Strain Name:
C57BL/6J-MtgxR6359Btlr/Mmmh
Stock Number:
044509-MU
Citation ID:
RRID:MMRRC_044509-MU
Other Names:
R6359 (G1)
Major Collection:

Strain Information

Lamb1
Name: laminin B1
Synonyms: Lamb1-1, C80098, C81607, Lamb-1, D130003D08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16777
HGNC: HGNC:6486
Homologene: 1722
Ints1
Name: integrator complex subunit 1
Synonyms: 1110015K06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68510
Homologene: 53111
Ccdc18
Name: coiled-coil domain containing 18
Synonyms: 1700021E15Rik, 4932411G06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73254
Homologene: 35455
Ipo8
Name: importin 8
Synonyms: 6230418K12Rik, Om1, Ranbp8, C130009K11Rik, OM-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320727
HGNC: HGNC:9853
Homologene: 48430
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Ddi2
Name: DNA-damage inducible protein 2
Synonyms: 1700027M01Rik, 9130022E05Rik, 1110056G13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68817
Homologene: 121661
Nlrp3
Name: NLR family, pyrin domain containing 3
Synonyms: Cias1, NALP3, Pypaf1, Mmig1, cryopyrin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216799
Homologene: 3600
Prkag1
Name: protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Synonyms: Prkaac
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19082
VEGA: 15
HGNC: HGNC:9385
Homologene: 99712
Nol8
Name: nucleolar protein 8
Synonyms: D13Ertd548e, 5730412B09Rik, 4921532D18Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 70930
VEGA: 13
Homologene: 41210
Dync1li1
Name: dynein cytoplasmic 1 light intermediate chain 1
Synonyms: LIC-1, 1110053F02Rik, Dnclic1, Dlic1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235661
VEGA: 9
Homologene: 9403
Gak
Name: cyclin G associated kinase
Synonyms: D130045N16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231580
HGNC: HGNC:4113
Homologene: 3846
Mapk3
Name: mitogen-activated protein kinase 3
Synonyms: p44mapk, Prkm3, p44 MAP kinase, Esrk1, p44erk1, Erk-1, Erk1, Mtap2k
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26417
HGNC: HGNC:6877
Homologene: 55682
Spata31d1c
Name: spermatogenesis associated 31 subfamily D, member 1C
Synonyms: Fam75d1c, 4932441B19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238683
VEGA: 13
Ttn
Name: titin
Synonyms: 2310036G12Rik, 2310057K23Rik, D330041I19Rik, mdm, connectin, D830007G01Rik, 1100001C23Rik, shru, 2310074I15Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Ces2a
Name: carboxylesterase 2A
Synonyms: Ces6, 9130231C15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102022
HGNC: HGNC:1864
Homologene: 136396
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Atp11b
Name: ATPase, class VI, type 11B
Synonyms: 1110019I14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76295
Homologene: 32919
Mrpl4
Name: mitochondrial ribosomal protein L4
Synonyms: 1110017G11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66163
VEGA: 9
Homologene: 32286
Igsf9b
Name: immunoglobulin superfamily, member 9B
Synonyms: AI414108, LOC235086
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235086
Homologene: 19472
Or52p1
Name: olfactory receptor family 52 subfamily P member 1
Synonyms: Olfr656, MOR27-1, GA_x6K02T2PBJ9-7245486-7246451
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259078
Homologene: 128072
Glp1r
Name: glucagon-like peptide 1 receptor
Synonyms: GLP-1R, GLP1Rc
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14652
VEGA: 17
HGNC: HGNC:4324
Homologene: 1558
Ncln
Name: nicalin
Synonyms: 3100002P13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103425
Homologene: 10604
Hsd11b1
Name: hydroxysteroid 11-beta dehydrogenase 1
Synonyms: 11beta-HSD-1, 11beta-hydroxysteroid dehydrogenase type 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15483
HGNC: HGNC:5208
Homologene: 68471
Plekha8
Name: pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
Synonyms: FAPP2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 231999
Homologene: 32284
Asic5
Name: acid-sensing ion channel family member 5
Synonyms: brain-liver-intestine amiloride-sensitive sodium channel, Accn5, BLINaC
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 58170
Homologene: 41171
Or11i1
Name: olfactory receptor family 11 subfamily I member 1
Synonyms: GA_x6K02T2N6GK-529983-529033, Olfr266, MOR122-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 258482
Homologene: 51728
Tmem30c
Name: transmembrane protein 30C
Synonyms: 4933401B01Rik, 4933409A18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71027
Homologene: 78138
Igkv13-84
Name: immunoglobulin kappa chain variable 13-84
Synonyms: Igk-V33
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 692152
Fbxo10
Name: F-box protein 10
Synonyms: LOC269529, FBX10
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269529
Homologene: 19544
Spata31d1a
Name: spermatogenesis associated 31 subfamily D, member 1A
Synonyms: Fam75d3, Fam75d1a, 1700013B16Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72219
VEGA: 13
Homologene: 122131
Eif1ad14
Name: eukaryotic translation initiation factor 1A domain containing 14
Synonyms: Gm2035
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100039076
VEGA: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 193,242,352 bp
  • T to C, chromosome 2 at 41,295,596 bp
  • T to G, chromosome 2 at 76,738,956 bp
  • T to C, chromosome 2 at 180,195,982 bp
  • A to G, chromosome 3 at 35,778,061 bp
  • A to T, chromosome 3 at 82,004,496 bp
  • A to T, chromosome 3 at 106,822,415 bp
  • A to T, chromosome 4 at 45,041,796 bp
  • T to A, chromosome 4 at 141,684,588 bp
  • C to T, chromosome 5 at 108,135,525 bp
  • T to C, chromosome 5 at 108,571,900 bp
  • G to T, chromosome 5 at 139,756,217 bp
  • G to T, chromosome 6 at 54,613,119 bp
  • T to G, chromosome 6 at 68,939,608 bp
  • A to G, chromosome 6 at 148,777,250 bp
  • T to C, chromosome 7 at 104,618,303 bp
  • A to G, chromosome 7 at 126,760,756 bp
  • A to G, chromosome 8 at 104,736,078 bp
  • T to A, chromosome 9 at 21,007,734 bp
  • C to A, chromosome 9 at 27,309,599 bp
  • A to G, chromosome 9 at 114,713,570 bp
  • C to T, chromosome 10 at 81,490,284 bp
  • G to A, chromosome 11 at 59,548,566 bp
  • A to G, chromosome 12 at 31,282,716 bp
  • G to A, chromosome 12 at 87,919,505 bp
  • A to G, chromosome 13 at 49,664,070 bp
  • A to G, chromosome 13 at 59,703,106 bp
  • A to T, chromosome 13 at 65,035,592 bp
  • T to C, chromosome 15 at 63,825,017 bp
  • T to C, chromosome 15 at 98,814,552 bp
  • A to T, chromosome 16 at 57,276,150 bp
  • G to T, chromosome 17 at 30,929,972 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6359 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044509-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.