Strain Name:
C57BL/6J-MtgxR6377Btlr/Mmmh
Stock Number:
044527-MU
Citation ID:
RRID:MMRRC_044527-MU
Other Names:
R6377 (G1)
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, DRP, Dmdl
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Atrn
Name: attractin
Synonyms: Mgca
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11990
HGNC: HGNC:885
Homologene: 22542
Eno1
Name: enolase 1, alpha non-neuron
Synonyms: Eno-1, 2-phospho-D-glycerate hydrolase, alpha-enolase, c-Myc promoter binding protein, MBP-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13806
HGNC: HGNC:3350
Homologene: 134343
Dysf
Name: dysferlin
Synonyms: 2310004N10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 26903
HGNC: HGNC:3097
Homologene: 20748
Gabarap
Name: gamma-aminobutyric acid receptor associated protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56486
HGNC: HGNC:4067
Homologene: 134119
Slco1a5
Name: solute carrier organic anion transporter family, member 1a5
Synonyms: Oatp3, Slc21a7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108096
Homologene: 56603
Igf1r
Name: insulin-like growth factor I receptor
Synonyms: IGF-1R, A330103N21Rik, hyft, CD221, line 186
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16001
HGNC: HGNC:5465
Homologene: 30997
Foxj3
Name: forkhead box J3
Synonyms: C330039G02Rik, Fhd6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230700
Homologene: 35243
Ankib1
Name: ankyrin repeat and IBR domain containing 1
Synonyms: 2310061P20Rik, 4631416I11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70797
Homologene: 19076
Kif5b
Name: kinesin family member 5B
Synonyms: Khc, kinesin heavy chain
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16573
HGNC: HGNC:6324
Homologene: 55829
Sp1
Name: trans-acting transcription factor 1
Synonyms: Sp1-1, 1110003E12Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20683
Homologene: 8276
Mtbp
Name: Mdm2, transformed 3T3 cell double minute p53 binding protein
Synonyms: MDM2BP
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105837
HGNC: HGNC:7417
Homologene: 11102
Zc3h3
Name: zinc finger CCCH type containing 3
Synonyms: Smicl
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223642
VEGA: 15
Homologene: 9029
Ncbp1
Name: nuclear cap binding protein subunit 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433702
HGNC: HGNC:7658
Homologene: 1859
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, XAP8, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki67, Ki-67, D630048A14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Fkbp15
Name: FK506 binding protein 15
Synonyms: FKBP133, C430014M02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 338355
Homologene: 28743
Lars2
Name: leucyl-tRNA synthetase, mitochondrial
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102436
VEGA: 9
Homologene: 6526
Mlh3
Name: mutL homolog 3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217716
VEGA: 12
HGNC: HGNC:7128
Homologene: 91153
Ipo8
Name: importin 8
Synonyms: OM-1, Ranbp8, Om1, C130009K11Rik, 6230418K12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320727
HGNC: HGNC:9853
Homologene: 48430
Drd3
Name: dopamine receptor D3
Synonyms: D3R, D3 receptor
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13490
VEGA: 16
HGNC: HGNC:3024
Homologene: 623
Ptprs
Name: protein tyrosine phosphatase receptor type S
Synonyms: PTP-NU3, Ptpt9, RPTPsigma, PTPsigma
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19280
HGNC: HGNC:9681
Homologene: 20626
Lsg1
Name: large 60S subunit nuclear export GTPase 1
Synonyms: D16Bwg1547e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224092
Homologene: 5917
Khdrbs1
Name: KH domain containing, RNA binding, signal transduction associated 1
Synonyms: Sam68, p62
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20218
Homologene: 4781
Pot1a
Name: protection of telomeres 1A
Synonyms: Pot1, 1500031H18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101185
Homologene: 32263
Dact2
Name: dishevelled-binding antagonist of beta-catenin 2
Synonyms: Dpr2, Frd2, 2900084M21Rik, dapper2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240025
VEGA: 17
Homologene: 18237
Cngb1
Name: cyclic nucleotide gated channel beta 1
Synonyms: BC016201, Cngb1, Cngb1b
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 333329
HGNC: HGNC:2151
Homologene: 136420
Zbed5
Name: zinc finger BED-type containing 5
Synonyms: Chchd2l, Zbed5, 2410018M08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71970
Homologene: 84838
Scd2
Name: stearoyl-Coenzyme A desaturase 2
Synonyms: Scd-2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20250
VEGA: 19
Homologene: 136612
Loxhd1
Name: lipoxygenase homology domains 1
Synonyms: 1700096C21Rik, sba
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240411
Tecta
Name: tectorin alpha
Synonyms: Tctna, [a]-tectorin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21683
Homologene: 3955
Lonp1
Name: lon peptidase 1, mitochondrial
Synonyms: LON, Prss15, 1200017E13Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74142
VEGA: 17
HGNC: HGNC:9479
Homologene: 3521
Vinac1
Name: vinculin/alpha-catenin family member 1
Synonyms: Gm14025
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668894
Homologene: 86340
Rubcnl
Name: RUN and cysteine rich domain containing beclin 1 interacting protein like
Synonyms: 5031414D18Rik, LOC380917
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 271221
VEGA: 14
Homologene: 57021
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20192
Homologene: 68151
Il23r
Name: interleukin 23 receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 209590
Homologene: 16930
Atp2c2
Name: ATPase, Ca++ transporting, type 2C, member 2
Synonyms: 1810010G06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69047
Homologene: 73463
Gm19410
Name: predicted gene, 19410
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100502846
Homologene: 132117
Nlrp4b
Name: NLR family, pyrin domain containing 4B
Synonyms: Nalp-gamma, Nalp4b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210045
Homologene: 65242
Gpat2
Name: glycerol-3-phosphate acyltransferase 2, mitochondrial
Synonyms: Gpat2, A530057A03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215456
Homologene: 19037
L3mbtl4
Name: L3MBTL4 histone methyl-lysine binding protein
Synonyms: D930040M24Rik, A730037L19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320858
Homologene: 114383
Ksr1
Name: kinase suppressor of ras 1
Synonyms: B-KSR1, D11Bhm183e, D11Bhm184e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16706
HGNC: HGNC:6465
Homologene: 8410
Cpb1
Name: carboxypeptidase B1
Synonyms: 1810063F02Rik, 0910001A18Rik, 2210008M23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76703
HGNC: HGNC:2299
Homologene: 68127
Trim50
Name: tripartite motif-containing 50
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 215061
Homologene: 14548
Scai
Name: suppressor of cancer cell invasion
Synonyms: A930041I02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320271
Homologene: 15523
Cntn5
Name: contactin 5
Synonyms: NB-2, 6720426O10Rik, A830025P08Rik, LOC244683
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244682
HGNC: HGNC:2175
Homologene: 28447
Clip1
Name: CAP-GLY domain containing linker protein 1
Synonyms: Clip 170, Clip50, CLIP-170, 4631429H07Rik, cytoplasmic linker protein 50, Rsn, restin, 1110007I12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56430
Homologene: 74455
Rnf31
Name: ring finger protein 31
Synonyms: HOIP, Paul
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268749
Homologene: 33228
Sdr39u1
Name: short chain dehydrogenase/reductase family 39U, member 1
Synonyms: 2310014G06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 654795
VEGA: 14
Homologene: 69295
Fndc1
Name: fibronectin type III domain containing 1
Synonyms: 1110027O12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68655
Vmn2r109
Name: vomeronasal 2, receptor 109
Synonyms: EG627814
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627814
Homologene: 129678
Ndufaf7
Name: NADH:ubiquinone oxidoreductase complex assembly factor 7
Synonyms: 2410091C18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73694
VEGA: 17
Homologene: 12508
Duxf1
Name: double homeobox family member 1
Synonyms: AW822073
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100504180
Homologene: 134545
Or4c11c
Name: olfactory receptor family 4 subfamily C member 11C
Synonyms: MOR230-3, Olfr1205, Olfr1203, MOR230-1, GA_x6K02T2Q125-50304328-50305251, GA_x6K02T2Q125-50336588-50337313
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258898
Homologene: 81567
Tedc1
Name: tubulin epsilon and delta complex 1
Synonyms: 4930427A07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104732
Homologene: 77129
Cyp4a14
Name: cytochrome P450, family 4, subfamily a, polypeptide 14
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13119
Homologene: 134697
Dcstamp
Name: dendrocyte expressed seven transmembrane protein
Synonyms: Tm7sf4, DC-STAMP, 4833414I07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75766
VEGA: 15
Homologene: 12769
Pet100
Name: PET100 homolog
Synonyms: 2900053A13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100503890
Homologene: 87502
Jph2
Name: junctophilin 2
Synonyms: JP-2, 1110002E14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 59091
Homologene: 10714
Myadml2
Name: myeloid-associated differentiation marker-like 2
Synonyms: 1110012N22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68515
Homologene: 19528
Ffar2
Name: free fatty acid receptor 2
Synonyms: Gpr43
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233079
HGNC: HGNC:4501
Homologene: 133911
Trarg1
Name: trafficking regulator of GLUT4 (SLC2A4) 1
Synonyms: LOST1, C130069F04Rik, Tusc5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237858
Homologene: 65330
Zscan4-ps1
Name: zinc finger and SCAN domain containing 4, pseudogene 1
Synonyms: EG545912
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545912
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 2 at 39,102,328 bp
  • C to T, chromosome 2 at 88,831,269 bp
  • A to T, chromosome 2 at 112,632,185 bp
  • G to C, chromosome 2 at 127,431,918 bp
  • T to A, chromosome 2 at 129,036,811 bp
  • A to G, chromosome 2 at 130,979,969 bp
  • C to T, chromosome 2 at 163,339,712 bp
  • A to C, chromosome 3 at 20,275,584 bp
  • A to G, chromosome 4 at 46,150,703 bp
  • T to C, chromosome 4 at 62,324,192 bp
  • A to G, chromosome 4 at 115,496,083 bp
  • A to T, chromosome 4 at 119,573,748 bp
  • C to A, chromosome 4 at 129,742,097 bp
  • A to T, chromosome 4 at 150,248,552 bp
  • A to G, chromosome 5 at 3,693,855 bp
  • A to G, chromosome 5 at 123,603,654 bp
  • T to C, chromosome 5 at 129,903,369 bp
  • A to G, chromosome 5 at 135,353,600 bp
  • A to G, chromosome 6 at 25,778,870 bp
  • A to T, chromosome 6 at 67,423,652 bp
  • T to A, chromosome 6 at 84,008,963 bp
  • A to T, chromosome 6 at 142,242,180 bp
  • A to T, chromosome 6 at 148,816,497 bp
  • A to T, chromosome 7 at 10,715,412 bp
  • C to T, chromosome 7 at 11,068,491 bp
  • C to T, chromosome 7 at 30,819,546 bp
  • A to T, chromosome 7 at 68,201,250 bp
  • ATGGCG to ATGGCGACGGTGGCG, chromosome 7 at 97,579,904 bp
  • CG to CGACGGCGGTG, chromosome 7 at 97,579,908 bp
  • A to T, chromosome 7 at 135,696,321 bp
  • T to C, chromosome 8 at 3,622,370 bp
  • T to A, chromosome 8 at 35,803,582 bp
  • C to A, chromosome 8 at 95,248,980 bp
  • A to G, chromosome 8 at 119,726,354 bp
  • A to T, chromosome 9 at 9,743,652 bp
  • A to G, chromosome 9 at 42,343,755 bp
  • A to G, chromosome 9 at 123,454,760 bp
  • A to G, chromosome 10 at 12,744,083 bp
  • T to C, chromosome 10 at 58,223,672 bp
  • T to C, chromosome 11 at 69,991,804 bp
  • T to C, chromosome 11 at 76,680,529 bp
  • C to T, chromosome 11 at 79,036,494 bp
  • C to A, chromosome 11 at 120,647,712 bp
  • A to G, chromosome 12 at 85,268,497 bp
  • G to T, chromosome 12 at 113,161,355 bp
  • A to G, chromosome 14 at 55,595,527 bp
  • A to C, chromosome 14 at 55,897,709 bp
  • A to T, chromosome 14 at 75,050,195 bp
  • A to T, chromosome 15 at 39,754,921 bp
  • A to G, chromosome 15 at 55,557,620 bp
  • A to G, chromosome 15 at 75,839,455 bp
  • A to T, chromosome 15 at 102,430,883 bp
  • A to G, chromosome 16 at 30,574,568 bp
  • G to T, chromosome 16 at 43,821,307 bp
  • A to G, chromosome 17 at 7,769,735 bp
  • A to G, chromosome 17 at 14,199,188 bp
  • A to C, chromosome 17 at 20,564,534 bp
  • A to T, chromosome 17 at 56,418,935 bp
  • A to G, chromosome 17 at 56,621,961 bp
  • G to T, chromosome 17 at 68,777,923 bp
  • A to T, chromosome 17 at 78,943,310 bp
  • A to T, chromosome 18 at 6,212,562 bp
  • T to A, chromosome 18 at 77,380,432 bp
  • G to T, chromosome 19 at 44,299,759 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6377 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044527-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.