Strain Name:
C57BL/6J-MtgxR6373Btlr/Mmmh
Stock Number:
044523-MU
Citation ID:
RRID:MMRRC_044523-MU
Other Names:
R6373 (G1)
Major Collection:

Strain Information

Nrxn2
Name: neurexin II
Synonyms: 6430591O13Rik, neurexin II beta, neurexin II alpha
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984
Ncoa3
Name: nuclear receptor coactivator 3
Synonyms: AIB1, TRAM-1, TRAM1, pCIP, bHLHe42, Src3, KAT13B, 2010305B15Rik, RAC3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17979
HGNC: HGNC:7670
Homologene: 4764
Chd1
Name: chromodomain helicase DNA binding protein 1
Synonyms: 4930525N21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12648
HGNC: HGNC:1915
Homologene: 68174
Kif16b
Name: kinesin family member 16B
Synonyms: N-3 kinesin, 8430434E15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16558
Homologene: 135708
Vangl1
Name: VANGL planar cell polarity 1
Synonyms: Lpp2, KITENIN, stbm, mStbm
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229658
Homologene: 44540
Helz
Name: helicase with zinc finger domain
Synonyms: 9430093I07Rik, 3110078M01Rik, 9630002H22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78455
Homologene: 8918
Cobl
Name: cordon-bleu WH2 repeat
Synonyms: C530045F18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12808
Homologene: 9058
Nav2
Name: neuron navigator 2
Synonyms: 5330421F07Rik, Unc53H2, HELAD1, RAINB2, Rainb1, POMFIL2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78286
Homologene: 52330
Parg
Name: poly (ADP-ribose) glycohydrolase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 26430
HGNC: HGNC:8605
Homologene: 50532
Rxrb
Name: retinoid X receptor beta
Synonyms: Rub, H-2RIIBP, RCoR-1, Nr2b2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20182
Homologene: 7923
Mex3c
Name: mex3 RNA binding family member C
Synonyms: BM-013, Rkhd2, A130001D14Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240396
Homologene: 9601
Aldh16a1
Name: aldehyde dehydrogenase 16 family, member A1
Synonyms: 2410004H02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69748
Homologene: 34938
Smurf2
Name: SMAD specific E3 ubiquitin protein ligase 2
Synonyms: 2810411E22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66313
Homologene: 41490
Fign
Name: fidgetin
Synonyms: Fgn
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 60344
Homologene: 5813
St3gal1
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Synonyms: Siat4a, Siat4, CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase, ST3GalI
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20442
VEGA: 15
Homologene: 7540
Spink5
Name: serine peptidase inhibitor, Kazal type 5
Synonyms: LEKT1, 2310065D10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 72432
Homologene: 4987
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Myh11
Name: myosin, heavy polypeptide 11, smooth muscle
Synonyms: SM2, smMHC, SM1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17880
VEGA: 16
HGNC: HGNC:7569
Homologene: 128512
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 229003
Homologene: 14118
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20192
Homologene: 68151
Deup1
Name: deuterosome assembly protein 1
Synonyms: Ccdc67, 4933401K09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234964
Homologene: 18760
Btn2a2
Name: butyrophilin, subfamily 2, member A2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238555
Homologene: 56012
Nrxn3
Name: neurexin III
Synonyms: 4933401A11Rik, neurexin III alpha, neurexin III beta, neurexin III alpha, neurexin III beta, 9330112C09Rik, D12Bwg0831e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18191
HGNC: HGNC:8010
Homologene: 83225
Syce1l
Name: synaptonemal complex central element protein 1 like
Synonyms: 4930481F22Rik, mmrp2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 668110
Homologene: 86343
Twnk
Name: twinkle mtDNA helicase
Synonyms: Twinl, Peo1, D19Ertd626e, twinkle
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226153
VEGA: 19
HGNC: HGNC:1160
Homologene: 11052
Sntg2
Name: syntrophin, gamma 2
Synonyms: 2210008K22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 268534
Homologene: 41298
Spata20
Name: spermatogenesis associated 20
Synonyms: Tisp78
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217116
Homologene: 11264
Pcdhb7
Name: protocadherin beta 7
Synonyms: Pcdhb4B, PcdhbG
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93878
HGNC: HGNC:8689
Homologene: 87123
Abhd13
Name: abhydrolase domain containing 13
Synonyms: 1110065L07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68904
Homologene: 6716
Nmt2
Name: N-myristoyltransferase 2
Synonyms: hNMT-2, A930001K02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18108
HGNC: HGNC:7858
Homologene: 101539
Vmn1r19
Name: vomeronasal 1 receptor 19
Synonyms: V1rc27
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171200
Homologene: 134034
Rigi
Name: RNA sensor RIG-I
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, Ddx58, RIG-I, 6430573D20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230073
Homologene: 32215
Or1e26
Name: olfactory receptor family 1 subfamily E member 26
Synonyms: Olfr385, MOR135-3, GA_x6K02T2P1NL-3760313-3759375
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259025
Homologene: 133670
Rpe
Name: ribulose-5-phosphate-3-epimerase
Synonyms: 5730518J08Rik, 2810429B02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66646
Homologene: 12005
Eva1a
Name: eva-1 homolog A, regulator of programmed cell death
Synonyms: Tmem166, Fam176a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232146
Homologene: 12969
Carns1
Name: carnosine synthase 1
Synonyms: Atpgd1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107239
VEGA: 19
Homologene: 26439
Gm6309
Name: predicted gene 6309
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 622306
Homologene: 86127
Mab21l1
Name: mab-21-like 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17116
HGNC: HGNC:6757
Homologene: 36183
Or5d20-ps1
Name: olfactory receptor family 5 subfamily D member 20, pseudogene 1
Synonyms: Olfr1165-ps, GA_x6K02T2Q125-49593880-49592930, MOR174-7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258642
H2ac7
Name: H2A clustered histone 7
Synonyms: Hist1h2ad
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319165
Homologene: 136769
Ppihl
Name: peptidyl prolyl isomerase H like
Synonyms: Gm7879
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 665989
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 66,715,980 bp
  • A to G, chromosome 2 at 3,324,951 bp
  • A to C, chromosome 2 at 63,979,645 bp
  • C to T, chromosome 2 at 76,788,616 bp
  • T to C, chromosome 2 at 88,101,845 bp
  • C to A, chromosome 2 at 112,656,544 bp
  • A to T, chromosome 2 at 142,699,698 bp
  • C to T, chromosome 2 at 166,059,347 bp
  • C to T, chromosome 2 at 181,233,467 bp
  • A to T, chromosome 3 at 55,783,084 bp
  • T to C, chromosome 3 at 102,158,448 bp
  • A to G, chromosome 4 at 40,216,487 bp
  • A to G, chromosome 5 at 43,913,551 bp
  • A to T, chromosome 5 at 146,170,275 bp
  • T to C, chromosome 6 at 57,405,332 bp
  • T to C, chromosome 6 at 82,091,866 bp
  • C to G, chromosome 7 at 45,146,271 bp
  • C to T, chromosome 7 at 49,453,175 bp
  • T to C, chromosome 8 at 9,988,240 bp
  • T to A, chromosome 8 at 113,649,511 bp
  • T to C, chromosome 9 at 15,561,342 bp
  • A to G, chromosome 11 at 12,253,118 bp
  • A to G, chromosome 11 at 73,588,898 bp
  • A to G, chromosome 11 at 94,483,400 bp
  • A to G, chromosome 11 at 106,833,769 bp
  • A to G, chromosome 11 at 107,595,184 bp
  • C to T, chromosome 12 at 30,258,041 bp
  • G to C, chromosome 12 at 89,976,469 bp
  • T to C, chromosome 13 at 23,481,829 bp
  • A to G, chromosome 13 at 23,574,853 bp
  • T to G, chromosome 14 at 32,209,497 bp
  • A to G, chromosome 15 at 67,111,346 bp
  • T to A, chromosome 16 at 14,205,130 bp
  • A to T, chromosome 17 at 15,738,636 bp
  • A to G, chromosome 17 at 34,033,559 bp
  • T to A, chromosome 18 at 37,342,211 bp
  • A to G, chromosome 18 at 43,990,672 bp
  • T to C, chromosome 18 at 73,589,994 bp
  • G to T, chromosome 19 at 4,166,516 bp
  • T to C, chromosome 19 at 6,509,830 bp
  • G to A, chromosome 19 at 45,009,381 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6373 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044523-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.