Strain Name:
C57BL/6J-MtgxR6451Btlr/Mmmh
Stock Number:
044587-MU
Citation ID:
RRID:MMRRC_044587-MU
Other Names:
R6451 (G1)
Major Collection:

Strain Information

Grin3a
Name: glutamate receptor ionotropic, NMDA3A
Synonyms: NR3A, NMDAR-L, A830097C19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242443
Homologene: 128613
Llgl2
Name: LLGL2 scribble cell polarity complex component
Synonyms: 9130006H11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217325
HGNC: HGNC:6629
Homologene: 3323
Carmil1
Name: capping protein regulator and myosin 1 linker 1
Synonyms: Lrrc16, 1110037D04Rik, Carmil, Lrrc16a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68732
Homologene: 9757
Ttc5
Name: tetratricopeptide repeat domain 5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219022
VEGA: 14
Homologene: 14397
Nsmce4a
Name: NSE4 homolog A, SMC5-SMC6 complex component
Synonyms: 2410003A14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67872
Homologene: 9745
Rnf216
Name: ring finger protein 216
Synonyms: F830018F18Rik, UIP83, Ubce7ip1, 2810055G22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108086
Homologene: 19442
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195018
Homologene: 9027
Son
Name: Son DNA binding protein
Synonyms: 2900011L12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20658
Homologene: 10551
Bbs9
Name: Bardet-Biedl syndrome 9
Synonyms: EST 3159894, E130103I17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319845
Homologene: 44480
Adam17
Name: a disintegrin and metallopeptidase domain 17
Synonyms: CD156b, Tace
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11491
HGNC: HGNC:195
Homologene: 2395
Samd8
Name: sterile alpha motif domain containing 8
Synonyms: Smsr, 1700010P07Rik, 1110053F04Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67630
Homologene: 41670
Dph1
Name: diphthamide biosynthesis 1
Synonyms: Dph2l1, Ovca1, 4930488F09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 116905
HGNC: HGNC:3003
Homologene: 1059
Tmc2
Name: transmembrane channel-like gene family 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 192140
Homologene: 25877
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: E030034C22Rik, Dnahc1, G1-415-19, MDHC7, ferf1, B230373P09Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Myo7a
Name: myosin VIIA
Synonyms: nmf371, polka, Myo7, Hdb, USH1B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17921
HGNC: HGNC:7606
Homologene: 219
Pigo
Name: phosphatidylinositol glycan anchor biosynthesis, class O
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56703
Homologene: 31761
Adgrf5
Name: adhesion G protein-coupled receptor F5
Synonyms: 8430401C09Rik, Gpr116
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224792
VEGA: 17
Homologene: 9065
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: Spna1, ihj, erythroid, Spna-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20739
Homologene: 74460
Intu
Name: inturned planar cell polarity protein
Synonyms: Pdzk6, 9230116I04Rik, 9430087H23Rik, Pdzd6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 380614
Homologene: 41059
Arhgap29
Name: Rho GTPase activating protein 29
Synonyms: 6720461J18Rik, B130017I01Rik, C76601, Parg1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214137
Homologene: 3539
Efcab7
Name: EF-hand calcium binding domain 7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230500
Homologene: 19952
Vmn1r179
Name: vomeronasal 1 receptor 179
Synonyms: V1rd17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404286
Homologene: 134022
Acnat2
Name: acyl-coenzyme A amino acid N-acyltransferase 2
Synonyms: C730036D15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 209186
Homologene: 28287
Phactr1
Name: phosphatase and actin regulator 1
Synonyms: Rpel1, 9630030F18Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218194
Homologene: 33597
Fbln2
Name: fibulin 2
Synonyms: 5730577E14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14115
HGNC: HGNC:3601
Homologene: 1514
Or5w20
Name: olfactory receptor family 5 subfamily W member 20
Synonyms: MOR177-7, Olfr1153, GA_x6K02T2Q125-49395950-49396882
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258633
Homologene: 27230
Zfp944
Name: zinc finger protein 944
Synonyms: 6330416L07Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 319615
VEGA: 17
Homologene: 133237
Spata7
Name: spermatogenesis associated 7
Synonyms: B230306G18Rik, HSD3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104871
Homologene: 10189
Arhgef40
Name: Rho guanine nucleotide exchange factor 40
Synonyms: E130112L23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268739
Homologene: 19560
Akr1d1
Name: aldo-keto reductase family 1, member D1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 208665
HGNC: HGNC:388
Homologene: 55943
Rnf19a
Name: ring finger protein 19A
Synonyms: XY body protein, Dorfin, Rnf19, XYbp
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 30945
VEGA: 15
Homologene: 8501
Or6c69c
Name: olfactory receptor family 6 subfamily C member 69C
Synonyms: Olfr822, GA_x6K02T2PULF-11745102-11746040, MOR113-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258666
Homologene: 133890
Hivep3
Name: human immunodeficiency virus type I enhancer binding protein 3
Synonyms: Shn3, E030045D18Rik, Krc, 2900056N03Rik, Schnurri-3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16656
Homologene: 7803
Esp18
Name: exocrine gland secreted peptide 18
Synonyms: Gm20579
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100126774
VEGA: 17
Abca7
Name: ATP-binding cassette, sub-family A member 7
Synonyms: Abc51
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 27403
HGNC: HGNC:37
Homologene: 22783
Taar3
Name: trace amine-associated receptor 3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 493809
HGNC: HGNC:4513
Homologene: 117490
Tox3
Name: TOX high mobility group box family member 3
Synonyms: 500-9, Tnrc9, CAGF9
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244579
Homologene: 18257
Gm15922
Name: predicted gene 15922
Type: Gene
Species: Mouse
Chromosome: 7
Tas2r107
Name: taste receptor, type 2, member 107
Synonyms: STC 5-1, mt2r43, T2R4, T2R07, Tas2r7, mGR06
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387342
Homologene: 137369
Cnep1r1
Name: CTD nuclear envelope phosphatase 1 regulatory subunit 1
Synonyms: Tmem188, 5033428A16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382030
Homologene: 14472
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 150,992,919 bp
  • G to A, chromosome 1 at 174,217,201 bp
  • T to C, chromosome 2 at 87,896,591 bp
  • A to G, chromosome 2 at 130,264,203 bp
  • T to A, chromosome 3 at 40,701,293 bp
  • T to A, chromosome 3 at 121,993,581 bp
  • G to A, chromosome 4 at 43,021,412 bp
  • A to G, chromosome 4 at 49,380,262 bp
  • C to T, chromosome 4 at 49,844,969 bp
  • T to A, chromosome 4 at 99,831,501 bp
  • T to A, chromosome 4 at 120,098,908 bp
  • G to T, chromosome 5 at 142,992,834 bp
  • G to A, chromosome 6 at 37,550,215 bp
  • T to A, chromosome 6 at 91,234,259 bp
  • T to A, chromosome 6 at 131,660,014 bp
  • C to G, chromosome 7 at 3,737,320 bp
  • A to G, chromosome 7 at 23,928,651 bp
  • C to T, chromosome 7 at 98,073,167 bp
  • G to T, chromosome 7 at 130,542,749 bp
  • A to G, chromosome 8 at 88,119,810 bp
  • C to A, chromosome 8 at 90,258,059 bp
  • A to G, chromosome 9 at 22,567,764 bp
  • A to T, chromosome 10 at 23,949,807 bp
  • T to A, chromosome 10 at 80,006,899 bp
  • A to T, chromosome 10 at 130,075,138 bp
  • A to T, chromosome 11 at 72,923,156 bp
  • G to T, chromosome 11 at 75,181,317 bp
  • G to A, chromosome 11 at 115,844,941 bp
  • A to T, chromosome 12 at 21,342,882 bp
  • T to A, chromosome 12 at 98,658,337 bp
  • T to A, chromosome 13 at 24,092,558 bp
  • T to A, chromosome 13 at 43,132,993 bp
  • T to C, chromosome 14 at 21,783,798 bp
  • T to A, chromosome 14 at 31,300,808 bp
  • A to G, chromosome 14 at 50,767,207 bp
  • G to A, chromosome 14 at 52,000,999 bp
  • A to G, chromosome 15 at 36,253,059 bp
  • T to A, chromosome 16 at 91,657,602 bp
  • T to C, chromosome 17 at 22,338,865 bp
  • G to T, chromosome 17 at 39,409,962 bp
  • A to T, chromosome 17 at 43,424,818 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6451 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044587-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.