Strain Name:
C57BL/6J-MtgxR6367Btlr/Mmmh
Stock Number:
044517-MU
Citation ID:
RRID:MMRRC_044517-MU
Other Names:
R6367 (G1)
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, DRP, Dmdl
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Secisbp2
Name: SECIS binding protein 2
Synonyms: 2210413N07Rik, 2810012K13Rik, SBP2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75420
Homologene: 11415
Tdg
Name: thymine DNA glycosylase
Synonyms: E130317C12Rik, Jza1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21665
Homologene: 2415
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: Lba, D3Ertd775e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Dip2b
Name: disco interacting protein 2 homolog B
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239667
Homologene: 72227
Safb
Name: scaffold attachment factor B
Synonyms: 5330423C17Rik, 3110021E02Rik, SAFB1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224903
Homologene: 2229
Wdr1
Name: WD repeat domain 1
Synonyms: D5Wsu185e, Aip1, rede
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22388
Homologene: 6628
Als2
Name: alsin Rho guanine nucleotide exchange factor
Synonyms: Als2cr6, 3222402C23Rik, 9430073A21Rik, Alsin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74018
HGNC: HGNC:443
Homologene: 23264
Fanci
Name: Fanconi anemia, complementation group I
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 208836
Homologene: 49530
Scp2
Name: sterol carrier protein 2, liver
Synonyms: SCPx, SCP-2, ns-LTP, NSL-TP, nonspecific lipid transfer protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20280
Homologene: 37717
Agk
Name: acylglycerol kinase
Synonyms: MuLK, 2610037M15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69923
Homologene: 41239
Gucy2c
Name: guanylate cyclase 2c
Synonyms: GC-C
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14917
HGNC: HGNC:4688
Homologene: 3641
Arhgap17
Name: Rho GTPase activating protein 17
Synonyms: WBP15, Nadrin, Nadrin2, 5730403H17Rik, Rich1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70497
Homologene: 9984
Tuba1c
Name: tubulin, alpha 1C
Synonyms: M[a]6, Tuba6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22146
VEGA: 15
Homologene: 69045
Wbp2
Name: WW domain binding protein 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22378
Homologene: 32160
Plekhm2
Name: pleckstrin homology domain containing, family M (with RUN domain) member 2
Synonyms: 2310034J19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69582
Homologene: 19575
Cachd1
Name: cache domain containing 1
Synonyms: Vwcd1, 1190007F10Rik, B430218L07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320508
Homologene: 10854
Mgat4c
Name: MGAT4 family, member C
Synonyms: 9130411I17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67569
Homologene: 8297
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Ets1
Name: E26 avian leukemia oncogene 1, 5' domain
Synonyms: Tpl1, Ets-1, p51Ets-1, p42Ets-1, vs
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23871
HGNC: HGNC:3488
Homologene: 3837
Enpep
Name: glutamyl aminopeptidase
Synonyms: Ly51, aminopeptidase-A, 6030431M22Rik, APA, Bp-1/6C3, Ly-51
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13809
HGNC: HGNC:3355
Homologene: 68216
Abca4
Name: ATP-binding cassette, sub-family A member 4
Synonyms: Rim protein, RmP, D430003I15Rik, Abc10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11304
HGNC: HGNC:34
Homologene: 298
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: LOC381311, Gm980, A230079K17Rik, Dnahc14
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329178
Homologene: 122243
Nckap1l
Name: NCK associated protein 1 like
Synonyms: Hem1, 4930568P13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105855
VEGA: 15
HGNC: HGNC:4862
Homologene: 3901
Fbxw28
Name: F-box and WD-40 domain protein 28
Synonyms: Gm9337
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 668758
Homologene: 110776
Atp11b
Name: ATPase, class VI, type 11B
Synonyms: 1110019I14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76295
Homologene: 32919
Vmn2r111
Name: vomeronasal 2, receptor 111
Synonyms: EG210876
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210876
Homologene: 86604
Trpm8
Name: transient receptor potential cation channel, subfamily M, member 8
Synonyms: CMR1, TRPP8, Trp-p8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 171382
Homologene: 23433
Kcng1
Name: potassium voltage-gated channel, subfamily G, member 1
Synonyms: OTTMUSG00000016048
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241794
HGNC: HGNC:6248
Homologene: 20515
Axl
Name: AXL receptor tyrosine kinase
Synonyms: Ufo, Ark, Tyro7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26362
HGNC: HGNC:905
Homologene: 7583
Igsf9b
Name: immunoglobulin superfamily, member 9B
Synonyms: AI414108, LOC235086
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235086
Homologene: 19472
Tpsab1
Name: tryptase alpha/beta 1
Synonyms: MMCP-7, Mcpt7, Mcp-7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100503895
Pacsin2
Name: protein kinase C and casein kinase substrate in neurons 2
Synonyms: Syndapin II
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 23970
VEGA: 15
HGNC: HGNC:8571
Homologene: 21414
Or51f5
Name: olfactory receptor family 51 subfamily F member 5
Synonyms: GA_x6K02T2PBJ9-5491151-5492095, MOR14-2, Olfr561
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259096
Homologene: 133029
Svopl
Name: SV2 related protein homolog (rat)-like
Synonyms: 9430071P14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320590
Homologene: 52168
Ptpru
Name: protein tyrosine phosphatase receptor type U
Synonyms: RPTPlambda, Ptprl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19273
HGNC: HGNC:9683
Homologene: 4168
Kndc1
Name: kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms: 2410012C07Rik, very-kind, VKIND, B830014K08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76484
Homologene: 45138
Or4c52
Name: olfactory receptor family 4 subfamily C member 52
Synonyms: Olfr1263, MOR234-2, GA_x6K02T2Q125-51447049-51447969
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258790
Homologene: 45043
Ssx2ip
Name: SSX family member 2 interacting protein
Synonyms: Adip
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99167
Homologene: 8522
Sp110
Name: Sp110 nuclear body protein
Synonyms: 5830484A20Rik, Ifi75, 5031415C07Rik, 52kDa, Ipr1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109032
HGNC: HGNC:5401
Homologene: 82192
Oacyl
Name: O-acyltransferase like
Synonyms: 5330437I02Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319888
Homologene: 129774
Tmem109
Name: transmembrane protein 109
Synonyms: mitsugumin23, MG23, 1110006I15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68539
Homologene: 11458
Or12e13
Name: olfactory receptor family 12 subfamily E member 13
Synonyms: GA_x6K02T2Q125-49334566-49335510, MOR264-7, Olfr1148
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258220
Homologene: 79465
Yod1
Name: YOD1 deubiquitinase
Synonyms: 9930028C20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226418
Homologene: 13176
Or2m12
Name: olfactory receptor family 2 subfamily M member 12
Synonyms: GA_x54KRFPKG5P-15738260-15737319, MOR279-2, Olfr164
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258443
Homologene: 51725
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 59,199,140 bp
  • T to C, chromosome 1 at 66,672,766 bp
  • C to T, chromosome 1 at 85,594,292 bp
  • A to G, chromosome 1 at 88,359,683 bp
  • G to A, chromosome 1 at 130,717,538 bp
  • A to G, chromosome 1 at 181,755,386 bp
  • T to C, chromosome 2 at 87,833,593 bp
  • A to G, chromosome 2 at 90,015,016 bp
  • C to A, chromosome 2 at 168,262,652 bp
  • A to G, chromosome 3 at 35,784,537 bp
  • G to C, chromosome 3 at 86,368,562 bp
  • A to C, chromosome 3 at 122,103,580 bp
  • G to T, chromosome 3 at 129,332,081 bp
  • A to G, chromosome 3 at 146,419,166 bp
  • A to G, chromosome 4 at 101,002,970 bp
  • T to A, chromosome 4 at 108,112,250 bp
  • T to C, chromosome 4 at 131,774,352 bp
  • T to C, chromosome 4 at 141,639,705 bp
  • G to T, chromosome 5 at 38,545,846 bp
  • A to T, chromosome 6 at 38,019,679 bp
  • T to C, chromosome 6 at 40,386,941 bp
  • C to T, chromosome 6 at 136,709,778 bp
  • A to T, chromosome 7 at 25,787,433 bp
  • T to C, chromosome 7 at 79,426,195 bp
  • C to A, chromosome 7 at 102,774,829 bp
  • T to C, chromosome 7 at 123,308,363 bp
  • T to C, chromosome 7 at 139,913,506 bp
  • G to A, chromosome 9 at 27,309,525 bp
  • C to T, chromosome 9 at 32,733,960 bp
  • A to G, chromosome 9 at 109,339,531 bp
  • A to G, chromosome 10 at 12,747,975 bp
  • T to C, chromosome 10 at 82,647,988 bp
  • G to T, chromosome 10 at 102,385,154 bp
  • A to G, chromosome 11 at 9,216,248 bp
  • G to T, chromosome 11 at 116,083,915 bp
  • A to G, chromosome 13 at 51,682,141 bp
  • C to T, chromosome 15 at 83,381,832 bp
  • T to C, chromosome 15 at 99,037,453 bp
  • A to T, chromosome 15 at 100,115,914 bp
  • G to A, chromosome 15 at 103,475,722 bp
  • C to T, chromosome 16 at 19,286,072 bp
  • T to C, chromosome 17 at 22,559,051 bp
  • G to T, chromosome 17 at 25,343,474 bp
  • A to G, chromosome 17 at 56,593,845 bp
  • G to T, chromosome 18 at 65,725,444 bp
  • A to G, chromosome 19 at 10,874,363 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6367 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044517-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.