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Strain Name:
C57BL/6J-MtgxR6339Btlr/Mmmh
Stock Number:
044493-MU
Citation ID:
RRID:MMRRC_044493-MU
Other Names:
R6339 (G1)
Major Collection:

Strain Information

Npr3
Name: natriuretic peptide receptor 3
Synonyms: Nppc receptor, lgj, longjohn, NPR-C, B430320C24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18162
VEGA: 15
HGNC: HGNC:7945
Homologene: 699
Sstr2
Name: somatostatin receptor 2
Synonyms: SSTR-2, sst2, Smstr2, Smstr-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20606
Homologene: 37427
Ubc
Name: ubiquitin C
Synonyms: 2700054O04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22190
Homologene: 128418
Ltbp3
Name: latent transforming growth factor beta binding protein 3
Synonyms: Ltbp2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16998
VEGA: 19
HGNC: HGNC:6716
Homologene: 7405
Slamf6
Name: SLAM family member 6
Synonyms: SF2000, NTB-A, KAL1b, KAL1, Ly108
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 30925
Homologene: 49945
Slc1a6
Name: solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
Synonyms: EAAT4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20513
VEGA: 10
Homologene: 21055
Taok3
Name: TAO kinase 3
Synonyms: A430105I05Rik, 2900006A08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330177
Homologene: 83279
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 12,838,440 bp
  • T to A, chromosome 1 at 26,682,505 bp
  • A to T, chromosome 1 at 36,710,461 bp
  • C to T, chromosome 1 at 40,461,856 bp
  • T to A, chromosome 1 at 52,640,910 bp
  • C to T, chromosome 1 at 55,696,315 bp
  • A to G, chromosome 1 at 93,214,032 bp
  • A to T, chromosome 1 at 143,646,902 bp
  • A to G, chromosome 1 at 171,948,048 bp
  • A to G, chromosome 2 at 28,734,448 bp
  • A to G, chromosome 2 at 88,852,871 bp
  • C to A, chromosome 3 at 87,752,520 bp
  • T to A, chromosome 3 at 95,617,439 bp
  • T to C, chromosome 3 at 133,133,662 bp
  • T to A, chromosome 3 at 133,486,417 bp
  • A to T, chromosome 4 at 11,285,111 bp
  • A to T, chromosome 4 at 83,742,997 bp
  • G to T, chromosome 4 at 100,411,931 bp
  • A to G, chromosome 4 at 101,161,926 bp
  • A to G, chromosome 5 at 31,256,583 bp
  • A to T, chromosome 5 at 31,286,945 bp
  • G to A, chromosome 5 at 107,503,717 bp
  • A to T, chromosome 5 at 117,228,030 bp
  • A to T, chromosome 5 at 125,387,342 bp
  • A to T, chromosome 5 at 137,785,688 bp
  • T to C, chromosome 5 at 138,093,305 bp
  • T to A, chromosome 6 at 81,946,496 bp
  • A to C, chromosome 6 at 86,426,656 bp
  • A to T, chromosome 7 at 109,321,465 bp
  • G to A, chromosome 8 at 21,703,469 bp
  • A to G, chromosome 8 at 80,613,015 bp
  • G to T, chromosome 8 at 85,640,558 bp
  • A to G, chromosome 8 at 92,359,853 bp
  • G to A, chromosome 8 at 109,844,368 bp
  • A to T, chromosome 8 at 119,632,954 bp
  • G to T, chromosome 9 at 41,969,742 bp
  • T to C, chromosome 9 at 44,313,491 bp
  • G to T, chromosome 9 at 61,401,924 bp
  • C to T, chromosome 9 at 95,405,750 bp
  • A to T, chromosome 9 at 101,101,750 bp
  • C to T, chromosome 9 at 108,956,633 bp
  • G to A, chromosome 9 at 119,074,991 bp
  • G to T, chromosome 10 at 14,434,347 bp
  • A to C, chromosome 10 at 78,800,085 bp
  • T to C, chromosome 11 at 57,529,772 bp
  • A to T, chromosome 11 at 97,344,176 bp
  • T to C, chromosome 11 at 113,624,549 bp
  • A to T, chromosome 12 at 8,016,188 bp
  • A to G, chromosome 12 at 75,989,153 bp
  • A to T, chromosome 12 at 103,604,969 bp
  • A to T, chromosome 12 at 110,646,205 bp
  • T to A, chromosome 13 at 67,362,364 bp
  • T to A, chromosome 14 at 24,158,060 bp
  • T to C, chromosome 14 at 43,101,485 bp
  • T to C, chromosome 14 at 55,499,849 bp
  • A to G, chromosome 14 at 56,082,337 bp
  • A to T, chromosome 14 at 70,775,718 bp
  • T to G, chromosome 14 at 99,107,398 bp
  • A to G, chromosome 15 at 7,167,049 bp
  • T to C, chromosome 15 at 11,845,275 bp
  • T to C, chromosome 15 at 75,665,656 bp
  • T to C, chromosome 15 at 78,940,833 bp
  • T to A, chromosome 15 at 79,308,816 bp
  • G to T, chromosome 15 at 82,299,045 bp
  • T to A, chromosome 15 at 89,335,499 bp
  • A to T, chromosome 17 at 18,583,862 bp
  • G to A, chromosome 17 at 56,771,490 bp
  • T to C, chromosome 18 at 37,300,945 bp
  • G to A, chromosome 18 at 61,975,571 bp
  • A to G, chromosome 18 at 65,349,806 bp
  • A to C, chromosome 19 at 3,362,152 bp
  • C to A, chromosome 19 at 5,747,477 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6339 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044493-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.