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Strain Name:
C57BL/6J-MtgxR6382Btlr/Mmmh
Stock Number:
044531-MU
Citation ID:
RRID:MMRRC_044531-MU
Other Names:
R6382 (G1)
Major Collection:

Strain Information

Notch2
Name: notch 2
Synonyms: Motch B, N2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18129
HGNC: HGNC:7882
Homologene: 7865
Unc93b1
Name: unc-93 homolog B1, TLR signaling regulator
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54445
Homologene: 41325
Hsp90aa1
Name: heat shock protein 90, alpha (cytosolic), class A member 1
Synonyms: hsp4, Hsp90, Hsp86-1, Hsp89, Hspca
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 15519
HGNC: HGNC:5253
Homologene: 68464
Ufc1
Name: ubiquitin-fold modifier conjugating enzyme 1
Synonyms: ESTM29, 1110021H02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66155
Homologene: 9500
Pard3
Name: par-3 family cell polarity regulator
Synonyms: ASIP, D8Ertd580e, PAR-3, Par3, Pard3a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 93742
Homologene: 10489
Mdm2
Name: transformed mouse 3T3 cell double minute 2
Synonyms: Mdm-2, 1700007J15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17246
HGNC: HGNC:6973
Homologene: 1793
Rps15
Name: ribosomal protein S15
Synonyms: rat insulinoma gene, rig, insulinoma
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20054
Homologene: 110643
Cspp1
Name: centrosome and spindle pole associated protein 1
Synonyms: 4930413O22Rik, 2310020J12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211660
Homologene: 23487
Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Synonyms: cytochrome P450 subfamily I, polypeptide 1, P450-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13076
VEGA: 9
HGNC: HGNC:2595
Homologene: 68062
Ripor2
Name: RHO family interacting cell polarization regulator 2
Synonyms: 1700108N18Rik, E430013J17Rik, 6330500D04Rik, Fam65b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 193385
Homologene: 9284
Pfkl
Name: phosphofructokinase, liver, B-type
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18641
HGNC: HGNC:8876
Homologene: 55668
Dag1
Name: dystroglycan 1
Synonyms: dystrophin associated glycoprotein 1, DG, D9Wsu13e, alpha-dystroglycan, beta-dystroglycan
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13138
HGNC: HGNC:2666
Homologene: 3234
Ubr2
Name: ubiquitin protein ligase E3 component n-recognin 2
Synonyms: 9930021A08Rik, E130209G04Rik, ENSMUSG00000043296
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224826
VEGA: 17
Homologene: 26151
Lrrc40
Name: leucine rich repeat containing 40
Synonyms: 2610040E16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67144
Homologene: 9825
Pgs1
Name: phosphatidylglycerophosphate synthase 1
Synonyms: 2610019F11Rik, 4933424M23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74451
Homologene: 5467
Zfp933
Name: zinc finger protein 933
Synonyms: 2810408P10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242747
Homologene: 138474
Clstn1
Name: calsyntenin 1
Synonyms: calsyntenin-1, Cst-1, 1810034E21Rik, alcadein alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 65945
Homologene: 8814
Pja2
Name: praja ring finger ubiquitin ligase 2
Synonyms: Neurodap1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224938
Homologene: 32233
Tpcn2
Name: two pore segment channel 2
Synonyms: D830047E22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233979
Homologene: 16375
Zfc3h1
Name: zinc finger, C3H1-type containing
Synonyms: Psrc2, Ccdc131
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216345
Homologene: 17017
H2-T23
Name: histocompatibility 2, T region locus 23
Synonyms: H-2T23, T18c(37), T18c, 37c, 37b, T23d, T23b, Qed-1, Qa1, Qa-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15040
HGNC: HGNC:4962
Homologene: 134018
Sppl2a
Name: signal peptide peptidase like 2A
Synonyms: C130089K23Rik, 2010106G01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66552
Homologene: 36411
Camta2
Name: calmodulin binding transcription activator 2
Synonyms: Kiaa0909-hp
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216874
Homologene: 9021
Pik3c2g
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18705
HGNC: HGNC:8973
Homologene: 3362
Ush2a
Name: usherin
Synonyms: MUSH2A, A930011D15Rik, LOC381317, LOC269160, A930037M10Rik, Ushrn, Ush2a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Col7a1
Name: collagen, type VII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12836
HGNC: HGNC:2214
Homologene: 73
Vmn1r76
Name: vomeronasal 1 receptor 76
Synonyms: V1rg4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171239
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Jakmip2
Name: janus kinase and microtubule interacting protein 2
Synonyms: 6430702L21Rik, D930046L20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 76217
VEGA: 18
Homologene: 8866
Snx25
Name: sorting nexin 25
Synonyms: LOC382008, SBBI31
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102141
Homologene: 23744
Gpat2
Name: glycerol-3-phosphate acyltransferase 2, mitochondrial
Synonyms: Gpat2, A530057A03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215456
Homologene: 19037
Shkbp1
Name: Sh3kbp1 binding protein 1
Synonyms: SB1, B930062H15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 192192
Homologene: 26700
Tektl1
Name: tektin like 1
Synonyms: 4931413A09Rik, Ccdc105
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70976
VEGA: 10
Homologene: 18299
Ccdc30
Name: coiled-coil domain containing 30
Synonyms: 1700111D19Rik, 4930445I03Rik, 1700001O02Rik, 1700041C02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73332
Homologene: 137391
Hpse2
Name: heparanase 2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 545291
VEGA: 19
Homologene: 19680
Hnf4a
Name: hepatic nuclear factor 4, alpha
Synonyms: HNF-4, Nr2a1, Nuclear receptor 2A1, HNF4 alpha, Tcf14, MODY1, Tcf4, Hnf4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15378
HGNC: HGNC:5024
Homologene: 395
Hsd17b6
Name: hydroxysteroid (17-beta) dehydrogenase 6
Synonyms: Rdh8, 17betaHSD9, Hsd17b9
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 27400
VEGA: 10
Homologene: 20811
Cuta
Name: cutA divalent cation tolerance homolog
Synonyms: 1810060C03Rik, 1810022E02Rik, 2700094G22Rik, 0610039D01Rik, CutA
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67675
VEGA: 17
Homologene: 9305
Txk
Name: TXK tyrosine kinase
Synonyms: Rlk, Btkl, PTK4, A130089B16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22165
Homologene: 2497
Cnot6l
Name: CCR4-NOT transcription complex, subunit 6-like
Synonyms: 4932442K20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231464
Homologene: 100830
Ifit1bl1
Name: interferon induced protein with tetratricpeptide repeats 1B like 1
Synonyms: Gm14446
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 667373
Homologene: 78213
Or2a14
Name: olfactory receptor family 2 subfamily A member 14
Synonyms: GA_x6K02T2P3E9-4404793-4403861, GA_x6K02T08UK8-1-481, MOR261-4, Olfr438, Olfr237-ps1, Olfr237
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258648
Homologene: 88438
Vmn1r32
Name: vomeronasal 1 receptor 32
Synonyms: V1rc15
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171188
Homologene: 115644
Mpp1
Name: membrane protein, palmitoylated
Synonyms: 55kDa, C130070C03Rik, erythrocyte protein p55, p55
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 17524
HGNC: HGNC:7219
Homologene: 1826
Ftdc1
Name: ferritin domain containing 1
Synonyms: LOC328695, LOC385656, Gm813
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 328695
VEGA: 16
Or7a35
Name: olfactory receptor family 7 subfamily A member 35
Synonyms: GA_x6K02T2QGN0-2794907-2793948, MOR139-4, Olfr1351
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 259042
Homologene: 133668
Slc23a4
Name: solute carrier family 23 member 4
Synonyms: LOC243753, 2010107G12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243753
Homologene: 134124
Abat
Name: 4-aminobutyrate aminotransferase
Synonyms: 9630038C02Rik, GABA-T
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268860
HGNC: HGNC:23
Homologene: 542
Igkv10-95
Name: immunoglobulin kappa variable 10-95
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 434031
Aldoc
Name: aldolase C, fructose-bisphosphate
Synonyms: Aldolase C, zebrin II, Aldo3, Scrg2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11676
HGNC: HGNC:418
Homologene: 21073
Igkv6-17
Name: immunoglobulin kappa variable 6-17
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 667865
HGNC: HGNC:5834
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 10,083,475 bp
  • C to T, chromosome 1 at 51,774,307 bp
  • A to G, chromosome 1 at 171,294,675 bp
  • A to G, chromosome 1 at 188,814,302 bp
  • A to T, chromosome 2 at 126,917,029 bp
  • G to C, chromosome 2 at 127,431,918 bp
  • A to T, chromosome 2 at 163,569,006 bp
  • A to G, chromosome 3 at 98,141,543 bp
  • A to G, chromosome 3 at 158,058,696 bp
  • T to C, chromosome 4 at 119,404,166 bp
  • T to C, chromosome 4 at 147,825,868 bp
  • A to T, chromosome 4 at 149,626,120 bp
  • C to T, chromosome 5 at 72,736,480 bp
  • C to A, chromosome 5 at 96,128,999 bp
  • T to A, chromosome 6 at 34,957,043 bp
  • T to A, chromosome 6 at 43,153,965 bp
  • T to A, chromosome 6 at 47,502,439 bp
  • A to G, chromosome 6 at 66,553,361 bp
  • A to G, chromosome 6 at 68,680,688 bp
  • C to T, chromosome 6 at 70,371,830 bp
  • A to G, chromosome 6 at 139,719,998 bp
  • A to G, chromosome 7 at 11,930,499 bp
  • C to A, chromosome 7 at 27,352,059 bp
  • A to G, chromosome 7 at 145,269,749 bp
  • T to A, chromosome 8 at 46,055,991 bp
  • T to A, chromosome 8 at 104,621,543 bp
  • T to A, chromosome 8 at 127,376,783 bp
  • T to A, chromosome 9 at 57,700,690 bp
  • C to A, chromosome 9 at 108,208,137 bp
  • G to A, chromosome 9 at 108,975,393 bp
  • T to C, chromosome 10 at 77,999,837 bp
  • G to A, chromosome 10 at 78,752,841 bp
  • C to A, chromosome 10 at 79,017,517 bp
  • A to G, chromosome 10 at 80,293,986 bp
  • A to G, chromosome 10 at 115,407,908 bp
  • A to G, chromosome 10 at 117,692,721 bp
  • A to T, chromosome 10 at 127,991,327 bp
  • C to T, chromosome 11 at 58,999,413 bp
  • A to T, chromosome 11 at 59,042,208 bp
  • T to C, chromosome 11 at 70,672,041 bp
  • T to C, chromosome 11 at 78,325,742 bp
  • T to C, chromosome 11 at 118,003,360 bp
  • A to T, chromosome 12 at 110,695,517 bp
  • T to C, chromosome 13 at 24,677,845 bp
  • T to A, chromosome 16 at 8,600,986 bp
  • T to C, chromosome 16 at 58,613,910 bp
  • T to C, chromosome 17 at 26,938,454 bp
  • T to C, chromosome 17 at 36,031,832 bp
  • C to G, chromosome 17 at 46,957,315 bp
  • A to G, chromosome 17 at 64,309,615 bp
  • G to A, chromosome 17 at 71,459,243 bp
  • A to G, chromosome 18 at 43,571,179 bp
  • C to A, chromosome 19 at 3,935,297 bp
  • T to A, chromosome 19 at 34,594,883 bp
  • A to G, chromosome 19 at 43,388,202 bp
  • TGAGACGAACTCTCCGAG to TGAG, chromosome X at 75,125,769 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6382 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044531-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.