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Strain Name:
C57BL/6J-MtgxR6392Btlr/Mmmh
Stock Number:
044541-MU
Citation ID:
RRID:MMRRC_044541-MU
Other Names:
R6392 (G1)
Major Collection:

Strain Information

Matr3
Name: matrin 3
Synonyms: D030046F20Rik, 2810017I02Rik, 1110061A14Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17184
HGNC: HGNC:6912
Homologene: 7830
Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: 2610103K11Rik, D230017O13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268281
Homologene: 6489
Ctcf
Name: CCCTC-binding factor
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13018
Homologene: 4786
Helz
Name: helicase with zinc finger domain
Synonyms: 9630002H22Rik, 9430093I07Rik, 3110078M01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78455
Homologene: 8918
Nup205
Name: nucleoporin 205
Synonyms: 3830404O05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70699
Homologene: 45971
Arid2
Name: AT-rich interaction domain 2
Synonyms: 4432409D24Rik, zipzap/p200, 1700124K17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 77044
Homologene: 14601
Ezh1
Name: enhancer of zeste 1 polycomb repressive complex 2 subunit
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14055
HGNC: HGNC:3526
Homologene: 20458
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 36,881,342 bp
  • T to A, chromosome 1 at 119,773,123 bp
  • T to C, chromosome 1 at 131,275,146 bp
  • A to T, chromosome 2 at 76,900,143 bp
  • A to T, chromosome 2 at 88,700,667 bp
  • T to C, chromosome 2 at 118,790,749 bp
  • T to C, chromosome 2 at 131,561,609 bp
  • A to G, chromosome 2 at 163,728,217 bp
  • T to C, chromosome 3 at 62,494,369 bp
  • C to T, chromosome 4 at 134,364,634 bp
  • C to T, chromosome 4 at 148,146,005 bp
  • T to C, chromosome 6 at 12,468,929 bp
  • T to C, chromosome 6 at 35,189,885 bp
  • T to C, chromosome 6 at 41,032,372 bp
  • A to G, chromosome 6 at 142,682,099 bp
  • A to T, chromosome 7 at 3,843,902 bp
  • G to A, chromosome 7 at 79,702,186 bp
  • A to C, chromosome 7 at 103,639,682 bp
  • C to A, chromosome 7 at 127,092,545 bp
  • A to T, chromosome 8 at 43,626,001 bp
  • C to T, chromosome 8 at 71,637,809 bp
  • T to C, chromosome 8 at 105,664,133 bp
  • T to C, chromosome 9 at 20,639,176 bp
  • T to C, chromosome 9 at 41,014,972 bp
  • T to C, chromosome 9 at 49,523,575 bp
  • A to G, chromosome 9 at 65,390,337 bp
  • T to A, chromosome 10 at 11,178,741 bp
  • A to T, chromosome 10 at 59,007,076 bp
  • A to T, chromosome 10 at 115,401,748 bp
  • T to A, chromosome 11 at 32,423,302 bp
  • G to T, chromosome 11 at 101,186,646 bp
  • G to T, chromosome 11 at 101,203,804 bp
  • G to T, chromosome 11 at 107,602,341 bp
  • T to A, chromosome 11 at 116,152,949 bp
  • T to C, chromosome 12 at 26,310,780 bp
  • C to T, chromosome 13 at 67,516,867 bp
  • G to A, chromosome 13 at 113,209,749 bp
  • C to T, chromosome 15 at 39,872,019 bp
  • C to T, chromosome 15 at 85,092,031 bp
  • A to G, chromosome 15 at 96,361,602 bp
  • T to A, chromosome 16 at 18,301,539 bp
  • T to C, chromosome 16 at 44,291,294 bp
  • G to T, chromosome 17 at 7,934,061 bp
  • C to T, chromosome 17 at 20,268,463 bp
  • C to G, chromosome 17 at 25,788,174 bp
  • T to C, chromosome 17 at 43,017,088 bp
  • A to T, chromosome 17 at 45,514,600 bp
  • A to G, chromosome 18 at 35,584,841 bp
  • C to T, chromosome 19 at 4,265,371 bp
  • T to C, chromosome 19 at 43,760,050 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6392 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044541-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.