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Strain Name:
C57BL/6J-MtgxR6323Btlr/Mmmh
Stock Number:
044477-MU
Citation ID:
RRID:MMRRC_044477-MU
Other Names:
R6323 (G1)
Major Collection:

Strain Information

Nsmf
Name: NMDA receptor synaptonuclear signaling and neuronal migration factor
Synonyms: Jacob, Nelf
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56876
Homologene: 10648
Dlc1
Name: deleted in liver cancer 1
Synonyms: p122-RhoGAP, STARD12, Arhgap7, A730069N07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50768
HGNC: HGNC:2897
Homologene: 4442
Wwp2
Name: WW domain containing E3 ubiquitin protein ligase 2
Synonyms: 1300010O06Rik, AIP2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66894
Homologene: 48490
Arfgef2
Name: ARF guanine nucleotide exchange factor 2
Synonyms: BIG2, E230011G24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99371
Homologene: 111880
Slc1a6
Name: solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
Synonyms: EAAT4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20513
VEGA: 10
Homologene: 21055
Ano1
Name: anoctamin 1, calcium activated chloride channel
Synonyms: Tmem16a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101772
Homologene: 75079
Diaph3
Name: diaphanous related formin 3
Synonyms: p134MDia2, mDia2, 4930417P13Rik, Drf3, Diap3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56419
VEGA: 14
Homologene: 84829
Baz2a
Name: bromodomain adjacent to zinc finger domain, 2A
Synonyms: Tip5, Walp3, C030005G16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 116848
VEGA: 10
HGNC: HGNC:962
Homologene: 8393
Rnf2
Name: ring finger protein 2
Synonyms: Ring1B, dinG
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19821
Homologene: 2199
Lars2
Name: leucyl-tRNA synthetase, mitochondrial
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102436
VEGA: 9
Homologene: 6526
Mnat1
Name: menage a trois 1
Synonyms: MAT1, E130115E11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17420
HGNC: HGNC:7181
Homologene: 1821
Casz1
Name: castor zinc finger 1
Synonyms: 2410019P08Rik, D4Ertd432e, castor, Cst
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69743
Homologene: 9824
Dnajc14
Name: DnaJ heat shock protein family (Hsp40) member C14
Synonyms: DRIP78, LIP6, HDJ3, 5730551F12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74330
VEGA: 10
Homologene: 12553
Gpn3
Name: GPN-loop GTPase 3
Synonyms: A930018B01Rik, D5Ertd708e, Atpbd1c
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68080
Homologene: 6487
Cdc20
Name: cell division cycle 20
Synonyms: p55CDC, 2310042N09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107995
HGNC: HGNC:1723
Homologene: 37459
Palld
Name: palladin, cytoskeletal associated protein
Synonyms: 2410003B16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72333
Homologene: 75052
Pax1
Name: paired box 1
Synonyms: Pax-1, wt, hbs, hunchback, wavy tail
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18503
HGNC: HGNC:8615
Homologene: 4514
Rpl7l1
Name: ribosomal protein L7-like 1
Synonyms: 1500016H10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66229
VEGA: 17
Homologene: 41632
Cfap74
Name: cilia and flagella associated protein 74
Synonyms: 2010015L04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 544678
Homologene: 129584
Galns
Name: galactosamine (N-acetyl)-6-sulfatase
Synonyms: N-acetylgalactosamine-6-sulfate sulfatase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50917
HGNC: HGNC:4122
Homologene: 55468
Celf5
Name: CUGBP, Elav-like family member 5
Synonyms: 4930565A21Rik, Brunol5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 319586
Homologene: 75172
Lrrc43
Name: leucine rich repeat containing 43
Synonyms: LOC381741
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381741
Homologene: 17662
Vmn2r111
Name: vomeronasal 2, receptor 111
Synonyms: EG210876
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210876
Homologene: 86604
Ctrb1
Name: chymotrypsinogen B1
Synonyms: Prt-2, 2200008D09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66473
Homologene: 88564
Chd5
Name: chromodomain helicase DNA binding protein 5
Synonyms: B230399N07Rik, 4930532L22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269610
Homologene: 56712
Or4k77
Name: olfactory receptor family 4 subfamily K member 77
Synonyms: GA_x6K02T2Q125-72420217-72421134, MOR248-19, Olfr1283
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228443
Homologene: 133657
Krt13
Name: keratin 13
Synonyms: Krt-1.13, K13, Krt1-13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16663
HGNC: HGNC:6415
Homologene: 40740
Arhgef4
Name: Rho guanine nucleotide exchange factor 4
Synonyms: 9330140K16Rik, Asef, C230030N03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226970
HGNC: HGNC:684
Homologene: 49414
Vmn2r79
Name: vomeronasal 2, receptor 79
Synonyms: EG621430
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 621430
Homologene: 115466
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Atp1a2
Name: ATPase, Na+/K+ transporting, alpha 2 polypeptide
Synonyms: Atpa-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98660
HGNC: HGNC:800
Homologene: 47947
Cadps2
Name: Ca2+-dependent activator protein for secretion 2
Synonyms: cpd2, A230044C21Rik, Caps2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320405
Homologene: 23060
Cpt1b
Name: carnitine palmitoyltransferase 1b, muscle
Synonyms: M-CPTI, M-CPT I, Cpt1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12895
HGNC: HGNC:2329
Homologene: 22548
Gstm1
Name: glutathione S-transferase, mu 1
Synonyms: Gstb-1, Gstb1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14862
Homologene: 115474
Ceacam1
Name: CEA cell adhesion molecule 1
Synonyms: CD66a, MHVR1, mmCGM1, mCEA1, mmCGM2, Hv-2, Bgp, Mhv-1, Cea-7, Cea-1, Cea1, Bgp1, C-CAM, Hv2, Cea7, Cc1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26365
Homologene: 128630
Slc17a2
Name: solute carrier family 17 (sodium phosphate), member 2
Synonyms: NPT3, C730032N17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218103
Homologene: 4260
Zfp593
Name: zinc finger protein 593
Synonyms: E130106C14Rik, 3110024A21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68040
Homologene: 41070
Akr1c6
Name: aldo-keto reductase family 1, member C6
Synonyms: estradiol 17-beta-dehydrogenase (A-specific), 3alpha-HSD, Akr1c1, Hsd17b5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 83702
Homologene: 84695
Or5ac16
Name: olfactory receptor family 5 subfamily AC member 16
Synonyms: GA_x54KRFPKG5P-55416332-55415412, MOR182-8, Olfr198
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258036
Homologene: 51800
Trav6-1
Name: T cell receptor alpha variable 6-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 667449
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 34,723,477 bp
  • T to C, chromosome 1 at 151,473,216 bp
  • C to G, chromosome 1 at 172,289,336 bp
  • A to G, chromosome 2 at 25,055,051 bp
  • A to G, chromosome 2 at 68,606,224 bp
  • G to T, chromosome 2 at 91,161,438 bp
  • T to C, chromosome 2 at 111,368,701 bp
  • T to A, chromosome 2 at 147,368,401 bp
  • A to G, chromosome 2 at 166,834,484 bp
  • A to G, chromosome 3 at 108,017,747 bp
  • T to C, chromosome 4 at 118,435,564 bp
  • A to G, chromosome 4 at 134,244,913 bp
  • T to C, chromosome 4 at 148,941,704 bp
  • C to A, chromosome 4 at 152,367,334 bp
  • A to G, chromosome 4 at 155,463,938 bp
  • C to T, chromosome 5 at 122,372,575 bp
  • G to T, chromosome 5 at 123,503,886 bp
  • T to A, chromosome 6 at 23,263,578 bp
  • A to C, chromosome 7 at 25,474,651 bp
  • T to A, chromosome 7 at 87,001,314 bp
  • T to A, chromosome 7 at 144,611,686 bp
  • T to C, chromosome 8 at 36,938,383 bp
  • A to T, chromosome 8 at 61,720,693 bp
  • A to T, chromosome 8 at 107,540,671 bp
  • A to G, chromosome 8 at 111,689,591 bp
  • T to C, chromosome 8 at 122,598,651 bp
  • A to T, chromosome 9 at 123,441,594 bp
  • G to A, chromosome 10 at 78,812,887 bp
  • A to G, chromosome 10 at 81,469,503 bp
  • G to A, chromosome 10 at 82,283,082 bp
  • A to G, chromosome 10 at 128,126,417 bp
  • A to G, chromosome 10 at 128,807,490 bp
  • C to A, chromosome 11 at 100,121,150 bp
  • A to G, chromosome 12 at 73,168,104 bp
  • A to G, chromosome 13 at 4,447,018 bp
  • A to G, chromosome 13 at 23,814,986 bp
  • T to C, chromosome 14 at 52,638,791 bp
  • C to T, chromosome 14 at 86,966,453 bp
  • C to A, chromosome 15 at 89,419,063 bp
  • A to G, chromosome 16 at 59,202,282 bp
  • T to C, chromosome 17 at 22,559,051 bp
  • C to A, chromosome 17 at 46,782,638 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6323 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044477-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.