Strain Name:
C57BL/6J-MtgxR6430Btlr/Mmmh
Stock Number:
044568-MU
Citation ID:
RRID:MMRRC_044568-MU
Other Names:
R6430 (G1)
Major Collection:

Strain Information

Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Prss12
Name: serine protease 12 neurotrypsin (motopsin)
Synonyms: motopsin, Bssp-3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19142
HGNC: HGNC:9477
Homologene: 7490
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: TRIP8, D630035I23Rik, 5430433L24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108829
Homologene: 3129
Cdyl
Name: chromodomain protein, Y chromosome-like
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12593
VEGA: 13
HGNC: HGNC:1811
Homologene: 3548
Arid2
Name: AT-rich interaction domain 2
Synonyms: zipzap/p200, 1700124K17Rik, 4432409D24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 77044
Homologene: 14601
Rttn
Name: rotatin
Synonyms: 4921538A15Rik, C530033I08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 246102
VEGA: 18
Homologene: 65275
Nr2c1
Name: nuclear receptor subfamily 2, group C, member 1
Synonyms: 4831444H07Rik, TR2, Eenr, Tr2-11
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22025
HGNC: HGNC:7971
Homologene: 55731
Cep350
Name: centrosomal protein 350
Synonyms: 4933409L06Rik, 6430546F08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74081
Homologene: 8879
Cmas
Name: cytidine monophospho-N-acetylneuraminic acid synthetase
Synonyms: CMP-sialic acid synthetase, D6Bwg0250e, CMP-Neu5Ac synthase
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12764
Homologene: 7670
Epg5
Name: ectopic P-granules 5 autophagy tethering factor
Synonyms: 5430411K18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 100502841
VEGA: 18
Homologene: 14575
Smc6
Name: structural maintenance of chromosomes 6
Synonyms: 3830418C19Rik, 2810489L22Rik, Smc6l1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67241
VEGA: 12
Homologene: 41575
Vps11
Name: VPS11, CORVET/HOPS core subunit
Synonyms: 1200011A11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71732
VEGA: 9
Homologene: 6673
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: Plc, perlecan, Pcn, per
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Ap2a1
Name: adaptor-related protein complex 2, alpha 1 subunit
Synonyms: Adtaa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11771
HGNC: HGNC:561
Homologene: 68997
Per1
Name: period circadian clock 1
Synonyms: m-rigui, Hftm, mPer1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18626
HGNC: HGNC:8845
Homologene: 1966
Dhx29
Name: DExH-box helicase 29
Synonyms: E130202M19Rik, DEAH (Asp-Glu-Ala-His) box polypeptide 29
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218629
VEGA: 13
Homologene: 10387
Cd207
Name: CD207 antigen
Synonyms: Langerin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 246278
Homologene: 9252
Slc9a4
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 4
Synonyms: NHE4, D730009J23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 110895
Homologene: 72232
Ank1
Name: ankyrin 1, erythroid
Synonyms: pale, Ank-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11733
HGNC: HGNC:492
Homologene: 55427
Tex15
Name: testis expressed gene 15 meiosis and synapsis associated
Synonyms: 2210014E14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 104271
Homologene: 12837
Zbtb41
Name: zinc finger and BTB domain containing 41
Synonyms: 9830132G07Rik, 8430415N23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226470
Homologene: 27795
Fcsk
Name: fucose kinase
Synonyms: L-fucose kinase, Fuk, 1110046B12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234730
Homologene: 15452
Man2c1
Name: mannosidase, alpha, class 2C, member 1
Synonyms: 1110025H24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73744
HGNC: HGNC:6827
Homologene: 4887
Rabl6
Name: RAB, member RAS oncogene family-like 6
Synonyms: B230208H17Rik, Rbel1a, Rbel1b, Rbel1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227624
Homologene: 11674
Kcng4
Name: potassium voltage-gated channel, subfamily G, member 4
Synonyms: 4921535I01Rik, KV6.4, KV6.3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66733
Homologene: 23553
Or14a259
Name: olfactory receptor family 14 subfamily A member 259
Synonyms: MOR219-2, Olfr305, GA_x6K02T2NHDJ-9744055-9745014
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258609
Homologene: 128128
Slc16a7
Name: solute carrier family 16 (monocarboxylic acid transporters), member 7
Synonyms: 4921534N07Rik, 9030411M13Rik, MCT2, D630004K10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20503
Homologene: 20990
Auh
Name: AU RNA binding protein/enoyl-coenzyme A hydratase
Synonyms: W91705
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 11992
HGNC: HGNC:890
Homologene: 1284
Or2j3
Name: olfactory receptor family 2 subfamily J member 3
Synonyms: MOR256-18, Olfr137, GA_x6K02T2PSCP-2749525-2748587
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258481
Homologene: 128084
AI661453
Name: expressed sequence AI661453
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224833
Homologene: 138294
Osbpl6
Name: oxysterol binding protein-like 6
Synonyms: 1110062M20Rik, ORP-6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99031
Homologene: 101447
Slco6c1
Name: solute carrier organic anion transporter family, member 6c1
Synonyms: 4933404A18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74441
Homologene: 65259
Tmem145
Name: transmembrane protein 145
Synonyms: B930076A02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330485
Homologene: 18333
Espnl
Name: espin-like
Synonyms: LOC227357
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227357
Homologene: 77795
Plekhn1
Name: pleckstrin homology domain containing, family N member 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 231002
VEGA: 4
Homologene: 12949
Kcnh7
Name: potassium voltage-gated channel, subfamily H (eag-related), member 7
Synonyms: Kv11.3, erg3, 9330137I11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170738
Homologene: 13249
Zmynd10
Name: zinc finger, MYND domain containing 10
Synonyms: Blu
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 114602
Homologene: 9293
B3gnt7
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
Synonyms: C330001H22Rik, beta-3GnT7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227327
Homologene: 17049
Klra9
Name: killer cell lectin-like receptor subfamily A, member 9
Synonyms: LY49I1, Ly49I
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16640
Homologene: 110821
Flacc1
Name: flagellum associated containing coiled-coil domains 1
Synonyms: 4933405P16Rik, 4933425F06Rik, Als2cr12
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108812
Homologene: 51399
Slc7a10
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 10
Synonyms: Asc-1, D7Bwg0847e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 53896
Homologene: 56767
Vmn1r3
Name: vomeronasal 1 receptor 3
Synonyms: Gm11778
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100312471
Homologene: 128342
Trim3
Name: tripartite motif-containing 3
Synonyms: Rnf22, BERP1, HAC1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 55992
Homologene: 21290
Pudp
Name: pseudouridine 5'-phosphatase
Synonyms: Hdhd1a, 1700121L12Rik, GS1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67365
VEGA: 18
Homologene: 8093
Klhl38
Name: kelch-like 38
Synonyms: 8230402K04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 268807
Homologene: 18622
Gatb
Name: glutamyl-tRNA amidotransferase subunit B
Synonyms: Pet112l, Pet112, 9430026F02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229487
HGNC: HGNC:8849
Homologene: 3357
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 40,600,854 bp
  • T to A, chromosome 1 at 58,678,289 bp
  • T to C, chromosome 1 at 86,306,117 bp
  • T to C, chromosome 1 at 91,322,248 bp
  • T to A, chromosome 1 at 97,075,974 bp
  • T to A, chromosome 1 at 139,447,207 bp
  • A to G, chromosome 1 at 155,894,673 bp
  • A to T, chromosome 2 at 25,584,837 bp
  • T to G, chromosome 2 at 62,850,532 bp
  • A to G, chromosome 2 at 76,579,276 bp
  • A to G, chromosome 3 at 85,637,038 bp
  • A to T, chromosome 3 at 123,479,594 bp
  • G to A, chromosome 4 at 3,184,971 bp
  • T to C, chromosome 4 at 137,539,396 bp
  • T to C, chromosome 4 at 156,221,804 bp
  • C to T, chromosome 6 at 83,675,887 bp
  • G to T, chromosome 6 at 130,179,032 bp
  • T to A, chromosome 6 at 142,767,924 bp
  • T to C, chromosome 7 at 25,309,038 bp
  • A to G, chromosome 7 at 35,197,658 bp
  • C to A, chromosome 7 at 44,903,829 bp
  • A to T, chromosome 7 at 86,363,973 bp
  • A to G, chromosome 7 at 105,618,005 bp
  • T to A, chromosome 8 at 23,132,109 bp
  • T to C, chromosome 8 at 33,571,301 bp
  • A to G, chromosome 8 at 110,884,116 bp
  • A to G, chromosome 8 at 119,633,050 bp
  • C to A, chromosome 9 at 44,361,550 bp
  • T to C, chromosome 9 at 57,131,233 bp
  • T to C, chromosome 9 at 67,272,665 bp
  • A to T, chromosome 9 at 107,548,712 bp
  • C to T, chromosome 10 at 67,224,160 bp
  • A to T, chromosome 10 at 94,195,341 bp
  • A to G, chromosome 10 at 125,231,018 bp
  • T to C, chromosome 11 at 69,104,296 bp
  • A to G, chromosome 12 at 11,309,234 bp
  • A to G, chromosome 13 at 35,871,606 bp
  • C to A, chromosome 13 at 52,929,410 bp
  • T to C, chromosome 13 at 112,944,619 bp
  • T to C, chromosome 15 at 58,322,311 bp
  • T to C, chromosome 15 at 96,363,694 bp
  • T to C, chromosome 17 at 38,305,358 bp
  • C to A, chromosome 17 at 47,466,797 bp
  • A to G, chromosome 18 at 50,568,236 bp
  • T to C, chromosome 18 at 77,975,885 bp
  • T to A, chromosome 18 at 89,021,685 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6430 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044568-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.