Strain Name:
C57BL/6J-MtgxR6392Btlr/Mmmh
Stock Number:
044541-MU
Citation ID:
RRID:MMRRC_044541-MU
Other Names:
R6392 (G1)
Major Collection:

Strain Information

Matr3
Name: matrin 3
Synonyms: 2810017I02Rik, D030046F20Rik, 1110061A14Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17184
HGNC: HGNC:6912
Homologene: 7830
Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: 2610103K11Rik, D230017O13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268281
Homologene: 6489
Ctcf
Name: CCCTC-binding factor
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13018
Homologene: 4786
Helz
Name: helicase with zinc finger domain
Synonyms: 9430093I07Rik, 3110078M01Rik, 9630002H22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78455
Homologene: 8918
Nup205
Name: nucleoporin 205
Synonyms: 3830404O05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70699
Homologene: 45971
Arid2
Name: AT-rich interaction domain 2
Synonyms: zipzap/p200, 1700124K17Rik, 4432409D24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 77044
Homologene: 14601
Ezh1
Name: enhancer of zeste 1 polycomb repressive complex 2 subunit
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14055
HGNC: HGNC:3526
Homologene: 20458
Tnfrsf21
Name: tumor necrosis factor receptor superfamily, member 21
Synonyms: TR7, Death receptor 6, DR6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 94185
VEGA: 17
Homologene: 8696
Cntnap1
Name: contactin associated protein-like 1
Synonyms: NCP1, Caspr, p190, paranodin, Nrxn4, shm
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53321
HGNC: HGNC:8011
Homologene: 2693
Tmem131
Name: transmembrane protein 131
Synonyms: 2610524E03Rik, CC28, Neg, D1Bwg0491e, Rw1, YR-23
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56030
Homologene: 32428
Ncam1
Name: neural cell adhesion molecule 1
Synonyms: NCAM-140, NCAM-180, CD56, NCAM-1, E-NCAM, NCAM-120, NCAM
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17967
HGNC: HGNC:7656
Homologene: 40754
Fbf1
Name: Fas binding factor 1
Synonyms: 1110033G01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217335
Homologene: 16531
Kif7
Name: kinesin family member 7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16576
Homologene: 72555
Zfp87
Name: zinc finger protein 87
Synonyms: Zfp72, 4631412O18Rik, 2210039O17Rik, Mzf22, KRAB4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 170763
Zfc3h1
Name: zinc finger, C3H1-type containing
Synonyms: Ccdc131, Psrc2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216345
Homologene: 17017
Ptpn4
Name: protein tyrosine phosphatase, non-receptor type 4
Synonyms: hPTP-MEG, PTPMEG, testis-enriched phosphatase, TEP, protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte), TEP/mPTPMEG
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19258
HGNC: HGNC:9656
Homologene: 2120
AI467606
Name: expressed sequence AI467606
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101602
Homologene: 18492
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Cutc
Name: cutC copper transporter
Synonyms: CGI-32, 2310039I18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66388
Homologene: 9318
Dhx36
Name: DEAH-box helicase 36
Synonyms: 2810407E23Rik, RHAU, Ddx36
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72162
Homologene: 6356
Lrp12
Name: low density lipoprotein-related protein 12
Synonyms: C820005L12Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239393
Homologene: 8385
Ada
Name: adenosine deaminase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11486
HGNC: HGNC:186
Homologene: 37249
Abcc9
Name: ATP-binding cassette, sub-family C member 9
Synonyms: Sur2, SUR2A, SUR2B
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20928
HGNC: HGNC:60
Homologene: 56521
Adam34l
Name: a disintegrin and metallopeptidase domain 34 like
Synonyms: Gm5346
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384813
Homologene: 78104
Unc13a
Name: unc-13 homolog A
Synonyms: Munc13-1, 2410078G03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382018
Homologene: 11279
Smc1b
Name: structural maintenance of chromosomes 1B
Synonyms: Smc1l2, SMC1beta
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 140557
VEGA: 15
Homologene: 13786
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330267
Homologene: 46582
Sh3pxd2b
Name: SH3 and PX domains 2B
Synonyms: Fad49, Tks4, G431001E03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268396
Homologene: 27952
Disp2
Name: dispatched RND transporter family member 2
Synonyms: DispB, B230210L08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214240
Homologene: 24916
Esm1
Name: endothelial cell-specific molecule 1
Synonyms: 0610042H23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 71690
HGNC: HGNC:3466
Homologene: 5107
Extl1
Name: exostosin-like glycosyltransferase 1
Synonyms: D430033M16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56219
HGNC: HGNC:3515
Homologene: 3277
Ccdc78
Name: coiled-coil domain containing 78
Synonyms: LOC381077, LOC381146
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381077
VEGA: 17
Homologene: 105408
Adra1d
Name: adrenergic receptor, alpha 1d
Synonyms: Adra-1, alpha1D-AR, Adra1a, Gpcr8, Adra1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11550
HGNC: HGNC:280
Homologene: 551
Aars2
Name: alanyl-tRNA synthetase 2, mitochondrial
Synonyms: Aarsl
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224805
VEGA: 17
Homologene: 56897
Or4a66
Name: olfactory receptor family 4 subfamily A member 66
Synonyms: GA_x6K02T2Q125-50181139-50180195, Olfr1196, MOR225-5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258456
Homologene: 123770
Sidt1
Name: SID1 transmembrane family, member 1
Synonyms: B830021E24Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320007
Homologene: 41189
Fbxl12
Name: F-box and leucine-rich repeat protein 12
Synonyms: 3110048D16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 30843
Homologene: 32198
Ikbke
Name: inhibitor of kappaB kinase epsilon
Synonyms: IKKepsilon, IKK-i
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56489
Homologene: 23168
Ssh3
Name: slingshot protein phosphatase 3
Synonyms: SSH-3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 245857
VEGA: 19
Homologene: 32372
Vmn2r106
Name: vomeronasal 2, receptor 106
Synonyms: EG224576
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224576
Homologene: 135824
Prss3b
Name: serine protease 3B
Synonyms: cationic trypsinogen (isoform T7), T7, 2210010C04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67373
Homologene: 134055
Sh3rf3
Name: SH3 domain containing ring finger 3
Synonyms: 4831416G18Rik, Sh3md4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237353
Homologene: 77551
Rnf144a
Name: ring finger protein 144A
Synonyms: UIP4, Rnf144
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 108089
VEGA: 12
Homologene: 40982
Pira2
Name: paired-Ig-like receptor A2
Synonyms: 6M23
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18725
Homologene: 134028
Ubash3b
Name: ubiquitin associated and SH3 domain containing, B
Synonyms: TULA-2, Sts-1, 2810457I06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72828
Homologene: 13152
Fbxo6
Name: F-box protein 6
Synonyms: Fbs2, FBG2, Fbxo6b, Fbx6b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50762
Homologene: 9274
Kbtbd13
Name: kelch repeat and BTB (POZ) domain containing 13
Synonyms: 5430433E21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74492
Homologene: 19285
Tagap
Name: T cell activation Rho GTPase activating protein
Synonyms: tcs1, Tcd-1, Tcd1a, tcs-1, Tcd1, TRD
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72536
Homologene: 44943
Or52a33
Name: olfactory receptor family 52 subfamily A member 33
Synonyms: MOR26-1, GA_x6K02T2PBJ9-6362863-6361910, Olfr622
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259087
Homologene: 100540
Tango2
Name: transport and golgi organization 2
Synonyms: D16H22S680E, T10
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 27883
Homologene: 44029
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 36,881,342 bp
  • T to A, chromosome 1 at 119,773,123 bp
  • T to C, chromosome 1 at 131,275,146 bp
  • A to T, chromosome 2 at 76,900,143 bp
  • A to T, chromosome 2 at 88,700,667 bp
  • T to C, chromosome 2 at 118,790,749 bp
  • T to C, chromosome 2 at 131,561,609 bp
  • A to G, chromosome 2 at 163,728,217 bp
  • T to C, chromosome 3 at 62,494,369 bp
  • C to T, chromosome 4 at 134,364,634 bp
  • C to T, chromosome 4 at 148,146,005 bp
  • T to C, chromosome 6 at 12,468,929 bp
  • T to C, chromosome 6 at 35,189,885 bp
  • T to C, chromosome 6 at 41,032,372 bp
  • A to G, chromosome 6 at 142,682,099 bp
  • A to T, chromosome 7 at 3,843,902 bp
  • G to A, chromosome 7 at 79,702,186 bp
  • A to C, chromosome 7 at 103,639,682 bp
  • C to A, chromosome 7 at 127,092,545 bp
  • A to T, chromosome 8 at 43,626,001 bp
  • C to T, chromosome 8 at 71,637,809 bp
  • T to C, chromosome 8 at 105,664,133 bp
  • T to C, chromosome 9 at 20,639,176 bp
  • T to C, chromosome 9 at 41,014,972 bp
  • T to C, chromosome 9 at 49,523,575 bp
  • A to G, chromosome 9 at 65,390,337 bp
  • T to A, chromosome 10 at 11,178,741 bp
  • A to T, chromosome 10 at 59,007,076 bp
  • A to T, chromosome 10 at 115,401,748 bp
  • T to A, chromosome 11 at 32,423,302 bp
  • G to T, chromosome 11 at 101,186,646 bp
  • G to T, chromosome 11 at 101,203,804 bp
  • G to T, chromosome 11 at 107,602,341 bp
  • T to A, chromosome 11 at 116,152,949 bp
  • T to C, chromosome 12 at 26,310,780 bp
  • C to T, chromosome 13 at 67,516,867 bp
  • G to A, chromosome 13 at 113,209,749 bp
  • C to T, chromosome 15 at 39,872,019 bp
  • C to T, chromosome 15 at 85,092,031 bp
  • A to G, chromosome 15 at 96,361,602 bp
  • T to A, chromosome 16 at 18,301,539 bp
  • T to C, chromosome 16 at 44,291,294 bp
  • G to T, chromosome 17 at 7,934,061 bp
  • C to T, chromosome 17 at 20,268,463 bp
  • C to G, chromosome 17 at 25,788,174 bp
  • T to C, chromosome 17 at 43,017,088 bp
  • A to T, chromosome 17 at 45,514,600 bp
  • A to G, chromosome 18 at 35,584,841 bp
  • C to T, chromosome 19 at 4,265,371 bp
  • T to C, chromosome 19 at 43,760,050 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6392 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044541-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.