Strain Name:
C57BL/6J-MtgxR6419Btlr/Mmmh
Stock Number:
044561-MU
Citation ID:
RRID:MMRRC_044561-MU
Other Names:
R6419 (G1)
Major Collection:

Strain Information

Adamts20
Name: ADAM metallopeptidase with thrombospondin type 1 motif 20
Synonyms: ADAMTS-20, bt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223838
Homologene: 11808
Notch2
Name: notch 2
Synonyms: Motch B, N2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18129
HGNC: HGNC:7882
Homologene: 7865
Ntrk2
Name: neurotrophic tyrosine kinase, receptor, type 2
Synonyms: Tkrb, C030027L06Rik, trkB
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18212
VEGA: 13
HGNC: HGNC:8032
Homologene: 4504
Cd36
Name: CD36 molecule
Synonyms: FAT, fatty acid translocase, Scarb3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12491
HGNC: HGNC:1663
Homologene: 73871
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461
Ufc1
Name: ubiquitin-fold modifier conjugating enzyme 1
Synonyms: 1110021H02Rik, ESTM29
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66155
Homologene: 9500
Mrpl58
Name: mitochondrial ribosomal protein L58
Synonyms: 1110001A02Rik, 1110002E03Rik, Ict1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68572
HGNC: HGNC:5359
Homologene: 1185
Cenpv
Name: centromere protein V
Synonyms: 3110013H01Rik, Prr6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73139
Homologene: 42965
Lactb2
Name: lactamase, beta 2
Synonyms: E430032H21Rik, Cgi-83
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 212442
Homologene: 9349
Baz1b
Name: bromodomain adjacent to zinc finger domain, 1B
Synonyms: Wbscr9, WSTF
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22385
HGNC: HGNC:961
Homologene: 22651
Dot1l
Name: DOT1 like histone lysine methyltransferase
Synonyms: mDot1, KMT4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 208266
Homologene: 32779
Dstn
Name: destrin
Synonyms: sid23p, ADF, 2610043P17Rik, corn1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56431
Homologene: 21362
Cnot8
Name: CCR4-NOT transcription complex, subunit 8
Synonyms: 1810022F04Rik, 1500015I04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69125
HGNC: HGNC:9207
Homologene: 48304
Knl1
Name: kinetochore scaffold 1
Synonyms: 2310043D08Rik, 5730505K17Rik, Casc5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76464
Homologene: 44890
Med4
Name: mediator complex subunit 4
Synonyms: MED4, DRIP36, Vdrip, 2410046H15Rik, HSPC126, p36 TRAP/SMCC/PC2 subunit, TRAP36
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67381
VEGA: 14
Homologene: 8568
Cog3
Name: component of oligomeric golgi complex 3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 338337
VEGA: 14
Homologene: 5854
Trip12
Name: thyroid hormone receptor interactor 12
Synonyms: 6720416K24Rik, Gtl6, 1110036I07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14897
Homologene: 44226
Polr3b
Name: polymerase (RNA) III (DNA directed) polypeptide B
Synonyms: A330032P03Rik, RPC2, 2700078H01Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70428
VEGA: 10
Homologene: 6981
Tiam1
Name: T cell lymphoma invasion and metastasis 1
Synonyms: D16Ium10, D16Ium10e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 21844
Homologene: 2443
B3galt2
Name: UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26878
HGNC: HGNC:917
Homologene: 74512
Otud6b
Name: OTU domain containing 6B
Synonyms: 2600013N14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72201
Homologene: 6064
Enpp3
Name: ectonucleotide pyrophosphatase/phosphodiesterase 3
Synonyms: CD203c
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 209558
VEGA: 10
HGNC: HGNC:3358
Homologene: 3683
Gcat
Name: glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase)
Synonyms: Kbl, aminoacetone synthase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 26912
VEGA: 15
HGNC: HGNC:4188
Homologene: 8475
Adgrl4
Name: adhesion G protein-coupled receptor L4
Synonyms: EGF-TM7 receptor, Etl, 1110033N21Rik, Eltd1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170757
Homologene: 11170
Adamts12
Name: ADAM metallopeptidase with thrombospondin type 1 motif 12
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239337
VEGA: 15
Homologene: 12808
Cldn18
Name: claudin 18
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56492
HGNC: HGNC:2039
Homologene: 9489
Ntng1
Name: netrin G1
Synonyms: A930010C08Rik, Lmnt1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80883
Homologene: 8949
Ints7
Name: integrator complex subunit 7
Synonyms: 5930412E23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77065
Homologene: 9136
Tmem231
Name: transmembrane protein 231
Synonyms: 4932417I16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234740
Homologene: 78035
Col4a4
Name: collagen, type IV, alpha 4
Synonyms: [a]4(IV), E130010M05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12829
HGNC: HGNC:2206
Homologene: 20071
Wdr19
Name: WD repeat domain 19
Synonyms: Ift144, DYF2, C330027H04Rik, D330023L08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 213081
Homologene: 11842
Tarbp1
Name: TAR RNA binding protein 1
Synonyms: Gm17296
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212728
Homologene: 38082
Vwa3b
Name: von Willebrand factor A domain containing 3B
Synonyms: A230074B11Rik, 4921511C04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70853
Homologene: 27053
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: D12Ertd777e, Cpfl8, dice, 6820443O06Rik, nesprin-2, syne-2, Nesp2g, diminished cone electroretinogram
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Tent4a
Name: terminal nucleotidyltransferase 4A
Synonyms: Pols, TRF4-1, TRF4, Papd7, LAK-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210106
Homologene: 5089
Egfem1
Name: EGF-like and EMI domain containing 1
Synonyms: 6130401L20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 75740
Homologene: 135950
Ccdc125
Name: coiled-coil domain containing 125
Synonyms: 5830436D01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76041
VEGA: 13
Homologene: 27932
Gabra2
Name: gamma-aminobutyric acid type A receptor subunit alpha 2
Synonyms: Gabra-2, C630048P16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14395
HGNC: HGNC:4076
Homologene: 20217
Sema6b
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
Synonyms: VIb, Sema, semaZ, Seman
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20359
VEGA: 17
Homologene: 8428
Impg1
Name: interphotoreceptor matrix proteoglycan 1
Synonyms: IMP150, SPACR, A930015H12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 63859
HGNC: HGNC:6055
Homologene: 1201
Grm3
Name: glutamate receptor, metabotropic 3
Synonyms: mGluR3, 0710001G23Rik, Gprc1c, mGlu3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108069
HGNC: HGNC:4595
Homologene: 651
Ltf
Name: lactotransferrin
Synonyms: lactoferrin, Lf
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17002
HGNC: HGNC:6720
Homologene: 1754
Cdh12
Name: cadherin 12
Synonyms: Br-cadherin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 215654
HGNC: HGNC:1751
Homologene: 37873
Vmn2r77
Name: vomeronasal 2, receptor 77
Synonyms: EG546983
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546983
Homologene: 115466
Ptprn
Name: protein tyrosine phosphatase receptor type N
Synonyms: IA-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19275
HGNC: HGNC:9676
Homologene: 48142
Atosa
Name: atos homolog A
Synonyms: 6330415I01Rik, C130047D21Rik, BC031353, Fam214a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235493
VEGA: 9
Homologene: 35065
Grin2b
Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Synonyms: NMDAR2B, NR2B, Nmdar2b, GluRepsilon2, GluN2B
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14812
HGNC: HGNC:4586
Homologene: 646
Dhh
Name: desert hedgehog
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13363
VEGA: 15
HGNC: HGNC:2865
Homologene: 22431
Gbp7
Name: guanylate binding protein 7
Synonyms: 9830147J24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229900
Homologene: 138296
Vmn2r13
Name: vomeronasal 2, receptor 13
Synonyms: Gm4867
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231589
Homologene: 129606
Rgsl1
Name: regulator of G-protein signaling like 1
Synonyms: Rgsl2, 4930415K13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240816
Homologene: 129962
Abcc2
Name: ATP-binding cassette, sub-family member 2
Synonyms: multidrug resistance protein 2, Mrp2, Cmoat
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12780
HGNC: HGNC:53
Homologene: 68052
Hdgfl1
Name: HDGF like 1
Synonyms: HRP-1, Hdgfrp1, Pwwp1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15192
Homologene: 56406
Or5b116
Name: olfactory receptor family 5 subfamily B member 116
Synonyms: GA_x6K02T2RE5P-3777626-3778570, Olfr1471, MOR202-38, MOR202-47_p
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258231
Homologene: 79417
Slfn8
Name: schlafen 8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276950
Homologene: 45432
Hmgxb3
Name: HMG box domain containing 3
Synonyms: 2510002C16Rik, A630042L21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106894
VEGA: 18
Homologene: 44229
Zfp974
Name: zinc finger protein 974
Synonyms: 1700049G17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73430
Zfp330
Name: zinc finger protein 330
Synonyms: Noa36, NOA 36, nucleolar autoantigen 36
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 30932
Homologene: 8714
Vmn2r86
Name: vomeronasal 2, receptor 86
Synonyms: EG625109
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 625109
Homologene: 129606
Vmn1r199
Name: vomeronasal 1 receptor 199
Synonyms: V1rh4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171247
Homologene: 110880
Asah1
Name: N-acylsphingosine amidohydrolase 1
Synonyms: acid ceramidase, 2310081N20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11886
HGNC: HGNC:735
Homologene: 10504
Zfp493
Name: zinc finger protein 493
Synonyms: 2900054J07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72958
Pcdhb20
Name: protocadherin beta 20
Synonyms: Pcdhb14, PcdhbT
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93891
HGNC: HGNC:8685
Homologene: 134303
Ndufs2
Name: NADH:ubiquinone oxidoreductase core subunit S2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226646
HGNC: HGNC:7708
Homologene: 56659
Cops5
Name: COP9 signalosome subunit 5
Synonyms: Sgn5, JUN activation binding protein, Jab1, COP9 complex S5, CSN5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26754
HGNC: HGNC:2240
Homologene: 55992
Lad1
Name: ladinin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16763
HGNC: HGNC:6472
Homologene: 4059
Wfdc17
Name: WAP four-disulfide core domain 17
Synonyms: Gm11428, Amwap
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100034251
Gm8439
Name: predicted gene 8439
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 667063
VEGA: 4
Igkv4-61
Name: immunoglobulin kappa chain variable 4-61
Synonyms: Gm16895
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 546244
4930578G10Rik
Name: RIKEN cDNA 4930578G10 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 102638670
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 10,033,307 bp
  • A to T, chromosome 1 at 13,638,235 bp
  • T to C, chromosome 1 at 37,157,376 bp
  • G to A, chromosome 1 at 75,264,037 bp
  • A to G, chromosome 1 at 82,466,486 bp
  • C to T, chromosome 1 at 84,793,870 bp
  • T to C, chromosome 1 at 135,831,892 bp
  • A to T, chromosome 1 at 143,647,101 bp
  • C to T, chromosome 1 at 153,822,371 bp
  • T to C, chromosome 1 at 171,241,099 bp
  • C to T, chromosome 1 at 171,288,956 bp
  • T to A, chromosome 1 at 191,602,302 bp
  • T to A, chromosome 2 at 119,069,003 bp
  • T to G, chromosome 2 at 143,939,987 bp
  • G to A, chromosome 3 at 29,657,249 bp
  • G to T, chromosome 3 at 98,100,389 bp
  • A to T, chromosome 3 at 109,782,853 bp
  • G to A, chromosome 3 at 142,546,453 bp
  • A to G, chromosome 3 at 151,439,316 bp
  • A to G, chromosome 4 at 14,822,766 bp
  • T to C, chromosome 4 at 42,812,473 bp
  • A to G, chromosome 4 at 120,609,558 bp
  • A to T, chromosome 4 at 141,476,310 bp
  • T to C, chromosome 5 at 9,570,201 bp
  • C to T, chromosome 5 at 17,797,152 bp
  • A to G, chromosome 5 at 65,215,893 bp
  • A to G, chromosome 5 at 70,962,083 bp
  • A to T, chromosome 5 at 109,175,219 bp
  • T to A, chromosome 5 at 135,242,494 bp
  • C to A, chromosome 6 at 69,417,154 bp
  • A to G, chromosome 6 at 135,740,967 bp
  • A to T, chromosome 7 at 27,911,515 bp
  • A to T, chromosome 7 at 86,811,559 bp
  • A to T, chromosome 8 at 41,343,766 bp
  • T to G, chromosome 8 at 82,764,916 bp
  • G to A, chromosome 8 at 111,926,892 bp
  • C to T, chromosome 8 at 126,459,044 bp
  • G to A, chromosome 9 at 75,009,337 bp
  • A to G, chromosome 9 at 80,380,018 bp
  • T to C, chromosome 9 at 99,692,748 bp
  • T to C, chromosome 9 at 111,031,022 bp
  • A to T, chromosome 10 at 24,808,191 bp
  • T to C, chromosome 10 at 80,791,481 bp
  • T to C, chromosome 10 at 84,638,111 bp
  • T to C, chromosome 10 at 130,446,926 bp
  • T to A, chromosome 11 at 58,114,065 bp
  • T to C, chromosome 11 at 62,525,182 bp
  • A to G, chromosome 11 at 83,004,055 bp
  • G to A, chromosome 11 at 83,704,808 bp
  • A to T, chromosome 11 at 115,410,247 bp
  • T to C, chromosome 12 at 76,096,966 bp
  • A to G, chromosome 13 at 22,383,607 bp
  • G to A, chromosome 13 at 26,770,092 bp
  • G to A, chromosome 13 at 58,861,299 bp
  • A to G, chromosome 13 at 67,786,407 bp
  • A to C, chromosome 13 at 69,510,666 bp
  • T to A, chromosome 13 at 100,690,326 bp
  • A to T, chromosome 14 at 73,513,923 bp
  • A to T, chromosome 14 at 75,724,738 bp
  • C to T, chromosome 15 at 11,215,673 bp
  • T to C, chromosome 15 at 21,520,397 bp
  • T to G, chromosome 15 at 79,036,064 bp
  • C to T, chromosome 15 at 94,333,675 bp
  • A to G, chromosome 15 at 98,894,401 bp
  • C to A, chromosome 16 at 89,898,024 bp
  • A to T, chromosome 17 at 56,132,784 bp
  • A to G, chromosome 18 at 37,505,555 bp
  • G to T, chromosome 18 at 61,152,224 bp
  • T to A, chromosome 19 at 13,445,767 bp
  • T to A, chromosome 19 at 43,837,508 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6419 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044561-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.