Strain Name:
C57BL/6J-MtgxR6407Btlr/Mmmh
Stock Number:
044552-MU
Citation ID:
RRID:MMRRC_044552-MU
Other Names:
R6407 (G1)
Major Collection:

Strain Information

Sphk2
Name: sphingosine kinase 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56632
Homologene: 32456
Htr3a
Name: 5-hydroxytryptamine (serotonin) receptor 3A
Synonyms: 5-HT3 receptor
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15561
VEGA: 9
HGNC: HGNC:5297
Homologene: 671
Slc17a7
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
Synonyms: Vglut1, 2900052E22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72961
Homologene: 113454
Mrpl39
Name: mitochondrial ribosomal protein L39
Synonyms: MRP-L5, Rpml5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 27393
Homologene: 9679
Rrp12
Name: ribosomal RNA processing 12 homolog
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107094
VEGA: 19
Homologene: 22370
Tut4
Name: terminal uridylyl transferase 4
Synonyms: Tent3a, 6030404K05Rik, 9230115F04Rik, Zcchc11
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230594
Homologene: 35279
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: 9430093H17Rik, Falz
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Gab1
Name: growth factor receptor bound protein 2-associated protein 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14388
HGNC: HGNC:4066
Homologene: 1542
Nhp2
Name: NHP2 ribonucleoprotein
Synonyms: NHP2, H/ACA small nucleolar RNPs, 2410130M07Rik, Nola2, D11Ertd175e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52530
Homologene: 5524
Yap1
Name: yes-associated protein 1
Synonyms: yorkie, Yki, Yap
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22601
Homologene: 4452
Rims2
Name: regulating synaptic membrane exocytosis 2
Synonyms: RIM2, 2810036I15Rik, Syt3-rs
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 116838
VEGA: 15
Homologene: 81639
C1ql2
Name: complement component 1, q subcomponent-like 2
Synonyms: CTRP10
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226359
Homologene: 18792
Zfp74
Name: zinc finger protein 74
Synonyms: Zfp66, KRAB8, 2810054M15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72723
Homologene: 51861
Sult1a1
Name: sulfotransferase family 1A, phenol-preferring, member 1
Synonyms: PST, Stp1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20887
Homologene: 128224
Il36rn
Name: interleukin 36 receptor antagonist
Synonyms: Il1f5, FIL1delta, If36rn, IL1F5, IL-1H3, IL1HY1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54450
Homologene: 10453
Pfkl
Name: phosphofructokinase, liver, B-type
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18641
HGNC: HGNC:8876
Homologene: 55668
Kif22
Name: kinesin family member 22
Synonyms: Kid, Kif22a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 110033
HGNC: HGNC:6391
Homologene: 32011
Lap3
Name: leucine aminopeptidase 3
Synonyms: peptidase S, LAP, Pep-S, Pep-7, Pep7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66988
Homologene: 41072
Slc38a6
Name: solute carrier family 38, member 6
Synonyms: EG625098
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 625098
Homologene: 27550
Sag
Name: S-antigen, retina and pineal gland (arrestin)
Synonyms: A930001K18Rik, arrestin 1, Arr1, rod arrestin, visual arrestin 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20215
Homologene: 455
Mfsd12
Name: major facilitator superfamily domain containing 12
Synonyms: gr, F630110N24Rik, Wdt1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73822
Homologene: 45488
Srgap3
Name: SLIT-ROBO Rho GTPase activating protein 3
Synonyms: D130026O08Rik, Arhgap14
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 259302
Homologene: 56686
Col5a2
Name: collagen, type V, alpha 2
Synonyms: 1110014L14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12832
HGNC: HGNC:2210
Homologene: 20119
Mast3
Name: microtubule associated serine/threonine kinase 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 546071
Homologene: 66191
Ighg2c
Name: immunoglobulin heavy constant gamma 2C
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 404711
Tshz1
Name: teashirt zinc finger family member 1
Synonyms: 5730407I04Rik, D18Bwg1409e, Mtsh1, Tsh1, Sdccag33, NY-CO-33, teashirt1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 110796
Homologene: 4227
Pex3
Name: peroxisomal biogenesis factor 3
Synonyms: 2810027F19Rik, 1700014F15Rik, 2900010N04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 56535
HGNC: HGNC:8858
Homologene: 2691
Alpk2
Name: alpha-kinase 2
Synonyms: Hak
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225638
Homologene: 50475
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Or14a260
Name: olfactory receptor family 14 subfamily A member 260
Synonyms: MOR219-1, GA_x6K02T2NHDJ-9772012-9772953, Olfr307
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258610
Spdye4a
Name: speedy/RINGO cell cycle regulator family, member E4A
Synonyms: 4930445A17Rik, speedy B, speedy/ringo, 4930451F05Rik, Spdyb
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74673
Homologene: 134531
Ighg3
Name: Immunoglobulin heavy constant gamma 3
Synonyms: AI324046, IgG3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380795
Tmem212
Name: transmembrane protein 212
Synonyms: E030011K20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 208613
Homologene: 28471
Tor4a
Name: torsin family 4, member A
Synonyms: A830007P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227612
Homologene: 17140
Mup8
Name: major urinary protein 8
Synonyms: Gm12809
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100041687
Homologene: 74304
Rnf223
Name: ring finger 223
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100045778
Homologene: 27073
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 45,376,778 bp
  • T to C, chromosome 1 at 87,814,806 bp
  • T to C, chromosome 1 at 120,341,611 bp
  • A to G, chromosome 2 at 24,281,353 bp
  • A to G, chromosome 2 at 25,194,940 bp
  • A to G, chromosome 3 at 27,884,839 bp
  • T to A, chromosome 4 at 60,220,394 bp
  • G to T, chromosome 4 at 108,558,782 bp
  • A to T, chromosome 4 at 156,132,359 bp
  • T to A, chromosome 5 at 45,511,925 bp
  • T to C, chromosome 5 at 143,225,699 bp
  • T to C, chromosome 6 at 112,723,006 bp
  • T to C, chromosome 7 at 29,935,623 bp
  • C to T, chromosome 7 at 45,169,926 bp
  • T to C, chromosome 7 at 45,712,600 bp
  • T to C, chromosome 7 at 86,336,069 bp
  • T to C, chromosome 7 at 126,673,184 bp
  • G to A, chromosome 7 at 127,033,203 bp
  • T to C, chromosome 8 at 70,782,128 bp
  • C to A, chromosome 8 at 80,788,597 bp
  • A to G, chromosome 9 at 7,962,372 bp
  • G to T, chromosome 9 at 48,901,055 bp
  • A to T, chromosome 9 at 88,840,414 bp
  • T to C, chromosome 10 at 13,546,368 bp
  • A to G, chromosome 10 at 77,988,673 bp
  • T to C, chromosome 10 at 81,362,233 bp
  • A to G, chromosome 10 at 82,293,811 bp
  • T to C, chromosome 11 at 51,619,903 bp
  • T to A, chromosome 11 at 107,111,126 bp
  • T to C, chromosome 12 at 73,310,175 bp
  • T to C, chromosome 12 at 113,288,651 bp
  • T to C, chromosome 12 at 113,360,150 bp
  • T to C, chromosome 15 at 39,452,328 bp
  • T to C, chromosome 16 at 84,732,385 bp
  • T to C, chromosome 18 at 65,289,738 bp
  • C to A, chromosome 18 at 84,015,966 bp
  • C to T, chromosome 19 at 41,883,742 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6407 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044552-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.