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Strain Name:
C57BL/6J-MtgxR6376Btlr/Mmmh
Stock Number:
044526-MU
Citation ID:
RRID:MMRRC_044526-MU
Other Names:
R6376 (G1)
Major Collection:

Strain Information

Nrp2
Name: neuropilin 2
Synonyms: NP2, Npn-2, Npn2, NP-2, 1110048P06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18187
HGNC: HGNC:8005
Homologene: 2875
Pank4
Name: pantothenate kinase 4
Synonyms: D030031I12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269614
Homologene: 41235
Ptch1
Name: patched 1
Synonyms: Ptc, Patched 1, Ptc1, A230106A15Rik, wig
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, XRCC7, DNA-PK, DOXNPH, dxnph
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 11,798,494 bp
  • T to C, chromosome 1 at 38,045,679 bp
  • A to G, chromosome 1 at 62,719,017 bp
  • T to C, chromosome 1 at 78,696,465 bp
  • T to C, chromosome 1 at 92,888,465 bp
  • T to A, chromosome 1 at 119,417,681 bp
  • T to C, chromosome 1 at 133,715,059 bp
  • C to T, chromosome 1 at 171,340,222 bp
  • A to G, chromosome 1 at 174,203,322 bp
  • C to T, chromosome 1 at 181,605,894 bp
  • T to A, chromosome 2 at 65,461,499 bp
  • T to A, chromosome 2 at 69,483,443 bp
  • T to A, chromosome 2 at 92,370,508 bp
  • T to A, chromosome 2 at 93,856,998 bp
  • A to C, chromosome 2 at 97,629,046 bp
  • T to A, chromosome 2 at 139,636,772 bp
  • C to A, chromosome 3 at 95,490,625 bp
  • C to T, chromosome 3 at 103,645,728 bp
  • T to A, chromosome 3 at 122,123,660 bp
  • T to G, chromosome 4 at 21,900,486 bp
  • T to C, chromosome 4 at 63,745,030 bp
  • C to A, chromosome 4 at 110,255,454 bp
  • C to T, chromosome 4 at 143,950,697 bp
  • T to C, chromosome 4 at 154,972,236 bp
  • A to T, chromosome 5 at 36,821,034 bp
  • A to T, chromosome 5 at 75,166,519 bp
  • G to A, chromosome 5 at 110,336,374 bp
  • G to T, chromosome 5 at 116,409,432 bp
  • A to T, chromosome 5 at 135,747,810 bp
  • A to T, chromosome 5 at 146,953,988 bp
  • A to T, chromosome 6 at 30,614,045 bp
  • T to A, chromosome 6 at 31,528,497 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • G to A, chromosome 7 at 19,469,710 bp
  • T to C, chromosome 7 at 104,306,034 bp
  • A to G, chromosome 7 at 107,128,641 bp
  • C to A, chromosome 7 at 123,300,504 bp
  • A to G, chromosome 7 at 127,344,720 bp
  • C to T, chromosome 7 at 132,599,511 bp
  • G to A, chromosome 7 at 140,228,729 bp
  • C to A, chromosome 7 at 141,067,422 bp
  • T to A, chromosome 8 at 85,358,942 bp
  • A to T, chromosome 9 at 7,165,703 bp
  • A to T, chromosome 9 at 53,428,156 bp
  • A to T, chromosome 9 at 120,018,491 bp
  • C to A, chromosome 9 at 121,664,574 bp
  • T to A, chromosome 10 at 80,312,654 bp
  • A to T, chromosome 10 at 91,023,811 bp
  • A to G, chromosome 10 at 96,038,798 bp
  • T to C, chromosome 11 at 60,203,535 bp
  • T to C, chromosome 11 at 68,954,970 bp
  • C to A, chromosome 11 at 70,798,067 bp
  • T to C, chromosome 12 at 16,699,579 bp
  • A to T, chromosome 12 at 112,732,068 bp
  • C to T, chromosome 12 at 112,909,329 bp
  • G to A, chromosome 12 at 117,721,253 bp
  • T to C, chromosome 13 at 63,543,608 bp
  • T to C, chromosome 13 at 105,119,965 bp
  • A to T, chromosome 14 at 20,660,634 bp
  • A to G, chromosome 14 at 31,275,608 bp
  • A to T, chromosome 14 at 47,052,962 bp
  • A to G, chromosome 14 at 53,545,343 bp
  • A to T, chromosome 14 at 56,101,653 bp
  • A to G, chromosome 14 at 57,722,509 bp
  • A to G, chromosome 14 at 68,505,097 bp
  • A to G, chromosome 14 at 75,032,394 bp
  • G to A, chromosome 14 at 78,514,896 bp
  • T to C, chromosome 15 at 91,742,266 bp
  • C to A, chromosome 15 at 102,937,089 bp
  • A to G, chromosome 16 at 15,769,885 bp
  • T to C, chromosome 16 at 18,079,985 bp
  • G to A, chromosome 16 at 18,405,132 bp
  • T to A, chromosome 16 at 29,237,252 bp
  • A to T, chromosome 16 at 33,975,991 bp
  • G to A, chromosome 16 at 95,718,993 bp
  • A to G, chromosome 17 at 27,095,475 bp
  • A to T, chromosome 17 at 27,707,905 bp
  • T to A, chromosome 17 at 33,847,517 bp
  • T to C, chromosome 17 at 46,508,563 bp
  • G to C, chromosome 18 at 20,837,075 bp
  • G to A, chromosome 18 at 24,701,485 bp
  • G to A, chromosome 18 at 31,954,462 bp
  • T to C, chromosome 19 at 5,728,729 bp
  • C to T, chromosome 19 at 47,015,125 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6376 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044526-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.