Strain Name:
C57BL/6J-MtgxR6400Btlr/Mmmh
Stock Number:
044547-MU
Citation ID:
RRID:MMRRC_044547-MU
Other Names:
R6400 (G1)
Major Collection:

Strain Information

Cd36
Name: CD36 molecule
Synonyms: Scarb3, FAT, fatty acid translocase
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12491
HGNC: HGNC:1663
Homologene: 73871
Wdr70
Name: WD repeat domain 70
Synonyms: 4833422F06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545085
VEGA: 15
Homologene: 9972
Setx
Name: senataxin
Synonyms: Als4, A930037J23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Lgr4
Name: leucine-rich repeat-containing G protein-coupled receptor 4
Synonyms: A330106J01Rik, A930009A08Rik, Gpr48
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107515
Homologene: 10226
Nbr1
Name: NBR1, autophagy cargo receptor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17966
HGNC: HGNC:6746
Homologene: 7438
Akap8l
Name: A kinase anchor protein 8-like
Synonyms: Nakap95
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 54194
VEGA: 17
Homologene: 8658
Aen
Name: apoptosis enhancing nuclease
Synonyms: Isg20l1, 2700083B06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68048
Homologene: 23382
Map3k1
Name: mitogen-activated protein kinase kinase kinase 1
Synonyms: MEKK1, Mekk
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26401
HGNC: HGNC:6848
Homologene: 8056
Dnajc14
Name: DnaJ heat shock protein family (Hsp40) member C14
Synonyms: DRIP78, LIP6, HDJ3, 5730551F12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74330
VEGA: 10
Homologene: 12553
Cd274
Name: CD274 antigen
Synonyms: Pdcd1lg1, PD-L1, B7-H1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 60533
Homologene: 8560
Clec1a
Name: C-type lectin domain family 1, member a
Synonyms: 5930406N14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243653
Homologene: 9549
Stim1
Name: stromal interaction molecule 1
Synonyms: SIM
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20866
Homologene: 20681
Trmt10b
Name: tRNA methyltransferase 10B
Synonyms: Rg9mtd3, 2610042J10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69934
Homologene: 12340
Med12l
Name: mediator complex subunit 12-like
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329650
Homologene: 43143
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 4833413O10Rik, D430029O09Rik, 1110021D17Rik, Polydom
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64817
Homologene: 23386
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: 9430031G15Rik, LTBP-1, b2b1000Clo, Ltbp1L
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC5, 2300002I04Rik, MUC9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Flg
Name: filaggrin
Synonyms: ft, fillagrin, profilaggrin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14246
VEGA: 3
Abcc9
Name: ATP-binding cassette, sub-family C member 9
Synonyms: SUR2A, Sur2, SUR2B
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20928
HGNC: HGNC:60
Homologene: 56521
Cog2
Name: component of oligomeric golgi complex 2
Synonyms: 1190002B08Rik, 2700012E02Rik, Cog2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76332
HGNC: HGNC:6546
Homologene: 7206
Kcnh7
Name: potassium voltage-gated channel, subfamily H (eag-related), member 7
Synonyms: Kv11.3, erg3, 9330137I11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170738
Homologene: 13249
Cyp2c65
Name: cytochrome P450, family 2, subfamily c, polypeptide 65
Synonyms: 2210009K14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72303
Homologene: 133566
Rasgrf1
Name: RAS protein-specific guanine nucleotide-releasing factor 1
Synonyms: Grfbeta, CDC25, Grf1, CDC25Mm
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19417
HGNC: HGNC:9875
Homologene: 74972
Dytn
Name: dystrotelin
Synonyms: LOC241073
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241073
Homologene: 104042
Or6k2
Name: olfactory receptor family 6 subfamily K member 2
Synonyms: MOR105-10, Olfr420, GA_x6K02T2P20D-20995211-20994246
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258302
Homologene: 17185
Celf3
Name: CUGBP, Elav-like family member 3
Synonyms: BRUNOL1, Tnrc4, ERDA4, CAGH4, 4930415M08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 78784
Homologene: 48510
Heatr4
Name: HEAT repeat containing 4
Synonyms: Gm17673
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 101055670
Homologene: 45728
Cbx8
Name: chromobox 8
Synonyms: polycomb 3, Pc3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 30951
Homologene: 32199
Or4x11
Name: olfactory receptor family 4 subfamily X member 11
Synonyms: MOR228-2, Olfr1265, GA_x6K02T2Q125-51469027-51469956
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258340
Homologene: 133727
Tcte2
Name: t-complex-associated testis expressed 2
Synonyms: Tcte-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21646
Hoxb1
Name: homeobox B1
Synonyms: Hox-2.9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15407
HGNC: HGNC:5111
Homologene: 1615
Nme9
Name: NME/NM23 family member 9
Synonyms: Txndc6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 623534
Homologene: 52255
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 63,641,176 bp
  • T to C, chromosome 1 at 174,159,264 bp
  • A to G, chromosome 2 at 29,130,274 bp
  • T to A, chromosome 2 at 62,739,344 bp
  • C to T, chromosome 2 at 90,037,395 bp
  • T to C, chromosome 2 at 109,991,133 bp
  • T to C, chromosome 3 at 59,247,911 bp
  • A to G, chromosome 3 at 93,279,921 bp
  • A to G, chromosome 3 at 94,480,286 bp
  • A to G, chromosome 4 at 45,308,562 bp
  • C to A, chromosome 4 at 58,049,169 bp
  • A to C, chromosome 5 at 17,814,723 bp
  • A to T, chromosome 6 at 129,435,353 bp
  • A to G, chromosome 6 at 142,692,709 bp
  • G to A, chromosome 7 at 78,907,394 bp
  • A to G, chromosome 7 at 102,430,950 bp
  • T to C, chromosome 7 at 141,858,665 bp
  • A to T, chromosome 8 at 124,550,306 bp
  • C to T, chromosome 9 at 89,991,630 bp
  • T to C, chromosome 9 at 99,469,707 bp
  • A to G, chromosome 10 at 128,807,490 bp
  • C to T, chromosome 11 at 96,365,992 bp
  • T to C, chromosome 11 at 101,565,774 bp
  • G to A, chromosome 11 at 119,038,868 bp
  • T to A, chromosome 12 at 83,955,010 bp
  • A to T, chromosome 13 at 111,755,725 bp
  • A to T, chromosome 15 at 8,042,841 bp
  • T to A, chromosome 17 at 13,722,452 bp
  • G to A, chromosome 17 at 32,336,320 bp
  • A to G, chromosome 17 at 75,151,402 bp
  • C to T, chromosome 19 at 29,385,408 bp
  • C to T, chromosome 19 at 39,061,114 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6400 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044547-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.