Strain Name:
C57BL/6J-MtgxR6437Btlr/Mmmh
Stock Number:
044575-MU
Citation ID:
RRID:MMRRC_044575-MU
Other Names:
R6437 (G1)
Major Collection:

Strain Information

Eif3h
Name: eukaryotic translation initiation factor 3, subunit H
Synonyms: Eif3s3, 9430017H16Rik, 1110008A16Rik, EIF3-gamma, EIF3-P40
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68135
VEGA: 15
HGNC: HGNC:3273
Homologene: 2785
Kifap3
Name: kinesin-associated protein 3
Synonyms: KAP3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16579
Homologene: 7799
Dido1
Name: death inducer-obliterator 1
Synonyms: dido, 6720461J16Rik, DIO-1, C130092D22Rik, Datf1, D130048F08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 23856
HGNC: HGNC:2680
Homologene: 34139
Agrn
Name: agrin
Synonyms: nmf380, NMF380, Agrin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11603
HGNC: HGNC:329
Homologene: 27907
Kntc1
Name: kinetochore associated 1
Synonyms: jgl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208628
Homologene: 32227
Pafah1b1
Name: platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
Synonyms: Pafaha, Lis1, PAF-AH 45, lissencephaly-1 protein, Mdsh, LIS-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18472
HGNC: HGNC:8574
Homologene: 371
Zmym2
Name: zinc finger, MYM-type 2
Synonyms: SCLL, MYM, RAMP, FIM, Zfp198
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76007
VEGA: 14
Homologene: 12631
Afg2a
Name: AFG2 AAA ATPase homolog A
Synonyms: C78064, Spaf, 2510048F20Rik, Spata5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 57815
Homologene: 56920
Pold1
Name: polymerase (DNA directed), delta 1, catalytic subunit
Synonyms: 125kDa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18971
HGNC: HGNC:9175
Homologene: 2014
Atg16l1
Name: autophagy related 16 like 1
Synonyms: APG16L, WDR30, 1500009K01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77040
Homologene: 41786
Dpp8
Name: dipeptidylpeptidase 8
Synonyms: 4932434F09Rik, 2310004I03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74388
VEGA: 9
Homologene: 57098
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: LOC381562, A930005E13Rik, D930005K06Rik, Zubr1, p600, 1810009A16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69116
Homologene: 10804
Rrp9
Name: ribosomal RNA processing 9, U3 small nucleolar RNA binding protein
Synonyms: Rnu3ip2, U3-55k, 55kDa, D9Wsu10e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 27966
Homologene: 3452
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72205
Homologene: 8125
Rfx7
Name: regulatory factor X, 7
Synonyms: 2510005N23Rik, D130086K05Rik, Rfxdc2, 9930116O05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319758
Homologene: 11275
Kcng3
Name: potassium voltage-gated channel, subfamily G, member 3
Synonyms: Kv10.1a, KV6.3, Kv10.1b
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225030
VEGA: 17
Homologene: 15168
Srcap
Name: Snf2-related CREBBP activator protein
Synonyms: D030022P06Rik, F630004O05Rik, B930091H02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043597
Homologene: 38213
Zfpm2
Name: zinc finger protein, multitype 2
Synonyms: FOG2, B330005D23Rik, FOG-2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22762
VEGA: 15
Homologene: 8008
Frmd4b
Name: FERM domain containing 4B
Synonyms: GRSP1, 6030440G05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232288
Homologene: 14916
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, D12Ertd777e, diminished cone electroretinogram, Cpfl8, Nesp2g, dice, syne-2, 6820443O06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Snrk
Name: SNF related kinase
Synonyms: SNRK, 2010012F07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20623
Homologene: 9797
Nynrin
Name: NYN domain and retroviral integrase containing
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 277154
VEGA: 14
Homologene: 19483
Fbn2
Name: fibrillin 2
Synonyms: Fib-2, sy, Sne
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Lipm
Name: lipase, family member M
Synonyms: Lipl3, 4632427C23Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 78753
VEGA: 19
Homologene: 28267
Plce1
Name: phospholipase C, epsilon 1
Synonyms: PLCepsilon, 4933403A21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74055
Homologene: 9478
Scoc
Name: short coiled-coil protein
Synonyms: 2810002J11Rik, short coiled-coil protein, 0610011C06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56367
Homologene: 134118
Smc1b
Name: structural maintenance of chromosomes 1B
Synonyms: SMC1beta, Smc1l2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 140557
VEGA: 15
Homologene: 13786
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329942
Homologene: 89034
Cracr2a
Name: calcium release activated channel regulator 2A
Synonyms: LOC243645, LOC381812, Efcab4b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381812
Homologene: 41883
Vmn2r37
Name: vomeronasal 2, receptor 37
Synonyms: V2r14
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22305
Homologene: 113703
Krt87
Name: keratin 87
Synonyms: Krt2-25, Krt83
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 406219
VEGA: 15
Homologene: 133804
Ttc7
Name: tetratricopeptide repeat domain 7
Synonyms: fsn, 1110035E02Rik, 1700007L07Rik, hea
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225049
Homologene: 12515
Thsd7b
Name: thrombospondin, type I, domain containing 7B
Synonyms: D130067I03Rik, 1700074E13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210417
Homologene: 18180
Pcdhb7
Name: protocadherin beta 7
Synonyms: Pcdhb4B, PcdhbG
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93878
HGNC: HGNC:8689
Homologene: 87123
Or2j6
Name: olfactory receptor family 2 subfamily J member 6
Synonyms: MOR251-3, Olfr531, GA_x6K02T2PBJ9-42551260-42550346
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258955
Ces3b
Name: carboxylesterase 3B
Synonyms: Gm4738, ES31L
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13909
HGNC: HGNC:1865
Homologene: 84407
Mrc2
Name: mannose receptor, C type 2
Synonyms: uPARAP, novel lectin, Endo180
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17534
Homologene: 4408
Efcab5
Name: EF-hand calcium binding domain 5
Synonyms: 4930563A03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319634
Homologene: 63366
Vmn2r106
Name: vomeronasal 2, receptor 106
Synonyms: EG224576
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224576
Homologene: 135824
Fars2
Name: phenylalanine-tRNA synthetase 2, mitochondrial
Synonyms: 2810431B21Rik, Fars1, 6720478K01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69955
VEGA: 13
Homologene: 4788
Gtpbp10
Name: GTP-binding protein 10 (putative)
Synonyms: 4930545J22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 207704
Homologene: 8114
Klk10
Name: kallikrein related-peptidase 10
Synonyms: NES1, 2300002A13Rik, PRSSL1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69540
HGNC: HGNC:6358
Homologene: 26428
Nek5
Name: NIMA (never in mitosis gene a)-related expressed kinase 5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330721
HGNC: HGNC:7748
Homologene: 87952
Nat1
Name: N-acetyl transferase 1
Synonyms: Nat-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17960
Homologene: 115468
Oog2
Name: oogenesin 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381570
Homologene: 77858
Samm50
Name: SAMM50 sorting and assembly machinery component
Synonyms: 1110030L07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68653
VEGA: 15
Homologene: 41034
Ldaf1
Name: lipid droplet assembly factor 1
Synonyms: Tmem159, 8430420C20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233806
Homologene: 10705
Yod1
Name: YOD1 deubiquitinase
Synonyms: 9930028C20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226418
Homologene: 13176
Cstdc3
Name: cystatin domain containing 3
Synonyms: Gm4758
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 209324
VEGA: 16
HGNC: HGNC:2481
Homologene: 86375
Smad9
Name: SMAD family member 9
Synonyms: SMAD8B, MADH6, SMAD8A, Madh9
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 55994
HGNC: HGNC:6774
Homologene: 21198
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 87,790,648 bp
  • T to C, chromosome 1 at 129,816,682 bp
  • T to C, chromosome 1 at 130,719,148 bp
  • T to A, chromosome 1 at 163,857,526 bp
  • C to T, chromosome 2 at 52,257,557 bp
  • C to T, chromosome 2 at 82,983,492 bp
  • A to G, chromosome 2 at 180,675,013 bp
  • T to A, chromosome 3 at 37,528,198 bp
  • C to T, chromosome 3 at 54,786,084 bp
  • T to G, chromosome 4 at 127,988,100 bp
  • T to A, chromosome 4 at 139,397,214 bp
  • T to A, chromosome 4 at 144,195,108 bp
  • C to T, chromosome 4 at 156,176,778 bp
  • A to G, chromosome 5 at 5,557,406 bp
  • T to G, chromosome 5 at 123,769,691 bp
  • G to T, chromosome 6 at 97,296,267 bp
  • A to G, chromosome 6 at 127,631,831 bp
  • G to T, chromosome 7 at 9,217,851 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • A to G, chromosome 7 at 43,782,817 bp
  • G to A, chromosome 7 at 44,538,778 bp
  • A to T, chromosome 7 at 120,116,361 bp
  • T to A, chromosome 7 at 127,528,550 bp
  • C to T, chromosome 7 at 140,400,521 bp
  • T to A, chromosome 8 at 22,085,460 bp
  • T to C, chromosome 8 at 67,491,736 bp
  • T to C, chromosome 8 at 83,437,987 bp
  • T to A, chromosome 8 at 105,092,606 bp
  • A to T, chromosome 9 at 65,074,578 bp
  • A to G, chromosome 9 at 72,618,486 bp
  • G to T, chromosome 9 at 106,482,951 bp
  • A to G, chromosome 9 at 122,166,813 bp
  • T to C, chromosome 11 at 74,677,731 bp
  • G to A, chromosome 11 at 77,137,902 bp
  • G to A, chromosome 11 at 105,349,843 bp
  • T to A, chromosome 12 at 75,990,414 bp
  • G to A, chromosome 13 at 36,204,863 bp
  • T to C, chromosome 14 at 55,871,770 bp
  • T to A, chromosome 14 at 56,903,004 bp
  • T to C, chromosome 15 at 41,099,397 bp
  • C to T, chromosome 15 at 51,799,264 bp
  • T to A, chromosome 15 at 84,204,097 bp
  • C to T, chromosome 15 at 85,092,031 bp
  • C to T, chromosome 15 at 101,438,392 bp
  • A to G, chromosome 16 at 36,312,637 bp
  • C to T, chromosome 17 at 20,268,463 bp
  • A to G, chromosome 17 at 83,631,129 bp
  • A to G, chromosome 17 at 87,330,106 bp
  • T to C, chromosome 18 at 37,342,690 bp
  • T to G, chromosome 18 at 58,113,363 bp
  • A to G, chromosome 19 at 34,121,257 bp
  • A to T, chromosome 19 at 38,525,132 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6437 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044575-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.