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Strain Name:
C57BL/6J-MtgxR6340Btlr/Mmmh
Stock Number:
044494-MU
Citation ID:
RRID:MMRRC_044494-MU
Other Names:
R6340 (G1)
Major Collection:

Strain Information

Uso1
Name: USO1 vesicle docking factor
Synonyms: transcytosis associated protein p115, TAP, Vdp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56041
Homologene: 2754
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Fiz1
Name: Flt3 interacting zinc finger protein 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23877
Homologene: 22663
Hmgcr
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Synonyms: HMG-CoAR, 3-hydroxy-3-methylglutaryl-CoA reductase, Red
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15357
HGNC: HGNC:5006
Homologene: 30994
Atp9b
Name: ATPase, class II, type 9B
Synonyms: IIb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 50771
VEGA: 18
Homologene: 21915
Igf2bp3
Name: insulin-like growth factor 2 mRNA binding protein 3
Synonyms: 2610101N11Rik, IMP3, Koc13
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 140488
Homologene: 4773
Melk
Name: maternal embryonic leucine zipper kinase
Synonyms: MPK38
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17279
Homologene: 32111
Pygo1
Name: pygopus 1
Synonyms: 2600014C22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72135
Homologene: 41050
Zfp277
Name: zinc finger protein 277
Synonyms: NIRF4, 2410017E24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 246196
VEGA: 12
Homologene: 11087
Chpf2
Name: chondroitin polymerizing factor 2
Synonyms: 2010209O12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100910
Homologene: 14763
Fam180a
Name: family with sequence similarity 180, member A
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 208164
Homologene: 18283
Il20
Name: interleukin 20
Synonyms: Zcyto10
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 58181
HGNC: HGNC:6002
Homologene: 10286
Pdia4
Name: protein disulfide isomerase associated 4
Synonyms: ERp72, Erp72, Cai, U48620
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12304
Homologene: 21020
Mnt
Name: max binding protein
Synonyms: Rox, bHLHd3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17428
HGNC: HGNC:7188
Homologene: 7842
Emc1
Name: ER membrane protein complex subunit 1
Synonyms: C230096C10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230866
Homologene: 9002
Pkd1l1
Name: polycystic kidney disease 1 like 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 171395
Homologene: 51376
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy-3, hy3, 1700034M11Rik, 4930545D19Rik, hyrh
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Gabra5
Name: gamma-aminobutyric acid type A receptor subunit alpha 5
Synonyms: A230018I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 110886
HGNC: HGNC:4079
Homologene: 20219
Ogfrl1
Name: opioid growth factor receptor-like 1
Synonyms: 2210417C17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70155
Homologene: 11595
Tdrd7
Name: tudor domain containing 7
Synonyms: 5730495N10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100121
Homologene: 8618
Vmn2r82
Name: vomeronasal 2, receptor 82
Synonyms: EG624845
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 624845
Homologene: 83483
Arhgef4
Name: Rho guanine nucleotide exchange factor 4
Synonyms: 9330140K16Rik, Asef, C230030N03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226970
HGNC: HGNC:684
Homologene: 49414
Nrap
Name: nebulin-related anchoring protein
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18175
HGNC: HGNC:7988
Homologene: 4499
Elmo3
Name: engulfment and cell motility 3
Synonyms: CED-12
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234683
Homologene: 23475
Mep1a
Name: meprin 1 alpha
Synonyms: meprin A alpha-subunit, Mep-1a, Mep-1, meprin alpha, Mep1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17287
HGNC: HGNC:7015
Homologene: 31323
Igsf11
Name: immunoglobulin superfamily, member 11
Synonyms: BT-IgSF, 1700025L02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207683
Homologene: 17613
Gm19684
Name: predicted gene, 19684
Type: Gene
Species: Mouse
Chromosome: 17
Or8d1b
Name: olfactory receptor family 8 subfamily D member 1B
Synonyms: GA_x6K02T2PVTD-32671531-32672457, MOR171-22, Olfr933
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258433
VEGA: 9
HGNC: HGNC:8481
Homologene: 79676
Babam1
Name: BRISC and BRCA1 A complex member 1
Synonyms: 5430437P03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68251
Homologene: 8574
Fnip2
Name: folliculin interacting protein 2
Synonyms: D630023B12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329679
Homologene: 46417
Tsga10
Name: testis specific 10
Synonyms: 4933432N21Rik, Mtsga10
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211484
Homologene: 23531
Sirpb1b
Name: signal-regulatory protein beta 1B
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 668101
Homologene: 82993
Or1j13
Name: olfactory receptor family 1 subfamily J member 13
Synonyms: GA_x6K02T2NLDC-33174915-33173974, MOR136-2, Olfr341
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258952
Homologene: 74160
Yae1d1
Name: Yae1 domain containing 1
Synonyms: 1600012F09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67008
VEGA: 13
Homologene: 10615
Trav14-1
Name: T cell receptor alpha variable 14-1
Synonyms: Gm5770
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 436467
B020011L13Rik
Name: RIKEN cDNA B020011L13 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 547097
Homologene: 140625
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 23,369,863 bp
  • C to T, chromosome 1 at 34,732,223 bp
  • C to A, chromosome 1 at 37,835,185 bp
  • G to A, chromosome 1 at 117,801,884 bp
  • A to G, chromosome 1 at 130,908,381 bp
  • T to C, chromosome 2 at 36,480,020 bp
  • A to T, chromosome 3 at 15,548,665 bp
  • A to G, chromosome 3 at 79,507,845 bp
  • A to G, chromosome 4 at 44,340,633 bp
  • T to A, chromosome 4 at 45,994,517 bp
  • A to T, chromosome 4 at 123,448,249 bp
  • T to A, chromosome 4 at 139,365,563 bp
  • T to C, chromosome 4 at 143,897,307 bp
  • T to C, chromosome 5 at 24,591,775 bp
  • T to A, chromosome 5 at 92,199,852 bp
  • A to C, chromosome 6 at 35,315,387 bp
  • A to G, chromosome 6 at 47,801,018 bp
  • A to G, chromosome 6 at 49,214,459 bp
  • C to T, chromosome 7 at 5,008,401 bp
  • A to T, chromosome 7 at 57,413,748 bp
  • T to A, chromosome 8 at 71,402,805 bp
  • T to A, chromosome 8 at 105,306,747 bp
  • T to G, chromosome 8 at 110,354,942 bp
  • T to G, chromosome 9 at 38,975,766 bp
  • T to A, chromosome 9 at 72,945,429 bp
  • A to T, chromosome 10 at 79,395,893 bp
  • T to G, chromosome 11 at 8,844,649 bp
  • A to G, chromosome 11 at 74,836,416 bp
  • A to G, chromosome 12 at 40,318,549 bp
  • C to A, chromosome 13 at 17,993,276 bp
  • A to G, chromosome 13 at 96,665,858 bp
  • A to G, chromosome 14 at 43,578,077 bp
  • T to C, chromosome 14 at 53,554,498 bp
  • A to T, chromosome 14 at 118,267,257 bp
  • A to G, chromosome 16 at 39,008,974 bp
  • G to A, chromosome 17 at 36,127,510 bp
  • C to T, chromosome 17 at 43,479,058 bp
  • A to T, chromosome 17 at 43,479,233 bp
  • T to C, chromosome 18 at 80,778,900 bp
  • A to G, chromosome 19 at 56,347,184 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6340 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044494-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.