome 18 at 77,962,398 bp
  • A to T, chromosome 19 at 40,570,561 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6320 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044475-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.