Strain Name:
C57BL/6J-MtgxR6433Btlr/Mmmh
Stock Number:
044571-MU
Citation ID:
RRID:MMRRC_044571-MU
Other Names:
R6433 (G1)
Major Collection:

Strain Information

Atrn
Name: attractin
Synonyms: Mgca
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11990
HGNC: HGNC:885
Homologene: 22542
Ndrg1
Name: N-myc downstream regulated gene 1
Synonyms: Ndr1, CMT4D, Ndrl, CAP43, TDD5, DRG1, Tdd5, PROXY1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17988
HGNC: HGNC:7679
Homologene: 55953
Aspm
Name: abnormal spindle microtubule assembly
Synonyms: Sha1, MCPH5, D330028K02Rik, Aspm, Calmbp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12316
Homologene: 7650
Caml
Name: calcium modulating ligand
Synonyms: Caml
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12328
HGNC: HGNC:1471
Homologene: 1323
Afdn
Name: afadin, adherens junction formation factor
Synonyms: AF6, S-afadin, 5033403D15Rik, Afadin, I-afadin, Mllt4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17356
HGNC: HGNC:7137
Homologene: 21202
Plxna4
Name: plexin A4
Synonyms: Plxa4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243743
HGNC: HGNC:9102
Homologene: 77587
Pex5
Name: peroxisomal biogenesis factor 5
Synonyms: ESTM1, Pxr1, PTS1R, peroxisome biogenesis factor 5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19305
HGNC: HGNC:9719
Homologene: 270
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319262
Homologene: 14127
Mfsd2a
Name: MFSD2 lysolipid transporter A, lysophospholipid
Synonyms: Mfsd2, major facilitator superfamily domain containing 2A, 1700018O18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76574
Homologene: 19229
Dnpep
Name: aspartyl aminopeptidase
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13437
HGNC: HGNC:2981
Homologene: 6110
Efl1
Name: elongation factor like GTPase 1
Synonyms: 4932434J20Rik, D7Ertd791e, 6030468D11Rik, Eftud1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101592
Homologene: 11599
Flcn
Name: folliculin
Synonyms: BHD, B430214A04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216805
Homologene: 14583
Atad2b
Name: ATPase family, AAA domain containing 2B
Synonyms: D530031C13Rik, 1110014E10Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320817
VEGA: 12
Homologene: 86351
Pla2g7
Name: phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Synonyms: PAF-AH, PAF acetylhydrolase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27226
HGNC: HGNC:9040
Homologene: 3725
Prkg1
Name: protein kinase, cGMP-dependent, type I
Synonyms: Prkgr1b, Prkg1b
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19091
HGNC: HGNC:9414
Homologene: 55964
Rdh10
Name: retinol dehydrogenase 10 (all-trans)
Synonyms: D1Ertd762e, 3110069K09Rik, m366Asp, 4921506A21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98711
Homologene: 14061
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: MLSN2, melastatin 2, 6330504P12Rik, LTRPC3, B930001P07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226025
VEGA: 19
Homologene: 62287
Dhx36
Name: DEAH-box helicase 36
Synonyms: RHAU, Ddx36, 2810407E23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72162
Homologene: 6356
Cd180
Name: CD180 antigen
Synonyms: Ly78, RP105
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17079
HGNC: HGNC:6726
Homologene: 4077
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: LOC381311, Gm980, A230079K17Rik, Dnahc14
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Aplnr
Name: apelin receptor
Synonyms: msr/apj, apelin receptor, APJ, Agtrl1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 23796
HGNC: HGNC:339
Homologene: 3784
Vmn2r6
Name: vomeronasal 2, receptor 6
Synonyms: EG667069, EG620718
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 667069
Homologene: 129754
Stab2
Name: stabilin 2
Synonyms: FEEL-2, STAB-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 192188
Homologene: 23022
Ppfia2
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Synonyms: E130120L08Rik, Liprin-alpha2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327814
VEGA: 10
HGNC: HGNC:9246
Homologene: 27953
Tpo
Name: thyroid peroxidase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22018
Homologene: 461
Galnt16
Name: polypeptide N-acetylgalactosaminyltransferase 16
Synonyms: Galntl1, 5730405L21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 108760
VEGA: 12
Homologene: 18907
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Exoc3
Name: exocyst complex component 3
Synonyms: 2810050O03Rik, E430013E20Rik, Sec6l1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 211446
VEGA: 13
Homologene: 38296
Cdhr2
Name: cadherin-related family member 2
Synonyms: Pcdh24, LOC268663
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 268663
Homologene: 134510
Or2j3
Name: olfactory receptor family 2 subfamily J member 3
Synonyms: MOR256-18, Olfr137, GA_x6K02T2PSCP-2749525-2748587
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258481
Homologene: 128084
Phlpp2
Name: PH domain and leucine rich repeat protein phosphatase 2
Synonyms: Phlppl, C130044A18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244650
Homologene: 71015
Mybpc1
Name: myosin binding protein C, slow-type
Synonyms: Slow-type C-protein, 8030451F13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 109272
HGNC: HGNC:7549
Homologene: 1846
Fbln2
Name: fibulin 2
Synonyms: 5730577E14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14115
HGNC: HGNC:3601
Homologene: 1514
Rtl1
Name: retrotransposon Gaglike 1
Synonyms: Mart1, Mor1, Mar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 353326
VEGA: 12
Homologene: 120261
Fam98c
Name: family with sequence similarity 98, member C
Synonyms: 1110006G06Rik, B230110F21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73833
Homologene: 45483
Itga10
Name: integrin, alpha 10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213119
HGNC: HGNC:6135
Homologene: 2697
Has2
Name: hyaluronan synthase 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 15117
HGNC: HGNC:4819
Homologene: 3892
Elovl4
Name: ELOVL fatty acid elongase 4
Synonyms: elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83603
Homologene: 41488
Sh3tc1
Name: SH3 domain and tetratricopeptide repeats 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231147
Homologene: 10360
Dsc2
Name: desmocollin 2
Synonyms: Dsc2a, Dsc2b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Poll
Name: polymerase (DNA directed), lambda
Synonyms: 1110003P06Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56626
VEGA: 19
HGNC: HGNC:9184
Homologene: 40863
Cyp4a31
Name: cytochrome P450, family 4, subfamily a, polypeptide 31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 666168
HGNC: HGNC:2642
Homologene: 128044
Klra9
Name: killer cell lectin-like receptor subfamily A, member 9
Synonyms: LY49I1, Ly49I
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16640
Homologene: 110821
Ido2
Name: indoleamine 2,3-dioxygenase 2
Synonyms: Ido2, Indol1, C230043N17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 209176
Homologene: 48830
H2-Ob
Name: histocompatibility 2, O region beta locus
Synonyms: H2-Ab2, vic1, H-2I, Ob, H2-Ab, A-beta2, A-beta-2, H-2Ob, H2-IAb2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15002
HGNC: HGNC:4937
Homologene: 1602
Skint4
Name: selection and upkeep of intraepithelial T cells 4
Synonyms: 9530098N22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320640
Timp4
Name: tissue inhibitor of metalloproteinase 4
Synonyms: TIMP-4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 110595
Homologene: 37748
Toporsl
Name: topoisomerase I binding, arginine/serine-rich like
Synonyms: 4930547C10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68274
Homologene: 130753
Vwa1
Name: von Willebrand factor A domain containing 1
Synonyms: WARP, 4932416A11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 246228
Homologene: 11270
Spc25
Name: SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
Synonyms: 2600017H08Rik, 2610205L13Rik, Spbc25
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66442
Homologene: 41387
Smtnl1
Name: smoothelin-like 1
Synonyms: 1110030K22Rik, Chasm
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68678
Homologene: 11488
Scgb2b3
Name: secretoglobin, family 2B, member 3
Synonyms: Abpbg3, Gm4362
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043326
Homologene: 83171
Timm22
Name: translocase of inner mitochondrial membrane 22
Synonyms: 2610511O07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56322
Homologene: 32173
Spata31d1b
Name: spermatogenesis associated 31 subfamily D, member 1B
Synonyms: Gm4934, Fam75d1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238662
VEGA: 13
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 16,107,855 bp
  • T to A, chromosome 1 at 75,315,378 bp
  • T to C, chromosome 1 at 139,473,683 bp
  • A to G, chromosome 1 at 181,651,657 bp
  • A to G, chromosome 2 at 69,206,102 bp
  • T to C, chromosome 2 at 76,751,714 bp
  • A to C, chromosome 2 at 84,818,368 bp
  • A to T, chromosome 2 at 85,136,673 bp
  • A to G, chromosome 2 at 131,023,027 bp
  • T to C, chromosome 3 at 62,484,974 bp
  • A to T, chromosome 3 at 64,547,380 bp
  • T to C, chromosome 3 at 96,658,041 bp
  • T to A, chromosome 4 at 52,611,548 bp
  • A to G, chromosome 4 at 112,146,510 bp
  • A to C, chromosome 4 at 115,570,269 bp
  • A to G, chromosome 4 at 122,950,457 bp
  • G to A, chromosome 4 at 155,772,769 bp
  • T to C, chromosome 5 at 35,706,597 bp
  • C to T, chromosome 6 at 32,215,678 bp
  • G to A, chromosome 6 at 91,233,272 bp
  • A to G, chromosome 6 at 115,247,220 bp
  • A to T, chromosome 6 at 124,413,613 bp
  • G to T, chromosome 6 at 130,179,032 bp
  • A to G, chromosome 7 at 29,156,128 bp
  • A to T, chromosome 7 at 31,359,067 bp
  • T to A, chromosome 7 at 82,674,568 bp
  • T to A, chromosome 8 at 24,533,923 bp
  • G to T, chromosome 8 at 109,934,685 bp
  • A to G, chromosome 9 at 83,785,178 bp
  • C to T, chromosome 10 at 86,901,567 bp
  • T to C, chromosome 10 at 88,560,355 bp
  • C to A, chromosome 10 at 106,913,698 bp
  • T to A, chromosome 11 at 59,051,558 bp
  • T to C, chromosome 11 at 59,801,082 bp
  • T to C, chromosome 11 at 76,409,744 bp
  • A to G, chromosome 12 at 4,952,642 bp
  • T to C, chromosome 12 at 30,084,754 bp
  • T to C, chromosome 12 at 80,575,903 bp
  • C to A, chromosome 12 at 109,595,196 bp
  • A to G, chromosome 13 at 54,718,512 bp
  • C to A, chromosome 13 at 55,623,249 bp
  • T to C, chromosome 13 at 59,717,185 bp
  • T to C, chromosome 13 at 74,189,187 bp
  • T to G, chromosome 13 at 102,705,633 bp
  • G to A, chromosome 15 at 56,667,798 bp
  • A to T, chromosome 15 at 66,933,872 bp
  • T to A, chromosome 17 at 13,881,299 bp
  • A to T, chromosome 17 at 34,243,886 bp
  • A to G, chromosome 17 at 38,305,413 bp
  • G to C, chromosome 17 at 43,599,126 bp
  • C to T, chromosome 18 at 20,051,175 bp
  • G to A, chromosome 18 at 37,964,084 bp
  • A to G, chromosome 19 at 22,901,305 bp
  • A to G, chromosome 19 at 30,781,346 bp
  • A to T, chromosome 19 at 45,553,604 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6433 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044571-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.