Strain Name:
C57BL/6J-MtgxR6441Btlr/Mmmh
Stock Number:
044579-MU
Citation ID:
RRID:MMRRC_044579-MU
Other Names:
R6441 (G1)
Major Collection:

Strain Information

Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Sema3c
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
Synonyms: Semae, 1110036B02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20348
Homologene: 36201
Zgrf1
Name: zinc finger, GRF-type containing 1
Synonyms: 4930422G04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71643
Homologene: 34708
Mccc2
Name: methylcrotonoyl-Coenzyme A carboxylase 2 (beta)
Synonyms: 4930552N12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78038
VEGA: 13
HGNC: HGNC:6937
Homologene: 11145
Nup37
Name: nucleoporin 37
Synonyms: 2410003L22Rik, 2810039M17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69736
VEGA: 10
Homologene: 11441
Ncapd3
Name: non-SMC condensin II complex, subunit D3
Synonyms: B130055D15Rik, 2810487N22Rik, 4632407J06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78658
VEGA: 9
Homologene: 41021
Gtf3c3
Name: general transcription factor IIIC, polypeptide 3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98488
HGNC: HGNC:4666
Homologene: 40805
Galnt4
Name: polypeptide N-acetylgalactosaminyltransferase 4
Synonyms: ppGaNTase-T4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14426
Homologene: 74511
Gucy2c
Name: guanylate cyclase 2c
Synonyms: GC-C
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14917
HGNC: HGNC:4688
Homologene: 3641
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Cdh9
Name: cadherin 9
Synonyms: T1-cadherin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12565
HGNC: HGNC:1768
Homologene: 9450
Svil
Name: supervillin
Synonyms: B430302E16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225115
Homologene: 25090
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: calcium release channel isoform 1, Ryr, skrr
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Cdh23
Name: cadherin related 23 (otocadherin)
Synonyms: nmf252, bob, USH1D, ahl, 4930542A03Rik, nmf181, sals, mdfw, nmf112
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22295
Homologene: 11142
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Or52h9
Name: olfactory receptor family 52 subfamily H member 9
Synonyms: Olfr651, GA_x6K02T2PBJ9-7179540-7180481, MOR31-11
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258809
Homologene: 64922
Mag
Name: myelin-associated glycoprotein
Synonyms: siglec-4a, Gma
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17136
HGNC: HGNC:6783
Homologene: 1771
Agl
Name: amylo-1,6-glucosidase, 4-alpha-glucanotransferase
Synonyms: 1110061O17Rik, 9630046L06Rik, 9430004C13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77559
HGNC: HGNC:321
Homologene: 536
Capn12
Name: calpain 12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 60594
Homologene: 77333
Myh2
Name: myosin, heavy polypeptide 2, skeletal muscle, adult
Synonyms: Myhsf1, MyHC-IIa, Myhs-f, MHC2A, Myhs-f1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17882
HGNC: HGNC:7572
Homologene: 23019
Pls1
Name: plastin 1 (I-isoform)
Synonyms: I-fimbrin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102502
HGNC: HGNC:9090
Homologene: 68270
Vmn2r75
Name: vomeronasal 2, receptor 75
Synonyms: EG546981
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546981
Homologene: 115466
Cimap1a
Name: ciliary microtubule associated protein 1A
Synonyms: SHIPPO1, 1700011O04Rik, Odf3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69287
Homologene: 12306
Slc27a6
Name: solute carrier family 27 (fatty acid transporter), member 6
Synonyms: FATP6, 4732438L20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225579
Homologene: 38385
Mybpc1
Name: myosin binding protein C, slow-type
Synonyms: Slow-type C-protein, 8030451F13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 109272
HGNC: HGNC:7549
Homologene: 1846
Cpb1
Name: carboxypeptidase B1
Synonyms: 2210008M23Rik, 0910001A18Rik, 1810063F02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76703
HGNC: HGNC:2299
Homologene: 68127
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329942
Homologene: 89034
Vmn2r28
Name: vomeronasal 2, receptor 28
Synonyms: EG665255
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 665255
Homologene: 129605
D6Ertd527e
Name: DNA segment, Chr 6, ERATO Doi 527, expressed
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52372
Rbm44
Name: RNA binding motif protein 44
Synonyms: LOC329207
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329207
Homologene: 66636
Tas1r2
Name: taste receptor, type 1, member 2
Synonyms: TR2, T1r2, Gpr71
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 83770
Homologene: 75323
Redic1
Name: regulator of DNA class I crossover intermediates 1
Synonyms: Gm5807, CN725425
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545126
Slfn3
Name: schlafen 3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20557
Homologene: 133236
Sh2d5
Name: SH2 domain containing 5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230863
Homologene: 20002
Lonrf2
Name: LON peptidase N-terminal domain and ring finger 2
Synonyms: 2900060P06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381338
Homologene: 18871
Trim31
Name: tripartite motif-containing 31
Synonyms: HCG1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224762
Homologene: 17137
Txndc9
Name: thioredoxin domain containing 9
Synonyms: ATP binding protein associated with cell differentiation, Apacd
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98258
Homologene: 4225
Pcdhgb5
Name: protocadherin gamma subfamily B, 5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93702
HGNC: HGNC:8712
Homologene: 55773
Lrit3
Name: leucine-rich repeat, immunoglobulin-like and transmembrane domains 3
Synonyms: LOC242235
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242235
Homologene: 19426
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 37,990,218 bp
  • T to C, chromosome 1 at 38,818,123 bp
  • T to A, chromosome 1 at 54,406,038 bp
  • A to T, chromosome 1 at 91,157,077 bp
  • A to G, chromosome 1 at 150,703,216 bp
  • T to C, chromosome 3 at 20,249,814 bp
  • A to T, chromosome 3 at 116,771,459 bp
  • A to T, chromosome 3 at 127,588,034 bp
  • A to T, chromosome 3 at 129,800,360 bp
  • C to A, chromosome 4 at 128,394,964 bp
  • A to T, chromosome 4 at 138,259,082 bp
  • T to A, chromosome 4 at 139,669,156 bp
  • C to T, chromosome 5 at 17,724,132 bp
  • C to G, chromosome 6 at 87,111,524 bp
  • A to T, chromosome 6 at 136,723,761 bp
  • T to A, chromosome 7 at 5,488,475 bp
  • T to A, chromosome 7 at 28,888,002 bp
  • T to C, chromosome 7 at 29,059,695 bp
  • T to C, chromosome 7 at 30,907,083 bp
  • A to T, chromosome 7 at 86,171,576 bp
  • C to T, chromosome 7 at 104,553,335 bp
  • T to C, chromosome 7 at 140,849,248 bp
  • A to G, chromosome 9 at 27,063,416 bp
  • A to G, chromosome 9 at 67,272,689 bp
  • A to G, chromosome 9 at 95,754,745 bp
  • A to T, chromosome 10 at 60,308,036 bp
  • A to G, chromosome 10 at 88,160,937 bp
  • A to T, chromosome 10 at 88,553,277 bp
  • A to G, chromosome 10 at 99,110,098 bp
  • A to G, chromosome 11 at 67,194,611 bp
  • C to T, chromosome 11 at 83,214,914 bp
  • A to T, chromosome 12 at 7,987,796 bp
  • T to C, chromosome 13 at 99,954,676 bp
  • A to T, chromosome 15 at 16,823,423 bp
  • T to C, chromosome 15 at 91,235,802 bp
  • C to A, chromosome 17 at 36,907,791 bp
  • T to G, chromosome 18 at 5,049,323 bp
  • A to G, chromosome 18 at 37,732,085 bp
  • C to T, chromosome 18 at 58,572,058 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6441 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044579-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.