Strain Name:
C57BL/6J-MtgxR6335Btlr/Mmmh
Stock Number:
044489-MU
Citation ID:
RRID:MMRRC_044489-MU
Other Names:
R6335 (G1)
Major Collection:

Strain Information

Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd237e, D7Ertd257e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514
Tead3
Name: TEA domain family member 3
Synonyms: DTEF-1, TEF-5, Tcf13r2, ETFR-1, TEAD-3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21678
Homologene: 81821
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: flat, RAPT1, 2610315D21Rik, RAFT1, Frap1, mechanistic target of rapamycin (serine/threonine kinase), FKBP-rapamycin-associated protein FRAP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Dcaf1
Name: DDB1 and CUL4 associated factor 1
Synonyms: Vprbp, B930007L02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 321006
Homologene: 8805
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: C030045D06Rik, 6230420N16Rik, Depdc2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109294
Homologene: 23523
Ticrr
Name: TOPBP1-interacting checkpoint and replication regulator
Synonyms: 5730590G19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77011
Homologene: 67120
Rexo1
Name: REX1, RNA exonuclease 1
Synonyms: 1700021P10Rik, Rex1, 2610511M11Rik, Tceb3bp1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66932
Homologene: 41391
Cdk5rap2
Name: CDK5 regulatory subunit associated protein 2
Synonyms: an, 2900018K03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214444
Homologene: 49533
Tango6
Name: transport and golgi organization 6
Synonyms: Tmco7, Tango6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 272538
Homologene: 52121
Tanc2
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Synonyms: 3526402J09Rik, 5730590C14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77097
Homologene: 64680
Fasn
Name: fatty acid synthase
Synonyms: A630082H08Rik, FAS
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14104
HGNC: HGNC:3594
Homologene: 55800
Ipo7
Name: importin 7
Synonyms: A330055O14Rik, RanBP7, Imp7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233726
HGNC: HGNC:9852
Homologene: 4659
Rasgrp1
Name: RAS guanyl releasing protein 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19419
HGNC: HGNC:9878
Homologene: 4195
Rnd2
Name: Rho family GTPase 2
Synonyms: Rohn, Arhn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11858
Homologene: 21123
Pacs1
Name: phosphofurin acidic cluster sorting protein 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107975
VEGA: 19
Homologene: 9970
Taf1c
Name: TATA-box binding protein associated factor, RNA polymerase I, C
Synonyms: mTAFI95
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21341
Homologene: 21163
Lmo7
Name: LIM domain only 7
Synonyms: LOC380928, FBXO20
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 380928
HGNC: HGNC:6646
Homologene: 83924
Camkv
Name: CaM kinase-like vesicle-associated
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235604
Homologene: 56983
C1qtnf1
Name: C1q and tumor necrosis factor related protein 1
Synonyms: CTRP1, 1600017K21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56745
Homologene: 10548
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, LOC385009, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Pbrm1
Name: polybromo 1
Synonyms: 2310032M22Rik, 2610016F04Rik, Pb1, BAF180
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66923
Homologene: 10044
Mecom
Name: MDS1 and EVI1 complex locus
Synonyms: Evi-1, Jbo, ZNFPR1B1, D630039M04Rik, Prdm3, Mds1, Evi1, MDS1-EVI1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14013
HGNC: HGNC:3498
Homologene: 21086
Cep192
Name: centrosomal protein 192
Synonyms: D430014P18Rik, 4631422C13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70799
VEGA: 18
Homologene: 73526
Ptprd
Name: protein tyrosine phosphatase receptor type D
Synonyms: 3000002J10Rik, 1110002J03Rik, B230219D21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19266
HGNC: HGNC:9668
Pcdh7
Name: protocadherin 7
Synonyms: BH-protocadherin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54216
HGNC: HGNC:8659
Homologene: 36101
Myef2
Name: myelin basic protein expression factor 2, repressor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17876
Homologene: 69079
Serpinb6e
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6e
Synonyms: Gm11396, SPI3B, ovalbumin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 435350
HGNC: HGNC:8950
Homologene: 50933
Sptbn5
Name: spectrin beta, non-erythrocytic 5
Synonyms: EG640524, Spnb5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 640524
Homologene: 41150
Nlrc5
Name: NLR family, CARD domain containing 5
Synonyms: AI451557
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 434341
Homologene: 88935
Scn9a
Name: sodium channel, voltage-gated, type IX, alpha
Synonyms: PN1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20274
Homologene: 2237
Naip1
Name: NLR family, apoptosis inhibitory protein 1
Synonyms: Birc1a, D13Lsd1, Naip
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17940
VEGA: 13
HGNC: HGNC:7634
Homologene: 113589
Parp10
Name: poly (ADP-ribose) polymerase family, member 10
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 671535
Homologene: 53133
Grik5
Name: glutamate receptor, ionotropic, kainate 5 (gamma 2)
Synonyms: GluRgamma2, KA2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14809
HGNC: HGNC:4583
Homologene: 1578
Or1j12
Name: olfactory receptor family 1 subfamily J member 12
Synonyms: Olfr340, MOR136-1, GA_x6K02T2NLDC-33147742-33148680
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258953
Homologene: 74159
Ss18l2
Name: SS18, nBAF chromatin remodeling complex subunit like 2
Synonyms: Band 47B, 1110020I04Rik, Deb1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26901
VEGA: 9
Homologene: 32307
Grik1
Name: glutamate receptor, ionotropic, kainate 1
Synonyms: GluK5, D16Ium24, Glurbeta1, Glur-5, D16Ium24e, A830007B11Rik, Glur5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14805
HGNC: HGNC:4579
Homologene: 68992
Dgkz
Name: diacylglycerol kinase zeta
Synonyms: mDGK[z], E130307B02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 104418
HGNC: HGNC:2857
Homologene: 37831
Ppef2
Name: protein phosphatase, EF hand calcium-binding domain 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19023
HGNC: HGNC:9244
Homologene: 55959
Or5w8
Name: olfactory receptor family 5 subfamily W member 8
Synonyms: MOR177-9, Olfr1151, GA_x6K02T2Q125-49358694-49359620
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258631
Homologene: 36999
Atp11a
Name: ATPase, class VI, type 11A
Synonyms: 4930558F19Rik, LOC100045280, 9130422H11Rik, Ih
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50770
Homologene: 75050
Dmrt2
Name: doublesex and mab-3 related transcription factor 2
Synonyms: Terra
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226049
VEGA: 19
HGNC: HGNC:2935
Homologene: 17111
Dpep1
Name: dipeptidase 1
Synonyms: MBD
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13479
HGNC: HGNC:3002
Homologene: 80192
Galc
Name: galactosylceramidase
Synonyms: galactocerebrosidase, A930008M05Rik, Gacy, 2310068B06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14420
VEGA: 12
HGNC: HGNC:4115
Homologene: 124
Nfasc
Name: neurofascin
Synonyms: D430023G06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269116
Homologene: 24945
Zscan29
Name: zinc finger SCAN domains 29
Synonyms: Zfp690
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99334
Homologene: 17586
Musk
Name: muscle, skeletal, receptor tyrosine kinase
Synonyms: Nsk2, Nsk3, MDK4, Nsk1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18198
HGNC: HGNC:7525
Homologene: 4084
Crocc2
Name: ciliary rootlet coiled-coil, rootletin family member 2
Synonyms: LOC381284, E030010N08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381284
Homologene: 141152
Vmn1r196
Name: vomeronasal 1 receptor 196
Synonyms: V1rh19
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100312484
Homologene: 110880
Upb1
Name: ureidopropionase, beta
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103149
Homologene: 9471
Tdrd9
Name: tudor domain containing 9
Synonyms: 4930441E05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74691
Homologene: 14311
Trpc4
Name: transient receptor potential cation channel, subfamily C, member 4
Synonyms: STRPC4, CCE1, Trrp4, Trp4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22066
Homologene: 22955
Vav3
Name: vav 3 oncogene
Synonyms: A530094I06Rik, Idd18.1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 57257
Homologene: 38143
Siae
Name: sialic acid acetylesterase
Synonyms: clone 165, Ysg2, LSE
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22619
Homologene: 8001
Best3
Name: bestrophin 3
Synonyms: mBest4, Vmd2l3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 382427
VEGA: 10
Homologene: 33850
Napa
Name: N-ethylmaleimide sensitive fusion protein attachment protein alpha
Synonyms: a-SNAP, SNARE, hyh, 1500039N14Rik, SNAPA, RA81
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108124
HGNC: HGNC:7641
Homologene: 2839
Fam221b
Name: family with sequence similarity 221, member B
Synonyms: 4930412F15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242408
Homologene: 52184
Or10q12
Name: olfactory receptor family 10 subfamily Q member 12
Synonyms: Olfr1495, GA_x6K02T2RE5P-4101369-4102328, MOR266-9
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258341
Homologene: 73965
Grpel2
Name: GrpE-like 2, mitochondrial
Synonyms: mt-GrpE#2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17714
VEGA: 18
Homologene: 41432
Sash3
Name: SAM and SH3 domain containing 3
Synonyms: 1200013B08Rik, SLY1
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 74131
Homologene: 10362
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 11,110,320 bp
  • A to T, chromosome 1 at 93,202,838 bp
  • T to A, chromosome 1 at 132,576,394 bp
  • A to G, chromosome 2 at 36,452,722 bp
  • T to A, chromosome 2 at 66,568,264 bp
  • T to A, chromosome 2 at 87,857,467 bp
  • T to C, chromosome 2 at 91,944,379 bp
  • T to C, chromosome 2 at 117,293,870 bp
  • C to A, chromosome 2 at 120,054,419 bp
  • T to C, chromosome 2 at 121,161,436 bp
  • T to C, chromosome 2 at 125,109,712 bp
  • A to G, chromosome 3 at 29,980,756 bp
  • T to C, chromosome 3 at 54,317,574 bp
  • A to G, chromosome 3 at 109,563,196 bp
  • G to T, chromosome 4 at 43,665,942 bp
  • A to G, chromosome 4 at 58,366,811 bp
  • A to C, chromosome 4 at 70,266,612 bp
  • A to G, chromosome 4 at 75,954,183 bp
  • G to T, chromosome 4 at 143,949,032 bp
  • A to G, chromosome 4 at 148,465,927 bp
  • A to T, chromosome 5 at 57,942,265 bp
  • T to C, chromosome 5 at 92,235,754 bp
  • G to T, chromosome 7 at 16,115,637 bp
  • A to G, chromosome 7 at 25,013,594 bp
  • A to C, chromosome 7 at 79,694,283 bp
  • A to G, chromosome 7 at 80,728,024 bp
  • A to G, chromosome 7 at 110,018,468 bp
  • T to C, chromosome 8 at 12,859,481 bp
  • A to G, chromosome 8 at 94,502,274 bp
  • C to A, chromosome 8 at 106,692,676 bp
  • A to G, chromosome 8 at 119,601,779 bp
  • T to G, chromosome 8 at 123,200,652 bp
  • T to A, chromosome 9 at 18,660,708 bp
  • C to T, chromosome 9 at 37,632,981 bp
  • A to G, chromosome 9 at 106,838,646 bp
  • T to C, chromosome 9 at 107,946,695 bp
  • C to T, chromosome 9 at 121,712,606 bp
  • A to T, chromosome 10 at 75,428,301 bp
  • A to T, chromosome 10 at 80,544,081 bp
  • G to T, chromosome 10 at 117,002,651 bp
  • C to T, chromosome 11 at 101,468,999 bp
  • C to T, chromosome 11 at 105,857,556 bp
  • A to G, chromosome 11 at 118,448,134 bp
  • A to T, chromosome 11 at 120,815,359 bp
  • T to C, chromosome 12 at 98,242,714 bp
  • G to T, chromosome 12 at 112,041,752 bp
  • T to A, chromosome 13 at 22,293,717 bp
  • C to A, chromosome 13 at 33,837,822 bp
  • A to G, chromosome 13 at 100,426,552 bp
  • G to T, chromosome 14 at 31,084,095 bp
  • T to C, chromosome 14 at 101,900,636 bp
  • A to G, chromosome 15 at 76,242,188 bp
  • A to G, chromosome 16 at 87,947,906 bp
  • A to T, chromosome 17 at 28,333,325 bp
  • T to C, chromosome 18 at 61,719,721 bp
  • T to A, chromosome 18 at 67,834,713 bp
  • G to T, chromosome 19 at 5,159,977 bp
  • T to C, chromosome 19 at 13,768,780 bp
  • T to A, chromosome 19 at 25,673,571 bp
  • C to T, chromosome X at 48,159,521 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6335 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044489-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.