Strain Name:
C57BL/6J-MtgxR6330Btlr/Mmmh
Stock Number:
044484-MU
Citation ID:
RRID:MMRRC_044484-MU
Other Names:
R6330 (G1)
Major Collection:

Strain Information

Mindy3
Name: MINDY lysine 48 deubiquitinase 3
Synonyms: 1810041E18Rik, 5830410F13Rik, 2310047O13Rik, Fam188a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66960
Homologene: 11478
Emb
Name: embigin
Synonyms: Gp70
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13723
Homologene: 7743
Mthfd1l
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Synonyms: 2410004L15Rik, Fthfsdc1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 270685
Homologene: 56706
Dock9
Name: dedicator of cytokinesis 9
Synonyms: B230309H04Rik, D14Wsu89e, Zizimin1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105445
Homologene: 41026
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: Lba, D3Ertd775e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Ccar1
Name: cell division cycle and apoptosis regulator 1
Synonyms: Carp1, 2610511G16Rik, 9430036H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67500
VEGA: 10
Homologene: 10086
Tbcd
Name: tubulin-specific chaperone d
Synonyms: A030005L14Rik, 2310057L06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108903
Homologene: 4368
Orc2
Name: origin recognition complex, subunit 2
Synonyms: Orc2l
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18393
HGNC: HGNC:8488
Homologene: 4512
Zfp74
Name: zinc finger protein 74
Synonyms: Zfp66, KRAB8, 2810054M15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72723
Homologene: 51861
Enpp5
Name: ectonucleotide pyrophosphatase/phosphodiesterase 5
Synonyms: D17Abb1e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 83965
Homologene: 23313
Celf2
Name: CUGBP, Elav-like family member 2
Synonyms: Napor-2, ETR-3, B230345P09Rik, Cugbp2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14007
HGNC: HGNC:2550
Homologene: 4783
Pfkp
Name: phosphofructokinase, platelet
Synonyms: PFK-C, 1200015H23Rik, 9330125N24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56421
HGNC: HGNC:8878
Homologene: 20579
Mfsd14b
Name: major facilitator superfamily domain containing 14B
Synonyms: 5730414C17Rik, Hiatl1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66631
Homologene: 64464
Dapk1
Name: death associated protein kinase 1
Synonyms: 2310039H24Rik, D13Ucla1, 2810425C21Rik, DAP-Kinase
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69635
VEGA: 13
HGNC: HGNC:2674
Homologene: 3626
Clec4f
Name: C-type lectin domain family 4, member f
Synonyms: kupffer cell receptor, D18063, Clecsf13
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 51811
Homologene: 9630
F7
Name: coagulation factor VII
Synonyms: FVII, Cf7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14068
HGNC: HGNC:3544
Homologene: 7710
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244646
Homologene: 14627
Rrad
Name: Ras-related associated with diabetes
Synonyms: Rad, REM3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56437
Homologene: 3071
Ralgps1
Name: Ral GEF with PH domain and SH3 binding motif 1
Synonyms: RALGPS1A, RALGEF2, 5830418G11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241308
Homologene: 65163
Stx18
Name: syntaxin 18
Synonyms: 1810035L21Rik, 4933425D03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71116
Homologene: 9655
Slc4a5
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 5
Synonyms: C330016K18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232156
Homologene: 31125
Lrrd1
Name: leucine rich repeats and death domain containing 1
Synonyms: 4932412H11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242838
Homologene: 18247
Kcnj6
Name: potassium inwardly-rectifying channel, subfamily J, member 6
Synonyms: Kir3.2, GIRK2, KCNJ7
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16522
VEGA: 16
HGNC: HGNC:6267
Homologene: 1688
Myo5b
Name: myosin VB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17919
HGNC: HGNC:7603
Homologene: 49481
Gbp7
Name: guanylate binding protein 7
Synonyms: 9830147J24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229900
Homologene: 138296
Gli3
Name: GLI-Kruppel family member GLI3
Synonyms: Bph, brachyphalangy
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14634
HGNC: HGNC:4319
Homologene: 139
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Fam111a
Name: family with sequence similarity 111, member A
Synonyms: 4632417K18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107373
Homologene: 49696
Mlxip
Name: MLX interacting protein
Synonyms: Mondoa, Mir, bHLHe36
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208104
Homologene: 22851
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, LOC384050, 1110020C03Rik, Wdr65
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68625
Homologene: 51350
Idua
Name: iduronidase, alpha-L
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15932
HGNC: HGNC:5391
Homologene: 170
Vwa5b2
Name: von Willebrand factor A domain containing 5B2
Synonyms: EG328644
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 328643
Homologene: 28056
Hhatl
Name: hedgehog acyltransferase-like
Synonyms: 1110011D13Rik, Gup1, Mitsugumin 56, Mg56
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74770
VEGA: 9
Homologene: 19287
Usp9y
Name: ubiquitin specific peptidase 9, Y chromosome
Synonyms: Dffry, Fafl2
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 107868
Homologene: 68408
Fam50b
Name: family with sequence similarity 50, member B
Synonyms: XAP-5-like, X5L, D0H6S2654E
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 108161
VEGA: 13
Homologene: 101669
Cyp4a31
Name: cytochrome P450, family 4, subfamily a, polypeptide 31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 666168
HGNC: HGNC:2642
Homologene: 128044
Vmn2r86
Name: vomeronasal 2, receptor 86
Synonyms: EG625109
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 625109
Homologene: 129606
Or14j7
Name: olfactory receptor family 14 subfamily J member 7
Synonyms: GA_x6K02T2PSCP-2374126-2375048, MOR218-13, Olfr128
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 383243
Homologene: 134080
Vmn2r69
Name: vomeronasal 2, receptor 69
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330581
Homologene: 115466
Slc2a12
Name: solute carrier family 2 (facilitated glucose transporter), member 12
Synonyms: Glut12, GLUT-12
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 353169
Homologene: 59263
Or1af1
Name: olfactory receptor family 1 subfamily AF member 1
Synonyms: GA_x6K02T2NLDC-33902472-33903401, MOR138-5P, MOR138-6, Olfr366
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 236509
Homologene: 114744
Mafk
Name: v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)
Synonyms: Nfe2u, p18 NF-E2, NF-E2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17135
HGNC: HGNC:6782
Homologene: 1770
Serpine3
Name: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3
Synonyms: E130113E03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 319433
VEGA: 14
Homologene: 53117
2310079G19Rik
Name: RIKEN cDNA 2310079G19 gene
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69699
Homologene: 137381
Zfp825
Name: zinc finger protein 825
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 235956
Cstdc2
Name: cystatin domain containing 2
Synonyms: mCST E2, 9230104L09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77705
Homologene: 87070
Ighv10-3
Name: immunoglobulin heavy variable V10-3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380809
HGNC: HGNC:5623
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 46,340,175 bp
  • C to A, chromosome 1 at 58,500,334 bp
  • A to G, chromosome 2 at 6,884,955 bp
  • C to T, chromosome 2 at 12,356,933 bp
  • A to T, chromosome 2 at 33,174,443 bp
  • A to T, chromosome 2 at 37,220,124 bp
  • G to T, chromosome 2 at 148,850,825 bp
  • A to G, chromosome 3 at 86,348,357 bp
  • A to T, chromosome 3 at 142,546,498 bp
  • C to T, chromosome 4 at 115,563,877 bp
  • T to C, chromosome 4 at 118,569,396 bp
  • T to A, chromosome 5 at 3,850,629 bp
  • T to A, chromosome 5 at 38,126,917 bp
  • T to A, chromosome 5 at 108,681,708 bp
  • G to A, chromosome 5 at 123,394,952 bp
  • A to G, chromosome 5 at 139,799,193 bp
  • T to G, chromosome 6 at 83,226,374 bp
  • T to C, chromosome 6 at 83,652,868 bp
  • A to T, chromosome 7 at 29,937,987 bp
  • T to C, chromosome 7 at 85,411,627 bp
  • C to T, chromosome 8 at 13,035,140 bp
  • T to G, chromosome 8 at 104,629,860 bp
  • T to C, chromosome 8 at 109,646,909 bp
  • C to T, chromosome 9 at 121,788,225 bp
  • A to T, chromosome 10 at 3,980,234 bp
  • A to G, chromosome 10 at 22,664,995 bp
  • A to G, chromosome 10 at 62,764,533 bp
  • A to G, chromosome 10 at 130,446,527 bp
  • T to C, chromosome 11 at 121,497,086 bp
  • T to A, chromosome 12 at 114,523,466 bp
  • C to T, chromosome 13 at 6,585,250 bp
  • T to A, chromosome 13 at 15,724,732 bp
  • T to G, chromosome 13 at 34,746,669 bp
  • T to C, chromosome 13 at 60,761,326 bp
  • T to C, chromosome 13 at 65,095,686 bp
  • T to C, chromosome 13 at 74,480,546 bp
  • T to G, chromosome 13 at 117,249,130 bp
  • T to C, chromosome 14 at 62,664,981 bp
  • A to T, chromosome 14 at 121,605,243 bp
  • T to A, chromosome 16 at 20,601,977 bp
  • T to A, chromosome 16 at 88,627,051 bp
  • T to A, chromosome 16 at 94,762,601 bp
  • T to C, chromosome 17 at 37,923,794 bp
  • G to A, chromosome 17 at 44,085,264 bp
  • G to A, chromosome 18 at 74,616,993 bp
  • T to A, chromosome 19 at 12,586,902 bp
  • T to C, chromosome Y at 1,340,123 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6330 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044484-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.