Strain Name:
C57BL/6J-MtgxR6427Btlr/Mmmh
Stock Number:
044566-MU
Citation ID:
RRID:MMRRC_044566-MU
Other Names:
R6427 (G1)
Major Collection:

Strain Information

Atn1
Name: atrophin 1
Synonyms: atrophin-1, Atr1, Drpla
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13498
HGNC: HGNC:3033
Homologene: 1461
Serpinb6a
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6a
Synonyms: 4930482L21Rik, D330015H01Rik, Spi3, ovalbumin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20719
HGNC: HGNC:8950
Homologene: 20956
Srsf11
Name: serine and arginine-rich splicing factor 11
Synonyms: Sfrs11, 0610009J05Rik, 2610019N13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69207
Homologene: 36164
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: C030045D06Rik, 6230420N16Rik, Depdc2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109294
Homologene: 23523
Arid1a
Name: AT-rich interaction domain 1A
Synonyms: BAF250a, Osa1, Smarcf1, 1110030E03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 93760
Homologene: 21216
Kat6b
Name: K(lysine) acetyltransferase 6B
Synonyms: Myst4, Morf, monocytic leukemia, qkf, querkopf, B130044K16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 54169
Homologene: 136480
Taf3
Name: TATA-box binding protein associated factor 3
Synonyms: 4933439M23Rik, mTAFII140
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209361
Homologene: 35415
Clasp2
Name: CLIP associating protein 2
Synonyms: 8030404L10Rik, CLASP2gamma, CLASP2beta, CLASP2, 1500004F14Rik, CLASP2alpha
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76499
VEGA: 9
Homologene: 24944
Fkbp15
Name: FK506 binding protein 15
Synonyms: FKBP133, C430014M02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 338355
Homologene: 28743
Nkiras2
Name: NFKB inhibitor interacting Ras-like protein 2
Synonyms: 2410003M04Rik, KBRAS2, 4930527H08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71966
Homologene: 9738
Polr1b
Name: polymerase (RNA) I polypeptide B
Synonyms: RPA116, D630020H17Rik, RPA2, Rpo1-2, 128kDa
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20017
Homologene: 7133
Cpt1a
Name: carnitine palmitoyltransferase 1a, liver
Synonyms: L-CPT I, Cpt1, CPTI
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12894
VEGA: 19
HGNC: HGNC:2328
Homologene: 1413
Lepr
Name: leptin receptor
Synonyms: OB-RGRP, Leprb, leptin receptor gene-related protein, LEPROT, Obr, obl, Modb1, obese-like
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16847
HGNC: HGNC:6554
Homologene: 1731
Anxa2
Name: annexin A2
Synonyms: 36-kDa calelectrin, Cal1h, annexin II, lipocortin II
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12306
Homologene: 20857
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4933421G18Rik, 4921518A06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71175
VEGA: 15
Homologene: 15850
Cab39l
Name: calcium binding protein 39-like
Synonyms: 1500031K13Rik, 2810425O13Rik, 4930520C08Rik, MO2L
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 69008
VEGA: 14
Homologene: 69422
Vps51
Name: VPS51 GARP complex subunit
Synonyms: 3110057M17Rik, 1110014N23Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68505
HGNC: HGNC:1172
Homologene: 34675
Obi1
Name: ORC ubiquitin ligase 1
Synonyms: 2610206B13Rik, Rnf219, 2810449K13Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72486
VEGA: 14
Homologene: 11578
Cngb1
Name: cyclic nucleotide gated channel beta 1
Synonyms: BC016201, Cngb1, Cngb1b
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 333329
HGNC: HGNC:2151
Homologene: 136420
Ddr1
Name: discoidin domain receptor family, member 1
Synonyms: Cak, CD167a
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12305
HGNC: HGNC:2730
Homologene: 68212
Cacna2d2
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 2
Synonyms: a2d2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56808
HGNC: HGNC:1400
Homologene: 4400
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Unc13b
Name: unc-13 homolog B
Synonyms: Munc13-2, Unc13h2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22249
Homologene: 31376
Cyp2j7
Name: cytochrome P450, family 2, subfamily j, polypeptide 7
Synonyms: OTTMUSG00000007941, Cyp2j7-ps
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 546837
HGNC: HGNC:2634
Stxbp5
Name: syntaxin binding protein 5 (tomosyn)
Synonyms: 4930565N16Rik, LGL3, 0710001E20Rik, tomosyn 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 78808
Homologene: 16402
Cfap251
Name: cilia and flagella associated protein 251
Synonyms: 4933428F06Rik, 4930415N18Rik, Wdr66
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269701
Homologene: 16964
Or52b4i
Name: olfactory receptor family 52 subfamily B member 4I
Synonyms: MOR31-13, GA_x6K02T2PBJ9-5263046-5263989, Olfr548
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258229
Zfp735
Name: zinc finger protein 735
Synonyms: 1700012C15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76390
Homologene: 88945
Ankmy2
Name: ankyrin repeat and MYND domain containing 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217473
VEGA: 12
Homologene: 10662
Daam2
Name: dishevelled associated activator of morphogenesis 2
Synonyms: 2310016D11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 76441
VEGA: 17
Homologene: 69186
Zfp759
Name: zinc finger protein 759
Synonyms: Rslcan-8
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 268670
VEGA: 13
Atp8b3
Name: ATPase, class I, type 8B, member 3
Synonyms: 1700056N23Rik, 1700042F02Rik, SAPLT
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67331
VEGA: 10
Homologene: 19034
Fbln5
Name: fibulin 5
Synonyms: EVEC
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 23876
VEGA: 12
HGNC: HGNC:3602
Homologene: 38170
Nlrp4e
Name: NLR family, pyrin domain containing 4E
Synonyms: Nalp4e, 4930406H16Rik, Nalp-epsilon
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 446099
Homologene: 75315
Vmn2r106
Name: vomeronasal 2, receptor 106
Synonyms: EG224576
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224576
Homologene: 135824
Otud4
Name: OTU domain containing 4
Synonyms: D8Ertd69e, 4930431L18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73945
Homologene: 35370
Mro
Name: maestro
Synonyms: 4933435E20Rik, 4930507C04Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71263
Homologene: 41729
Ccnc
Name: cyclin C
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 51813
HGNC: HGNC:1581
Homologene: 3803
Ech1
Name: enoyl coenzyme A hydratase 1, peroxisomal
Synonyms: dienoyl-CoA isomerase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 51798
HGNC: HGNC:3149
Homologene: 1069
Abat
Name: 4-aminobutyrate aminotransferase
Synonyms: GABA-T, 9630038C02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268860
HGNC: HGNC:23
Homologene: 542
Pcdha4
Name: protocadherin alpha 4
Synonyms: Crnr1, Cnr1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12936
HGNC: HGNC:8670
Homologene: 130626
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 11,182,031 bp
  • G to T, chromosome 1 at 150,697,476 bp
  • A to T, chromosome 2 at 9,951,353 bp
  • G to T, chromosome 2 at 129,123,261 bp
  • C to T, chromosome 3 at 158,023,344 bp
  • T to A, chromosome 4 at 21,747,578 bp
  • A to G, chromosome 4 at 43,176,966 bp
  • T to C, chromosome 4 at 62,323,202 bp
  • C to A, chromosome 4 at 96,227,667 bp
  • G to A, chromosome 4 at 101,774,257 bp
  • G to T, chromosome 4 at 133,681,524 bp
  • T to C, chromosome 5 at 123,326,533 bp
  • G to T, chromosome 6 at 124,746,176 bp
  • T to A, chromosome 7 at 23,320,633 bp
  • A to G, chromosome 7 at 28,825,885 bp
  • A to T, chromosome 7 at 102,542,688 bp
  • T to C, chromosome 8 at 79,668,497 bp
  • C to T, chromosome 8 at 95,297,759 bp
  • T to A, chromosome 9 at 69,476,149 bp
  • G to T, chromosome 9 at 107,515,442 bp
  • C to T, chromosome 9 at 113,892,444 bp
  • T to C, chromosome 10 at 9,899,254 bp
  • A to T, chromosome 10 at 80,520,323 bp
  • G to A, chromosome 11 at 73,690,314 bp
  • C to T, chromosome 11 at 100,625,035 bp
  • A to G, chromosome 12 at 36,187,711 bp
  • T to C, chromosome 12 at 101,761,822 bp
  • A to T, chromosome 13 at 33,918,259 bp
  • A to G, chromosome 13 at 67,139,098 bp
  • T to C, chromosome 14 at 21,517,412 bp
  • A to C, chromosome 14 at 59,506,270 bp
  • T to C, chromosome 14 at 104,480,226 bp
  • A to T, chromosome 15 at 8,351,565 bp
  • C to T, chromosome 16 at 8,602,436 bp
  • C to T, chromosome 17 at 20,268,463 bp
  • C to A, chromosome 17 at 35,687,222 bp
  • C to T, chromosome 17 at 49,469,376 bp
  • T to C, chromosome 18 at 36,953,733 bp
  • T to A, chromosome 18 at 73,872,033 bp
  • T to A, chromosome 19 at 3,362,156 bp
  • T to C, chromosome 19 at 6,070,917 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6427 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044566-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.